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Stuart H. Orkin
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Journal Articles

Polycomb Repressive Complex 2 Regulates Differentiation-Stage-Specific Autophagy Gene Expression and Safeguards Normal Erythropoiesis

Jiazhuo Li, Panpan Zhu, Zhiling Shi, Longping Wen, Stuart H Orkin, Huafeng Xie
Journal: Blood
Blood (2024) 144 (Supplement 1): 538.
https://doi.org/10.1182/blood-2024-209436
Published: 2024
Journal Articles

Blood Flow Directs Yap/Taz-Mediated Transcriptional Regulation of Self-Renewal Programs to Control Developmental HSPC Expansion By Mechanical Stimulation of Piezo1

Wade W Sugden, Zachary LeBlanc, Mayuri Tanaka-Yano, Ran Jing, Maria Gonzalez di Tillio, Mohamad Najia, Yang Tang, Elizabeth Molnar, Stephan George, Brittney Love, Caroline Kubaczka, Nan Liu, Nah-Young Shin, Thorsten M. Schlaeger, Edroaldo Lummertz da Rocha, Alan B. Cantor, Stuart H Orkin, Robert Grant Rowe, Wolfram Goessling, George Q. Daley, Trista E. North
Journal: Blood
Blood (2023) 142 (Supplement 1): 1309.
https://doi.org/10.1182/blood-2023-190416
Published: 2023
Journal Articles

Dynamic Expression of Erg Controls Fetal-to-Adult Maturation of the Hematopoietic System

Mayuri Tanaka-Yano, Dahai Wang, Diana Chen, Biju Isaac, Tianxin Scarlett Liu, Liang Sun, Edroaldo Lummertz da Rocha, Berkley Gryder, Stuart H Orkin, Robert Grant Rowe
Journal: Blood
Blood (2023) 142 (Supplement 1): 2678.
https://doi.org/10.1182/blood-2023-181089
Published: 2023
Journal Articles

Tetramer Formation of BCL11A Is Required for Both Protein Stability and Fetal Hemoglobin Silencing

Ge Zheng, Stuti Mehta, Maolu Yin, Linus Marx, Altantsetseq Buyanbat, Karin Tenglin, Benjamin Sewell-Grossman, Jiyoung Hong, Stuart H Orkin
Journal: Blood
Blood (2023) 142 (Supplement 1): 554.
https://doi.org/10.1182/blood-2023-175042
Published: 2023
Journal Articles

Rapid-Kinetics Degron Benchmarking Reveals Off-Target Activities and Mixed Agonism-Antagonism of MYB Inhibitors

Taku Harada, Monika Perez, Jeremie Kalfon, Rashad Batley, Flora Dievenich Braes, Stuart H Orkin, Maxim Pimkin
Journal: Blood
Blood (2023) 142 (Supplement 1): 3638.
https://doi.org/10.1182/blood-2023-186841
Published: 2023
Journal Articles

Targeting a Putative Intronic Splicing Silencer Salvages Expression from the Recurrent SBDS C.258+2T>C Mutant Allele in Shwachman-Diamond Syndrome Patient Cells and Mouse Model

Michael J. Peters, Anna Deck, April Hu, Yuko Fujiwara, Jinkuk Kim, Aubrie Soucy, Kevin Zhang, Julianna Kenny, Linda Y. Lin, Alyssa L. Kennedy, Caitlin Bowers, Chad E. Harris, Chi Yuan Zhang, Karthik Ponnienselvan, Pengpeng Liu, Kevin Luk, Davide Seruggia, R. Coleman Lindsley, John P. Manis, Christian Brendel, Scot A. Wolfe, Stuart H. Orkin, Timothy Yu, Akiko Shimamura, Daniel E. Bauer
Journal: Blood
Blood (2022) 140 (Supplement 1): 2944–2945.
https://doi.org/10.1182/blood-2022-169379
Published: 2022
Journal Articles

Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1

Leif S. Ludwig, Caleb A. Lareau, Erik L. Bao, Nan Liu, Taiju Utsugisawa, Alex M. Tseng, Samuel A. Myers, Jeffrey M. Verboon, Jacob C. Ulirsch, Wendy Luo, Christoph Muus, Claudia Fiorini, Meagan E. Olive, Christopher M. Vockley, Mathias Munschauer, Abigail Hunter, Hiromi Ogura, Toshiyuki Yamamoto, Hiroko Inada, Shinichiro Nakagawa, Shuichi Ohzono, Vidya Subramanian, Roberto Chiarle, Bertil Glader, Steven A. Carr, Martin J. Aryee, Anshul Kundaje, Stuart H. Orkin, Aviv Regev, Timothy L. McCavit, Hitoshi Kanno, Vijay G. Sankaran
Journal: Blood
Blood (2022) 139 (16): 2534–2546.
https://doi.org/10.1182/blood.2021013753
Published: 2022
Includes: Supplemental data
Journal Articles

