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Journal Articles

Decade-Long Remissions of Leukemia Sustained By the Persistence of Activated CD4+ CAR T-Cells

J. Joseph Melenhorst, Gregory M Chen, Meng Wang, David L. Porter, Peng Gao, Shovik Bandyopadhyay, Iulian Pruteanu-Malinici, Christopher L Nobles, Sayantan Maji, Noelle V Frey, Saar Gill, Lifeng Tian, Irina Kulikovskaya, Megan M Davis, Joseph A Fraietta, Jennifer L Brogdon, Regina Young, David E Ambrose, Anne Chew, Bruce L Levine, Don L. Siegel, Cécile Alanio, E. John Wherry, Frederic D. Bushman, Simon F Lacey, Kai Tan, Carl H June
Journal: Blood
Blood (2021) 138 (Supplement 1): 166.
https://doi.org/10.1182/blood-2021-152664
Published: 2021
Journal Articles

Long-Term Remission of CLL Sustained By Pauciclonal Anti-CD19 Chimeric Antigen Receptor T (CTL019) Cell Clones

J. Joseph Melenhorst, PhD, David L. Porter, MD, Lifeng Tian, PhD, Simon F Lacey, PhD BS, Christopher L Nobles, PhD, Joseph A Fraietta, PhD, Noelle V. Frey, MD, Irina Kulikovskaya, Minnal Gupta, Regina M Young, PhD, David E Ambrose, BS, Don L. Siegel, MD PhD, Frederic D Bushman, PhD, Carl H June, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 699.
https://doi.org/10.1182/blood-2018-99-117390
Published: 2018
Journal Articles

Nonviral RNA chimeric antigen receptor–modified T cells in patients with Hodgkin lymphoma

Clinical Trials & Observations Brief Report
Jakub Svoboda, Susan R. Rheingold, Saar I. Gill, Stephan A. Grupp, Simon F. Lacey, Irina Kulikovskaya, Megan M. Suhoski, J. Joseph Melenhorst, Brandon Loudon, Anthony R. Mato, Sunita Dwivedy Nasta, Daniel J. Landsburg, Matthew R. Youngman, Bruce L. Levine, David L. Porter, Carl H. June, Stephen J. Schuster
Journal: Blood
Blood (2018) 132 (10): 1022–1026.
https://doi.org/10.1182/blood-2018-03-837609
Published: 2018
Journal Articles

Identification of Functional Determinants of Response and Resistance to CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy of Chronic Lymphocytic Leukemia

Joseph A Fraietta, PhD, Simon F Lacey, PhD BS, Elena Orlando, PhD, Julian Pruteanu, PhD, Mercy Gohil, Yan Wang, PhD, Alina Boesteanu, PhD, Roddy OConnor, PhD, David E Ambrose, BS, Wei-Ting Hwang, PhD, Nicholas Wilcox, Felipe Bedoya, PhD, Corin Dorfmeier, Fang Chen, PhD, Harit Parakandi, Minnal Gupta, Edward Pequignot, MS, F. Brad Johnson, PhD, Irina Kulikovskaya, Li Liu, Stefan M Lundh, BS, Jun Xu, PhD, Megan M Davis, PhD, Regina M Young, PhD, Bruce L Levine, PhD, Don L. Siegel, MD PhD, Alexander Huang, PhD, E. John Wherry, PhD, Jing Zhou, Patrick Paczkowski, Sean Mackay, Jennifer Brogdon, PhD, Hans Bitter, PhD, David L Porter, MD, Carl H June, MD, J. Joseph Melenhorst, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3181.
https://doi.org/10.1182/blood.V130.Suppl_1.3181.3181
Published: 2017
Journal Articles

Clinical Evidence That Deficiency of the Methylcytosine Dioxygenase TET2 Gene Promotes the Clonal Expansion and Therapeutic Efficacy of CD19-Directed T Cells

Joseph A Fraietta, PhD, Christopher L Nobles, PhD, Morgan A Sammons, PhD, Shannon A. Carty, MD, Stefan M Lundh, BS, Tyler Reich, Alexandria P Cogdill, BS, MB, Mercy Gohil, Jennifer J.D. Morrissette, PhD, Irina Kulikovskaya, Farzana Nazimuddin, MS, Minnal Gupta, Yan Wang, PhD, Xiaojun Liu, Regina M Young, PhD, David E Ambrose, Martha S Jordan, PhD, Katherine T Marcucci, PhD, Bruce L Levine, PhD, Yangbing Zhao, PhD MD, Michael Kalos, PhD, David L Porter, MD, Simon F Lacey, PhD BS, Shelley L Berger, PhD BS, Frederic D Bushman, PhD, Carl H June, MD, J. Joseph Melenhorst, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1909.
https://doi.org/10.1182/blood.V130.Suppl_1.1909.1909
Published: 2017
Journal Articles

