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Journal Articles

Rapid Personalized Manufacture (RPM) of Sleeping Beauty System-Generated NY-ESO-1-Specific TCR-T Cells Co-Expressing Membrane-Bound IL-15 Yields Anti-Tumor Responses

Lenka V Hurton, PhD, Tiejuan Mi, Kirsten C Switzer, PhD, Ling Zhang, Cuiping Dai, Misun Kim, Karishma R Bavisi, Matthew J Figliola, Vazquez M Lydia, Sourindra N Maiti, Shihuang Su, Drew C Deniger, PhD, Simon Olivares, Laurence J N Cooper, MD PhD, Harjeet Singh, MSc, PhD

Blood (2019) 134 (Supplement_1): 3218.

https://doi.org/10.1182/blood-2019-131419

Published: 2019

Journal Articles

Adoptive T-Cell Therapy with TCL1-Specific TCR for B-Cell Lymphomas

Jinsheng Weng, MD PhD, Kelsey Moriarty, BD, Yong Pan, Man Chun John MA, PhD, Rohit Mathur, PhD, Zheng Zhang, Hiroki Torikai, MD, Sourindra N Maiti, Fuliang Chu, PhD, Xiaoyun Cheng, Swathi Karri, Deepshika Medapalli, Laurence J N Cooper, MD PhD, R. Eric Davis, MD, Sattva S. Neelapu, MD

Blood (2018) 132 (Supplement 1): 3488.

https://doi.org/10.1182/blood-2018-99-115424

Published: 2018

Journal Articles

Genetically Engineered Regulatory T Cells for Treatment of Graft-Versus-Host-Disease

Eric Tu, PhD, Jennifer Fox, PhD, Christina Ly, BS, Christine Steinhart, PhD, Mike Laporte, MS, James Brennan, PhD, Cheryl Bolinger, PhD, Laurence J N Cooper, MDPhD, Hanspeter Waldner, PhD

Blood (2017) 130 (Supplement 1): 3176.

https://doi.org/10.1182/blood.V130.Suppl_1.3176.3176

Published: 2017

Journal Articles

CD19-Specific Chimeric Antigen Receptor-Modified T Cells with Safety Switch Produced Under "Point-of-Care" Using the Sleeping Beauty System for the Very Rapid Manufacture and Treatment of B-Cell Malignancies

Tim Chan, PhD, John Gallagher, Nai-Lin Cheng, PhD, Fernando Carvajal-Borda, DVM, Jacques Plummer, Adeline Govekung, John A Barrett, PhD, Pranay D. Khare, PhD, Laurence J N Cooper, MDPhD, Rutul R Shah

Blood (2017) 130 (Supplement 1): 1324.

https://doi.org/10.1182/blood.V130.Suppl_1.1324.1324

Published: 2017

Journal Articles

Long Term Follow up after Adoptive Transfer of CD19-Specific CAR + T Cells Genetically Modified Via Non-Viral Sleeping Beauty S ystem Following Hematopoietic Stem Cell Transplantation (HSCT)

Blood (2017) 130 (Supplement 1): 2059.

https://doi.org/10.1182/blood.V130.Suppl_1.2059.2059

Published: 2017

Journal Articles

Shortening the Time to Manufacture CAR + T Cells with Sleeping Beauty System Supports T-Cell Engraftment and Anti-Tumor Effects in Patients with Refractory CD19 + Tumors

Partow Kebriaei, MD, Helen Huls, Susan Lynn Neel, RN, OCN, Simon Olivares, Aaron F Orozco, Shihuang Su, Sourindra N Maiti, Amy Smith, Elenanor De Groot, Hagop M. Kantarjian, MD, Maro Ohanian, DO, Katy Rezvani, MD PhD, Elizabeth J Shpall, MD, Richard E Champlin, MD, Laurence J N Cooper, MDPhD, Harjeet Singh, MSc, PhD

Blood (2017) 130 (Supplement 1): 2060.

https://doi.org/10.1182/blood.V130.Suppl_1.2060.2060

Published: 2017

Journal Articles

Autologous T Cells Modified to Co-Express CD33-Specific Chimeric Antigen Receptor and a Kill Switch for Treatment of CD33 + Acute Myeloid Leukemia

Degang Song, PhD, Michael H Swartz, Linhua Tian, Fernando Carvajal-Borda, DVM, Jacques Plummer, Rutul R Shah, William G Wierda, MD PhD, Laurence J N Cooper, MDPhD, Tim Chan, PhD

Blood (2017) 130 (Supplement 1): 1376.

https://doi.org/10.1182/blood.V130.Suppl_1.1376.1376

Published: 2017

Journal Articles

Phase 1 studies of central memory–derived CD19 CAR T–cell therapy following autologous HSCT in patients with B-cell NHL

Blood (2016) 127 (24): 2980–2990.

