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Journal Articles

Targeting Senescent Stemlike Subpopulations in Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia

Yang-Yang Ding, Jonathan H Sussman, Kellyn Madden, Joseph P Loftus, Robert K Chen, Catherine D Falkenstein, Diego Alberto Barcenas Lopez, David A Hottman, Benjamin Mathier, Wenbao Yu, Jason Xu, Changya Chen, Chia-Hui Chen, Bing He, Shovik Bandyopadhyay, Zhan Zhang, DongGeun Lee, Hong Wang, Junmin Peng, Chi V Dang, Kai Tan, Sarah K Tasian
Journal: Blood
Blood blood.2024026482.
https://doi.org/10.1182/blood.2024026482
Published: 2025
Includes: Supplemental data
Journal Articles

Multimodal Single-Cell Profiling of Minimal Residual Disease in B Acute Lymphoblastic Leukemia Reveals Genetic and Non-Genetic Factors of Early Drug Resistance

Rushabh Mehta, Changya Chen, Fatemeh Alikarami, Steven Foltz, Avi Loren, Elizabeth Li, Jason Xu, Marilyn M. Li, Kathrin M. Bernt, Kai Tan
Journal: Blood
Blood (2024) 144 (Supplement 1): 316.
https://doi.org/10.1182/blood-2024-210504
Published: 2024
Journal Articles

Lymph Node Stromal Cells Underlie the Clinicopathologic Features of Castleman Disease

Vinodh Pillai, David Smith, Anna Eichinger, Andrew Rech, Julia Wang, Eduardo Esteva, Arta Seyedian, Xiaoxu Yang, Mei Zhang, Dan Martinez, Kai Tan, Minjie Luo, Christopher Y. Park, Boris Reizis
Journal: Blood
Blood (2024) 144 (Supplement 1): 2989.
https://doi.org/10.1182/blood-2024-198024
Published: 2024
Journal Articles

Interferon-Activated Gene Signatures Associate with Chemotherapy Resistance and Sensitivity to JAK-Inhibition in Refractory ETP-ALL

Jason Xu, Jonathan Sussman, Austin Yang, Satoshi Yoshimura, Changya Chen, Omar Elghawy, Tiffaney Vincent, Caroline Diorio, Shovik Bandyopadyay, Jianzhong Hu, Alexander Lai Li, Gregory M. Chen, Chia-Hui Chen, Rawan Shraim, Haley Newman, Yang Ding, Elizabeth Li, Wenbao Yu, Anusha Thadi, Kyung Jin Ahn, Petri Pölönen, Abdelrahman Elsayed, David Frank, Elizabeth A. Raetz, Mignon L. Loh, Brent L. Wood, Stuart S. Winter, Kimberly P. Dunsmore, Meenakshi Devidas, Chunxu Qu, Stanley Pounds, Stephen P. Hunger, Charles G. Mullighan, Jun J. Yang, Kai Tan, David T. Teachey
Journal: Blood
Blood (2024) 144 (Supplement 1): 1464.
https://doi.org/10.1182/blood-2024-211090
Published: 2024
Journal Articles

Identification of the Saga Complex As a Key Regulator of Hematopoiesis

Michael Haney, Archana Shankar, Leonid Olender, Ian Hsu, Masashi Miyauchi, Grace Meaker, Satoshi Kaito, Ola Rizq, Hwei Minn Khoo, Yavor Bozhilov, Robert Palovics, Kyomi Igarashi, Joydeep Bhadury, Christy Munson, Paul K. Mack, Tze-Kai Tan, Jan Rehwinkel, Atsushi Iwama, Tony Wyss-Coray, Hiromitsu Nakauchi, Adam Wilkinson
Journal: Blood
Blood (2024) 144 (Supplement 1): 5623.
https://doi.org/10.1182/blood-2024-205547
Published: 2024
Journal Articles

Genomic Biomarkers of Poor Outcome in Patients with T-Cell Lymphoblastic Lymphoma

Haley Newman, Lahari Uppuluri, Rawan Shraim, Carl E Allen, Kara L. Davis, Meenakshi Devidas, Caroline Diorio, Kimberly P. Dunsmore, Amira Elhachimi, David Frank, Lia Gore, Thomas Gross, Robert J. Hayashi, Terzah M. Horton, Andrew Hughes, Stephen P. Hunger, John Kim, Yimei Li, Stephanie Si Lim, Mignon L. Loh, Charles G. Mullighan, Adam B. Olshen, Petri Pölönen, Rachel E. Rau, Gongping Shi, Kai Tan, Tiffaney Vincent, Stuart S. Winter, Birte Wistinghausen, Brent L. Wood, Jason Xu, Jun J. Yang, Rodney R. Miles, Michelle L. Hermiston, David T. Teachey
Journal: Blood
Blood (2024) 144 (Supplement 1): 313.
https://doi.org/10.1182/blood-2024-203827
Published: 2024
Journal Articles