Pilot Study of Non-Viral, RNA-Redirected Autologous Anti-CD19 Chimeric Antigen Receptor Modified T-Cells in Patients with Refractory/Relapsed Hodgkin Lymphoma (HL)

Jakub Svoboda, MD, Susan R. Rheingold, MD, Saar I Gill, MD PhD, Stephan A Grupp, MD PhD, Simon F Lacey, PhD BS, J. Joseph Melenhorst, PhD, Irina Kulikovskaya, Brandon Loudon, Naseem Kerr, MPH, Katherine T Marcucci, PhD, Kim-Marie Shea, RN, Aliza Schmidt, MS, Lester Lledo, RN,MSN,CNP, Amy Marshall, Anthony R. Mato, MD, Sunita Dwivedy Nasta, MD, Daniel J. Landsburg, MD, Matthew R. Youngman, BS, Bruce L Levine, PhD, David L Porter, MD, Carl H June, MD, Stephen J. Schuster, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 653.
https://doi.org/10.1182/blood.V130.Suppl_1.653.653
Published: 2017
Journal Articles

Safety and Efficacy of B-Cell Maturation Antigen (BCMA)-Specific Chimeric Antigen Receptor T Cells (CART-BCMA) with Cyclophosphamide Conditioning for Refractory Multiple Myeloma (MM)

Adam D. Cohen, MD, Alfred L. Garfall, MD, Edward A. Stadtmauer, MD FACP, Simon F Lacey, PhD BS, Eric Lancaster, Dan T. Vogl, MD, Brendan M Weiss, MD, David E Ambrose, BS, Anne Marie Nelson, Fang Chen, PhD, Gabriela Plesa, MD, Irina Kulikovskaya, Vanessa Gonzalez, Minnal Gupta, Regina M Young, PhD, Karen Dengel, BSN, RN, Laura O'keefe, Samantha Le, Celeste Richardson, PhD, Randi E. Isaacs, MD, J. Joseph Melenhorst, PhD, Bruce L Levine, PhD, Carl H June, MD, Michael C. Milone, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 505.
https://doi.org/10.1182/blood.V130.Suppl_1.505.505
Published: 2017
Journal Articles

Cars in Leukemia: Relapse with Antigen-Negative Leukemia Originating from a Single B Cell Expressing the Leukemia-Targeting CAR

Simon Francis Lacey, PhD BS, Jun Xu, PhD, Marco Ruella, MD, David M. Barrett, MD PhD, Irina Kulikovskaya, PhD, David E Ambrose, BS, Prachi R. Patel, BS, Tyler Reich, John Scholler, Farzana Nazimuddin, Joseph A. Fraietta, PhD, Shannon L Maude, MD PhD, Saar I. Gill, MD PhD, Bruce L Levine, PhD, Christopher L Nobles, PhD, Frederic D Bushman, PhD, Elena Orlando, PhD, Stephan A. Grupp, MD PhD, Carl H June, MD, Jan Joseph Melenhorst, PhD
Journal: Blood
Blood (2016) 128 (22): 281.
https://doi.org/10.1182/blood.V128.22.281.281
Published: 2016
Journal Articles

B-Cell Maturation Antigen (BCMA)-Specific Chimeric Antigen Receptor T Cells (CART-BCMA) for Multiple Myeloma (MM): Initial Safety and Efficacy from a Phase I Study

Adam D. Cohen, MD, Alfred L. Garfall, MD, Edward A Stadtmauer, MD, Simon Francis Lacey, PhD BS, Eric Lancaster, MD PhD, Dan T. Vogl, MD, Karen Dengel, BSN, RN, David E Ambrose, BS, Fang Chen, PhD, Gabriela Plesa, PhD, Irina Kulikovskaya, PhD, Vanessa E Gonzalez, M.B.A, Minnal Gupta, MSc, Regina M Young, PhD, Tenesia Carey, Regina Ferthio, Brendan M. Weiss, MD, Celeste Richardson, PhD, Randi E. Isaacs, MD, J. Joseph Melenhorst, PhD, Bruce L. Levine, PhD, Carl H June, MD, Michael C. Milone, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1147.
https://doi.org/10.1182/blood.V128.22.1147.1147
Published: 2016
Journal Articles

