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Journal Articles

Retrotransposon Reactivation in Mesenchymal Stromal Cells Promotes Clonal Expansion of Dnmt3a -Mutated HSCs

Qiongdi Zhang, Joshua Theriot, Donghong Cai, Jian Xu, Sisi Zheng
Journal: Blood
Blood (2024) 144 (Supplement 1): 1303.
https://doi.org/10.1182/blood-2024-212199
Published: 2024
Journal Articles

Context matters: role of ATF4 in hematopoiesis

Junhua Lyu, Jian Xu
Journal: Blood
Blood (2024) 144 (7): 684–686.
https://doi.org/10.1182/blood.2024025066
Published: 2024
Journal Articles

Structural variation cooperates with permissive chromatin to control enhancer hijacking–mediated oncogenic transcription

Giovanni A. Botten, Yuannyu Zhang, Kseniia Dudnyk, Yoon Jung Kim, Xin Liu, Jacob T. Sanders, Aygun Imanci, Nathalie Droin, Hui Cao, Pranita Kaphle, Kathryn E. Dickerson, Kirthi R. Kumar, Mingyi Chen, Weina Chen, Eric Solary, Peter Ly, Jian Zhou, Jian Xu
Journal: Blood
Blood (2023) 142 (4): 336–351.
https://doi.org/10.1182/blood.2022017555
Published: 2023
Includes: Supplemental data
Journal Articles

Epo-IGF1R cross talk expands stress-specific progenitors in regenerative erythropoiesis and myeloproliferative neoplasm

Hsi-Hsien Hsieh, Huiyu Yao, Yue Ma, Yuannyu Zhang, Xue Xiao, Helen Stephens, Naureen Wajahat, Stephen S. Chung, Lin Xu, Jian Xu, Raajit K. Rampal, Lily Jun-shen Huang
Journal: Blood
Blood (2022) 140 (22): 2371–2384.
https://doi.org/10.1182/blood.2022016741
Published: 2022
Includes: Supplemental data
Journal Articles

Targeting Cell Adhesion Molecules in IDH Mutant Myeloid Malignances

Junhua Lyu, Yuxuan Liu, Yuannyu Zhang, Feng Cai, Giovanni A. Botten, Hui Cao, Pranita Kaphle, Ralph J Deberardinis, Jian Xu
Journal: Blood
Blood (2022) 140 (Supplement 1): 8704–8705.
https://doi.org/10.1182/blood-2022-168313
Published: 2022
Journal Articles

High Mutational Burden of Chromatin-Modifying Genes Defines a Relatively Indolent Subgroup of Plasma Cell Dyscrasias

Xuezhu Wang, Bing Qiao, Yanying Yu, Jian Xu, Liping Zuo, Jia Chen, Hao Cai, Hong-xiao Han, Xin-xin Cao, Chunyan Sun, Jian Li
Journal: Blood
Blood (2022) 140 (Supplement 1): 12452–12453.
https://doi.org/10.1182/blood-2022-164477
Published: 2022
Journal Articles

Structural Variation Cooperates with Permissive Chromatin to Control Enhancer Hijacking-Mediated Oncogenic Transcription

Giovanni A. Botten, Yuannyu Zhang, Kseniia Dudnyk, Xin Liu, Jacob T. Sanders, Aygun Imanci, Nathalie Droin, Hui Cao, Pranita Kaphle, Kathryn E. Dickerson, Mingyi Chen, Weina Chen, Eric Solary, Peter Ly, Jian Zhou, Jian Xu
Journal: Blood
Blood (2022) 140 (Supplement 1): 1007–1008.
https://doi.org/10.1182/blood-2022-169565
Published: 2022
Journal Articles

Elucidating Mechanisms of Acquired Resistance to IDH Inhibition By Saturation Variant Screening of Base-Edited Leukemia Cells