https://doi.org/10.1182/blood-2015-12-686725

Published: 2016

Includes: Supplemental data

Journal Articles

Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation

Blood (2015) 125 (19): 2885–2892.

https://doi.org/10.1182/blood-2015-01-607366

Published: 2015

Journal Articles

Targeting An Ancient Retrovirus In Tumor Using Engineered T Cells

Janani Krishnamurthy, Brian Rabinovich, Simon Olivares, BS, Mi Teijuan, Kirsten Switzer, Joshua Plummer, Sourindra Maiti, PHD, Harjeet Singh, PhD, Helen Huls, BS, Feng-wang Johanning, Laurence J N Cooper, MD, PhD

Blood (2013) 122 (21): 4206.

https://doi.org/10.1182/blood.V122.21.4206.4206

Published: 2013

Journal Articles

Adoptive Immunotherapy Following Umbilical Cord Blood Transplantation Using The Sleeping Beauty System and Artificial Antigen Presenting Cells To Generate Donor-Derived T Cells Expressing a CD19-Specific Chimeric Antigen Receptor

Partow Kebriaei, MD, Helen Huls, BS, Harjeet Singh, PhD, Simon Olivares, BS, Matthew Figliola, BS, Pappanaicken R Kumar, BS, Bipulendu Jena, PhD, Rineka N Jackson, BBA, Tingting Liu, BS, Ian K. McNiece, PhD, Gabriela Rondon, MD, Perry Hackett, PhD, Richard E Champlin, MD, Elizabeth J Shpall, MD, Laurence J N Cooper, MD, PhD

Blood (2013) 122 (21): 4208.

https://doi.org/10.1182/blood.V122.21.4208.4208

Published: 2013

Journal Articles

Stable Expression Of Chimeric Antigen Receptors (CARs) By Sleeping Beauty-Mediated Gene Transfer and Efficient Expansion Of Leukemia-Specific Cytokine-Induced Killer (CIK) Cells

Chiara Francesca Magnani, PhD, Nice Turazzi, Fabrizio Benedicenti, Greta Maria Paola Giordano Attianese, PhD, Sarah Tettamanti, PhD, Eugenio Montini, PhD, Laurence J N Cooper, MD, PhD, Alessandro Aiuti, MD, PhD, Andrea Biondi, MD, Ettore Biagi, MD, PhD

Blood (2013) 122 (21): 1663.

https://doi.org/10.1182/blood.V122.21.1663.1663

Published: 2013

Journal Articles

Ex Vivo Fucosylation Of Cord Blood Accelerates Neutrophil and Platelet Engraftment

Blood (2013) 122 (21): 691.

https://doi.org/10.1182/blood.V122.21.691.691

Published: 2013

Journal Articles

ZFN-Driven Gene Editing Prevents HLA-A Expression On Hematopoietic Stem Cells -Improving The Chance Of Finding An HLA-Matched Donor

Hiroki Torikai, Tiejuan Mi, Sonny O Ang, PhD, Loren Gragert, Martin Maiers, Sourindra Maiti, PHD, Kirsten Switzer, Helen Huls, BS, Andreas Reik, Michael C. Holmes, PhD, Philip D Gregory, PhD, Richard E Champlin, MD, Elizabeth J Shpall, MD, Laurence J N Cooper, MD, PhD

Blood (2013) 122 (21): 1655.

https://doi.org/10.1182/blood.V122.21.1655.1655

Published: 2013

Journal Articles

First Clinical Trials Employing Sleeping Beauty Gene Transfer System and Artificial Antigen Presenting Cells To Generate and Infuse T Cells Expressing CD19-Specific Chimeric Antigen Receptor

Partow Kebriaei, MD, Helen Huls, BS, Harjeet Singh, PhD, Simon Olivares, BS, Matthew Figliola, BS, Pappanaicken R. Kumar, BS, Bipulendu Jena, PhD, Marie Andree Forget, Sonny Ang, PhD, Rineka N. Jackson, BBA, Tingting Liu, BS, Doyle Bosque, ADN, Ian K. McNiece, PhD, Gabriela Rondon, MD, Perry Hackett, PhD, Chitra M. Hosing, MD, Elizabeth J. Shpall, MD, Richard E. Champlin, MD, Laurence J N. Cooper, MD, PhD

Blood (2013) 122 (21): 166.

https://doi.org/10.1182/blood.V122.21.166.166

Published: 2013

Journal Articles

Immune Reconstitution With Activated T Cells In Companion Canines With Lymphoma

Colleen M. O'Connor, PhD, Sonny Ang, PhD, Sourindra Maiti, PHD, George McNamara, PHD, Sabina Sheppard, MS, Tasha Miller, BS, Helen Huls, BS, Richard E Champlin, MD, Heather Wilson, DVM, Laurence J N Cooper, MD, PhD

Blood (2013) 122 (21): 5153.