Lin28b- Let-7 -PRC1 Axis Guides Developmental Maturation of the Hematopoietic System

Mayuri Tanaka-Yano, Dahai Wang, Eleanor Meader, Melissa A. Kinney, Vivian Morris, Edroaldo Lummertz da Rocha, Nan Liu, Stuart H. Orkin, Trista E. North, George Q. Daley, Robert Grant Rowe
Journal: Blood
Blood (2021) 138 (Supplement 1): 21.
https://doi.org/10.1182/blood-2021-146004
Published: 2021
Journal Articles

Inner Nuclear Protein Matrin-3 Coordinates Hematopoietic Cell Transcription and Differentiation By Stabilizing Chromatin Architecture

Hye Ji Cha, Özgün Uyan, Job Dekker, Stuart H. Orkin
Journal: Blood
Blood (2021) 138 (Supplement 1): 285.
https://doi.org/10.1182/blood-2021-151070
Published: 2021
Journal Articles

Unleashing Cell-Intrinsic Inflammation As a Strategy to Kill AML Blasts

Jana M Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Maxim Pimkin, Linda Ross, Neekesh V Dharia, Amanda L Robinchaud, Amy Conway, Delan Khalid, Mark Wunderlich, Lina Benajiba, Behnam Nabet, Nathanael S Gray, Stuart H. Orkin, Kimberly Stegmaier
Journal: Blood
Blood (2021) 138 (Supplement 1): 3305.
https://doi.org/10.1182/blood-2021-151511
Published: 2021
Journal Articles

Transcriptional Immunoediting of AML Cells after Allogeneic Hematopoietic Stem Cell Transplantation

Kenneth Eagle, Taku Harada, Jeremie Kalfon, Monika Perez, Yaser Heshmati, Jazmin Ewers, Kimberly Stegmaier, Stuart H. Orkin, Maxim Pimkin
Journal: Blood
Blood (2021) 138 (Supplement 1): 647.
https://doi.org/10.1182/blood-2021-151180
Published: 2021
Journal Articles

Core Transcriptional Regulatory Circuitries in AML

Maxim Pimkin, MD PhD, Juliana Xavier Ferrucio, PhD, Neekesh Vijay Dharia, MD PhD, Taku Harada, Andrew Kossenkov, Selma Elsarrag, Jazmin Ewers, Charles Y Lin, PhD, Kimberly Stegmaier, MD, Stuart H. Orkin, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 280.
https://doi.org/10.1182/blood-2019-129297
Published: 2019
Journal Articles

Control of Human Hemoglobin Switching By LIN28B-Mediated Regulation of BCL11A Translation

Anindita Basak, PhD, Mathias Munschauer, PhD, Jacob C. Ulirsch, BS, Kara E. Montbleau, Christina R. Hartigan, BS, Monica Schenone, PhD, John Lian, PhD, Yaomei Wang, Yumin Huang, Xianfang Wu, Lee Gehrke, Charles M. Rice, Xiuli An, MD PhD, Helen A. Christou, Mohandas Narla, DSc, Steven A. Carr, PhD, Stuart H. Orkin, MD, Jane-Jane Chen, PhD, Eric S. Lander, Vijay G. Sankaran, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 412.
https://doi.org/10.1182/blood-2018-99-117440
Published: 2018
Journal Articles

Optimized Beta-Globin Expression and Enucleation from Induced Red Blood Cells for In Vitro Modeling of Sickle Cell Disease

Tolulope O Rosanwo, BA, Melissa Kinney, PhD, Martha A Clark, PhD, Linda T Vo, PhD, R. Grant Rowe, MD PhD, Natasha M. Archer, MD, Matthew M Heeney, MD, Thorsten Schlaeger, PhD, Daniel E. Bauer, MD PhD, Mark D. Fleming, MD DPhil, Manoj T Duraisingh, PhD, Stuart H. Orkin, MD, Carlo Brugnara, MD, Trista North, PhD, George Q. Daley, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2359.
https://doi.org/10.1182/blood-2018-99-114136
Published: 2018
Journal Articles

