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Jeff Wrana
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Journal Articles

Ibrutinib Sensitizes AML Cells to ROS Inducers Via a BTK-Independent Mechanism

Lianne E Rotin, BHSc, Marcela Gronda, MSc, Neil Maclean, BSc, Feng-Hsu Lin, PhD, Jeff Wrana, PhD, Alessandro Datti, PhD, Dwayne L Barber, PhD, Michael F Moran, PhD, Mark D Minden, MDPhD, Malik Slassi, PhD, Aaron D Schimmer, MDPhD
Journal: Blood
Blood (2014) 124 (21): 2226.
https://doi.org/10.1182/blood.V124.21.2226.2226
Published: 2014
Journal Articles

Inhibition of Fatty Acid Oxidation with Avocatin B Selectively Targets AML Cells and Leukemia Stem Cells

Eric A Lee, Leonard Angka, Sarah-Grace Rota, Thomas Hanlon, Rose Hurren, Xiao Ming Wang, Marcela Gronda, MSc, Dannie Bernard, Mark D. Minden, MD PhD, Andrew Mitchell, Andrea Edginton, PhD, Shrivani Sriskanthadevan, PhD, Alessandro Datti, PhD, Jeff Wrana, PhD, Jamie W Joseph, PhD, Joe Quadrilatero, PhD, Aaron D. Schimmer, MD PhD, Paul A Spagnuolo, PhD
Journal: Blood
Blood (2014) 124 (21): 268.
https://doi.org/10.1182/blood.V124.21.268.268
Published: 2014
Journal Articles

A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside

Sean P. McDermott, Kolja Eppert, Faiyaz Notta, Methvin Isaac, Alessandro Datti, Rima Al-awar, Jeff Wrana, Mark D. Minden, John E. Dick
Journal: Blood
Blood (2012) 119 (5): 1200–1207.
https://doi.org/10.1182/blood-2011-01-330019
Published: 2012
Includes: Supplemental data
Journal Articles

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

Sumaiya Sharmeen, Marko Skrtic, Mahadeo A. Sukhai, Rose Hurren, Marcela Gronda, Xiaoming Wang, Sonali B. Fonseca, Hong Sun, Tabitha E. Wood, Richard Ward, Mark D. Minden, Robert A. Batey, Alessandro Datti, Jeff Wrana, Shana O. Kelley, Aaron D. Schimmer
Journal: Blood
Blood (2010) 116 (18): 3593–3603.
https://doi.org/10.1182/blood-2010-01-262675
Published: 2010
Includes: Supplemental data
Journal Articles

Activation of Chloride Channels with the Anti-Parasitic Agent Ivermectin Induces Membrane Hyperpolarization and Cell Death in Leukemia Cells.

Sumaiya Sharmeen, BSc, Marko Skrtic, Mahadeo Sukhai, BSc, MSc, PhD, Joyce Sun, Rose Hurren, Marcela Gronda, Xiaoming Wang, Tabitha E Wood, PhD, Robert A. Batey, PhD, Sonali Fonesca, Shana Kelley, Alessandro Datti, Jeff Wrana, Aaron D. Schimmer, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 410.
https://doi.org/10.1182/blood.V114.22.410.410
Published: 2009
Journal Articles

A Small Molecule Inhibitor of D-Cyclin Transactivation Displays Preclinical Efficacy in Myeloma and Leukemia.

Xinliang Mao, MD, PhD, Tabitha E Wood, PhD, Rose Hurren, Jiefei Tong, PhD, Xiaoming Wang, Paul A. Spagnuolo, PhD, Neil MacLean, Michael F. Moran, PhD, Alessandro Datti, Jeff Wrana, PhD, Robert A. Batey, PhD, Aaron D. Schimmer, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 2036.
https://doi.org/10.1182/blood.V114.22.2036.2036
Published: 2009
Journal Articles

The off-Patent Anti-Fungal Ciclopirox Olamine Displays Preclinical Activity in Leukemia and Myeloma.

Yanina Eberhard, Amudha Venugopal, Marcela Gronda, Rose Hurren, Alessandro Datti, Jeff Wrana, William E Antholine, Aaron D. Schimmer
Journal: Blood
Blood (2008) 112 (11): 944.
https://doi.org/10.1182/blood.V112.11.944.944
Published: 2008
Journal Articles

A Novel Chromene-Based Pan-PI3 Kinase Inhibitor Displays Preclinical Activity in Leukemia and Myeloma.

Xinliang Mao, MD, PhD, Tabitha W. Wood, PhD, Xiaoming Wang, PhD, Johnathan St-Germain, BSc, Michael F. Moran, PhD, Alessandro Datti, PhD, Jeff Wrana, PhD, Robert A. Batey, PhD, Aaron D. Schimmer, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1605.
https://doi.org/10.1182/blood.V112.11.1605.1605
Published: 2008
Journal Articles

A Chemical Biology Screen Identifies Glucocorticoids as Inhibitors of C-Maf and C-Maf-Dependent Transactivation of Cyclin D2.

Xinliang Mao, A. Keith Stewart, Rose Hurren, Alessandro Datti, Chang Xin Shi, Yuan-Xiao Zhu, Kyle Lee, Rodger Tiedemann, Yanina Eberhard, Seth J. Corey, Jeff Wrana, Aaron D. Schimmer
Journal: Blood
Blood (2006) 108 (11): 368.
https://doi.org/10.1182/blood.V108.11.368.368
Published: 2006