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Journal Articles

Posttranslational Changes in Histone Modification Driven By USP48 Loss Increase Sensitivity to Hypomethylating Agents in Acute Myeloid Leukemia

Constanze Schneider, Gabriela Alexe, Ashleigh Meyer, Lucy A Merickel, Allen T Basanthakumar, Audrey Taillon, Silvi Salhotra, Yara Rodriguez, Björn Häupl, David E. Root, Thomas Oellerich, Kimberly Stegmaier
Journal: Blood
Blood (2024) 144 (Supplement 1): 205.
https://doi.org/10.1182/blood-2024-206333
Published: 2024
Journal Articles

Riboflavin Drives Nucleotide Biosynthesis and Iron-Sulfur Metabolism to Promote Acute Myeloid Leukemia

Stefan Bjelosevic, Rahel Fauth, Brian T Do, Gabriela Alexe, Birgitta Ryback, Allen T Basanthakumar, Lucy A Merickel, Silvi Salhotra, Audrey Taillon, Thomas D Jackson, Giulia DiGiovanni, Muhammad Bin Munim, Ryan Elbashir, Shan Lin, Pere Puigserver, David E. Root, Matthew G Vander Heiden, Kimberly Stegmaier
Journal: Blood
Blood (2024) 144 (Supplement 1): 626.
https://doi.org/10.1182/blood-2024-208370
Published: 2024
Journal Articles

ADAR1 Is a Vulnerability in TP53 -Mutant Acute Myeloid Leukemia

Yara Rodriguez, Gabriela Alexe, Audrey Taillon, Constanze Schneider, Kimberly Stegmaier
Journal: Blood
Blood (2024) 144 (Supplement 1): 2717.
https://doi.org/10.1182/blood-2024-208594
Published: 2024
Journal Articles

The Splicing-Associated Network PAK1-Clk-SRRM1 Is a Critical Vulnerability to Overcome Chemoresistance in Acute Myeloid Leukemia

Camille Vaganay, Frank Ling, Lois M. Kelly, Duong Ho Nhat, Antoine Forget, Paul-Arthur Meslin, Hélène Pasquer, Rathana Kim, Marie Passet, Sofiane Fodil, Tony Huynh, Angela H Su, Christopher F Bassil, Matthieu Duchmann, Gabriela Alexe, Gael Fortin, Carine Legrand, Khansa Saadallah, Christopher Delaney, Kim Pacchiardi, Anja Kocijancic, Lisa Aziez, Nina Fenouille, Marie Sebert, Lionel Ades, Emmanuel Raffoux, Emmanuelle Clappier, Lina Benajiba, Kimberly Stegmaier, Kris C. Wood, Raphael Itzykson, Camille Lobry, Alexandre Puissant
Journal: Blood
Blood (2023) 142 (Supplement 1): 409.
https://doi.org/10.1182/blood-2023-186264
Published: 2023
Journal Articles

The UBE2J2/UBE2K-MARCH5 Ubiquitination Machinery Regulates Apoptosis in Response to Venetoclax in Acute Myeloid Leukemia

Constanze Schneider, Shan Lin, Angela H Su, Gabriela Alexe, Kimberly Stegmaier
Journal: Blood
Blood (2023) 142 (Supplement 1): 2785.
https://doi.org/10.1182/blood-2023-182312
Published: 2023
Journal Articles

Combining Menin and MEK Inhibition to Target Poor Prognostic KMT2A -Rearranged RAS Pathway-Mutant Acute Leukemia

Nastassja Scheidegger, Gabriela Alexe, Delan Khalid, Rhonda E Ries, Jim Wang, Todd A. Alonzo, Jennifer Perry, Scott A Armstrong, Soheil Meshinchi, Yana Pikman, Kimberly Stegmaier
Journal: Blood
Blood (2023) 142 (Supplement 1): 166.
https://doi.org/10.1182/blood-2023-185561
Published: 2023
Journal Articles

