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Journal Articles

Distinct patterns of clonal evolution in patients with concurrent myelo- and lymphoproliferative neoplasms

James A. Kennedy, Jessie J. F. Medeiros, Stephanie M. Dobson, Andrea Arruda, Mahadeo A. Sukhai, Tracy Stockley, Anne Tierens, Mark D. Minden, Suzanne Kamel-Reid, John E. Dick, Vikas Gupta

Blood (2018) 132 (20): 2201–2205.

https://doi.org/10.1182/blood-2018-04-845065

Published: 2018

Includes: Supplemental data

Journal Articles

Utility of Next Generation Sequencing in Prognostication and Therapeutic Decision Making in Cytogenetically Normal AML with DNMT3A Mutations

Arjun Datt Law, MBBS, MDDM, Mahadeo A. Sukhai, BSc, MSc, PhD, Mariam Thomas, PhD, Andrea Arruda, MSc., Narmin Ibrahimova, Steven M. Chan, MD PhD, Vikas Gupta, MD FRCP, FRCPath, Mark D. Minden, MD PhD, Aaron D. Schimmer, MD PhD, Hassan Sibai, MD, Karen W.L. Yee, MD, Dwayne L. Barber, PhD, Tracy L. Stockley, PhD, Suzanne Kamel-Reid, PhD DABMG, FACMG, Andre C. Schuh, MD FRCPC

Blood (2016) 128 (22): 2886.

https://doi.org/10.1182/blood.V128.22.2886.2886

Published: 2016

Journal Articles

Prospective Next-Generation Sequencing Molecular Profiling of Myeloid Malignancies: Assessment of Information Benefit and Impact on Patient Care

Blood (2015) 126 (23): 3848.

https://doi.org/10.1182/blood.V126.23.3848.3848

Published: 2015

Journal Articles

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Blood (2015) 125 (13): 2120–2130.

https://doi.org/10.1182/blood-2014-08-594408

Published: 2015

Includes: Supplemental data

Journal Articles

Mutations In UBA3 Confer Resistance To The NEDD8-Activating Enzyme Inhibitor MLN4924 In Human Leukemic Cells

G. Wei Xu, MD, PhD, Julia I. Toth, PhD, Sara R. da Silva, BSc, Stacey-Lynn Paiva, BSc, Julie L. Lukkarila, PhD, Rose Hurren, Neil Maclean, BSc, Mahadeo A. Sukhai, PhD, Rabindra N. Bhattacharjee, PhD, Carolyn A. Goard, PhD, Bruno C Medeiros, MD, Patrick T. Gunning, PhD, Sirano Dhe-Paganon, PhD, Matthew D. Petroski, PhD, Aaron Schimmer, PhD, MD

Blood (2013) 122 (21): 2527.

https://doi.org/10.1182/blood.V122.21.2527.2527

Published: 2013

Journal Articles

A 7-Gene Microrna Signature Characteristic of Mantle Cell Lymphoma Reveals Focal Adhesion and Integrin Signalling, Proteasome-Mediated Degradation, and the PI3K Signalling Cascade As Important to MCL Pathogenesis

Blood (2012) 120 (21): 1586.

https://doi.org/10.1182/blood.V120.21.1586.1586

Published: 2012

Journal Articles

Chronic Inhibition of Mitochondrial Translation Alters Metabolism and Stemness in AML

Jhas Bozhena, BSc, Shrivani Sriskanthadevan, PhD, Marko Skrtic, PhD, Mahadeo A. Sukhai, PhD, Veronique Voisin, PhD, Yulia Jitkova, PhD, Marcela Gronda, MSc, Rose Hurren, BSc, Xiaoming Wang, Rob C. Laister, PhD, Gary D. Bader, Ph.D., Mark D. Minden, MD, PhD, Aaron D. Schimmer, MD

Blood (2012) 120 (21): 1364.

https://doi.org/10.1182/blood.V120.21.1364.1364

Published: 2012

Journal Articles

Targeting the Mammalian Mitochondrial Clpp (mClpP) As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

Alicia Cole, PhD, Zezhou Wang, PhD, Rachel Mattson, Rose Hurren, BSc, Fengshu Lin, PhD, Marcela Gronda, MSc, Neil Maclean, BSc, Methvin Isaac, PhD, Elisa Leung, BSc., Mohan Babu, PhD, Mahadeo A. Sukhai, PhD, Walid A. Houry, PhD, Aaron D. Schimmer, MD

Blood (2012) 120 (21): 3603.

https://doi.org/10.1182/blood.V120.21.3603.3603

Published: 2012

Journal Articles

AML Cells Have Altered Mitochondrial Biogenesis and Low Spare Reserve Capacity in Their Respiratory Chain That Renders Them Susceptible to Oxidative Metabolic Stress.

