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Alessandro Datti
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Journal Articles

Ibrutinib Sensitizes AML Cells to ROS Inducers Via a BTK-Independent Mechanism

Lianne E Rotin, BHSc, Marcela Gronda, MSc, Neil Maclean, BSc, Feng-Hsu Lin, PhD, Jeff Wrana, PhD, Alessandro Datti, PhD, Dwayne L Barber, PhD, Michael F Moran, PhD, Mark D Minden, MDPhD, Malik Slassi, PhD, Aaron D Schimmer, MDPhD
Journal: Blood
Blood (2014) 124 (21): 2226.
https://doi.org/10.1182/blood.V124.21.2226.2226
Published: 2014
Journal Articles

Inhibition of Fatty Acid Oxidation with Avocatin B Selectively Targets AML Cells and Leukemia Stem Cells

Eric A Lee, Leonard Angka, Sarah-Grace Rota, Thomas Hanlon, Rose Hurren, Xiao Ming Wang, Marcela Gronda, MSc, Dannie Bernard, Mark D. Minden, MD PhD, Andrew Mitchell, Andrea Edginton, PhD, Shrivani Sriskanthadevan, PhD, Alessandro Datti, PhD, Jeff Wrana, PhD, Jamie W Joseph, PhD, Joe Quadrilatero, PhD, Aaron D. Schimmer, MD PhD, Paul A Spagnuolo, PhD
Journal: Blood
Blood (2014) 124 (21): 268.
https://doi.org/10.1182/blood.V124.21.268.268
Published: 2014
Journal Articles

A 7-Gene Microrna Signature Characteristic of Mantle Cell Lymphoma Reveals Focal Adhesion and Integrin Signalling, Proteasome-Mediated Degradation, and the PI3K Signalling Cascade As Important to MCL Pathogenesis

Rashmi S. Goswami, MD, FRCPC, Yali Xuan, Levi Waldron, Ph.D., Mahadeo A. Sukhai, PhD, Patricia P Reis, Ph.D., Thomas Sun, Alessandro Datti, PhD, Wei Xu, Ph.D., John Kuruvilla, MD, FRCPC, David Good, MD, FRCPC, Raymond Lai, MD, Ph.D., Wilson Lam, Alanna Church, MD, David LeBrun, MD, Laurie H. Sehn, MD, Pedro Farinha, MD, Igor Jurisica, Ph.D., Denis Bailey, MD, Randy D. Gascoyne, MD, Michael Crump, MD, FRCPC, Suzanne Kamel-Reid, PhD
Journal: Blood
Blood (2012) 120 (21): 1586.
https://doi.org/10.1182/blood.V120.21.1586.1586
Published: 2012
Journal Articles

A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside

Sean P. McDermott, Kolja Eppert, Faiyaz Notta, Methvin Isaac, Alessandro Datti, Rima Al-awar, Jeff Wrana, Mark D. Minden, John E. Dick
Journal: Blood
Blood (2012) 119 (5): 1200–1207.
https://doi.org/10.1182/blood-2011-01-330019
Published: 2012
Includes: Supplemental data
Journal Articles

Inhibition of Mitochondrial Translation As a Therapeutic Strategy for Acute Myeloid Leukemia (AML)

Marko Skrtic, BSc, Shrivani Sriskanthadevan, PhD, Bozhena Livak, BSc, Marinella Gebbia, PhD, Xiaoming Wang, Zezhou Wang, PhD, Rose Hurren, BSc, Yulia Jitkova, PhD, Marcela Gronda, MSc, Neil Maclean, BSc, Courteney Lai, BSc, Yanina Eberhard, BSc, PhD, Justyna Bartoszko, BSc, Paul A. Spagnuolo, PhD, Angela Rutledge, PhD, Alessandro Datti, PhD, Troy Ketela, Jason Moffat, Brian H Robinson, PhD, Jessie M Cameron, PhD, Jeff L. Wrana, PhD, Connie J. Eaves, PhD, Mark D. Minden, MD, PhD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD, R. Keith Humphries, MD, PhD, Corey Nislow, PhD, Guri Giaever, PhD, Aaron D Schimmer, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 233.
https://doi.org/10.1182/blood.V118.21.233.233
Published: 2011
Journal Articles