Identifying Targeted Therapies for CBFA2T3 - GLIS2 Acute Myeloid Leukemia

Fanny Gonzales, Shan Lin, Delan Khalid, Jana M Ellegast, Gabriela Alexe, Kimberly Stegmaier
Journal: Blood
Blood (2023) 142 (Supplement 1): 4174.
https://doi.org/10.1182/blood-2023-187187
Published: 2023
Journal Articles

Functional Dissection of Cellular Programs to Uncover Novel Gene Dependencies in AML

Jana M Ellegast, Gabriela Alexe, Subha Baniya, Amanda Hamze, Audrey Taillon, Biniam Adane, Amy Saur Conway, Tinghu Zhang, Nathanael S Gray, Scott A Armstrong, Kimberly Stegmaier
Journal: Blood
Blood (2023) 142 (Supplement 1): 1393.
https://doi.org/10.1182/blood-2023-189304
Published: 2023
Journal Articles

Proteomic Characterization of Acute Myeloid Leukemia

Sebastian Wolf, Ashok Kumar Jayavelu, Florian Buettner, Gabriela Alexe, Björn Häupl, Constanze Schneider, Anne C Wilke, Alena Zindel, Dominique Jahn, Bianca Splettstoesser, Julius Christoph Enssle, Anjali Cremer, Christoph Röllig, Christian Thiede, Björn Steffen, Martin Bornhäuser, Henning Urlaub, Kimberly Stegmaier, Hubert Serve, Matthias Mann, Thomas Oellerich
Journal: Blood
Blood (2022) 140 (Supplement 1): 3456–3457.
https://doi.org/10.1182/blood-2022-169242
Published: 2022
Journal Articles

Breaking the Pump: Targeting the Sodium-Potassium Pump As a Therapeutic Strategy in Acute Myeloid Leukemia

Constanze Schneider, Hermes Spaink, Gabriela Alexe, Neekesh V. Dharia, Ashleigh Meyer, Delan Khalid, Sebastian Scheich, Björn Häupl, Louis M. Staudt, Thomas Oellerich, Kimberly Stegmaier
Journal: Blood
Blood (2022) 140 (Supplement 1): 4936–4937.
https://doi.org/10.1182/blood-2022-168226
Published: 2022
Journal Articles

DHODH: A Promising New Therapeutic Target in Pediatric T-ALL

Amy N Sexauer, Gabriela Alexe, Varsha Gandhi, Kimberly Stegmaier, David Sykes
Journal: Blood
Blood (2022) 140 (Supplement 1): 7795–7797.
https://doi.org/10.1182/blood-2022-167569
Published: 2022
Journal Articles

Mechanisms of the CBFA2T3-GLIS2 Fusion in AML Maintenance

Fanny C Gonzales, Shan Lin, Delan Khalid, Jana M Ellegast, Gabriela Alexe, Kimberly Stegmaier
Journal: Blood
Blood (2022) 140 (Supplement 1): 5864–5865.
https://doi.org/10.1182/blood-2022-166664
Published: 2022
Journal Articles

Unleashing Cell-Intrinsic Inflammation As a Strategy to Kill AML Blasts

Jana M Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Maxim Pimkin, Linda Ross, Neekesh V Dharia, Amanda L Robinchaud, Amy Conway, Delan Khalid, Mark Wunderlich, Lina Benajiba, Behnam Nabet, Nathanael S Gray, Stuart H. Orkin, Kimberly Stegmaier
Journal: Blood
Blood (2021) 138 (Supplement 1): 3305.
https://doi.org/10.1182/blood-2021-151511
Published: 2021
Journal Articles

SLC5A3 Transports Myo-Inositol to Support the Growth of Acute Myeloid Leukemia

Shan Lin, Nastassja K. Scheidegger, Gabriela Alexe, Bo Kyung A. Seong, Neekesh V Dharia, Caroline Wechsler, Guillaume Kugener, Amanda L Robinchaud, Amy Conway, Biniam Adane, Scott Younger, Federica Piccioni, Lynn Lee, Mark Wunderlich, Kimberly Stegmaier
Journal: Blood
Blood (2021) 138 (Supplement 1): 3319.
https://doi.org/10.1182/blood-2021-152023
Published: 2021
Journal Articles

