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    Journal Articles

    Treatment Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Pre-Clinical AML and DLBCL Models

    Michael Milhollen, Michael Thomas, Tary Traore, Usha Narayanan, Jessica Riceberg, Todd Sells, PhD, Ben Amidon, PhD, Mark Manfredi, PhD, Neil Bence, PhD, James Brownell, PhD, Larry Dick, PhD, Erik Koenig, James Gavin, Peter G Smith, PhD
    Journal: Blood
    Blood (2011) 118 (21): 1413.
    https://doi.org/10.1182/blood.V118.21.1413.1413
    Published: 2011
    Journal Articles

    MLN4924, a Potent and Novel Small Molecule Inhibitor of Nedd8 Activating Enzyme, Induces DNA Re-Replication and Apoptosis in Cultured Human Tumor Cells

    Michael Milhollen, MSc, Usha Narayanan, Jennifer Duffy, Ben Amidon, Teresa A Soucy, PhD, Allison J Berger, PhD, Steven P. Langston, Todd Sells, Peter G Smith, PhD
    Journal: Blood
    Blood (2008) 112 (11): 3621.
    https://doi.org/10.1182/blood.V112.11.3621.3621
    Published: 2008

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