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Timothy Lockey
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Journal Articles

SAGES1: Clinical Translation of CRISPR Genome Editing Strategy to Induce Fetal Hemoglobin to Treat Sickle Cell Disease

Rachel M Levine, Erin A Dempsey, Nikitha Nimmagadda, Yoonjeong Jang, Kalin Mayberry, Jingjing Zhang, David Cullins, Catherine Willis, Alicia Powers, Young-In Kim-Hoehammer, Jie Lin, Fei Zhang, Neha Das Gupta, Will Lewis, Varun Katta, Yichao Li, Timothy Lockey, Yong Cheng, Patti Lehigh, Frank Fazio, Alexis Kristine Leonard, Akshay Sharma, Sheng Zhou, Shengdar Q Tsai, Mitchell J Weiss, Jonathan S Yen
Journal: Blood
Blood (2024) 144 (Supplement 1): 146.
https://doi.org/10.1182/blood-2024-211182
Published: 2024
Journal Articles

CD123-CAR T Cells Manufactured in the Presence of Dasatinib Induce High Grade CRS and/or IEC-HS without Improving Efficacy in Pediatric Patients with Recurrent/Refractory Leukemia

Swati Naik, Madden Renee, Aimee C. Talleur, Rebecca Epperly, Timothy Lockey, Jennyfer Bran, Liqing Tian, Ying Li, Dinesh Keerthi, Alexandra Boyd, Amanda Lipsitt, Jeffrey E. Rubnitz, Jeffery M Klco, Barry Shulkin, Sarah Schell, Polly Adams, Jeoungeun John Park, Janice Riberdy, Na Shang, Jaquelyn T. Zoine, Raghuvaran Shanmugam, Chris Nevitt, Unmesha Thanekar, Jennifer Wallace, Elaine Harstead, Scott Perry, Catherine Willis, Jean-Yves Metais, Deanna M. Langfitt, Sheng Zhou, Salem M. Akel, Caitlin Zebley, Jeremy Chase Crawford, Benjamin Youngblood, Paul G. Thomas, Frank Fazio, Brandon M Triplett, Stephen Gottschalk, Mireya Paulina Velasquez
Journal: Blood
Blood (2024) 144 (Supplement 1): 2076.
https://doi.org/10.1182/blood-2024-208795
Published: 2024
Journal Articles

Safety and Anti-Leukemic Activity of CD123-CAR T Cells in Pediatric Patients with AML: Preliminary Results from a Phase 1 Trial

Swati Naik, Renee M. Madden, Amanda Lipsitt, Timothy Lockey, Jennyfer Bran, Jeffrey E. Rubnitz, Jeffery Klco, Barry Shulkin, Sagar L. Patil, Sarah Schell, Jeoungeun John Park, Janice Riberdy, Na Shang, Jaquelyn T. Zoine, Jennifer Wallace, Elaine Harstead, Catherine Willis, Jean-Yves Metais, Deanna M. Langfitt, Sheng Zhou, Salem M. Akel, Michael M. Meagher, Brandon M. Triplett, Stephen Gottschalk, Mireya Paulina Velasquez
Journal: Blood
Blood (2022) 140 (Supplement 1): 4584–4585.
https://doi.org/10.1182/blood-2022-170201
Published: 2022
Journal Articles

CD19-CAR T Cells Develop Exhaustion Epigenetic Programs during a Clinical Response

Caitlin C. Zebley, Charmaine Brown, Tian Mi, Yiping Fan, Shanta Alli, Shannon Boi, Giovanni Galletti, Enrico Lugli, Deanna Langfitt, Jean-Yves Metais, Timothy Lockey, Michael M Meagher, Brandon M Triplett, Aimee C Talleur, Stephen Gottschalk, Benjamin Youngblood
Journal: Blood
Blood (2021) 138 (Supplement 1): 2782.
https://doi.org/10.1182/blood-2021-151177
Published: 2021
Journal Articles

Allogeneic Hematopoietic Cell Transplantation Is Critical to Maintain Remissions after CD19-CAR T-Cell Therapy for Pediatric ALL: A Single Center Experience

Aimee C Talleur, MD, Renee M. Madden, MS, MD, Amr Qudeimat, MD, Ewelina Mamcarz, MD, Akshay Sharma, MBBS, Ashok Srinivasan, MD, Ali Y Suliman, MD, Mireya Paulina Velasquez, MD, Timothy Lockey, PhD, Alisha Gaboriault, Seth E. Karol, MD, Hiroto Inaba, MD PhD, Ying Li, MD PhD, Pam Young, Guolian Kang, PhD, Cheng Cheng, PhD, Wenting Zheng, PhD, Sheng Zhou, PhD, Salem M. Akel, PhD, Terrence L Geiger, MD PhD, Michael M Meagher, PhD, Ching-Hon Pui, MD, Brandon M Triplett, MD, Stephen Gottschalk, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-138528
Published: 2020
Journal Articles

