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Journal Articles

AML Cells Have Increased Mitochondrial RNA Degradation and Inhibiting This Degradation Promotes Cell Differentiation, Decreases Viability, and Increases Sensitivity to Immune-Mediated Killing

Geethu Emily Thomas, Kazem Nouri, Rose Hurren, JongBok Lee, Veronique Voisin, Yongran Yan, Neil Maclean, Marcela Gronda, Yulia Jitkova, Taylor Barbieri, Li Ma, Xiaoming Wang, Andrea Arruda, Mark D. Minden, Li Zhang, Aaron D Schimmer

Blood (2024) 144 (Supplement 1): 2723.

https://doi.org/10.1182/blood-2024-194861

Published: 2024

Journal Articles

Inhibiting Mitochondrial RNA Degradosome Complex SUV3 and PNPT1 Increases dsRNA in the Cytoplasm, Triggers Viral Mimicry Response and Sensitizes AML Cells to Immune Mediated Killing

Geethu Emily Thomas, Kazem Nouri, Jong Bok Lee, Rose Hurren, Yongran Yan, Neil Maclean, Yulia Jitkova, Li Ma, Xiaoming Wang, Chaitra Sarathy, Andrea Arruda, Mark D. Minden, Li Zhang, Vito Spadavecchio, Aaron D. Schimmer

Blood (2023) 142 (Supplement 1): 2742.

https://doi.org/10.1182/blood-2023-178696

Published: 2023

Journal Articles

A Multicenter Clinical Study with Reduced Intensive Chemotherapy for Induction Remission of Pediatric Acute Megakaryoblastic Leukemia

Blood (2023) 142 (Supplement 1): 4276.

https://doi.org/10.1182/blood-2023-190821

Published: 2023

Journal Articles

Inhibiting the Mitochondrial RNA Degradosome Complex SUV3 and Pnpase Increases dsRNA in the Cytoplasm, Triggers a Viral Mimicry Response and Kills AML Cells and Progenitors

Geethu Emily Thomas, Kazem Nouri, Rose Hurren, Yongran Yan, Neil MacLean, Yulia Jitkova, Li Ma, Xiaoming Wang, Chaitra Sarathy, Andrea Arruda, Mark D. Minden, Vito Spadevecchio, Aaron D. Schimmer

Blood (2022) 140 (Supplement 1): 8723–8724.

https://doi.org/10.1182/blood-2022-158326

Published: 2022

Journal Articles

Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production

Jong Bok Lee, Dilshad H. Khan, Rose Hurren, Mingjing Xu, Yoosu Na, Hyeonjeong Kang, Sara Mirali, Xiaoming Wang, Marcela Gronda, Yulia Jitkova, Neil MacLean, Andrea Arruda, Zoe Alaniz, Marina Y. Konopleva, Michael Andreeff, Mark D. Minden, Li Zhang, Aaron D. Schimmer

Blood (2021) 138 (3): 234–245.

https://doi.org/10.1182/blood.2020009081

Published: 2021

Includes: Supplemental data

Journal Articles

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-135858

Published: 2020

Journal Articles

IPO11 Regulates the Nuclear Import of BZW1/2 and Is Necessary for AML Cells and Stem Cells

Boaz Nachmias, MDPhD, Veronique Voisin, PhD, Geethu Emily Thomas, PhDMSc,BSc, Dilshad H. Khan, Rose Hurren, BSc, Aaron Botham, Xiaoming Wang, Neil Maclean, Ayesh K Seneviratne, BSc, MSc, Changjiang Xu, Jonathan St-Germain, Andrea Arruda, MSc, Elias Orouji, Liran I. Shlush, MD, Mark D. Minden, Brian Raught, Gary D Bader, Aaron D Schimmer, MD PhD

Blood (2020) 136 (Supplement 1): 22–23.

https://doi.org/10.1182/blood-2020-134787

Published: 2020

Journal Articles

Mitochondrial carrier homolog 2 is necessary for AML survival

Blood (2020) 136 (1): 81–92.

https://doi.org/10.1182/blood.2019000106

Published: 2020

Includes: Supplemental data

Journal Articles

The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Complex and Supercomplex Formation and Is Necessary for AML Viability

Blood (2019) 134 (Supplement_1): 729.

https://doi.org/10.1182/blood-2019-122784

Published: 2019

Journal Articles

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

Geethu Emily Thomas, PhDMSc,BSc, Grace Egan, MD, Laura Garcia Prat, Boaz Nachmias, MD PhD, Jordan M Chin, Fieke W Hoff, BSc, Kerstin Kaufmann, PhD, Rose Hurren, BSc, Marcela Gronda, MSc, Neil MacLean, Xiaoming Wang, Veronique Voisin, PhD, Aaron Botham, Andrea Arruda, Mark D. Minden, MD PhD, Gary D Bader, Steven M. Kornblau, MD, John E. Dick, PhD, Aaron D Schimmer, MD PhD

