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Journal Articles

An Essential Role for the N-Terminus of GATA1 in Metabolic Regulation during Erythropoiesis

Te Ling, Lavanya Bezavada, Rashid Mehmood, Kevin Zhang, Jeremy Chase Crawford, Yan Ju, Chun-Wei David Chen, Yichao Li, Yong Cheng, John D. Crispino
Journal: Blood
Blood (2024) 144 (Supplement 1): 940.
https://doi.org/10.1182/blood-2024-210865
Published: 2024
Journal Articles

SAGES1: Clinical Translation of CRISPR Genome Editing Strategy to Induce Fetal Hemoglobin to Treat Sickle Cell Disease

Rachel M Levine, Erin A Dempsey, Nikitha Nimmagadda, Yoonjeong Jang, Kalin Mayberry, Jingjing Zhang, David Cullins, Catherine Willis, Alicia Powers, Young-In Kim-Hoehammer, Jie Lin, Fei Zhang, Neha Das Gupta, Will Lewis, Varun Katta, Yichao Li, Timothy Lockey, Yong Cheng, Patti Lehigh, Frank Fazio, Alexis Kristine Leonard, Akshay Sharma, Sheng Zhou, Shengdar Q Tsai, Mitchell J Weiss, Jonathan S Yen
Journal: Blood
Blood (2024) 144 (Supplement 1): 146.
https://doi.org/10.1182/blood-2024-211182
Published: 2024
Journal Articles

Reduced Polycomb Repressor Complex 2 (PRC2) Activity and Increased TP53 Activity Mediate Hematopoietic Stem Cell Dysfunction in RPS19-Mutated Diamond-Blackfan Anemia

Senthil V Bhoopalan, Ruopeng Feng, Thiyagaraj Mayuranathan, Kalin Mayberry, Yoonjeong Jang, Jonathan S Yen, Yu Yao, Lance Palmer, Yong Cheng, Marcin W Wlodarski, Mitchell J. Weiss
Journal: Blood
Blood (2023) 142 (Supplement 1): 2732.
https://doi.org/10.1182/blood-2023-190069
Published: 2023
Journal Articles

Non-Canonical Transcription Activator Activity of RNA-Binding Protein MBNL1 Uniquely Controls FLT3 expression in MLL-Rearranged Leukemias

Siqi Yi, Shaela Wright, Meixia Che, Judith Hyle, Shelby Mryncza, Beisi Xu, Yong Cheng, Yajun Jiang, Chunliang Li
Journal: Blood
Blood (2023) 142 (Supplement 1): 2760.
https://doi.org/10.1182/blood-2023-185123
Published: 2023
Journal Articles

NR2F1 : A Novel Candidate for Gamma Globin Activation

Ruiqiong Wu, Siqi Yi, Yichao Li, Dewan Shrestha, Minzhang Zheng, Jingjing Zhang, Yong Cheng
Journal: Blood
Blood (2023) 142 (Supplement 1): 1106.
https://doi.org/10.1182/blood-2023-190312
Published: 2023
Journal Articles

Increased Potency and Uniformity of Fetal Hemoglobin Induction from Base Editing Compared to Cas9 Nuclease

Thiyagaraj Mayuranathan, Gregory A. Newby, Ruopeng Feng, Yu Yao, Kalin Mayberry, Guolian Kang, Cicera Lazzarotto, Yichao Li, Rachel Levine, Erin Dempsey, Shaina N. Porter, Phillip A Doerfler, Jingjing Zhang, Yoonjeong Jang, Senthil Bhoopalan, Nikitha Nimmagadda, Akshay Sharma, John Tisdale, Shondra Miller, Yong Cheng, Shengdar Tsai, Mitchell J. Weiss, David R. Liu, Jonathan S Yen
Journal: Blood
Blood (2022) 140 (Supplement 1): 7784–7785.
https://doi.org/10.1182/blood-2022-162639
Published: 2022
Journal Articles

