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Journal Articles

PSTK inhibition activates cGAS-STING, precipitating ferroptotic cell death in leukemic stem cells

Blood (2025) 145 (17): 1903–1914.

https://doi.org/10.1182/blood.2024026040

Published: 2025

Includes: Supplemental data

Journal Articles

AML Stem Cell Clearance By Inhibiting Selenoprotein Biosynthesis That Causes Cgas-Sting Activation and Ferroptosis

Lingli He, Ting Zhao, Wei Zhong Leong, Azeem Sharda, Christina Mayerhofer, Shenglin Mei, Gracia M. Bonilla, Juan Bautista Menendez-Gonzalez, Karin Gustafsson, Tsuyoshi Fukushima, Trine A. Kristiansen, Ji-Won Lee, Yanxin Xu, Bogdan Budnik, Ruslan Sadreyev, Zhixun Dou, David B. Sykes, David Scadden

Blood (2024) 144 (Supplement 1): 1354.

https://doi.org/10.1182/blood-2024-211314

Published: 2024

Journal Articles

Pyrimidine Starvation Is a Targetable Cancer Vulnerability: Mechanisms of Nucleotide Homeostasis

Jelena Milosevic, Johannes Elferich, Kashish Chetal, Mary Ayres, Varsha Gandhi, Ruslan Sadreyev, Nikolaus Grigorieff, Shobha Vasudevan, David Sykes

Blood (2023) 142 (Supplement 1): 4113.

https://doi.org/10.1182/blood-2023-186615

Published: 2023

Journal Articles

Gsdme Promotes PAD4 Activation and DNA Externalization from Apoptotic Neutrophils

Yanfang Peipei Zhu, Mary Helen Speir, ZheHao G Tan, Harold M Hoffman, Lai Ping Wong, Ruslan Sadreyev, Kate L Jeffrey, Ben A Croker

Blood (2023) 142 (Supplement 1): 2535.

https://doi.org/10.1182/blood-2023-178476

Published: 2023