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Merlin Crossley
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Journal Articles

Editing Combinations of Transcription Factor Binding Sites to Maximise Fetal Hemoglobin Production

Nivedhitha Devaraju, Harish Prakash, Anila George, Nithinsam Ravi, Saravanabhavan Thangavel, Merlin Crossley, Alok Srivastava, Mohankumar K Murugesan
Journal: Blood
Blood (2024) 144 (Supplement 1): 2476.
https://doi.org/10.1182/blood-2024-210995
Published: 2024
Journal Articles

Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression

Sarah K. Topfer, Ruopeng Feng, Peng Huang, Lana C. Ly, Gabriella E. Martyn, Gerd A. Blobel, Mitchell J. Weiss, Kate G. R. Quinlan, Merlin Crossley
Journal: Blood
Blood (2022) 139 (14): 2107–2118.
https://doi.org/10.1182/blood.2021014205
Published: 2022
Includes: Supplemental data
Journal Articles

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Xianjiang Lan, PhD, Ren Ren, PhD, Ruopeng Feng, PhD, Lana C Ly, Yemin Lan, PhD, Zhe Zhang, PhD, Nicholas Aboreden, Kunhua Qin, John R Horton, Jeremy D. Grevet, PhD, Thiyagaraj Mayuranathan, Osheiza Abdulmalik, DVM, Cheryl A. Keller, PhD, Belinda Giardine, Ross C. Hardison, PhD, Merlin Crossley, PhD, Mitchell J. Weiss, MD PhD, Xiaodong Cheng, PhD, Junwei Shi, PhD, Gerd A. Blobel, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 54.
https://doi.org/10.1182/blood-2020-137564
Published: 2020
Journal Articles

A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site

Brief Report
Gabriella E. Martyn, Beeke Wienert, Ryo Kurita, Yukio Nakamura, Kate G. R. Quinlan, Merlin Crossley
Journal: Blood
Blood (2019) 133 (8): 852–856.
https://doi.org/10.1182/blood-2018-07-863951
Published: 2019
Includes: Supplemental data
Journal Articles

Charting a noncoding gene for γ-globin activation

Gerd A. Blobel, Merlin Crossley
Journal: Blood
Blood (2018) 132 (18): 1865–1867.
https://doi.org/10.1182/blood-2018-09-873620
Published: 2018
Journal Articles

KLF1 drives the expression of fetal hemoglobin in British HPFH

Brief Report
Beeke Wienert, Gabriella E. Martyn, Ryo Kurita, Yukio Nakamura, Kate G. R. Quinlan, Merlin Crossley
Journal: Blood
Blood (2017) 130 (6): 803–807.
https://doi.org/10.1182/blood-2017-02-767400
Published: 2017
Includes: Supplemental data
Journal Articles

Fine-Tuning Erythropoiesis By Competition Between Krüppel-like Factors for Promoters and Enhancers

Melissa Ilsley, BSc, Kevin R. Gillinder, PhD, Graham Magor, MB BS (Hons), Merlin Crossley, DPhil, Andrew C Perkins, PhD
Journal: Blood
Blood (2016) 128 (22): 1036.
https://doi.org/10.1182/blood.V128.22.1036.1036
Published: 2016
Journal Articles

The LRF/ZBTB7A Transcription Factor Is a BCL11A-Independent Repressor of Fetal Hemoglobin

Takeshi Masuda, PhD, Xin Wang, PhD, Manami Maeda, MD, PhD, Matthew C. Canver, B.S., Falak Sher, PhD, Alister P.W. Funnell, PhD, Chris Fisher, PhD, Maria Suciu, Gabriella E. Martyn, Laura J. Norton, Ruijia Zhu, Ryo Kurita, PhD, Yukio Nakamura, MD, PhD, Jian Xu, PhD, Douglas R. Higgs, FRS, Merlin Crossley, DPhil, Daniel E. Bauer, MD, PhD, Stuart H. Orkin, MD, Peter V. Kharchenko, PhD, Takahiro Maeda, MD, PhD
Journal: Blood
Blood (2015) 126 (23): 2.
https://doi.org/10.1182/blood.V126.23.2.2
Published: 2015
Journal Articles

Programming of marginal zone B-cell fate by basic Krüppel-like factor (BKLF/KLF3)

Gleb Turchinovich, Thi Thanh Vu, Friederike Frommer, Jan Kranich, Sonja Schmid, Melanie Alles, Jean-Baptiste Loubert, Jean-Philippe Goulet, Ursula Zimber-Strobl, Pascal Schneider, Jürgen Bachl, Richard Pearson, Merlin Crossley, Fabien Agenès, Jörg Kirberg
Journal: Blood
Blood (2011) 117 (14): 3780–3792.
https://doi.org/10.1182/blood-2010-09-308742
Published: 2011
Includes: Supplemental data
Journal Articles

Hls5, a Novel Ubiquitin E3 Ligase, Modulates Levels of Sumoylated GATA-1.

Louise Natalie Winteringham, BSc, MSc, PhD, Raelene Endersby, PhD, Jennifer Beaumont, Jean-Philippe Lalonde, BSc, MSc, MD, Merlin Crossley, PhD, Svend Peter Klinken, PhD
Journal: Blood
Blood (2009) 114 (22): 253.
https://doi.org/10.1182/blood.V114.22.253.253
Published: 2009
Journal Articles

Hls5 regulated erythroid differentiation by modulating GATA-1 activity

Brief Report
Raelene Endersby, Ian J. Majewski, Louise Winteringham, Jennifer G. Beaumont, Amy Samuels, Robin Scaife, Esther Lim, Merlin Crossley, S. Peter Klinken, Jean-Philippe Lalonde
Journal: Blood
Blood (2008) 111 (4): 1946–1950.
https://doi.org/10.1182/blood-2007-04-085746
Published: 2008
Journal Articles

X-linked thrombocytopenia caused by a novel mutation of GATA-1

Michele G. Mehaffey, Anthea L. Newton, Manish J. Gandhi, Merlin Crossley, Jonathan G. Drachman
Journal: Blood
Blood (2001) 98 (9): 2681–2688.
https://doi.org/10.1182/blood.V98.9.2681
Published: 2001