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Angela Su, Frank Ling, Camille Vaganay, Bryann Pardieu, Lina Benajiba, MD/PhD, Gaetano Sodaro, Justine Pasanisi, Kevin H Lin, BS, Justine Rutter, PhD, Christopher F. Bassil, Iléana Antony-Debre, PhD, Gabriela Alexe, PhD, Jean-François Benoist, MD, Yana Pikman, MD, Jun Qi, PhD, Herve Dombret, MD PhD, Claude Preudhomme, PharmD, PhD, Nina Fenouille, Hava M. Golan, Kimberly Stegmaier, MD, Camille Lobry, Kris C Wood, PhD, Raphael Itzykson, Alexandre Puissant, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 877.
https://doi.org/10.1182/blood-2019-131255
Published: 2019
Journal Articles

Resistance Mechanisms to SYK Inhibition in AML

Anjali Cremer, MD, Jana M Ellegast, MD, Yana Pikman, MD, Gabriela Alexe, PhD, Linda Ross, PhD, Amy Goodale, Federica Piccioni, PhD, Elizabeth S Frank, Thomas Oellerich, MD, Kimberly Stegmaier, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2638.
https://doi.org/10.1182/blood-2018-99-114996
Published: 2018
Journal Articles

Creatine Kinase Pathway Inhibition Alters GSK3 and WNT Signaling in EVI1-Positive Acute Myeloid Leukemia

Lina Benajiba, Gabriela Alexe, Olivier Hermine, MD PhD, Michael Hemann, Alexandre Puissant, Kimberly Stegmaier, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1191.
https://doi.org/10.1182/blood.V130.Suppl_1.1191.1191
Published: 2017
Journal Articles

Exploiting an Asp-Glu "Switch" in Glycogen Synthase Kinase 3 to Design Paralog Selective Inhibitors for Acute Myeloid Leukemia Treatment

Lina Benajiba, Florence Wagner, PhD, Arthur Campbell, Michel Weiwer, Sacher Joshua, Jennifer Gale, Linda Ross, Alexandre Puissant, Gabriela Alexe, Amy Conway, Morgan Back, Yana Pikman, MD, Ilene Galinsky, Daniel J. DeAngelo, MD, Richard M. Stone, MD, Taner Kaya, Xi Shi, Matthew Robers, Thomas Machleidt, Olivier Hermine, MD PhD, Andrew L. Kung, MD PhD, Adam Stein, Michael Hemann, Edward Scolnick, Yan-Ling Zhang, Jen Pan, Edward Holson, Kimberly Stegmaier, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2075.
https://doi.org/10.1182/blood.V130.Suppl_1.2075.2075
Published: 2017
Journal Articles

The Activated TGFβ Pathway in Shwachman Diamond Syndrome Impairs Hematopoiesis and Is Down-Regulated By Deletion of 7q

Melisa Ruiz-Gutierrez, MD PhD, Cailin Joyce, PhD, Ozge Vargel Bolukbasi, PhD, Andriana Kotini, PhD, Gabriela Alexe, Jennifer Whangbo, MD PhD, David Russell, MDPhD, Kimberly Stegmaier, MD, Carl D. Novina, MD PhD, Eirini P. Papapetrou, MD PhD, Akiko Shimamura, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 875.
https://doi.org/10.1182/blood.V130.Suppl_1.875.875
Published: 2017
Journal Articles

Vcp-Regulated Homologous Recombination Represents a New Druggable Vulnerability in Acute Myeloid Leukemia

Lina Benajiba, Nina Fenouille, Edyta Malolepsza, Jana M Ellegast, MD, Gabriela Alexe, Yana Pikman, MD, Frédéric Luciano, Ilene Galinsky, Daniel J. DeAngelo, MD, Richard M. Stone, MD, Patrick Auberger, PhD, Josee Guirouilh-Barbat, Bernard Lopez, Mehdi Khaled, Kasper Lage, Olivier Hermine, MD PhD, Michael Hemann, Alexandre Puissant, Kimberly Stegmaier, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 880.
https://doi.org/10.1182/blood.V130.Suppl_1.880.880
Published: 2017