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Journal Articles

A Moonlighting Job for alpha-Globin in Blood Vessels

Prabhodh Abbineni, Srishti Baid, Mitchell J. Weiss

Blood blood.2023022192.

https://doi.org/10.1182/blood.2023022192

Published: 2024

Journal Articles

Iron Restriction Alleviates β-Thalassemia By Stimulating ULK1-Mediated Autophagy of Free α-Globin

Alfonso G. Fernandez, Georgios E. Christakopoulos, Dudley E. Michael, Razan B. A. Sweileh, Rahul Telange, Heather Sheppard, Yu Yao, Jingjing Zhang, Vania Manolova, Elizabeta Nemeth, Tomas Ganz, Mitchell J. Weiss

Blood (2023) 142 (Supplement 1): 558.

https://doi.org/10.1182/blood-2023-185008

Published: 2023

Journal Articles

A Genotype Validated Bimodal Method for the Large-Scale Identification and Phenotyping of Persons with Sickle Cell Disease Using Electronic Health Record Data

Kristin Wuichet, Clifford M Takemoto, Robert Cronin, Martha Barton, Pei-Lin Chen, Santosh L. Saraf, Mitchell J. Weiss, Michael R. DeBaun

Blood (2023) 142 (Supplement 1): 7164.

https://doi.org/10.1182/blood-2023-190521

Published: 2023

Journal Articles

Reduced Polycomb Repressor Complex 2 (PRC2) Activity and Increased TP53 Activity Mediate Hematopoietic Stem Cell Dysfunction in RPS19-Mutated Diamond-Blackfan Anemia

Senthil V Bhoopalan, Ruopeng Feng, Thiyagaraj Mayuranathan, Kalin Mayberry, Yoonjeong Jang, Jonathan S Yen, Yu Yao, Lance Palmer, Yong Cheng, Marcin W Wlodarski, Mitchell J. Weiss

Blood (2023) 142 (Supplement 1): 2732.

https://doi.org/10.1182/blood-2023-190069

Published: 2023

Journal Articles

Loss of miR-144/451 alleviates β-thalassemia by stimulating ULK1-mediated autophagy of free α-globin

Julia Keith, Georgios E. Christakopoulos, Alfonso G. Fernandez, Yu Yao, Jingjing Zhang, Kalin Mayberry, Rahul Telange, Razan B. A. Sweileh, Michael Dudley, Camilla Westbrook, Heather Sheppard, Mitchell J. Weiss, Christophe Lechauve

Blood (2023) 142 (10): 918–932.

https://doi.org/10.1182/blood.2022017265

Published: 2023

Includes: Supplemental data

Journal Articles

Increased Potency and Uniformity of Fetal Hemoglobin Induction from Base Editing Compared to Cas9 Nuclease

Blood (2022) 140 (Supplement 1): 7784–7785.

https://doi.org/10.1182/blood-2022-162639

Published: 2022

Journal Articles

ETV6 Represses TNF during Stress Hematopoiesis and Regulates HSC Self Renewal

Mackenzie Bloom, Rebekah Baskin-Doerfler, Ninad Oak, Ruopeng Feng, Xujie Zhao, Chunliang Li, Patrick Ozark, Katherine Verbist, Alexa Stroh, Sabrin Albeituni, JaQuel Maise, Mitchell J. Weiss, Shannon McKinney-Freeman, Jun J.J. Yang, Kim E. Nichols

Blood (2022) 140 (Supplement 1): 2849–2850.

https://doi.org/10.1182/blood-2022-168076

Published: 2022

Journal Articles

Base Editing for Therapeutic Induction of Fetal Hemoglobin in β-Thalassemia

Georgios E. Christakopoulos, Thiyagaraj Mayuranathan, Alfonso G. Fernandez, Kalin Mayberry, Yu Yao, Rahul Telange, Michael Dudley, Rachel Levine, Erin Dempsey, David R. Liu, Jonathan S Yen, Mitchell J. Weiss

Blood (2022) 140 (Supplement 1): 10660–10661.

