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Journal Articles

REM-422, a Small Molecule MYB mRNA Degrader, Demonstrates Anti-Leukemic Activity As Monotherapy and in Combination with Standards of Care in Preclinical Models of AML

Samantha Levin-Furtney, Michael Thomas, Alycen M. Harney, Mengge Shan, Alexander Ivliev, Adam Stefek, Michael Cameron, Sudeep Prajapati, Michael Seiler, Dominic Reynolds, Silvia Buonamici, Charles Kung
Journal: Blood
Blood (2024) 144 (Supplement 1): 826.
https://doi.org/10.1182/blood-2024-208725
Published: 2024
Journal Articles

Development of Next Generation Antibody-Polymer-Drug Conjugates for Treatment of Multiple Myeloma

Jiahui Li, Michael Thomas Gambles, Shannuo Li, Jindřich Kopeček, Douglas Sborov, Jiyuan Yang
Journal: Blood
Blood (2023) 142 (Supplement 1): 3308.
https://doi.org/10.1182/blood-2023-186661
Published: 2023
Journal Articles

Splicing Modulation Perturbs Key Survival Pathways and Sensitizes Chronic Lymphocytic Leukemia to Venetoclax Treatment

Elisa Ten Hacken, PhD, Rebecca Valentin, MD, Jing Sun, PhD, Jing Deng, PhD, Angela Brooks, PhD, Lillian Werner, MS, Fara Faye Regis, BS, Michaela Gruber, MD PhD, Jessica Wong, BS, Zachary Cartun, BS, Michael Seiler, PhD, Peter Smith, PhD, Michael Thomas, PhD, Silvia Buonamici, PhD, Emanuela M. Ghia, PhD, Ekaterina Kim, PhD, Laura Z. Rassenti, PhD, Jan A. Burger, MD PhD, Thomas J. Kipps, MD, Matthew Meyerson, MDPhD, Donna S. Neuberg, ScD, Ruben D. Carrasco, MD PhD, Lili Wang, MD PhD, Matthew S. Davids, MD, Anthony Letai, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 264.
https://doi.org/10.1182/blood.V130.Suppl_1.264.264
Published: 2017
Journal Articles

H3B-8800, an Orally Bioavailable Modulator of the SF3b Complex, Shows Efficacy in Spliceosome-Mutant Myeloid Malignancies

Silvia Buonamici, PhD, Akihide Yoshimi, MD PhD, Michael Thomas, Michael Seiler, PhD, Betty Chan, PhD, Benjamin Caleb, Rachel Darman, PhD, Peter Fekkes, PhD, Craig Karr, PhD, Gregg F. Keaney, PhD, Virginia M. Klimek, MD, Kaiko Kunii, Linda Lee, Stanley Chun-Wei Lee, PhD, Xiang Liu, PhD, Carol Meeske, Yoshiharu Mizui, PhD, Eric Padron, MD, Eunice Park, PhD, Ermira Pazolli, PhD, Sudeep Prajapati, PhD, Justin Taylor, MD, John Wang, PhD, Markus Warmuth, MD, Lihua Yu, PhD, Ping Zhu, MD, Omar Abdel-Wahab, MD, Peter G Smith, PhD
Journal: Blood
Blood (2016) 128 (22): 966.
https://doi.org/10.1182/blood.V128.22.966.966
Published: 2016
Journal Articles

Therapeutic Targeting of Spliceosomal Mutant Myeloid Leukemias through Modulation of Splicing Catalysis

Stanley Chun-Wei Lee, PhD, Heidi Dvinge, Eunhee Kim, PhD, Hana Cho, Young Rock Chung, MS, Jean-Baptiste Micol, MD, Benjamin Durham, MD PhD, Young Joon Kim, Michael Thomas, Camille Lobry, PhD, Silvia Buonamici, PhD, Peter Smith, Robert K. Bradley, PhD, Omar Abdel-Wahab
Journal: Blood
Blood (2015) 126 (23): 4.
https://doi.org/10.1182/blood.V126.23.4.4
Published: 2015
Journal Articles

Heterozygous Hotspot SF3B1 Mutations Found in Myelodysplastic Syndromes Downregulate Genes Involved in Differentiation of Erythroid Cells