Blood (2019) 134 (Supplement_1): 2532.

https://doi.org/10.1182/blood-2019-123121

Published: 2019

Journal Articles

5-Fluorotroxacitabine Displays Potent Anti-Leukemic Effects and Circumvents Resistance to Ara-C

Aniket Bankar, MBBS, MD DM, Thirushi Piyumika Siriwardena, Biljana Rizoska, PhD, Christina Rydergård, BSc, Helen Kylefjord, BSc, Vilma Rraklli, PhD, Anders Eneroth, PhD, Pedro Pinho, PhD, Stefan Norin, MD PhD, Johan Bylund, PhD, Sara Moses, PhD, Richard Bethell, PhD, Simon Kavanagh, MBBS(Hons), FRACP, FRCPA, Xiaoming Wang, Rose Hurren, BSc, Mark D. Minden, MD PhD, Paul Targett-Adams, PhD BSc, Aaron D Schimmer, MD PhD, Mark Albertella, PhD

Blood (2018) 132 (Supplement 1): 3939.

https://doi.org/10.1182/blood-2018-99-114345

Published: 2018

Journal Articles

The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Supercomplex Formation and Represents a New Therapeutic Target for AML

Sara Mirali, Botham Aaron, Veronique Voisin, PhD, Yihua Qiu, Fieke W Hoff, BSc, Rose Hurren, BSc, Marcela Gronda, MSc, Yulia Jitkova, PhD, G. Wei Xu, Neil MacLean, Xiaoming Wang, Terzah M. Horton, MD PhD, Steven M. Kornblau, MD, Steven M Chan, MD PhD, Gary D Bader, Aaron Schimmer, MD PhD

Blood (2018) 132 (Supplement 1): 1335.

https://doi.org/10.1182/blood-2018-99-110869

Published: 2018

Journal Articles

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism

Blood (2018) 132 (Supplement 1): 1339.

https://doi.org/10.1182/blood-2018-99-111015

Published: 2018

Journal Articles

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

Geethu Thomas, PhD MSc, BSc, Laura Garcia Prat, Marcela Gronda, MSc, Rose Hurren, BSc, Neil MacLean, Xiaoming Wang, Botham Aaron, John E. Dick, Aaron D Schimmer, MD PhD

Blood (2018) 132 (Supplement 1): 2795.

https://doi.org/10.1182/blood-2018-99-110021

Published: 2018

Journal Articles

The Thymidine Dideoxynucleoside Analogue, Alovudine, Inhibits the Mitochondrial DNA Polyermase, POLG, Impairs Oxidative Phosphorylation and Promotes Monocytic Differentiation in AML

Dana Yehudai-Ofir, MD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Rose Hurren, BSc, Marcela Gronda, MSc, Danny V. Jeyaraju, PhD, Xiaoming Wang, Thirushi Siriwardena, Yulia Jitkova, PhD, Aaron D. Schimmer, MDPhD, Biljana Rizoska, PhD, Paul Targett-Adams, PhD, Mark Albertella, PhD

Blood (2017) 130 (Supplement 1): 2524.

https://doi.org/10.1182/blood.V130.Suppl_1.2524.2524

Published: 2017

Journal Articles

TAK-243 Is a Selective UBA1 Inhibitor That Displays Preclinical Activity in Acute Myeloid Leukemia (AML)

Samir H. Barghout, BSPharm, MSc, Parasvi Patel, BSc (Hons), Xiaoming Wang, G. Wei Xu, Simon Kavanagh, Marcela Gronda, MSc, Rose Hurren, BSc, Danny V. Jeyaraju, PhD, Neil MacLean, Marc Hyer, PhD, Allison Berger, PhD, Tary Traore, Michael Sintchak, Michael Milhollen, Mark D. Minden, MD PhD, Razq Hakem, PhD, Aaron D. Schimmer, MDPhD

Blood (2017) 130 (Supplement 1): 814.

https://doi.org/10.1182/blood.V130.Suppl_1.814.814

Published: 2017

Journal Articles

Mitochondrial Carrier Homolog 2 (MTCH2) Regulates the Differentiation of AML Cells By Controlling Pyruvate Entry into the Mitochondria, Nuclear Localization of Pyruvate Dehydrogenase Complex and H3 and H4 Histone Acetylation

Dilshad H. Khan, Michael Mullokandov, Yan Wu, Marcela Gronda, MSc, Rose Hurren, BSc, Xiaoming Wang, Neil MacLean, Danny V. Jeyaraju, PhD, G. Wei Xu, Rob C. Laister, PhD, Zachary Blatman, Troy Ketela, Mark D. Minden, MD PhD, Atan Gross, PhD, Aaron D. Schimmer, MDPhD