Posterior Reversible Encephalopathy Syndrome (PRES) after Infusion of Anti-Bcma CAR T Cells (CART-BCMA) for Multiple Myeloma: Successful Treatment with Cyclophosphamide

Alfred L. Garfall, MD, Eric Lancaster, MD PhD, Edward A Stadtmauer, MD, Simon F. Lacey, PhD, Karen Dengel, BSN, RN, David E Ambrose, BS, Fang Chen, PhD, Minnal Gupta, MSc, Irina Kulikovskaya, PhD, Dan T. Vogl, MD, Gabriela Plesa, PhD, Brendan M Weiss, MD, Regina Ferthio, Celeste Richardson, PhD, Jan Joseph Melenhorst, PhD, Bruce L Levine, PhD, Carl H June, MD, Michael Milone, MD PhD, Adam D. Cohen, MD
Journal: Blood
Blood (2016) 128 (22): 5702.
https://doi.org/10.1182/blood.V128.22.5702.5702
Published: 2016
Journal Articles

Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CTL019) in Conjunction with Salvage Autologous Stem Cell Transplantation for Advanced Multiple Myeloma

Alfred L. Garfall, MD, Edward A Stadtmauer, MD, Marcela V. Maus, MD PhD, Wei-Ting Hwang, PhD, Dan T. Vogl, MD, Adam D. Cohen, MD, Brendan M Weiss, MD, David L Porter, MD, Noelle Frey, MD MS, Michael Milone, MD PhD, Patricia Mangan, MSN, CRNP, Maria Krevvata, PhD, Emily Ayers, MD, Karen Dengel, BSN, RN, Naseem DS Kerr, MPH, Simon F. Lacey, PhD, Jan Joseph Melenhorst, PhD, David E Ambrose, BS, Fang Chen, PhD, Vanessa E Gonzalez, M.B.A, Irina Kulikovskaya, PhD, Minnal Gupta, MSc, Jeffrey Finklestein, MSc, Anne Lamontagne, MSc, Matthew O'Rourke, MSc, Megan Suhoski Davis, PhD, Alexander Malykhin, MSc, Bruce L Levine, PhD, Carl H June, MD
Journal: Blood
Blood (2016) 128 (22): 974.
https://doi.org/10.1182/blood.V128.22.974.974
Published: 2016
Journal Articles

Efficient Trafficking of Chimeric Antigen Receptor (CAR)-Modified T Cells to CSF and Induction of Durable CNS Remissions in Children with CNS/Combined Relapsed/Refractory ALL

Susan R. Rheingold, MD, Lanyi Nora Chen, BS, Shannon L Maude, MD PhD, Richard Aplenc, MD PhD, Christine Barker, BS, David M. Barrett, MD PhD, Colleen Callahan, MSN, Katherine Cebry, Irina Kulikovskaya, PhD, Simon F. Lacey, PhD BS, Bruce L. Levine, PhD, Jan J. Melenhorst, PhD, Pamela A Shaw, PhD, Anna Sparrow, David T Teachey, MD, Mark Duckworth, BS, Carl H. June, MD, Stephan A. Grupp, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3769.
https://doi.org/10.1182/blood.V126.23.3769.3769
Published: 2015
Journal Articles

Efficacy and Safety of Humanized Chimeric Antigen Receptor (CAR)-Modified T Cells Targeting CD19 in Children with Relapsed/Refractory ALL

Shannon L Maude, MD PhD, David M. Barrett, MD PhD, David E Ambrose, Susan R. Rheingold, MD, Richard Aplenc, MD PhD, David T Teachey, MD, Colleen Callahan, MSN, Christine S Barker, Maya Mudambi, Pamela A Shaw, PhD, Jennifer Brogdon, PhD, Regina M Young, PhD, John Scholler, Andreas Loew, PhD, Katherine T. Marcucci, PhD, Jeffrey Finklestein, Irina Kulikovskaya, PhD, Farzana Nazimuddin, Zhaohui Zheng, MS, Bruce L. Levine, PhD, David L Porter, MD, Simon F. Lacey, PhD BS, Jan J. Melenhorst, PhD, Carl H. June, MD, Stephan A. Grupp, MD PhD
Journal: Blood
Blood (2015) 126 (23): 683.
https://doi.org/10.1182/blood.V126.23.683.683
Published: 2015
Journal Articles