Silvia Buonamici, PhD, Rachel Darman, PhD, Samantha Perino, BS, Anant Agrawal, PhD, Shouyong Peng, PhD, Michael Seiler, PhD, Kian Huat Lim, PhD, Erica B. Bhavsar, Jacob Feala, PhD, Esther A. Obeng, MDPhD, Suzanna Bailey, PhD, Betty Chan, PhD, Peter Fekkes, PhD, Gregg F. Keaney, PhD, Pavan Kumar, PhD, Kaiko Kunii, Linda Lee, MS, Crystal Mackenzie, Mark Matijevic, Yoshiharu Mizui, PhD, Khin Myint, Eunice Park, Ermira Pazolli, Michael Thomas, John Wang, Markus Warmuth, MD, Lihua Yu, PhD, Ping Zhu, Richard R. Furman, MD, Benjamin L Ebert, MD PhD, Peter G Smith, PhD
Journal: Blood
Blood (2015) 126 (23): 1643.
https://doi.org/10.1182/blood.V126.23.1643.1643
Published: 2015
Journal Articles

Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation

Uday Popat, Rohtesh S. Mehta, Katayoun Rezvani, Patricia Fox, Kayo Kondo, David Marin, Ian McNiece, Betul Oran, Chitra Hosing, Amanda Olson, Simrit Parmar, Nina Shah, Michael Andreeff, Partow Kebriaei, Indreshpal Kaur, Eric Yvon, Marcos de Lima, Laurence J. N. Cooper, Priti Tewari, Richard E. Champlin, Yago Nieto, Borje S. Andersson, Amin Alousi, Roy B. Jones, Muzaffar H. Qazilbash, Qaiser Bashir, Stefan Ciurea, Sairah Ahmed, Paolo Anderlini, Doyle Bosque, Catherine Bollard, Jeffrey J. Molldrem, Julianne Chen, Gabriela Rondon, Michael Thomas, Leonard Miller, Steve Wolpe, Paul Simmons, Simon Robinson, Patrick A. Zweidler-McKay, Elizabeth J. Shpall
Journal: Blood
Blood (2015) 125 (19): 2885–2892.
https://doi.org/10.1182/blood-2015-01-607366
Published: 2015
Journal Articles

Cancer-Associated Mutations in SF3B1 Exhibit Neomorphic Splicing Activity and Block Erythroid Differentiation

Silvia Buonamici, PhD, Samantha Perino, Kian Huat Lim, Jacob Feala, Esther A. Obeng, MDPhD, Michelle Aicher, Daniel Aird, Suzanna Bailey, Anna Berkenblit, Betty Chan, Corcoran Erik, Laura Corson, PhD, Rachel Darman, Peter Fekkes, Richard R. Furman, MD, Gregg F Keaney, PhD, Pavan Kumar, Kaiko Kunii, Linda Lee, Crystal Mackenzie, Eunice Park, Xiaoling Puyang, Anand Selvaraj, Michael Thomas, John Wang, Markus Warmuth, MD, Lihua Yu, PhD, Ping Zhu, Yoshiharu Mizui, PhD, Benjamin L. Ebert, MDPhD, Peter G Smith, PhD
Journal: Blood
Blood (2014) 124 (21): 4615.
https://doi.org/10.1182/blood.V124.21.4615.4615
Published: 2014
Journal Articles

Treatment Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Pre-Clinical AML and DLBCL Models

Michael Milhollen, Michael Thomas, Tary Traore, Usha Narayanan, Jessica Riceberg, Todd Sells, PhD, Ben Amidon, PhD, Mark Manfredi, PhD, Neil Bence, PhD, James Brownell, PhD, Larry Dick, PhD, Erik Koenig, James Gavin, Peter G Smith, PhD
Journal: Blood
Blood (2011) 118 (21): 1413.
https://doi.org/10.1182/blood.V118.21.1413.1413
Published: 2011
Journal Articles

MLN4924, a Novel Small Molecule Inhibitor of Nedd8-Activating Enzyme, Demonstrates Potent Anti-Tumor Activity in Diffuse Large B-Cell Lymphoma

