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Marko Skrtic
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Journal Articles

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Shrivani Sriskanthadevan, Danny V. Jeyaraju, Timothy E. Chung, Swayam Prabha, Wei Xu, Marko Skrtic, Bozhena Jhas, Rose Hurren, Marcela Gronda, Xiaoming Wang, Yulia Jitkova, Mahadeo A. Sukhai, Feng-Hsu Lin, Neil Maclean, Rob Laister, Carolyn A. Goard, Peter J. Mullen, Stephanie Xie, Linda Z. Penn, Ian M. Rogers, John E. Dick, Mark D. Minden, Aaron D. Schimmer
Journal: Blood
Blood (2015) 125 (13): 2120–2130.
https://doi.org/10.1182/blood-2014-08-594408
Published: 2015
Includes: Supplemental data
Journal Articles

Chronic Inhibition of Mitochondrial Translation Alters Metabolism and Stemness in AML

Jhas Bozhena, BSc, Shrivani Sriskanthadevan, PhD, Marko Skrtic, PhD, Mahadeo A. Sukhai, PhD, Veronique Voisin, PhD, Yulia Jitkova, PhD, Marcela Gronda, MSc, Rose Hurren, BSc, Xiaoming Wang, Rob C. Laister, PhD, Gary D. Bader, Ph.D., Mark D. Minden, MD, PhD, Aaron D. Schimmer, MD
Journal: Blood
Blood (2012) 120 (21): 1364.
https://doi.org/10.1182/blood.V120.21.1364.1364
Published: 2012
Journal Articles

AML Cells Have Altered Mitochondrial Biogenesis and Low Spare Reserve Capacity in Their Respiratory Chain That Renders Them Susceptible to Oxidative Metabolic Stress.

Shrivani Sriskanthadevan, PhD, Timothy E Chung, Marko Skrtic, PhD, Bozhena Jhas, BSc, Rose Hurren, BSc, Marcela Gronda, MSc, Xiao Ming Wang, Yulia Jitkova, PhD, Mahadeo A. Sukhai, PhD, Feng-Hsu Lin, PhD, Neil Maclean, BSc, Rob C. Laister, PhD, Peter Mullen, PhD, Stephanie Xie, Linda Penn, PhD, Ian M. Rogers, PhD, John E. Dick, PhD $, Mark D. Minden, MD, PhD, Aaron D Schimmer, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2581.
https://doi.org/10.1182/blood.V120.21.2581.2581
Published: 2012
Journal Articles

Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML)

Marko Skrtic, BSc, Shrivani Sriskanthadevan, PhD, Bozhena Livak, BSc, Marinella Gebbia, PhD, Xiaoming Wang, Zezhou Wang, PhD, Rose Hurren, BSc, Yulia Jitkova, PhD, Marcela Gronda, MSc, Neil Maclean, BSc, Courteney Lai, BSc, Yanina Eberhard, BSc, PhD, Justyna Bartoszko, BSc, Paul A. Spagnuolo, PhD, Angela Rutledge, PhD, Alessandro Datti, PhD, Troy Ketela, Jason Moffat, Brian H Robinson, PhD, Jessie M Cameron, PhD, Jeff L. Wrana, PhD, Connie J. Eaves, PhD, Mark D. Minden, MD, PhD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD, R. Keith Humphries, MD, PhD, Corey Nislow, PhD, Guri Giaever, PhD, Aaron D Schimmer, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 233.
https://doi.org/10.1182/blood.V118.21.233.233
Published: 2011
Journal Articles

Lysosomal Disruption Selectively Targets Leukemia Cells and Leukemia Stem Cells Through A Mechanism Related to Increased Reactive Oxygen Species Production

Mahadeo A. Sukhai, PhD, Rose Hurren, BSc, Angela Rutledge, PhD, Bozena Livak, Xiaoming Wang, Ayesh Seneviratne, Maria Christine Cusimano, Marinella Gebbia, PhD, Marko Skrtic, Hong Sun, Marcela Gronda, MSc, Paul A. Spagnuolo, PhD, Malene Urbanus, PhD, Kolja Eppert, PhD, Dilan Dissanayake, Xiaoming Li, PhD, Thomas Sun, Frederick Vizeacoumar, Alessandro Datti, PhD, Pamela Ohashi, PhD, FRSC, Jeff L. Wrana, PhD, Ian M. Rogers, PhD, Mark D. Minden, MD, PhD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD, Seth J. Corey, MD, Corey Nislow, PhD, Guri Giaever, PhD, Aaron D Schimmer, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 61.
https://doi.org/10.1182/blood.V118.21.61.61
Published: 2011
Journal Articles

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

Sumaiya Sharmeen, Marko Skrtic, Mahadeo A. Sukhai, Rose Hurren, Marcela Gronda, Xiaoming Wang, Sonali B. Fonseca, Hong Sun, Tabitha E. Wood, Richard Ward, Mark D. Minden, Robert A. Batey, Alessandro Datti, Jeff Wrana, Shana O. Kelley, Aaron D. Schimmer
Journal: Blood
Blood (2010) 116 (18): 3593–3603.
https://doi.org/10.1182/blood-2010-01-262675
Published: 2010
Includes: Supplemental data
Journal Articles

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

G. Wei Xu, Mohsin Ali, Tabitha E. Wood, Derek Wong, Neil Maclean, Xiaoming Wang, Marcela Gronda, Marko Skrtic, Xiaoming Li, Rose Hurren, Xinliang Mao, Meenakshi Venkatesan, Reza Beheshti Zavareh, Troy Ketela, John C. Reed, David Rose, Jason Moffat, Robert A. Batey, Sirano Dhe-Paganon, Aaron D. Schimmer
Journal: Blood
Blood (2010) 115 (11): 2251–2259.
https://doi.org/10.1182/blood-2009-07-231191
Published: 2010
Includes: Supplemental data
Journal Articles

Activation of Chloride Channels with the Anti-Parasitic Agent Ivermectin Induces Membrane Hyperpolarization and Cell Death in Leukemia Cells.

Sumaiya Sharmeen, BSc, Marko Skrtic, Mahadeo Sukhai, BSc, MSc, PhD, Joyce Sun, Rose Hurren, Marcela Gronda, Xiaoming Wang, Tabitha E Wood, PhD, Robert A. Batey, PhD, Sonali Fonesca, Shana Kelley, Alessandro Datti, Jeff Wrana, Aaron D. Schimmer, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 410.
https://doi.org/10.1182/blood.V114.22.410.410
Published: 2009