Junhua Lyu, Yuxuan Liu, PhD, Hui Cao, MS, Mingyi Chen, MD PhD, Yazan F. Madanat, MD, Yuannyu Zhang, PhD, Zhimin Gu, PhD, Pranita Kaphle, MS, Kathryn E. Dickerson, MD, Paul Yenerall, PhD, Rahul Kollipara, PhD, Ralf Kittler, PhD, John Minna, MD, Weina Chen, MD PhD, Stephen Chung, MD, Robert H. Collins, MD, Xin Liu, PhD, Jian Xu, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3.
https://doi.org/10.1182/blood-2020-141433
Published: 2020
Journal Articles

Fto Promotes Extramedullary Progression of Multiple Myeloma By Regulation of HSF1 through m 6 a RNA Methylation

Aoshuang Xu, MD, Jiasi Zhang, MD, Liping Zuo, MD, Jian Xu, PhD, Xuejiao Yin, MD, Qianwen Cheng, MD, Yuyang Zhang, MD, Lei Chen, PhD, Fei Zhao, PhD, Fengjuan Fan, PhD, Yu Hu, Chunyan Sun, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3063.
https://doi.org/10.1182/blood-2019-125635
Published: 2019
Journal Articles

MiR-221/222 Promote Dexamethasone Resistance of Multiple Myeloma through Inhibition of Autophagy By Targeting ATG12

Jian Xu, MD, Yan Su, MD, Aoshuang Xu, MD, Fengjuan Fan, PhD, Haifan Huang, MD, Yu Hu, MD PhD, Chunyan Sun, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4469.
https://doi.org/10.1182/blood-2018-99-111637
Published: 2018
Journal Articles

GATA/Heme Multi-Omics Reveals a Trace Metal-Dependent Erythrocyte Developmental Mechanism

Nobuyuki Tanimura, PhD, Ruiqi Liao, PhD, Gary M Wilson, Matthew R Dent, Miao Cao, Judith N Burstyn, PhD, Peiman Hematti, MD, Xin Liu, PhD, Yuannyu Zhang, PhD, Ye Zheng, Sunduz Keles, PhD, Jian Xu, PhD, Joshua J Coon, PhD, Emery H Bresnick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 500.
https://doi.org/10.1182/blood-2018-99-115324
Published: 2018
Journal Articles

Acute Deletion of Tet2 or Tet3 Transiently Dysregulate Murine Erythropoiesis

Aishwarya Swaminathan, PhD, Daniel Hidalgo, MA, Hien Nguyen, Scott Shaffer, Maria Figueroa, Jian Xu, PhD, Merav Socolovsky, MBBS, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 11.
https://doi.org/10.1182/blood.V130.Suppl_1.11.11
Published: 2017
Journal Articles

Targeting the Epigenetic and Metabolic Vulnerabilities of Ezh2-Deficiency-Induced Myeloid Neoplasms

Zhimin Gu, PhD, Yuxuan Liu, PhD, Hui Cao, MS, Mingyi Chen, MD PhD, Yuannyu Zhang, PhD, Le Qi, Xin Liu, PhD, Kailong Li, PhD, Kathryn Dickerson, MD, Feng Cai, PhD, Weina Chen, MD PhD, Min Ni, PhD, Ralph Deberardinis, MD PhD, Jian Xu, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 380.
https://doi.org/10.1182/blood.V130.Suppl_1.380.380
Published: 2017
Journal Articles

Fetal Hemoglobin (HbF) Silencer BCL11A Acts through a Novel DNA-Motif in the Gamma-Globin Promoters, Simplifying the Model for Hemoglobin Switching

Nan Liu, PhD, Victoria V Hargreaves, PhD, Jiyoung Hong, PhD, Woojin Kim, PhD, Jesse Kurland, PhD, Qian Zhu, PhD, Falak Sher, PhD, Claudio Macias-Trevino, BS, Jill Rogers, PhD, Guo-Cheng Yuan, PhD, Daniel E. Bauer, MD PhD, Jian Xu, PhD, Martha L Bulyk, PhD, Stuart Orkin
Journal: Blood
Blood (2017) 130 (Supplement 1): 283.
https://doi.org/10.1182/blood.V130.Suppl_1.283.283
Published: 2017
Journal Articles

