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Carolyn A. Goard
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Journal Articles

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Shrivani Sriskanthadevan, Danny V. Jeyaraju, Timothy E. Chung, Swayam Prabha, Wei Xu, Marko Skrtic, Bozhena Jhas, Rose Hurren, Marcela Gronda, Xiaoming Wang, Yulia Jitkova, Mahadeo A. Sukhai, Feng-Hsu Lin, Neil Maclean, Rob Laister, Carolyn A. Goard, Peter J. Mullen, Stephanie Xie, Linda Z. Penn, Ian M. Rogers, John E. Dick, Mark D. Minden, Aaron D. Schimmer
Journal: Blood
Blood (2015) 125 (13): 2120–2130.
https://doi.org/10.1182/blood-2014-08-594408
Published: 2015
Includes: Supplemental data
Journal Articles

FV-162 Is a Novel Orally Bioavailable Proteasome Inhibitor With Improved Pharmacokinetics That Displays Preclinical Efficacy In Vitro and In Vivo

Zezhou Wang, PhD, Peter Dove, Xiaoming Wang, Carolyn A. Goard, PhD, Zhihua Li, Alex Nachman, Yoonsun Jenny Oh, Rose Hurren, Amy Ruschak, PhD, Shane Climie, PhD, David O'Neill, PhD, Barry Press, PhD, Carly Griffin, PhD, Elijus Undzys, Ahmed Aman, PhD, Rima Al-awar, PhD, Lewis Kay, PhD, Suzanne Trudel, MD, MSC, FRCPC, Malik Slassi, PhD, Aaron Schimmer, PhD, MD
Journal: Blood
Blood (2013) 122 (21): 1988.
https://doi.org/10.1182/blood.V122.21.1988.1988
Published: 2013
Journal Articles

Mutations In UBA3 Confer Resistance To The NEDD8-Activating Enzyme Inhibitor MLN4924 In Human Leukemic Cells

G. Wei Xu, MD, PhD, Julia I. Toth, PhD, Sara R. da Silva, BSc, Stacey-Lynn Paiva, BSc, Julie L. Lukkarila, PhD, Rose Hurren, Neil Maclean, BSc, Mahadeo A. Sukhai, PhD, Rabindra N. Bhattacharjee, PhD, Carolyn A. Goard, PhD, Bruno C Medeiros, MD, Patrick T. Gunning, PhD, Sirano Dhe-Paganon, PhD, Matthew D. Petroski, PhD, Aaron Schimmer, PhD, MD
Journal: Blood
Blood (2013) 122 (21): 2527.
https://doi.org/10.1182/blood.V122.21.2527.2527
Published: 2013