Regulation of Fetal Hemoglobin Expression By the VHL-HIF1α Oxygen Sensing System

Ruopeng Feng, Thiyagaraj Mayuranathan, Peng Huang, Phillip A Doerfler, Yichao Li, Yu Yao, Jingjing Zhang, Lance E. Palmer, Peng Xu, Kalin Mayberry, Shaela Wright, Chunliang Li, Yong Cheng, Gerd A. Blobel, M. Celeste Simon, Mitchell J. Weiss
Journal: Blood
Blood (2021) 138 (Supplement 1): 574.
https://doi.org/10.1182/blood-2021-149901
Published: 2021
Journal Articles

Impairment of human terminal erythroid differentiation by histone deacetylase 5 deficiency

Yaomei Wang, Wei Li, Vincent P. Schulz, Huizhi Zhao, Xiaoli Qu, Qian Qi, Yong Cheng, Xinhua Guo, Shijie Zhang, Xin Wei, Donghao Liu, Karina Yazdanbakhsh, Christopher D. Hillyer, Narla Mohandas, Lixiang Chen, Patrick G. Gallagher, Xiuli An
Journal: Blood
Blood (2021) 138 (17): 1615–1627.
https://doi.org/10.1182/blood.2020007401
Published: 2021
Includes: Supplemental data
Journal Articles

Dynamic CTCF binding directly mediates interactions among cis -regulatory elements essential for hematopoiesis

Qian Qi, Li Cheng, Xing Tang, Yanghua He, Yichao Li, Tiffany Yee, Dewan Shrestha, Ruopeng Feng, Peng Xu, Xin Zhou, Shondra Pruett-Miller, Ross C. Hardison, Mitchell J. Weiss, Yong Cheng
Journal: Blood
Blood (2021) 137 (10): 1327–1339.
https://doi.org/10.1182/blood.2020005780
Published: 2021
Includes: Supplemental data
Journal Articles

FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis

Peng Xu, Daniel C. Scott, Beisi Xu, Yu Yao, Ruopeng Feng, Li Cheng, Kalin Mayberry, Yong-Dong Wang, Wenjian Bi, Lance E. Palmer, Moeko T. King, Hong Wang, Yuxin Li, Yiping Fan, Arno F. Alpi, Chunliang Li, Junmin Peng, James Papizan, Shondra M. Pruett-Miller, Ria Spallek, Florian Bassermann, Yong Cheng, Brenda A. Schulman, Mitchell J. Weiss
Journal: Blood
Blood (2021) 137 (2): 155–167.
https://doi.org/10.1182/blood.2020007809
Published: 2021
Includes: Supplemental data
Journal Articles

The DNA Methylation Maintenance Protein UHRF1 Regulates Fetal Globin Expression Independent of HBG Promoter DNA Methylation

Ruopeng Feng, PhD, Phillip A Doerfler, PhD, Yu Yao, MD, Xing Tang, PhD, Yong-Dong Wang, PhD, Chunliang Li, PhD, David E. Root, PhD, Yong Cheng, PhD, Mitchell J. Weiss, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 410.
https://doi.org/10.1182/blood-2018-99-115589
Published: 2018
Journal Articles

Precision Medicine for Sickle Cell Disease through Whole Genome Sequencing

Evadnie Rampersaud, PhD, Lance E. Palmer, PhD, Jane S. Hankins, MD MS, Vivien A Sheehan, MD PhD, Wenjian Bi, PhD, Heather Mulder, BS, Guolian Kang, PhD, Jeremie H. Estepp, MD, Shuoguo Wang, PhD, Andrew Thrasher, PhD, Martha Villavicencio, PhD, Jason R Hodges, PhD MA, Wenan Chen, PhD, Ti-Cheng Chang, PhD, Yong Cheng, PhD, Michael Rusch, BS, Yadav Sapkota, PhD, Akshay Sharma, MBBS, Pavel Sumazin, PhD, Xing Tang, PhD, Amanda M. Brandow, DO, MS, Shawn Levy, Nidal Boulos, PhD, Celeste Rosencrance, BS, Donald Yergeau, PhD, Jeffrey Lebensburger, DO, MSPH, Winfred Wang, MD, Yutaka Yasui, PhD, John Easton, PhD, Michael R. DeBaun, MD, James R. Downing, MD, Jinghui Zhang, Gang Wu, PhD, Mitchell J. Weiss, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3641.
https://doi.org/10.1182/blood-2018-99-117606
Published: 2018
Journal Articles

