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Journal Articles

PTK7 Is Involved in the Chemotherapy Resistance of T-Cell Acute Lymphoblastic Leukemia through Interaction with FADD-Death Domain

Hideki Goto, MD PhD, Rachel Wilkie Grantham, PhD, Motoaki Mizuuchi, Tetsuji Yamaguchi, Takanori Teshima, MD PhD, John C. Reed, MD PhD, Shu-ichi Matsuzawa, PhD

Blood (2015) 126 (23): 3701.

https://doi.org/10.1182/blood.V126.23.3701.3701

Published: 2015

Journal Articles

Inhibition of Mcl-1 with the pan–Bcl-2 family inhibitor (–)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia

Rongqing Pan, Vivian R. Ruvolo, Jun Wei, Marina Konopleva, John C. Reed, Maurizio Pellecchia, Michael Andreeff, Peter P. Ruvolo

Blood (2015) 126 (3): 363–372.

https://doi.org/10.1182/blood-2014-10-604975

Published: 2015

Includes: Supplemental data

Journal Articles

Sabutoclax, a Novel Pan BCL2 Family Inhibitor, Sensitizes Dormant Blast Crisis Chronic Myeloid Leukemia Stem Cells to Dasatinib

Heather S. Leu, B.S., Daniel J Goff, PhD, Janine Low-Marchelli, PhD, Angela C Court Recart, BS, MS, Kristen M. Smith, Ph.D., Wenxue Ma, M.D., Ph.D., Anil Sadarangani, Ph.D., Alice Y. Shih, B.S., Jun Wei, Ph.D., Dayong Zhai, Ph.D., Jason Gotlib, M.D., M.S., Mark D. Minden, MD, PhD, Giovanni Martinelli, MD, Marco A. Marra, PhD, Kelly A Frazer, Ph.D., Maurizio Pellecchia, PhD, John C. Reed, MD, PhD, Catriona Jamieson, MD, PhD

Blood (2012) 120 (21): 3739.

https://doi.org/10.1182/blood.V120.21.3739.3739

Published: 2012

Journal Articles

Chemical Biology Strategy Reveals Cell Lineage- and Cell Differentiation-Specific Small Molecule Inhibitors of NF-κB.

Hideki Goto, MD, PhD, Paul Diaz, PhD, Shu-ichi Matsuzawa, PhD, Eduard Sergienko, PhD, Steve Vasile, PhD, Thomas Chung, PhD, Carina Wimer, Michael Hedrick, PhD, Ricardo Correa, PhD, Thomas J Kipps, MD, PhD, Anthony Pinkerton, PhD, John C. Reed, MD, PhD

Blood (2012) 120 (21): 2421.

https://doi.org/10.1182/blood.V120.21.2421.2421

Published: 2012

Journal Articles

Discovery and Characterization of Chemical Inhibitors of UBC13.

Charitha Madiraju, PhD, Shu-ichi Matsuzawa, PhD, Robert Ardecky, PhD, Ian Pass, PhD, Tram Ngo, Yasuko Matsuzawa, Carina Wimer, Michael Cuddy, Paul Diaz, PhD, Correa Ricardo, PhD, Craig Tamble, PhD, Chih-Wen Shu, PhD, Anthony Pinkerton, PhD, Eduard Sergienko, PhD, Chris Hassig, PhD, Thomas Chung, PhD, John C. Reed, MD, PhD

Blood (2012) 120 (21): 2950.

https://doi.org/10.1182/blood.V120.21.2950.2950

Published: 2012

Journal Articles

BCL2 Splice Isoform Switching Promotes Leukemia Stem Cell Survival and Sensitivity to a Novel Pan BCL2 Inhibitor

Blood (2011) 118 (21): 2735.

https://doi.org/10.1182/blood.V118.21.2735.2735

Published: 2011

Journal Articles

Gene Risk Scores Based on Expression of 6 Genes Quanitated by Nuclease Protection Assay in Formalin Fixed Paraffin-Embedded Tissue (FFPET) Specimens From CHOP and RCHOP Treated Patients with Diffuse Large B-Cell Lymphoma (DLBCL) Predict Outcome: An ECOG and SWOG Study

