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David Sykes
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Journal Articles

Pyrimidine Starvation Is a Targetable Cancer Vulnerability: Mechanisms of Nucleotide Homeostasis

Jelena Milosevic, Johannes Elferich, Kashish Chetal, Mary Ayres, Varsha Gandhi, Ruslan Sadreyev, Nikolaus Grigorieff, Shobha Vasudevan, David Sykes
Journal: Blood
Blood (2023) 142 (Supplement 1): 4113.
https://doi.org/10.1182/blood-2023-186615
Published: 2023
Journal Articles

DHODH Inhibitor Therapy for the Treatment of T-ALL Spares the Developing Thymus

Amy Sexauer, David Sykes
Journal: Blood
Blood (2023) 142 (Supplement 1): 2777.
https://doi.org/10.1182/blood-2023-187673
Published: 2023
Journal Articles

The Thymus Is Critical for Adult Immune Function

Kameron Kooshesh, Karin Gustafsson, Brody Foy, David Sykes, David T. Scadden
Journal: Blood
Blood (2022) 140 (Supplement 1): 1648–1649.
https://doi.org/10.1182/blood-2022-170925
Published: 2022
Journal Articles

DHODH: A Promising New Therapeutic Target in Pediatric T-ALL

Amy N Sexauer, Gabriela Alexe, Varsha Gandhi, Kimberly Stegmaier, David Sykes
Journal: Blood
Blood (2022) 140 (Supplement 1): 7795–7797.
https://doi.org/10.1182/blood-2022-167569
Published: 2022
Journal Articles

Cap-Independent Protein Translation in Hematopoiesis

Michael Mazzola, Ting Zhao, Karin Gustafsson, Trine Kristiansen, Giulia Schiroli, Jelena Milosevic, Youmna Kfoury, Tsuyoshi Fukushima, Anna Kiem, Azeem Sharda, Hiroki Kato, David Sykes, Pavel Ivanov, Vijay G. Sankaran, David T. Scadden
Journal: Blood
Blood (2022) 140 (Supplement 1): 1983–1984.
https://doi.org/10.1182/blood-2022-170506
Published: 2022
Journal Articles

Spatial Transcriptomics Reveals DPP4 As Novel Marker of a More Proliferative Phenotype in Early AML Progression

Christa Haase, Karin Gustafsson, Shenglin Mei, Jelena Milosevic, Shu-Chi Yeh, David Sykes, Peter Kharchenko, David T. Scadden, Charles Lin
Journal: Blood
Blood (2021) 138 (Supplement 1): 3310.
https://doi.org/10.1182/blood-2021-151917
Published: 2021
Journal Articles

Rigidity of Cell Fate and Function Among Monocytes

Catherine Rhee, Elizabeth W Scadden, Lai Ping Wong, Giulia Schiroli, Michael Mazzola, Phillip Chea, Hiroki Kato, Friedrich F Hoyer, Meeta Mistry, Bum-Kyu Lee, Jonghwan Kim, Matthias Nahrendorf, Michael K Mansour, David Sykes, Ruslan I Sadreyev, David T. Scadden
Journal: Blood
Blood (2021) 138 (Supplement 1): 2057.
https://doi.org/10.1182/blood-2021-151110
Published: 2021
Journal Articles

Repurposing Nelarabine to Induce Differentiation of Acute Myeloid Leukemia

Hanying Wang, Xin He, MD, Feiteng Huang, MS, Haojie Dong, PhD, Wei Chen, PhD, Zheng Li, MS, Jie Sun, PhD, Yinghui Zhu, PhD, Lei Zhang, MD, Yuhui Wu, MD, Lifeng Feng, PhD, Jing Zhang, PhD, Samer Khaled, MD, Guido Marcucci, MD, David Sykes, MD PhD, Hongchuan Jin, MD PhD, Xian Wang, MD PhD, Ling Li, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 26.
https://doi.org/10.1182/blood-2020-139922
Published: 2020
Journal Articles

Identification of a Gene Expression Signature Characterizing Clonal Fitness and Dominance in Vivo in a Murine Model of MLL-AF9 Leukemia

Francois Mercier, MD, Jiantao Shi, PhD, David Sykes, MDPhD, Youmna Sami Kfoury, PhD, Rushdia Z. Yusuf, MBBS, MPH, Elizabeth Miller, Radovan Vasic, Alex Zhu, Franziska Michor, PhD, Winston Hide, PhD, David T. Scadden, MD
Journal: Blood
Blood (2014) 124 (21): 2383.
https://doi.org/10.1182/blood.V124.21.2383.2383
Published: 2014