Michael Milhollen, MSc, Usha Narayanan, Allison J Berger, PhD, Michael Thomas, Tary Traore, Jie Yu, Julie Zhang, Erik Koenig, James J. Garnsey, Steven P. Langston, Teresa A Soucy, PhD, Peter G Smith, PhD
Journal: Blood
Blood (2008) 112 (11): 606.
https://doi.org/10.1182/blood.V112.11.606.606
Published: 2008
Journal Articles

Mesenchymal Stromal Cells Derived from Human Non-Small Cell Lung Cancer, Normal Lung Tissue, and Bone Marrow: Differences in Frequency, Cytogenetics, Proliferation Behavior, and Chemosensitivity - Implications for Cancer Therapy.

Sandra Gottschling, MD, Michael Meister, PhD, Anna Jauch, PhD, Ulf C. Krause, MD, Anja Seckinger, MD, Hans Hoffmann, MD, Hendrik Dienemann, MD, Ho D. Anthony, MD PhD, Michael Thomas, MD
Journal: Blood
Blood (2007) 110 (11): 1925.
https://doi.org/10.1182/blood.V110.11.1925.1925
Published: 2007
Journal Articles

Efficacy of ‘Off-the-Shelf’, Commercially-Available, Third-Party Mesenchymal Stem Cells (MSC) in Ex Vivo Cord Blood (CB) Co-Culture Expansion.

Simon N. Robinson, PhD, Paul J. Simmons, Ph.D., Nathalie Brouard, Ph.D., Shannon Kidd, BS, Hong Yang, MD,Ph.D, William K. Decker, Ph.D., Dongxia Xing, Ph.D., David Steiner, Ph.D., Jingjing Ng, MS, Michael Thomas, MS, Richard E. Champlin, MD, Marcos de Lima, MD, Chitra M. Hosing, MD, Laurence Cooper, MD,Ph.D., Harjeet Singh, Ph.D., Patrick A. Zweidler-McKay, MD,Ph.D., Elizabeth J. Shpall, MD
Journal: Blood
Blood (2007) 110 (11): 4106.
https://doi.org/10.1182/blood.V110.11.4106.4106
Published: 2007
Journal Articles

Manipulation of Oxygen Tension and Medium Composition To Enhance CD34+ Cell Numbers and Megakaryocytic Potential of Cord Blood Progenitors.

Shannon M. Kidd, BS, Nathalie Brouard, Ph.D., Kevin Cao, Simon N. Robinson, Ph.D., Michael Thomas, MS, Tuongvan Nguyen, BS, Wei Qiao, MS, Peter Thall, Ph.D., Patrick Zweidler-McKay, MD, Ph.D., Elizabeth J. Shpall, MD, Paul J. Simmons, Ph.D.
Journal: Blood
Blood (2007) 110 (11): 772.
https://doi.org/10.1182/blood.V110.11.772.772
Published: 2007
Journal Articles

Ex Vivo Expansion of Cord Blood NK Cell Have In Vivo Efficacy Against Leukemia.

Dongxia Xing, PhD, Wendy Fang, MD, William K. Decker, PhD, Sufang Li, Simon N. Robinson, MD, Hong Yang, MD, PhD, David Steiner, PhD, Michael Thomas, Richard E. Champlin, MD, John D. McMannis, PhD, Elizabeth J. Shpall, MD, Patrick A. Zweidler-Mckay, MD, PhD
Journal: Blood
Blood (2007) 110 (11): 2741.
https://doi.org/10.1182/blood.V110.11.2741.2741
Published: 2007
Journal Articles

Characterization of optimal T Cell/Dendritic Cell (DC) Co-Culture Conditions for Ex Vivo Expansion of Antigen-Specific Human T Cells.

Krishna V. Komanduri, MD, Michael Thomas, Lisa S. St. John, Ph.D., Dongxia Xing, Ph.D., William Decker, Ph.D., Simon Robinson, Ph.D., Hong Yang, Ph.D., Jeffrey J. Molldrem, M.D., Richard E. Champlin, M.D., John D. McMannis, Ph.D., Elizabeth J. Shpall, M.D.
Journal: Blood
Blood (2006) 108 (11): 3654.
https://doi.org/10.1182/blood.V108.11.3654.3654
Published: 2006