Shrivani Sriskanthadevan, PhD, Timothy E Chung, Marko Skrtic, PhD, Bozhena Jhas, BSc, Rose Hurren, BSc, Marcela Gronda, MSc, Xiao Ming Wang, Yulia Jitkova, PhD, Mahadeo A. Sukhai, PhD, Feng-Hsu Lin, PhD, Neil Maclean, BSc, Rob C. Laister, PhD, Peter Mullen, PhD, Stephanie Xie, Linda Penn, PhD, Ian M. Rogers, PhD, John E. Dick, PhD $, Mark D. Minden, MD, PhD, Aaron D Schimmer, MD, PhD

Blood (2012) 120 (21): 2581.

https://doi.org/10.1182/blood.V120.21.2581.2581

Published: 2012

Journal Articles

Lysosomal Disruption Selectively Targets Leukemia Cells and Leukemia Stem Cells Through A Mechanism Related to Increased Reactive Oxygen Species Production

Blood (2011) 118 (21): 61.

https://doi.org/10.1182/blood.V118.21.61.61

Published: 2011

Journal Articles

New sources of drugs for hematologic malignancies

Mahadeo A. Sukhai, Paul A. Spagnuolo, Scott Weir, James Kasper, Lavonne Patton, Aaron D. Schimmer

Blood (2011) 117 (25): 6747–6755.

https://doi.org/10.1182/blood-2011-02-315283

Published: 2011

Journal Articles

The Anti-Malarial Mefloquine Demonstrates Preclinical Activity In Leukemia and Myeloma, and Is Dependent Upon Toll-Like Receptor Signaling for Its Cytotoxicity

Mahadeo A. Sukhai, PhD, Xiaoming Li, PhD, Rose Hurren, Xiaoming Wang, Skrtic Marko, B.Sc., Hong Sun, Marcela Gronda, Ayesh Seneviratne, Dilan Dissanayake, Sue Chow, Rod Bremner, PhD, David Hedley, MD, Mark D. Minden, MD, PhD, Ohashi Pamela, PhD, FRSC, Aaron Schimmer, MD, PhD

Blood (2010) 116 (21): 290.

https://doi.org/10.1182/blood.V116.21.290.290

Published: 2010

Journal Articles

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

Sumaiya Sharmeen, Marko Skrtic, Mahadeo A. Sukhai, Rose Hurren, Marcela Gronda, Xiaoming Wang, Sonali B. Fonseca, Hong Sun, Tabitha E. Wood, Richard Ward, Mark D. Minden, Robert A. Batey, Alessandro Datti, Jeff Wrana, Shana O. Kelley, Aaron D. Schimmer

Blood (2010) 116 (18): 3593–3603.

https://doi.org/10.1182/blood-2010-01-262675

Published: 2010

Includes: Supplemental data

Journal Articles

The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma

Paul A. Spagnuolo, Jiayi Hu, Rose Hurren, Xiaoming Wang, Marcela Gronda, Mahadeo A. Sukhai, Ashley Di Meo, Jonathan Boss, Iman Ashali, Reza Beheshti Zavareh, Noah Fine, Craig D. Simpson, Sumaiya Sharmeen, Rob Rottapel, Aaron D. Schimmer

Blood (2010) 115 (23): 4824–4833.

https://doi.org/10.1182/blood-2009-09-243055

Published: 2010

Includes: Supplemental data

Journal Articles

Assessment of Microrna Expression in Mantle Cell Lymphoma Using High Throughput Techniques

Rashmi S Goswami, MD, FRCPC, Nilva de Karla Cervigne, MSc, Patricia Pintor dos Reis, PhD, Mahadeo A Sukhai, PhD, John Kuruvilla, MD, FRCPC, Michael Crump, MD, FRCPC, Denis Bailey, MD, FRCPC, Suzanne Kamel-Reid, PhD, FACMG

Blood (2008) 112 (11): 2824.

https://doi.org/10.1182/blood.V112.11.2824.2824

Published: 2008

Journal Articles

Comparative Analysis of Downstream Genetic Targets of the Variant Acute Promyelocytic Leukemia Fusion Proteins NPM-RARA and NuMA-RARA.