Jane N. Winter, MD, Fangxin Hong, PhD, Lisa M. Rimsza, MD, Michael LeBlanc, Ph.D., Daina Variakojis, M.D., Maryla Krajewska, M.D., Thomas M. Habermann, MD, Ari Melnick, MD, James K. Weick, MD, Frederick Pollock, Ihab Botros, Ph.D., John C. Reed, MD, PhD, Richard I Fisher, MD, Brad S. Kahl, MD, Sandra J. Horning, MD, Randy D. Gascoyne, MD

Blood (2011) 118 (21): 87.

https://doi.org/10.1182/blood.V118.21.87.87

Published: 2011

Journal Articles

Increased Incidence of Therapy Related Myeloid Neoplasia (t-MN) After Initial Therapy for CLL with Fludarabine-Cyclophosphamide (FC) Vs Fludarabine (F): Long-Term Follow-up of US Intergroup Study E2997

Blood (2010) 116 (21): 924.

https://doi.org/10.1182/blood.V116.21.924.924

Published: 2010

Journal Articles

Targeting XIAP and ARC (apoptosis repressor with caspase recruitment domain) Overcomes Imatinib Resitance In Blast Crisis CML Cells.

Bing Carter, Ph.D., Duncan H. Mak, M.S., Wendy D. Schober, Marina Konopleva, MD, PhD, Jorge E. Cortes, MD, Hagop M. Kantarjian, MD, Erich Koller, Ziwei Huang, John C. Reed, MD, PhD, Michael Andreeff, M.D., Ph.D.

Blood (2010) 116 (21): 3415.

https://doi.org/10.1182/blood.V116.21.3415.3415

Published: 2010

Journal Articles

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

Blood (2010) 115 (11): 2251–2259.

https://doi.org/10.1182/blood-2009-07-231191

Published: 2010

Includes: Supplemental data

Journal Articles

Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML

Bing Z. Carter, Duncan H. Mak, Wendy D. Schober, Erich Koller, Clemencia Pinilla, Lyubomir T. Vassilev, John C. Reed, Michael Andreeff

Blood (2010) 115 (2): 306–314.

https://doi.org/10.1182/blood-2009-03-212563

Published: 2010

Includes: Supplemental data

Journal Articles

Comparison of in Vitro Apoptotic Response of Chronic Lymphocytic Leukemia (CLL) Cells to Bcl-2 Antagonist ABT-737 and IAP Antagonist BV6.

Shinichi Kitada, MD, PhD, Ryuji Yamaguchi, Ph.D., Laura Z. Rassenti, PhD, Thomas J. Kipps, MD, PhD, John C. Reed, MD, PhD

Blood (2009) 114 (22): 4386.

https://doi.org/10.1182/blood.V114.22.4386.4386

Published: 2009

Journal Articles

Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer

Juan M. Zapata, David Llobet, Maryla Krajewska, Sophie Lefebvre, Christina L. Kress, John C. Reed

Blood (2009) 113 (19): 4595–4603.

https://doi.org/10.1182/blood-2008-07-165456

Published: 2009

Includes: Supplemental data

Journal Articles

Simultaneous Activation of p53 and Inhibition of XIAP Enhance the Activation of Apoptosis Signaling Pathways in AML.

Bing Z. Carter, PhD, Duncan H. Mak, Wendy D. Schober, Erich Koller, PhD, Clemencia Pinilla, PhD, Lyubomir T. Vassilev, PhD, John C. Reed, MD, PhD, Michael Andreeff, MD, PhD

Blood (2008) 112 (11): 1941.

https://doi.org/10.1182/blood.V112.11.1941.1941

Published: 2008

Journal Articles

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5

Bing Z. Carter, Duncan H. Mak, Wendy D. Schober, Martin F. Dietrich, Clemencia Pinilla, Lyubomir T. Vassilev, John C. Reed, Michael Andreeff

Blood (2008) 111 (7): 3742–3750.

https://doi.org/10.1182/blood-2007-05-091504

Published: 2008

Journal Articles

Bcl-2–family proteins and hematologic malignancies: history and future prospects

John C. Reed

Blood (2008) 111 (7): 3322–3330.

https://doi.org/10.1182/blood-2007-09-078162

Published: 2008

Journal Articles

Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2–transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)

Shinichi Kitada, Christina L. Kress, Maryla Krajewska, Lee Jia, Maurizio Pellecchia, John C. Reed