Engineered T-Cells Expressing An HLA-Restricted Affinity-Enhanced TCR In Advanced Multiple Myeloma Patients Post Auto-SCT Engraft and Are Associated With Encouraging Post Auto-SCT Responses

Aaron P. Rapoport, MD, Edward A. Stadtmauer, MD, Dan T. Vogl, MD, MSCE, Brendan M Weiss, MD, Gwendolyn K. Binder-Scholl, PhD, Dominic P. Smethurst, MD, Jeffrey Finklestein, Irina Kulikovskaya, Minnal Gupta, Joanna E. Brewer, PhD, Alan D. Bennett, PhD, Andrew B. Gerry, PhD, Nicholas J. Pumphrey, PhD, Helen K. Tayton-Martin, PhD, Lilliam C. Ribeiro, MBe, Ashraf Badros, MD, Saul Yanovich, MD, Gorgun Akpek, MD, MS, Naseem Kerr, MPH, Sunita Philip, Sandra Westphal, Bruce L. Levine, PhD, Bent K. Jakobsen, PhD, Michael Kalos, PhD, Carl H. June, MD
Journal: Blood
Blood (2013) 122 (21): 766.
https://doi.org/10.1182/blood.V122.21.766.766
Published: 2013
Journal Articles

Long-Term Functional Persistence, B Cell Aplasia and Anti-Leukemia Efficacy In Refractory B Cell Malignancies Following T Cell Immunotherapy Using CAR-Redirected T Cells Targeting CD19

Michael Kalos, PhD, Farzana Nazimuddin, Jeffrey M. Finklestein, Minnal Gupta, Irina Kulikovskaya, David E. Ambrose, Saar Gill, MD, PhD, Simon F. Lacey, PhD, BSc, Zhaohui Zheng, J. Joseph. Melenhorst, PhD, Bruce L. Levine, PhD, Noelle V. Frey, MD, Stephan A. Grupp, MD, PhD, David L. Porter, MD, Carl H. June, MD
Journal: Blood
Blood (2013) 122 (21): 163.
https://doi.org/10.1182/blood.V122.21.163.163
Published: 2013
Journal Articles

Sustained Functional T Cell Persistence and B Cell Aplasia Following CD19-Targeting Adoptive T Cell Immunotherapy for Relapsed, Refractory CD19+ Malignacy

Michael Kalos, PhD, Bruce L. Levine, PhD, Timothy L Macatee, Irina Kulikovskaya, Erica Suppa, Bipulendu Jena, Saar I. Gill, MBBS, Laurence J N Cooper, MD, PhD, Stephan A. Grupp, MD, PhD, David L Porter, MD, Carl H. June, MD
Journal: Blood
Blood (2012) 120 (21): 756.
https://doi.org/10.1182/blood.V120.21.756.756
Published: 2012
Journal Articles

Prolonged T Cell Persistence, Homing to Marrow and Selective Targeting of Antigen Positive Tumor in Multiple Myeloma Patients Following Adoptive Transfer of T Cells Genetically Engineered to Express an Affinity-Enhanced T Cell Receptor Against the Cancer Testis Antigens NY-ESO-1 and Lage-1

Michael Kalos, PhD, Aaron P. Rapoport, MD, Edward A. Stadtmauer, MD, Dan T. Vogl, MD, Brendan M Weiss, MD, Gwendolyn K. Binder-Scholl, PhD, Dominic P. Smethurst, MD, Irina Kulikovskaya, Minnal Gupta, Timothy L Macatee, Jeffrey M Finklestein, Joanna E. Brewer, PhD, Alan D. Bennett, PhD, Andrew B. Gerry, PhD, Nick J. Pumphrey, PhD, Helen K. Tayton-Martin, PhD, Elizabeth Veloso, JD, BSN, Zhaohui Zheng, MA, Ashraf Z. Badros, MD, Saul Yanovich, MD, Gorgun Akpek, MD, MHS, Holly McConville, RN, BSN, Sunita Philip, Bruce L. Levine, PhD, Bent K. Jakobsen, PhD, Carl H. June, MD
Journal: Blood
Blood (2012) 120 (21): 755.
https://doi.org/10.1182/blood.V120.21.755.755
Published: 2012