Mariam Thomas, BSc (Hon), Mahadeo A. Sukhai, Ph.D, Yali Xuan, B.Sc, Soheila A. Hamadanizadeh, Ph.D, Rashmi S. Goswami, M.D, Rikki R. Bharadwaj, M.Sc, Patricia P. Reis, Ph.D, Suzanne Kamel-Reid, Ph.D

Blood (2007) 110 (11): 3166.

https://doi.org/10.1182/blood.V110.11.3166.3166

Published: 2007

Journal Articles

Nuclear Localization of the NuMA-RARα/RXRα Complex Is Necessary for Leukemogenesis in hCG-NuMA-RAR α Transgenic Mice.

Mahadeo A. Sukhai, BSc, MSc, Mariam Thomas, BSc, Yali Xuan, BSc, Soheila A. Hamadanizadeh, BSc, MSc, Rikki R. Bharadwaj, BSc, MSc, Andre Schuh, MD, Richard A. Wells, MD, DPhil, Suzanne Kamel-Reid

Blood (2006) 108 (11): 1403.

https://doi.org/10.1182/blood.V108.11.1403.1403

Published: 2006

Journal Articles

Systems Analysis Reveals Regulators of Apoptosis, Cell Cycle, Signal Transduction and Transcription as Novel Direct Targets of the Acute Promyelocytic Leukemia Fusion Protein NuMA-RAR α

Mahadeo A. Sukhai, BSc, MSc, Mariam Thomas, BSc, Yali Xuan, BSc, Patricia P. Reis, PhD, Rikki R. Bharadwaj, MSc, Suzanne Kamel-Reid, PhD

Blood (2006) 108 (11): 2247.

https://doi.org/10.1182/blood.V108.11.2247.2247

Published: 2006

Journal Articles

EAR-2: Identification of a Gene Involved in Maintenance of Clonogenicity in Haematopoiesis.

Christine V. Ichim, MSc, Mahadeo A. Sukhai, MSc, J. Brandwein, MD, Mark D. Minden, MD, PhD, Aaron D. Schimmer, MD, PhD, Andre C. Schuh, MD, Suzanne Kamel-Reid, PhD, Norman N. Iscove, MD, PhD, Richard A. Wells, MD, DPhil

Blood (2004) 104 (11): 3226.

https://doi.org/10.1182/blood.V104.11.3226.3226

Published: 2004

NARROW

Distinct patterns of clonal evolution in patients with concurrent myelo- and lymphoproliferative neoplasms

Utility of Next Generation Sequencing in Prognostication and Therapeutic Decision Making in Cytogenetically Normal AML with DNMT3A Mutations

Prospective Next-Generation Sequencing Molecular Profiling of Myeloid Malignancies: Assessment of Information Benefit and Impact on Patient Care

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Mutations In UBA3 Confer Resistance To The NEDD8-Activating Enzyme Inhibitor MLN4924 In Human Leukemic Cells

A 7-Gene Microrna Signature Characteristic of Mantle Cell Lymphoma Reveals Focal Adhesion and Integrin Signalling, Proteasome-Mediated Degradation, and the PI3K Signalling Cascade As Important to MCL Pathogenesis

Chronic Inhibition of Mitochondrial Translation Alters Metabolism and Stemness in AML

Targeting the Mammalian Mitochondrial Clpp (mClpP) As a Novel Therapeutic Strategy for Acute Myeloid Leukemia

AML Cells Have Altered Mitochondrial Biogenesis and Low Spare Reserve Capacity in Their Respiratory Chain That Renders Them Susceptible to Oxidative Metabolic Stress.

Lysosomal Disruption Selectively Targets Leukemia Cells and Leukemia Stem Cells Through A Mechanism Related to Increased Reactive Oxygen Species Production

New sources of drugs for hematologic malignancies

The Anti-Malarial Mefloquine Demonstrates Preclinical Activity In Leukemia and Myeloma, and Is Dependent Upon Toll-Like Receptor Signaling for Its Cytotoxicity

The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells

The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma

Assessment of Microrna Expression in Mantle Cell Lymphoma Using High Throughput Techniques

Comparative Analysis of Downstream Genetic Targets of the Variant Acute Promyelocytic Leukemia Fusion Proteins NPM-RARA and NuMA-RARA.

Nuclear Localization of the NuMA-RARα/RXRα Complex Is Necessary for Leukemogenesis in hCG-NuMA-RAR α Transgenic Mice.

Systems Analysis Reveals Regulators of Apoptosis, Cell Cycle, Signal Transduction and Transcription as Novel Direct Targets of the Acute Promyelocytic Leukemia Fusion Protein NuMA-RAR α

EAR-2: Identification of a Gene Involved in Maintenance of Clonogenicity in Haematopoiesis.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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