Lentiviral Gene Therapy with Low Dose Busulfan for Infants with X-SCID Results in the Development of a Functional Normal Immune System: Interim Results of an Ongoing Phase I/II Clinical Study

Ewelina Mamcarz, MD, Sheng Zhou, PhD, Timothy Lockey, PhD, Shannon Boi, PhD, Yan Koon-Kiu, PhD, Shane Cross, Pharm.D., Guolian Kang, PhD, Zhijun Ma, MD, Jose Marcos Condori, PhD, Jolanta Dowdy, M.S., Jean-Yves Metais, PhD, Deanna Langfitt, PhD, Brandon Triplett, MD, Chen Li, M.S., Xiwen Zhao, MSPH, Gabriela Maron, MD, Sneha Suresh, MD, Juan Carlos Aldave Becerra, MD, Joseph Church, MD, Elif Dokmeci, MD, James T Love, MD, PhD, Hedi van der Watt, MD, Ana C da Matta Ain, MD, Christa Krupski, DO, MPH, Jiyang Yu, PhD, Lance E. Palmer, PhD, William Janssen, PhD, Suk See De Ravin, MD, PhD, Mitchell J. Weiss, MD, PhD, Benjamin Youngblood, PhD, Janel R Long-Boyle, PharmD, PhD, Michael M Meagher, PhD, Harry L. Malech, MD, Jennifer Puck, MD, Morton J Cowan, MD, Stephen Gottschalk, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2058.
https://doi.org/10.1182/blood-2019-126746
Published: 2019
Journal Articles

Interim Results from a Phase I/II Clinical Gene Therapy Study for Newly Diagnosed Infants with X-Linked Severe Combined Immunodeficiency Using a Safety-Modified Lentiviral Vector and Targeted Reduced Exposure to Busulfan

Ewelina Mamcarz, MD, Sheng Zhou, PhD, Timothy Lockey, PhD, Hossam Abdelsamed, PhD, Shane Cross, Pharm D, Zhijun Ma, MD, Jola Dowdy, Brandon Triplett, MD, Mitchell J. Weiss, MD PhD, Byoung Y. Ryu, PhD, Elif Dokmeci, MD, Juan Carlos Aldave, MD, Suk See De Ravin, MD PhD, Benjamin Youngblood, PhD, Janel R. Long-Boyle, PharmD, PhD, Michael M Meagher, PhD, Harry L Malech, MD, Jennifer Puck, MD, Morton Jerome Cowan, MD, Brian Sorrentino, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 523.
https://doi.org/10.1182/blood.V130.Suppl_1.523.523
Published: 2017
Journal Articles

Transduction of Human CD34+ Derived NSG Repopulating Cells with An Insulated SIN Lentiviral Vector for SCID-X1 From a Stable Producer Cell Line At Clinical Scale

Michael R. Greene, MD, Timothy Lockey, PhD, John T. Gray, PhD, Paul W. Eldridge, PhD, Yoon-Sang Kim, MD, PhD, Perdeep K. Mehta, PhD, Brian P. Sorrentino, MD
Journal: Blood
Blood (2011) 118 (21): 670.
https://doi.org/10.1182/blood.V118.21.670.670
Published: 2011
Journal Articles

Efficient construction of producer cell lines for a SIN lentiviral vector for SCID-X1 gene therapy by concatemeric array transfection

Robert E. Throm, Annastasia A. Ouma, Sheng Zhou, Anantharaman Chandrasekaran, Timothy Lockey, Michael Greene, Suk See De Ravin, Morvarid Moayeri, Harry L. Malech, Brian P. Sorrentino, John T. Gray
Journal: Blood
Blood (2009) 113 (21): 5104–5110.
https://doi.org/10.1182/blood-2008-11-191049
Published: 2009
Journal Articles

Expanded Natural Killer Cells for Cellular Therapy of Acute Myeloid Leukemia.

Hiroyuki Fujisaki, MD, PhD, Harumi Kakuda, MD, PhD, Timothy Lockey, PhD, Paul W. Eldridge, PhD, Wing Leung, MD, PhD, Dario Campana, MD, PhD
Journal: Blood
Blood (2007) 110 (11): 2743.
https://doi.org/10.1182/blood.V110.11.2743.2743
Published: 2007