https://doi.org/10.1182/blood.V122.21.5153.5153

Published: 2013

Journal Articles

Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

Blood (2013) 122 (8): 1341–1349.

https://doi.org/10.1182/blood-2013-03-478255

Published: 2013

Includes: Supplemental data

Journal Articles

Sustained Functional T Cell Persistence and B Cell Aplasia Following CD19-Targeting Adoptive T Cell Immunotherapy for Relapsed, Refractory CD19+ Malignacy

Michael Kalos, PhD, Bruce L. Levine, PhD, Timothy L Macatee, Irina Kulikovskaya, Erica Suppa, Bipulendu Jena, Saar I. Gill, MBBS, Laurence J N Cooper, MD, PhD, Stephan A. Grupp, MD, PhD, David L Porter, MD, Carl H. June, MD

Blood (2012) 120 (21): 756.

https://doi.org/10.1182/blood.V120.21.756.756

Published: 2012

Journal Articles

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR

Hiroki Torikai, Andreas Reik, Pei-Qi Liu, Yuanyue Zhou, Ling Zhang, Sourindra Maiti, Helen Huls, Jeffrey C. Miller, Partow Kebriaei, Brian Rabinovitch, Dean A. Lee, Richard E. Champlin, Chiara Bonini, Luigi Naldini, Edward J. Rebar, Philip D. Gregory, Michael C. Holmes, Laurence J. N. Cooper

Blood (2012) 119 (24): 5697–5705.

https://doi.org/10.1182/blood-2012-01-405365

Published: 2012

Includes: Supplemental data

Journal Articles

Engineering lymph node homing of ex vivo–expanded human natural killer cells via trogocytosis of the chemokine receptor CCR7

Srinivas S. Somanchi, Anitha Somanchi, Laurence J. N. Cooper, Dean A. Lee

Blood (2012) 119 (22): 5164–5172.

https://doi.org/10.1182/blood-2011-11-389924

Published: 2012

Includes: Supplemental data

NARROW

Rapid Personalized Manufacture (RPM) of Sleeping Beauty System-Generated NY-ESO-1-Specific TCR-T Cells Co-Expressing Membrane-Bound IL-15 Yields Anti-Tumor Responses

Adoptive T-Cell Therapy with TCL1-Specific TCR for B-Cell Lymphomas

Genetically Engineered Regulatory T Cells for Treatment of Graft-Versus-Host-Disease

CD19-Specific Chimeric Antigen Receptor-Modified T Cells with Safety Switch Produced Under "Point-of-Care" Using the Sleeping Beauty System for the Very Rapid Manufacture and Treatment of B-Cell Malignancies

Long Term Follow up after Adoptive Transfer of CD19-Specific CAR + T Cells Genetically Modified Via Non-Viral Sleeping Beauty S ystem Following Hematopoietic Stem Cell Transplantation (HSCT)

Shortening the Time to Manufacture CAR + T Cells with Sleeping Beauty System Supports T-Cell Engraftment and Anti-Tumor Effects in Patients with Refractory CD19 + Tumors

Autologous T Cells Modified to Co-Express CD33-Specific Chimeric Antigen Receptor and a Kill Switch for Treatment of CD33 + Acute Myeloid Leukemia

Phase 1 studies of central memory–derived CD19 CAR T–cell therapy following autologous HSCT in patients with B-cell NHL

Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation

Targeting An Ancient Retrovirus In Tumor Using Engineered T Cells

Adoptive Immunotherapy Following Umbilical Cord Blood Transplantation Using The Sleeping Beauty System and Artificial Antigen Presenting Cells To Generate Donor-Derived T Cells Expressing a CD19-Specific Chimeric Antigen Receptor

Stable Expression Of Chimeric Antigen Receptors (CARs) By Sleeping Beauty-Mediated Gene Transfer and Efficient Expansion Of Leukemia-Specific Cytokine-Induced Killer (CIK) Cells

Ex Vivo Fucosylation Of Cord Blood Accelerates Neutrophil and Platelet Engraftment

ZFN-Driven Gene Editing Prevents HLA-A Expression On Hematopoietic Stem Cells -Improving The Chance Of Finding An HLA-Matched Donor

First Clinical Trials Employing Sleeping Beauty Gene Transfer System and Artificial Antigen Presenting Cells To Generate and Infuse T Cells Expressing CD19-Specific Chimeric Antigen Receptor

Immune Reconstitution With Activated T Cells In Companion Canines With Lymphoma

Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

Sustained Functional T Cell Persistence and B Cell Aplasia Following CD19-Targeting Adoptive T Cell Immunotherapy for Relapsed, Refractory CD19+ Malignacy

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR

Engineering lymph node homing of ex vivo–expanded human natural killer cells via trogocytosis of the chemokine receptor CCR7

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American Society of Hematology

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American Society of Hematology

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