FBXO11 Activates Erythroid Gene Transcription By Degrading Heterochromatin-Associated Protein BAHD1

Peng Xu, PhD, Daniel C. Scott, PhD, Xing Tang, PhD, Yu Yao, MD, Yong-Dong Wang, PhD, Wenjian Bi, PhD, Lance E. Palmer, PhD, Ruopeng Feng, PhD, Arno F. Alpi, PhD, Chunliang Li, PhD, Yong Cheng, PhD, Brenda A. Schulman, PhD, Mitchell J. Weiss, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 529.
https://doi.org/10.1182/blood-2018-99-117362
Published: 2018
Journal Articles

Whole-genome noncoding sequence analysis in T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations

Shaoyan Hu, Maoxiang Qian, Hui Zhang, Yu Guo, Jin Yang, Xujie Zhao, Hailong He, Jun Lu, Jian Pan, Meimei Chang, Guoqing Du, Ting-Nien Lin, Shirley Kow-Yin Kham, Thuan Chong Quah, Hany Ariffin, Ah-Moy Tan, Yong Cheng, Chunliang Li, Allen Eng-Juh Yeoh, Ching-Hon Pui, Anders Jacobsen Skanderup, Jun J. Yang
Journal: Blood
Blood (2017) 129 (24): 3264–3268.
https://doi.org/10.1182/blood-2017-03-771162
Published: 2017
Includes: Supplemental data
Journal Articles

Lineage-Specific Mitotic Bookmarking by Hematopoietic Transcription Factor GATA1

Stephan Kadauke, Jan M Pawlicki, PhD, Maheshi Udugama, PhD, Jordan C Achtman, Yong Cheng, PhD, Ross C Hardison, PhD, Gerd A. Blobel, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 547.
https://doi.org/10.1182/blood.V118.21.547.547
Published: 2011
Journal Articles

The Effects of SB1518, a Novel Oral JAK2 Inhibitor, On Ex Vivo Expanded PV Erythroid Progenitors Correlate with Clinical Observations.

Kee Chuan Goh, Ph.D., Stefan Hart, Ph.D., Yong Cheng Tan, M.Sc., Amalini Chithra, B.Sc., Kiat H. Ong, MBBS, MRCP, FRCPA, Jeanette Wood, PhD
Journal: Blood
Blood (2009) 114 (22): 2913.
https://doi.org/10.1182/blood.V114.22.2913.2913
Published: 2009
Journal Articles

Pharmacodynamic (PD) Biomarker Assay Validation for SB1518, a Novel Oral JAK2 Inhibitor in Phase 1 Clinical Trials for Advanced Leukemias, Myeloproliferative Diseases and Lymphoma.

Stefan Hart, Ph.D., Kee Chuan Goh, Ph.D., Yong Cheng Tan, M.Sc., Amalini Chithra, B.Sc., Jeanette Wood, PhD
Journal: Blood
Blood (2009) 114 (22): 1888.
https://doi.org/10.1182/blood.V114.22.1888.1888
Published: 2009
Journal Articles

SCL and associated proteins distinguish active from repressive GATA transcription factor complexes

Tamara Tripic, Wulan Deng, Yong Cheng, Ying Zhang, Christopher R. Vakoc, Gregory D. Gregory, Ross C. Hardison, Gerd A. Blobel
Journal: Blood
Blood (2009) 113 (10): 2191–2201.
https://doi.org/10.1182/blood-2008-07-169417
Published: 2009
Includes: Supplemental data
Journal Articles

SCL and Associated Proteins Distinguish Active from Repressive GATA Transcription Factor Complexes.

Wulan Deng, Tamara Tripic, PhD, Yong Cheng, Ying Zhang, Christopher Vakoc, PhD, Ross Hardison, PhD, Gerd Blobel, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1379.
https://doi.org/10.1182/blood.V112.11.1379.1379
Published: 2008