Blood (2017) 130 (Supplement 1): 299.

https://doi.org/10.1182/blood.V130.Suppl_1.299.299

Published: 2017

Journal Articles

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Danny V. Jeyaraju, PhD, Veronique Voisin, Changjiang Xu, Samir H. Barghout, BSPharm, MSc, Dilshad H. Khan, Rose Hurren, BSc, Marcela Gronda, MSc, Xiaoming Wang, Yulia Jitkova, PhD, David Sharon, PhD, Sanduni U. Liyanage, Hon. B. Sc, PhD, Joelle Soriano, Eric R. Lechman, PhD, Neil MacLean, Mark D. Minden, MD PhD, Steven M. Chan, MDPhD, John E. Dick, PhD, Gary D Bader, Aaron D. Schimmer, MDPhD

Blood (2017) 130 (Supplement 1): 881.

https://doi.org/10.1182/blood.V130.Suppl_1.881.881

Published: 2017

Journal Articles

Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML

Sanduni U. Liyanage, Rose Hurren, Veronique Voisin, Gaëlle Bridon, Xiaoming Wang, ChangJiang Xu, Neil MacLean, Thirushi P. Siriwardena, Marcela Gronda, Dana Yehudai, Shrivani Sriskanthadevan, Daina Avizonis, Aisha Shamas-Din, Mark D. Minden, Gary D. Bader, Rebecca Laposa, Aaron D. Schimmer

Blood (2017) 129 (19): 2657–2666.

https://doi.org/10.1182/blood-2016-10-741207

Published: 2017

Includes: Supplemental data

Journal Articles

The Mitochondrial Carrier Homolog 2 (MTCH2) Regulates the Differentiation of AML Cells By Influencing the Localization of Pyruvate Dehydrogenase Complex and H3 and H4 Histone Acetylation

Dilshad H. Khan, PhD, Michael Mullokandov, Yan Wu, Marcela Gronda, Rose Hurren, Xiaoming Wang, Neil MacLean, Rob C. Laister, PhD, Atan Gross, Aaron D. Schimmer, MD PhD

Blood (2016) 128 (22): 1562.

https://doi.org/10.1182/blood.V128.22.1562.1562

Published: 2016

NARROW

AML Cells Have Increased Mitochondrial RNA Degradation and Inhibiting This Degradation Promotes Cell Differentiation, Decreases Viability, and Increases Sensitivity to Immune-Mediated Killing

Inhibiting Mitochondrial RNA Degradosome Complex SUV3 and PNPT1 Increases dsRNA in the Cytoplasm, Triggers Viral Mimicry Response and Sensitizes AML Cells to Immune Mediated Killing

A Multicenter Clinical Study with Reduced Intensive Chemotherapy for Induction Remission of Pediatric Acute Megakaryoblastic Leukemia

Inhibiting the Mitochondrial RNA Degradosome Complex SUV3 and Pnpase Increases dsRNA in the Cytoplasm, Triggers a Viral Mimicry Response and Kills AML Cells and Progenitors

Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

IPO11 Regulates the Nuclear Import of BZW1/2 and Is Necessary for AML Cells and Stem Cells

Mitochondrial carrier homolog 2 is necessary for AML survival

The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Complex and Supercomplex Formation and Is Necessary for AML Viability

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

5-Fluorotroxacitabine Displays Potent Anti-Leukemic Effects and Circumvents Resistance to Ara-C

The Mitochondrial Protease, Neurolysin (NLN), Regulates Respiratory Chain Supercomplex Formation and Represents a New Therapeutic Target for AML

Targeting the Mitochondrial Metallochaperone Cox17 Reduces DNA Methylation and Promotes AML Differentiation through a Copper Dependent Mechanism

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

The Thymidine Dideoxynucleoside Analogue, Alovudine, Inhibits the Mitochondrial DNA Polyermase, POLG, Impairs Oxidative Phosphorylation and Promotes Monocytic Differentiation in AML

TAK-243 Is a Selective UBA1 Inhibitor That Displays Preclinical Activity in Acute Myeloid Leukemia (AML)

Mitochondrial Carrier Homolog 2 (MTCH2) Regulates the Differentiation of AML Cells By Controlling Pyruvate Entry into the Mitochondria, Nuclear Localization of Pyruvate Dehydrogenase Complex and H3 and H4 Histone Acetylation

Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells

Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML

The Mitochondrial Carrier Homolog 2 (MTCH2) Regulates the Differentiation of AML Cells By Influencing the Localization of Pyruvate Dehydrogenase Complex and H3 and H4 Histone Acetylation

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American Society of Hematology

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American Society of Hematology

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