https://doi.org/10.1182/blood-2022-169391

Published: 2022

Journal Articles

Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression

Sarah K. Topfer, Ruopeng Feng, Peng Huang, Lana C. Ly, Gabriella E. Martyn, Gerd A. Blobel, Mitchell J. Weiss, Kate G. R. Quinlan, Merlin Crossley

Blood (2022) 139 (14): 2107–2118.

https://doi.org/10.1182/blood.2021014205

Published: 2022

Includes: Supplemental data

Journal Articles

Optimization of Autologous Hematopoietic Progenitor Stem Cell Apheresis Collection from Plerixafor-Mobilized Patients with Sickle Cell Disease

Blood (2021) 138 (Supplement 1): 1770.

https://doi.org/10.1182/blood-2021-146669

Published: 2021

Journal Articles

Regulation of Fetal Hemoglobin Expression By the VHL-HIF1α Oxygen Sensing System

Ruopeng Feng, Thiyagaraj Mayuranathan, Peng Huang, Phillip A Doerfler, Yichao Li, Yu Yao, Jingjing Zhang, Lance E. Palmer, Peng Xu, Kalin Mayberry, Shaela Wright, Chunliang Li, Yong Cheng, Gerd A. Blobel, M. Celeste Simon, Mitchell J. Weiss

Blood (2021) 138 (Supplement 1): 574.

https://doi.org/10.1182/blood-2021-149901

Published: 2021

Journal Articles

A Novel RPS19 -Edited Hematopoietic Stem Cell Model of Diamond-Blackfan Anemia for Development of Lentiviral Vector Gene Therapy

Senthil Velan Bhoopalan, Jonathan Yen, Thiyagaraj Mayuranathan, Yu Yao, Kalin Mayberry, Sheng Zhou, Robert Throm, Marcin W. Wlodarski, Mitchell J. Weiss

Blood (2021) 138 (Supplement 1): 859.

https://doi.org/10.1182/blood-2021-147557

Published: 2021

Journal Articles

Dynamic CTCF binding directly mediates interactions among cis -regulatory elements essential for hematopoiesis

Qian Qi, Li Cheng, Xing Tang, Yanghua He, Yichao Li, Tiffany Yee, Dewan Shrestha, Ruopeng Feng, Peng Xu, Xin Zhou, Shondra Pruett-Miller, Ross C. Hardison, Mitchell J. Weiss, Yong Cheng

Blood (2021) 137 (10): 1327–1339.

https://doi.org/10.1182/blood.2020005780

Published: 2021

Includes: Supplemental data

Journal Articles

FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis

Blood (2021) 137 (2): 155–167.

https://doi.org/10.1182/blood.2020007809

Published: 2021

Includes: Supplemental data

Journal Articles

Control of Fetal Hemoglobin Levels By NFI Transcription Factors

Kunhua Qin, Peng Huang, PhD, Anran Huang, BS, Ruopeng Feng, PhD, Thiyagaraj Mayuranathan, Cheryl A. Keller, PhD, Belinda Giardine, Ross C. Hardison, PhD, Mitchell J. Weiss, MD PhD, Junwei Shi, PhD, Gerd A. Blobel, MDPhD

Blood (2020) 136 (Supplement 1): 54.

https://doi.org/10.1182/blood-2020-136167

Published: 2020

Journal Articles

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Blood (2020) 136 (Supplement 1): 54.

https://doi.org/10.1182/blood-2020-137564

Published: 2020

Journal Articles

Adenosine Base Editing of γ-Globin Promoters Induces Fetal Hemoglobin and Inhibit Erythroid Sickling

Thiyagaraj Mayuranathan, Jonathan S. Yen, PhD, Gregory A. Newby, PhD, Yu Yao, MD, Shaina N. Porter, PhD, Kaitly J. Woodard, BS, Jingjing Zhang, MS, Kalin Mayberry, BS, Akshay Sharma, MBBS, Shondra M. preutt-Miller, PhD, John F. Tisdale, MD, Shengdar Q. Tsai, PhD, David R. Liu, PhD, Mitchell J. Weiss, MD PhD

Blood (2020) 136 (Supplement 1): 21–22.

