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Michael Milhollen
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Journal Articles

TAK-243 Is a Selective UBA1 Inhibitor That Displays Preclinical Activity in Acute Myeloid Leukemia (AML)

Samir H. Barghout, BSPharm, MSc, Parasvi Patel, BSc (Hons), Xiaoming Wang, G. Wei Xu, Simon Kavanagh, Marcela Gronda, MSc, Rose Hurren, BSc, Danny V. Jeyaraju, PhD, Neil MacLean, Marc Hyer, PhD, Allison Berger, PhD, Tary Traore, Michael Sintchak, Michael Milhollen, Mark D. Minden, MD PhD, Razq Hakem, PhD, Aaron D. Schimmer, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 814.
https://doi.org/10.1182/blood.V130.Suppl_1.814.814
Published: 2017
Journal Articles

Treatment Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Pre-Clinical AML and DLBCL Models

Michael Milhollen, Michael Thomas, Tary Traore, Usha Narayanan, Jessica Riceberg, Todd Sells, PhD, Ben Amidon, PhD, Mark Manfredi, PhD, Neil Bence, PhD, James Brownell, PhD, Larry Dick, PhD, Erik Koenig, James Gavin, Peter G Smith, PhD
Journal: Blood
Blood (2011) 118 (21): 1413.
https://doi.org/10.1182/blood.V118.21.1413.1413
Published: 2011
Journal Articles

Azacitidine/Decitabine Synergism with the NEDD8-Activating Enzyme Inhibitor MLN4924 in Pre-Clinical AML Models

Peter G Smith, PhD, Tary Traore, Steve Grossman, Usha Narayanan, Jennifer S Carew, PhD, Anya Lublinksky, Michael Kuranda, PhD, Michael Milhollen
Journal: Blood
Blood (2011) 118 (21): 578.
https://doi.org/10.1182/blood.V118.21.578.578
Published: 2011
Journal Articles

MLN4924, a Potent and Novel Small Molecule Inhibitor of Nedd8 Activating Enzyme, Induces DNA Re-Replication and Apoptosis in Cultured Human Tumor Cells

Michael Milhollen, MSc, Usha Narayanan, Jennifer Duffy, Ben Amidon, Teresa A Soucy, PhD, Allison J Berger, PhD, Steven P. Langston, Todd Sells, Peter G Smith, PhD
Journal: Blood
Blood (2008) 112 (11): 3621.
https://doi.org/10.1182/blood.V112.11.3621.3621
Published: 2008
Journal Articles

MLN4924, a Novel Small Molecule Inhibitor of Nedd8-Activating Enzyme, Demonstrates Potent Anti-Tumor Activity in Diffuse Large B-Cell Lymphoma

Michael Milhollen, MSc, Usha Narayanan, Allison J Berger, PhD, Michael Thomas, Tary Traore, Jie Yu, Julie Zhang, Erik Koenig, James J. Garnsey, Steven P. Langston, Teresa A Soucy, PhD, Peter G Smith, PhD
Journal: Blood
Blood (2008) 112 (11): 606.
https://doi.org/10.1182/blood.V112.11.606.606
Published: 2008