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Journal Articles

Pyrimidine Starvation Is a Targetable Cancer Vulnerability: Mechanisms of Nucleotide Homeostasis

Jelena Milosevic, Johannes Elferich, Kashish Chetal, Mary Ayres, Varsha Gandhi, Ruslan Sadreyev, Nikolaus Grigorieff, Shobha Vasudevan, David Sykes

Blood (2023) 142 (Supplement 1): 4113.

https://doi.org/10.1182/blood-2023-186615

Published: 2023

Journal Articles

Effects of Glutaminase Inhibition on Venetoclax, Ibrutinib, and AZD-5991 Resistance in Chronic Lymphocytic Leukemia Cell Lines

Natalia Timofeeva, Varsha Gandhi, Marina Konopleva, Mary Ayres

Blood (2022) 140 (Supplement 1): 9862–9864.

https://doi.org/10.1182/blood-2022-170746

Published: 2022

Journal Articles

Pre-Clincial Evaluation of a Novel Purine Analogue 8-NH 2 -Adenosine in Mantle Cell Lymphoma Indicates Efficacy Via Alterations in RNA/DNA Synthesis and Cellular Bioenergetics

Mala Shanmugam, Ph.D., Jennifer Dennison, Ph.D., Jun Qian, M.D., Varsha Gandhi, PhD, Mary Ayres, Amareshwar Singh, PhD, Samuel McBrayer, Carter Neugarten, Priya Shanmugam, Karthik Singh, Leo I. Gordon, MD, Nancy Krett, PhD, Steven T. Rosen, MD

Blood (2008) 112 (11): 4987.

https://doi.org/10.1182/blood.V112.11.4987.4987

Published: 2008

Journal Articles

A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)

Varsha Gandhi, John M. Kilpatrick, William Plunkett, Mary Ayres, Leigh Harman, Min Du, Shanta Bantia, Jan Davisson, William G. Wierda, Stefan Faderl, Hagop Kantarjian, Deborah Thomas

Blood (2005) 106 (13): 4253–4260.

https://doi.org/10.1182/blood-2005-03-1309

Published: 2005

Journal Articles

Cell death of bioenergetically compromised and transcriptionally challenged CLL lymphocytes by chlorinated ATP

Kumudha Balakrishnan, Christine M. Stellrecht, Davide Genini, Mary Ayres, William G. Wierda, Michael J. Keating, Lorenzo M. Leoni, Varsha Gandhi

Blood (2005) 105 (11): 4455–4462.

https://doi.org/10.1182/blood-2004-05-1699

Published: 2005

NARROW

Pyrimidine Starvation Is a Targetable Cancer Vulnerability: Mechanisms of Nucleotide Homeostasis

Effects of Glutaminase Inhibition on Venetoclax, Ibrutinib, and AZD-5991 Resistance in Chronic Lymphocytic Leukemia Cell Lines

Pre-Clincial Evaluation of a Novel Purine Analogue 8-NH 2 -Adenosine in Mantle Cell Lymphoma Indicates Efficacy Via Alterations in RNA/DNA Synthesis and Cellular Bioenergetics

A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)

Cell death of bioenergetically compromised and transcriptionally challenged CLL lymphocytes by chlorinated ATP

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ASH Publications

American Society of Hematology

Pyrimidine Starvation Is a Targetable Cancer Vulnerability: Mechanisms of Nucleotide Homeostasis

Effects of Glutaminase Inhibition on Venetoclax, Ibrutinib, and AZD-5991 Resistance in Chronic Lymphocytic Leukemia Cell Lines

Pre-Clincial Evaluation of a Novel Purine Analogue 8-NH 2 -Adenosine in Mantle Cell Lymphoma Indicates Efficacy Via Alterations in RNA/DNA Synthesis and Cellular Bioenergetics

A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)

Cell death of bioenergetically compromised and transcriptionally challenged CLL lymphocytes by chlorinated ATP

Email alerts

ASH Publications

American Society of Hematology

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