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Stuart Orkin
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Journal Articles

Genome-Wide CRISPR/Cas9 Screen Reveals That the Dcps Scavenger Decapping Enzyme Is Essential for AML Cell Survival

Takuji Yamauchi, MDPhD, Takeshi Masuda, PhD, Matthew C. Canver, BS, Michael Seiler, PhD, Mohammad Shboul, Manami Maeda, MDPhD, Vivien Schoonenberg, BS, Mitchel A. Cole, BS, Claudio Macias-Trevino, BS, Yuichiro Semba, MD, Yuichi Ishikawa, MD PhD, Michitaka Nakano, MD, Fumio Arai, PhD, Stuart Orkin, Bruno Reversade, Silvia Buonamici, PhD, Luca Pinello, PhD, Koichi Akashi, MD PhD, Daniel E. Bauer, MD PhD, Takahiro Maeda, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 782.
https://doi.org/10.1182/blood.V130.Suppl_1.782.782
Published: 2017
Journal Articles

High-Resolution CRISPR Functional Genomics Reveals Critical Vulnerabilities of the NuRD Complex for Fetal Hemoglobin Control

Falak Sher, PhD, Vivien Schoonenberg, BS, Mitchel A. Cole, BS, Claudio Macias-Trevino, BS, Paolo Cifani, PhD, Patrick G Schupp, BS, Matthew C. Canver, BS, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Stuart Orkin, Alex Kentsis, MD PhD, Luca Pinello, PhD, Takahiro Maeda, MDPhD, Daniel E. Bauer, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 286.
https://doi.org/10.1182/blood.V130.Suppl_1.286.286
Published: 2017
Journal Articles

Fetal Hemoglobin (HbF) Silencer BCL11A Acts through a Novel DNA-Motif in the Gamma-Globin Promoters, Simplifying the Model for Hemoglobin Switching

Nan Liu, PhD, Victoria V Hargreaves, PhD, Jiyoung Hong, PhD, Woojin Kim, PhD, Jesse Kurland, PhD, Qian Zhu, PhD, Falak Sher, PhD, Claudio Macias-Trevino, BS, Jill Rogers, PhD, Guo-Cheng Yuan, PhD, Daniel E. Bauer, MD PhD, Jian Xu, PhD, Martha L Bulyk, PhD, Stuart Orkin
Journal: Blood
Blood (2017) 130 (Supplement 1): 283.
https://doi.org/10.1182/blood.V130.Suppl_1.283.283
Published: 2017
Journal Articles

Reawakening of Human Fetal Hemoglobin and an Epigenetic Path to the Clinic for Sickle Cell Disease and Beta-Thalassemia: Identification of an Orally-Available, Potent, and Selective Euchromatic Histone Lysine Methyltransferase 1 and 2 (EHMT1/2) Inhibitor

Elayne Chan-Penebre, Veronica Gibaja, John Campbell, Ogunbodede Olu, Elizabeth Admirand, Dorothy Brach, Cuyue Tang, Alejandra Raimondi, Tami Hood, Alexis Cocozaki, Sule Karaman, Kimberly Stickland, Christopher Plescia, Michael Munchhof, Kelli Armstrong, Thomas Riera, Stuart Orkin, Ann Boriack-Sjodin, William Janzen, Stephen Blakemore, Scott A Ribich, Richard Chesworth, Jesse J Smith, Kenneth W Duncan
Journal: Blood
Blood (2017) 130 (Supplement 1): 537.
https://doi.org/10.1182/blood.V130.Suppl_1.537.537
Published: 2017