FANCD2 and HES1 Synergistically Regulate the Immunometabolism of Hematopoietic Stem Cells through Transcriptional Suppression of Pparg- mediated Fatty Acid Oxidation and Oxidative Phosphorylation

Limei Wu, MD PhD, Jian Xu, Ms, Ingrid Weterrins, Peter Mathers, PhD, Wei Du, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 712.
https://doi.org/10.1182/blood.V130.Suppl_1.712.712
Published: 2017
Journal Articles

In Situ Capture of the Molecular Composition of Erythroid Transcriptional Enhancers

Jian Xu, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): SCI-17.
https://doi.org/10.1182/blood.V130.Suppl_1.SCI-17.SCI-17
Published: 2017
Journal Articles

Mitochondria Coordinate Intracellular Metabolism and Epigenetic Gene Regulation during Erythropoiesis

Xin Liu, PhD, Yuannyu Zhang, PhD, Min Ni, PhD, Hui Cao, M.S., Robert Signer, PhD, Dan Li, B.S., Zhimin Gu, PhD, Zeping Hu, PhD, Navdeep Chandel, Ralph DeBerardinis, MD PhD, Feng Zhou, PhD, Zhen Shao, PhD, Jian Xu, PhD
Journal: Blood
Blood (2016) 128 (22): 1038.
https://doi.org/10.1182/blood.V128.22.1038.1038
Published: 2016
Journal Articles

Quantitative Proteomic and Transcriptomic Analysis Reveals Post-Transcriptional Regulation of Mitochondrial Biogenesis during Erythropoiesis

Xin Liu, PhD, Yuannyu Zhang, PhD, Feng Zhou, PhD, Zhen Shao, PhD, Robert Signer, PhD, Hui Cao, M.S., Zeping Hu, PhD, Ralph DeBerardinis, MD PhD, Jian Xu, PhD
Journal: Blood
Blood (2015) 126 (23): 47.
https://doi.org/10.1182/blood.V126.23.47.47
Published: 2015
Journal Articles

The LRF/ZBTB7A Transcription Factor Is a BCL11A-Independent Repressor of Fetal Hemoglobin

Takeshi Masuda, PhD, Xin Wang, PhD, Manami Maeda, MD, PhD, Matthew C. Canver, B.S., Falak Sher, PhD, Alister P.W. Funnell, PhD, Chris Fisher, PhD, Maria Suciu, Gabriella E. Martyn, Laura J. Norton, Ruijia Zhu, Ryo Kurita, PhD, Yukio Nakamura, MD, PhD, Jian Xu, PhD, Douglas R. Higgs, FRS, Merlin Crossley, DPhil, Daniel E. Bauer, MD, PhD, Stuart H. Orkin, MD, Peter V. Kharchenko, PhD, Takahiro Maeda, MD, PhD
Journal: Blood
Blood (2015) 126 (23): 2.
https://doi.org/10.1182/blood.V126.23.2.2
Published: 2015
Journal Articles

Inflammatory Signaling Regulates Embryonic Hematopoietic Stem and Lymphoid Progenitor Cell Formation

Yan Li, Virginie Esain, PhD, Li Teng, Jian Xu, PhD, Isaura Frost, Wanda Kwan, PhD, Amanda D Yzaguirre, Marijke W Maijenberg, Stuart H. Orkin, MD, Kai Tan, PhD, Trista E North, PhD, Nancy A. Speck, PhD
Journal: Blood
Blood (2014) 124 (21): 2902.
https://doi.org/10.1182/blood.V124.21.2902.2902
Published: 2014