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Lorenzo M. Leoni
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Journal Articles

SDX-308, a Structural Analog of Etodolac, Inhibits NF-κB Activity Resulting in Significant Inhibition of Osteoclast Formation/Activity and Multiple Myeloma Cell Growth.

Rentian Feng, PhD, Gulsum Anderson, PhD, Guozhi Xiao, MD, PhD, Gary Elliott, PhD, Lorenzo M. Leoni, MD, Markus Y. Mapara, MD, PhD, David Roodman, MD, PhD, Suzanne Lentzsch, MD, PhD
Journal: Blood
Blood (2006) 108 (11): 3456.
https://doi.org/10.1182/blood.V108.11.3456.3456
Published: 2006
Journal Articles

Cytotoxic Effect of R-Etodolac (SDX-101) in Combination with Purine Analogues or Monoclonal Antibodies on Ex-Vivo B-Cell Chronic Lymphocytic Leukemia Cells.

Pawel Robak, Anna Linke, Barbara Cebula, Lorenzo M. Leoni, Tadeusz Robak, Piotr Smolewski
Journal: Blood
Blood (2005) 106 (11): 2122.
https://doi.org/10.1182/blood.V106.11.2122.2122
Published: 2005
Journal Articles

R-Etodolac and a Novel Indole-Pyran Structural Analog, SDX-308, Induce Cytotoxicity and Overcome Drug Resistance in Multiple Myeloma.

Hiroshi Yasui, Teru Hideshima, Paola Neri, Janice Jin, Tanyel Kiziltepe, Norihiko Shiraishi, Kenji Ishitsuka, Catley P. Laurence, Noopur Raje, Klaus Podar, Pierfrancesco Tassone, Dharminder Chauhan, Paul G. Richardson, Lorenzo M. Leoni, Sarath Kanekal, Gary T. Elliott, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2005) 106 (11): 1580.
https://doi.org/10.1182/blood.V106.11.1580.1580
Published: 2005
Journal Articles

SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma

Hiroshi Yasui, Teru Hideshima, Makoto Hamasaki, Aldo M. Roccaro, Norihiko Shiraishi, Shaji Kumar, Pierfrancesco Tassone, Kenji Ishitsuka, Noopur Raje, Yu-Tzu Tai, Klaus Podar, Dharminder Chauhan, Lorenzo M. Leoni, Sarath Kanekal, Gary Elliott, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2005) 106 (2): 706–712.
https://doi.org/10.1182/blood-2005-02-0838
Published: 2005
Journal Articles

Cell death of bioenergetically compromised and transcriptionally challenged CLL lymphocytes by chlorinated ATP

Kumudha Balakrishnan, Christine M. Stellrecht, Davide Genini, Mary Ayres, William G. Wierda, Michael J. Keating, Lorenzo M. Leoni, Varsha Gandhi
Journal: Blood
Blood (2005) 105 (11): 4455–4462.
https://doi.org/10.1182/blood-2004-05-1699
Published: 2005
Journal Articles

Mechanism of Action and Safety of Second Generation Analogs of SDX-101 (R-Etodolac).

Lorenzo M. Leoni, Ph.D., Brian Crain, Brandi Bailey, Mimi Phillips, Heather Bendall, Ph.D., Qi Chao, Ph.D., Jack Reifert, Christina Niemeyer, Ph.D., Gary Elliott, Ph.D.
Journal: Blood
Blood (2004) 104 (11): 3411.
https://doi.org/10.1182/blood.V104.11.3411.3411
Published: 2004
Journal Articles

SDX-105 (Treanda™), Active in Non-Hodgkin’s Lymphoma Cells, Induces the Mitotic Catastrophe Death Pathway.

Lorenzo M. Leoni, Ph.D., Christina Niemeyer, Ph.D., Heather Bendall, Ph.D., Jack Reifert, Brandi Bailey
Journal: Blood
Blood (2004) 104 (11): 4593.
https://doi.org/10.1182/blood.V104.11.4593.4593
Published: 2004
Journal Articles

Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1

Clinical Trials & Observations
Irene M. Pedersen, Shinichi Kitada, Lorenzo M. Leoni, Juan M. Zapata, James G. Karras, Nobuhiro Tsukada, Thomas J. Kipps, Yong Sung Choi, Frank Bennett, John C. Reed
Journal: Blood
Blood (2002) 100 (5): 1795–1801.
https://doi.org/10.1182/blood.V100.5.1795.h81702001795_1795_1801
Published: 2002
Journal Articles

Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria

Davide Genini, Souichi Adachi, Qi Chao, David W. Rose, Carlos J. Carrera, Howard B. Cottam, Dennis A. Carson, Lorenzo M. Leoni
Journal: Blood
Blood (2000) 96 (10): 3537–3543.
https://doi.org/10.1182/blood.V96.10.3537
Published: 2000