https://doi.org/10.1182/blood-2020-141498

Published: 2020

Journal Articles

Base Editing Eliminates the Sickle Cell Mutation and Pathology in Hematopoietic Stem Cells Derived Erythroid Cells

Jonathan S Yen, PhD, Gregory A. Newby, PhD, Thiyagaraj Mayuranathan, Shaina N. Porter, PhD, Yu Yao, MD, Kaitly J. Woodard, BS, Kalin Mayberry, BS, Kelcee Everette, Jingjing Zhang, MS, Jordana M Henderson, MS, Anton P Mccaffrey, Jonathan Yen, John F. Tisdale, MD, Shengdar Q. Tsai, PhD, David R. Liu, PhD, Mitchell J. Weiss, MD PhD

Blood (2020) 136 (Supplement 1): 13–14.

https://doi.org/10.1182/blood-2020-139016

Published: 2020

Journal Articles

Disease Modeling and Phenotype Rescue Using Inducible Pluripotent Stem Cells from Patients with Diamond-Blackfan Anemia

Senthil Velan Bhoopalan, MD PhD, Min-Joon Han, PhD, Steven Ellis, PhD, Harry Lesmana, MD, Jeremie H. Estepp, MD, Yoonjeong Jang, DVM,PhD, Mitchell J. Weiss, MD PhD, Marcin W. Wlodarski, MD PhD

Blood (2019) 134 (Supplement_1): 2496.

https://doi.org/10.1182/blood-2019-131354

Published: 2019

Journal Articles

CRISPR-Cas9 Genome Editing of γ-Globin Promoters in Human Hematopoietic Stem Cells to Induce Erythrocyte Fetal Hemoglobin for Treatment of β-Hemoglobinopathies

Blood (2019) 134 (Supplement_1): 2066.

https://doi.org/10.1182/blood-2019-131318

Published: 2019

NARROW

A Moonlighting Job for alpha-Globin in Blood Vessels

Iron Restriction Alleviates β-Thalassemia By Stimulating ULK1-Mediated Autophagy of Free α-Globin

A Genotype Validated Bimodal Method for the Large-Scale Identification and Phenotyping of Persons with Sickle Cell Disease Using Electronic Health Record Data

Reduced Polycomb Repressor Complex 2 (PRC2) Activity and Increased TP53 Activity Mediate Hematopoietic Stem Cell Dysfunction in RPS19-Mutated Diamond-Blackfan Anemia

Loss of miR-144/451 alleviates β-thalassemia by stimulating ULK1-mediated autophagy of free α-globin

Increased Potency and Uniformity of Fetal Hemoglobin Induction from Base Editing Compared to Cas9 Nuclease

ETV6 Represses TNF during Stress Hematopoiesis and Regulates HSC Self Renewal

Base Editing for Therapeutic Induction of Fetal Hemoglobin in β-Thalassemia

Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression

Optimization of Autologous Hematopoietic Progenitor Stem Cell Apheresis Collection from Plerixafor-Mobilized Patients with Sickle Cell Disease

Regulation of Fetal Hemoglobin Expression By the VHL-HIF1α Oxygen Sensing System

A Novel RPS19 -Edited Hematopoietic Stem Cell Model of Diamond-Blackfan Anemia for Development of Lentiviral Vector Gene Therapy

Dynamic CTCF binding directly mediates interactions among cis -regulatory elements essential for hematopoiesis

FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis

Control of Fetal Hemoglobin Levels By NFI Transcription Factors

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Adenosine Base Editing of γ-Globin Promoters Induces Fetal Hemoglobin and Inhibit Erythroid Sickling

Base Editing Eliminates the Sickle Cell Mutation and Pathology in Hematopoietic Stem Cells Derived Erythroid Cells

Disease Modeling and Phenotype Rescue Using Inducible Pluripotent Stem Cells from Patients with Diamond-Blackfan Anemia

CRISPR-Cas9 Genome Editing of γ-Globin Promoters in Human Hematopoietic Stem Cells to Induce Erythrocyte Fetal Hemoglobin for Treatment of β-Hemoglobinopathies

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American Society of Hematology

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American Society of Hematology

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