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Journal Articles

Rational Targeting of a NuRD Sub-Complex for Fetal Hemoglobin Induction Following Comprehensive in Situ Mutagenesis

Mir Hossain, PhD, Falak Sher, PhD, Davide Seruggia, PhD, Vivien Schoonenberg, BS, Mitchel A. Cole, BS, Paolo Cifani, PhD, Laura Dassama, PhD, Claudio Macias-Trevino, BS, Matthew C. Canver, MD PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Luca Pinello, PhD, Takahiro Maeda, MD PhD, Alex Kentsis, MD PhD, Stuart H. Orkin, MD, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2342.
https://doi.org/10.1182/blood-2018-99-117043
Published: 2018
Journal Articles

High-Resolution CRISPR Functional Genomics Reveals Critical Vulnerabilities of the NuRD Complex for Fetal Hemoglobin Control

Falak Sher, PhD, Vivien Schoonenberg, BS, Mitchel A. Cole, BS, Claudio Macias-Trevino, BS, Paolo Cifani, PhD, Patrick G Schupp, BS, Matthew C. Canver, BS, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Stuart Orkin, Alex Kentsis, MD PhD, Luca Pinello, PhD, Takahiro Maeda, MDPhD, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 286.
https://doi.org/10.1182/blood.V130.Suppl_1.286.286
Published: 2017
Journal Articles

Fetal Hemoglobin (HbF) Silencer BCL11A Acts through a Novel DNA-Motif in the Gamma-Globin Promoters, Simplifying the Model for Hemoglobin Switching

Nan Liu, PhD, Victoria V Hargreaves, PhD, Jiyoung Hong, PhD, Woojin Kim, PhD, Jesse Kurland, PhD, Qian Zhu, PhD, Falak Sher, PhD, Claudio Macias-Trevino, BS, Jill Rogers, PhD, Guo-Cheng Yuan, PhD, Daniel E. Bauer, MD PhD, Jian Xu, PhD, Martha L Bulyk, PhD, Stuart Orkin
Journal: Blood
Blood (2017) 130 (Supplement 1): 283.
https://doi.org/10.1182/blood.V130.Suppl_1.283.283
Published: 2017
Journal Articles

An Essential Erythroid-Specific Enhancer of ATP2B4 Associated with Red Blood Cell Traits and Malaria Susceptibility

Emily N Stern, B.S., Samuel Lessard, B.S., Patrick G. Schupp, B.S., Falak Sher, PhD, Guillaume Lettre, PhD, Daniel E. Bauer, MD, PhD
Journal: Blood
Blood (2016) 128 (22): 1250.
https://doi.org/10.1182/blood.V128.22.1250.1250
Published: 2016
Journal Articles

Strict in vivo specificity of the Bcl11a erythroid enhancer

Brief Report
Elenoe C. Smith, Sidinh Luc, Donyell M. Croney, Mollie B. Woodworth, Luciano C. Greig, Yuko Fujiwara, Minh Nguyen, Falak Sher, Jeffrey D. Macklis, Daniel E. Bauer, Stuart H. Orkin
Journal: Blood
Blood (2016) 128 (19): 2338–2342.
https://doi.org/10.1182/blood-2016-08-736249
Published: 2016
Journal Articles

The LRF/ZBTB7A Transcription Factor Is a BCL11A-Independent Repressor of Fetal Hemoglobin

Takeshi Masuda, PhD, Xin Wang, PhD, Manami Maeda, MD, PhD, Matthew C. Canver, B.S., Falak Sher, PhD, Alister P.W. Funnell, PhD, Chris Fisher, PhD, Maria Suciu, Gabriella E. Martyn, Laura J. Norton, Ruijia Zhu, Ryo Kurita, PhD, Yukio Nakamura, MD, PhD, Jian Xu, PhD, Douglas R. Higgs, FRS, Merlin Crossley, DPhil, Daniel E. Bauer, MD, PhD, Stuart H. Orkin, MD, Peter V. Kharchenko, PhD, Takahiro Maeda, MD, PhD
Journal: Blood
Blood (2015) 126 (23): 2.
https://doi.org/10.1182/blood.V126.23.2.2
Published: 2015
Journal Articles

Crispr-Cas9 Saturating Mutagenesis Reveals an Achilles Heel in the BCL11A Erythroid Enhancer for Fetal Hemoglobin Induction (by Genome Editing)

Daniel E. Bauer, MD, PhD, Matthew C. Canver, B.S., Elenoe C. Smith, PhD, Falak Sher, PhD, Luca Pinello, PhD, Neville E. Sanjana, PhD, Ophir Shalem, PhD, Diane D. Chen, B.S., Patrick G. Schupp, B.S., Divya S. Vinjamur, PhD, Sara P. Garcia, PhD, Sidinh Luc, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD, PhD, Yuko Fujiwara, PhD, Takahiro Maeda, MD, PhD, Guo-Cheng Yuan, PhD, Guillaume Lettre, PhD, Feng Zhang, PhD, Stuart H. Orkin, MD
Journal: Blood
Blood (2015) 126 (23): 638.
https://doi.org/10.1182/blood.V126.23.638.638
Published: 2015