Blood (2008) 111 (6): 3211–3219.

https://doi.org/10.1182/blood-2007-09-113647

Published: 2008

Includes: Supplemental data

Journal Articles

Small-molecule XIAP antagonist restores caspase-9–mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells

Saskia A. G. M. Cillessen, John C. Reed, Kate Welsh, Clemencia Pinilla, Richard Houghten, Erik Hooijberg, José Deurhof, Kitty C. M. Castricum, Pim Kortman, Corine J. Hess, Gert J. Ossenkoppele, Chris J. L. M. Meijer, Joost J. Oudejans

Blood (2008) 111 (1): 369–375.

https://doi.org/10.1182/blood-2007-04-085480

Published: 2008

Journal Articles

Small-Molecule XIAP Antagonist Restores Caspase-9-Mediated Apoptosis in XIAP-Positive Diffuse Large B-Cell Lymphoma Cells.

Saskia A.G.M. Cillessen, MSc, John C. Reed, PhD MD, Clemencia Pinilla, PhD, Chris J.L.M. Meijer, PhD MD, Erik Hooijberg, PhD, Corine J. Hess, MD, Kitty C.M. Castricum, Pim Kortman, Gert J. Ossenkoppele, PhD MD, Joost J. Oudejans, PhD MD

Blood (2007) 110 (11): 803.

https://doi.org/10.1182/blood.V110.11.803.803

Published: 2007

Journal Articles

Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma

Frederic Luciano, Maryla Krajewska, Paulina Ortiz-Rubio, Stan Krajewski, Dayong Zhai, Benjamin Faustin, Jean-Marie Bruey, Beatrice Bailly-Maitre, Alan Lichtenstein, Siva Kumar Kolluri, Arnold C. Satterthwait, Xiao-Kun Zhang, John C. Reed

Blood (2007) 109 (9): 3849–3855.

https://doi.org/10.1182/blood-2006-11-056879

Published: 2007

Includes: Supplemental data

NARROW

PTK7 Is Involved in the Chemotherapy Resistance of T-Cell Acute Lymphoblastic Leukemia through Interaction with FADD-Death Domain

Inhibition of Mcl-1 with the pan–Bcl-2 family inhibitor (–)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia

Sabutoclax, a Novel Pan BCL2 Family Inhibitor, Sensitizes Dormant Blast Crisis Chronic Myeloid Leukemia Stem Cells to Dasatinib

Chemical Biology Strategy Reveals Cell Lineage- and Cell Differentiation-Specific Small Molecule Inhibitors of NF-κB.

Discovery and Characterization of Chemical Inhibitors of UBC13.

BCL2 Splice Isoform Switching Promotes Leukemia Stem Cell Survival and Sensitivity to a Novel Pan BCL2 Inhibitor

Gene Risk Scores Based on Expression of 6 Genes Quanitated by Nuclease Protection Assay in Formalin Fixed Paraffin-Embedded Tissue (FFPET) Specimens From CHOP and RCHOP Treated Patients with Diffuse Large B-Cell Lymphoma (DLBCL) Predict Outcome: An ECOG and SWOG Study

Increased Incidence of Therapy Related Myeloid Neoplasia (t-MN) After Initial Therapy for CLL with Fludarabine-Cyclophosphamide (FC) Vs Fludarabine (F): Long-Term Follow-up of US Intergroup Study E2997

Targeting XIAP and ARC (apoptosis repressor with caspase recruitment domain) Overcomes Imatinib Resitance In Blast Crisis CML Cells.

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML

Comparison of in Vitro Apoptotic Response of Chronic Lymphocytic Leukemia (CLL) Cells to Bcl-2 Antagonist ABT-737 and IAP Antagonist BV6.

Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer

Simultaneous Activation of p53 and Inhibition of XIAP Enhance the Activation of Apoptosis Signaling Pathways in AML.

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5

Bcl-2–family proteins and hematologic malignancies: history and future prospects

Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2–transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)

Small-molecule XIAP antagonist restores caspase-9–mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells

Small-Molecule XIAP Antagonist Restores Caspase-9-Mediated Apoptosis in XIAP-Positive Diffuse Large B-Cell Lymphoma Cells.

Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma

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American Society of Hematology

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ASH Publications

American Society of Hematology

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