PRC2 Inactivation Induces Resistance to Chemotherapy-Induced Apoptosis By Upregulating the TRAP1 Mitochondrial Chaperone in T-ALL

Kimberly Bodaar, MD, Ingrid M. Aries, PhD MSc, Salmaan Karim, Triona Ni Chonghaile, PhD BSc, Melissa A. Burns, MD, Laura Hinze, Maren Pfirrmann, James Degar, Jack Landrigan, Sebastian Balbach, Sofie Peirs, PhD, Bjorn Menten, PhD, Kristen E. Stevenson, MS, Donna S Neuberg, ScD, Meenakshi Devidas, PhD, Mignon L. Loh, MD, Stephen P. Hunger, MD, David T Teachey, MD, Karen R. Rabin, MD PhD, Stuart S. Winter, MD, Kimberly P. Dunsmore, MD, Brent Wood, MD PhD, Lewis B. Silverman, MD, Stephen E. Sallan, MD, Pieter Van Vlierberghe, PhD, Stuart H. Orkin, MD, Birgit Knoechel, MDPhD, Anthony Letai, MD PhD, Alejandro Gutierrez, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 889.
https://doi.org/10.1182/blood-2018-99-113518
Published: 2018
Journal Articles

Rational Targeting of a NuRD Sub-Complex for Fetal Hemoglobin Induction Following Comprehensive in Situ Mutagenesis

Mir Hossain, PhD, Falak Sher, PhD, Davide Seruggia, PhD, Vivien Schoonenberg, BS, Mitchel A. Cole, BS, Paolo Cifani, PhD, Laura Dassama, PhD, Claudio Macias-Trevino, BS, Matthew C. Canver, MD PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Luca Pinello, PhD, Takahiro Maeda, MD PhD, Alex Kentsis, MD PhD, Stuart H. Orkin, MD, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2342.
https://doi.org/10.1182/blood-2018-99-117043
Published: 2018
Journal Articles

Target of Erythropoietin, Fam210b , Regulates Erythroid Heme Synthesis By Control of Mitochondrial Iron Import and Regulation of Fech Activity

Yvette Y Yien, PhD, Jiahai Shi, PhD, Caiyong Chen, PhD, Jesmine Cheung, Anthony Grillo, PhD, Rishna Shrestha, Liangtao Li, PhD, Xuedi Zhang, Martin Daniel Kafina, MS, BA, Paul D. Kingsley, PhD, Matthew King, Julien Ablain, PhD, Leonard I. Zon, MD, James Palis, MD, Martin Burke, Daniel E. Bauer, MD PhD, Stuart H. Orkin, MD, Carla Koehler, PhD, John D. Phillips, PhD, Jerry Kaplan, PhD, Diane Ward, PhD, Harvey Lodish, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 849.
https://doi.org/10.1182/blood-2018-99-120299
Published: 2018
Journal Articles

Erythropoietin Signaling Regulates Heme Biosynthesis

Jacky Chung, PhD, Johannes G. Wittig, Alireza Ghamari, Manami Maeda, MD, PhD, Harvey Lodish, PhD, Daniel E. Bauer, MD, PhD, Stuart H. Orkin, MD, Alan B. Cantor, MD, PhD, Takahiro Maeda, MD PhD, Harry A. Dailey, PhD, Barry H. Paw, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 543.
https://doi.org/10.1182/blood.V128.22.543.543
Published: 2016
Journal Articles

Strict in vivo specificity of the Bcl11a erythroid enhancer

Brief Report
Elenoe C. Smith, Sidinh Luc, Donyell M. Croney, Mollie B. Woodworth, Luciano C. Greig, Yuko Fujiwara, Minh Nguyen, Falak Sher, Jeffrey D. Macklis, Daniel E. Bauer, Stuart H. Orkin
Journal: Blood
Blood (2016) 128 (19): 2338–2342.
https://doi.org/10.1182/blood-2016-08-736249
Published: 2016
Journal Articles

Interferon-α signaling promotes embryonic HSC maturation

Peter Geon Kim, Matthew C. Canver, Catherine Rhee, Samantha J. Ross, June V. Harriss, Ho-Chou Tu, Stuart H. Orkin, Haley O. Tucker, George Q. Daley
Journal: Blood
Blood (2016) 128 (2): 204–216.
https://doi.org/10.1182/blood-2016-01-689281
Published: 2016
Includes: Supplemental data