Lysosomal Disruption Selectively Targets Leukemia Cells and Leukemia Stem Cells Through A Mechanism Related to Increased Reactive Oxygen Species Production

Mahadeo A. Sukhai, PhD, Rose Hurren, BSc, Angela Rutledge, PhD, Bozena Livak, Xiaoming Wang, Ayesh Seneviratne, Maria Christine Cusimano, Marinella Gebbia, PhD, Marko Skrtic, Hong Sun, Marcela Gronda, MSc, Paul A. Spagnuolo, PhD, Malene Urbanus, PhD, Kolja Eppert, PhD, Dilan Dissanayake, Xiaoming Li, PhD, Thomas Sun, Frederick Vizeacoumar, Alessandro Datti, PhD, Pamela Ohashi, PhD, FRSC, Jeff L. Wrana, PhD, Ian M. Rogers, PhD, Mark D. Minden, MD, PhD, Jean C.Y. Wang, MD, PhD, John E. Dick, PhD, Seth J. Corey, MD, Corey Nislow, PhD, Guri Giaever, PhD, Aaron D Schimmer, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 61.
https://doi.org/10.1182/blood.V118.21.61.61
Published: 2011
Journal Articles

A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway

Xinliang Mao, Biyin Cao, Tabitha E. Wood, Rose Hurren, Jiefei Tong, Xiaoming Wang, Wenjie Wang, Jie Li, Yueping Jin, Wenxian Sun, Paul A. Spagnuolo, Neil MacLean, Michael F. Moran, Alessandro Datti, Jeffery Wrana, Robert A. Batey, Aaron D. Schimmer
Journal: Blood
Blood (2011) 117 (6): 1986–1997.
https://doi.org/10.1182/blood-2010-05-284810
Published: 2011
Includes: Supplemental data
Journal Articles

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

Sumaiya Sharmeen, Marko Skrtic, Mahadeo A. Sukhai, Rose Hurren, Marcela Gronda, Xiaoming Wang, Sonali B. Fonseca, Hong Sun, Tabitha E. Wood, Richard Ward, Mark D. Minden, Robert A. Batey, Alessandro Datti, Jeff Wrana, Shana O. Kelley, Aaron D. Schimmer
Journal: Blood
Blood (2010) 116 (18): 3593–3603.
https://doi.org/10.1182/blood-2010-01-262675
Published: 2010
Includes: Supplemental data
Journal Articles

Activation of Chloride Channels with the Anti-Parasitic Agent Ivermectin Induces Membrane Hyperpolarization and Cell Death in Leukemia Cells.

Sumaiya Sharmeen, BSc, Marko Skrtic, Mahadeo Sukhai, BSc, MSc, PhD, Joyce Sun, Rose Hurren, Marcela Gronda, Xiaoming Wang, Tabitha E Wood, PhD, Robert A. Batey, PhD, Sonali Fonesca, Shana Kelley, Alessandro Datti, Jeff Wrana, Aaron D. Schimmer, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 410.
https://doi.org/10.1182/blood.V114.22.410.410
Published: 2009
Journal Articles

A Small Molecule Inhibitor of D-Cyclin Transactivation Displays Preclinical Efficacy in Myeloma and Leukemia.

Xinliang Mao, MD, PhD, Tabitha E Wood, PhD, Rose Hurren, Jiefei Tong, PhD, Xiaoming Wang, Paul A. Spagnuolo, PhD, Neil MacLean, Michael F. Moran, PhD, Alessandro Datti, Jeff Wrana, PhD, Robert A. Batey, PhD, Aaron D. Schimmer, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 2036.
https://doi.org/10.1182/blood.V114.22.2036.2036
Published: 2009
Journal Articles

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells

Yanina Eberhard, Sean P. McDermott, Xiaoming Wang, Marcela Gronda, Amudha Venugopal, Tabitha E. Wood, Rose Hurren, Alessandro Datti, Robert A. Batey, Jeffrey Wrana, William E. Antholine, John E. Dick, Aaron D. Schimmer
Journal: Blood
Blood (2009) 114 (14): 3064–3073.
https://doi.org/10.1182/blood-2009-03-209965
Published: 2009
Includes: Supplemental data
Journal Articles

A Novel Chromene-Based Pan-PI3 Kinase Inhibitor Displays Preclinical Activity in Leukemia and Myeloma.

Xinliang Mao, MD, PhD, Tabitha W. Wood, PhD, Xiaoming Wang, PhD, Johnathan St-Germain, BSc, Michael F. Moran, PhD, Alessandro Datti, PhD, Jeff Wrana, PhD, Robert A. Batey, PhD, Aaron D. Schimmer, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1605.
https://doi.org/10.1182/blood.V112.11.1605.1605
Published: 2008
Journal Articles

The off-Patent Anti-Fungal Ciclopirox Olamine Displays Preclinical Activity in Leukemia and Myeloma.

Yanina Eberhard, Amudha Venugopal, Marcela Gronda, Rose Hurren, Alessandro Datti, Jeff Wrana, William E Antholine, Aaron D. Schimmer
Journal: Blood
Blood (2008) 112 (11): 944.
https://doi.org/10.1182/blood.V112.11.944.944
Published: 2008
Journal Articles

Cyproheptadine displays preclinical activity in myeloma and leukemia

Xinliang Mao, Sheng-ben Liang, Rose Hurren, Marcela Gronda, Sue Chow, G. Wei Xu, Xiaoming Wang, Reza Beheshti Zavareh, Nazir Jamal, Hans Messner, David W. Hedley, Alessandro Datti, Jeff L. Wrana, Yuanxiao Zhu, Chang-xin Shi, Kyle Lee, Rodger Tiedemann, Suzanne Trudel, A. Keith Stewart, Aaron D. Schimmer
Journal: Blood
Blood (2008) 112 (3): 760–769.
https://doi.org/10.1182/blood-2008-02-142687
Published: 2008
Includes: Supplemental data
Journal Articles

A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin

Xinliang Mao, A. Keith Stewart, Rose Hurren, Alessandro Datti, Xuegong Zhu, Yuanxiao Zhu, Changxin Shi, Kyle Lee, Rodger Tiedemann, Yanina Eberhard, Suzanne Trudel, Shengben Liang, Seth J. Corey, Lisa C. Gillis, Dwayne L. Barber, Jeffery L. Wrana, Shereen Ezzat, Aaron D. Schimmer
Journal: Blood
Blood (2007) 110 (12): 4047–4054.
https://doi.org/10.1182/blood-2007-05-088666
Published: 2007
Journal Articles

A Chemical Biology Screen Identifies Glucocorticoids as Inhibitors of C-Maf and C-Maf-Dependent Transactivation of Cyclin D2.

Xinliang Mao, A. Keith Stewart, Rose Hurren, Alessandro Datti, Chang Xin Shi, Yuan-Xiao Zhu, Kyle Lee, Rodger Tiedemann, Yanina Eberhard, Seth J. Corey, Jeff Wrana, Aaron D. Schimmer
Journal: Blood
Blood (2006) 108 (11): 368.
https://doi.org/10.1182/blood.V108.11.368.368
Published: 2006
Journal Articles

A High Throughput Seeking Myeloma Therapeutics Identifies Glucocorticoids as Inhibitors of c-Maf-Dependent Transactivation of Cyclin D2.

Xinliang Mao, MD, PhD, A. Keith Stewart, MD, Alessandro Datti, Aaron D. Schimmer, MD, PhD
Journal: Blood
Blood (2005) 106 (11): 3384.
https://doi.org/10.1182/blood.V106.11.3384.3384
Published: 2005