Aberrant Stemness Transcription Signature Unveils a Mechanism of Chemotherapy Resistance through Blunting p53-Mediated Response in Acute Myeloid Leukemia

Fatemeh Alikarami, Hongbo Xie, Simone Stefanie Riedel, Haley Goodrow, Declan Barrett, Leila Mahdavi, Alexandra Lenard, Changya Chen, Taylor Yamauchi, Etienne Danis, Zhendong Cao, Vu L. Tran, Mabel M. Jung, Yapeng Li, Hua Huang, Junwei Shi, Kai Tan, David T. Teachey, Emery H. Bresnick, Tobias Neff, Kathrin M. Bernt
Journal: Blood
Blood (2024) 144 (Supplement 1): 725.
https://doi.org/10.1182/blood-2024-199215
Published: 2024
Journal Articles

Checkpoint Immunotherapy Is Associated with Preferential Activation of Tumor-Antigen Specific CD4 + T Cells in MDS

Elizabeth A. Griffiths, Pragya Srivastava, Eduardo Cortes Gomez, Junko Matsuzaki, Kunle Odunsi, Laura W Dillon, Devdeep Mukherjee, Christopher S. Hourigan, Jacqueline Peng, Shovik Bandyopadhyay, Kai Tan, Krista Belko, Amanda C. Przespolewski, Eunice S. Wang, Prashant Singh, Jianmin Wang, Michael J. Nemeth
Journal: Blood
Blood (2023) 142 (Supplement 1): 4602.
https://doi.org/10.1182/blood-2023-178756
Published: 2023
Journal Articles

Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

Shovik Bandyopadhyay, Michael Duffy, Kyung Jin Ahn, Minxing Pang, David Smith, Gwendolyn Duncan, Jonathan Sussman, Jihan Zhang, Jeffrey Huang, Yulieh Lin, Barbara Xiong, Tamjid Imtiaz, Chia Hui Chen, Anusha Thadi, Changya Chen, Jason Xu, Melissa Reichart, Vinodh Pillai, Oraine Snaith, Derek Oldridge, Siddharth Bhattacharyya, Ivan Maillard, Martin Carroll, Charles Nelson, Ling Qin, Kai Tan
Journal: Blood
Blood (2023) 142 (Supplement 1): 4072.
https://doi.org/10.1182/blood-2023-179280
Published: 2023
Journal Articles

Transcriptional Rewiring and Therapeutic Resistance in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia

Yang Y Ding, Joseph Patrick Loftus, Benjamin Mathier, Wenbao Yu, David Hottman Allen, Bing He, Catherine D Falkenstein, Sarah K Tasian, Kai Tan
Journal: Blood
Blood (2022) 140 (Supplement 1): 354–355.
https://doi.org/10.1182/blood-2022-169341
Published: 2022
Journal Articles

The Influence of Genetic Ancestry on Disease Biology in Pediatric T-Cell Acute Lymphoblastic Leukemia

Haley Newman, Shawn Lee, Petri Pölönen, Rawan Shraim, Yimei Li, Hongyan Liu, Tiffaney L. Vincent, Richard Aplenc, Changya Chen, Zhiguo Chen, Caroline Diorio, Kimberly P. Dunsmore, Sumit Gupta, Gang Wu, Kai Tan, Meenakshi Devidas, Stuart S. Winter, Brent L. Wood, Lena E. Winestone, Jason Xu, Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger, Stanley B. Pounds, Kira O Bona, Charles G. Mullighan, Jun J. Yang, David T. Teachey
Journal: Blood
Blood (2022) 140 (Supplement 1): 3458–3460.
https://doi.org/10.1182/blood-2022-159159
Published: 2022
Journal Articles

Single-Cell Pan-Cancer Analysis Reveals Treatment Resistance Stem/Progenitor-like Subpopulation in the High-Risk Pediatric Leukemia

Changya Chen, Jason Xu, Tiffaney L. Vincent, Wenbao Yu, Yang Y Ding, Chia-hui Chen, Samuel Kim, Elizabeth Li, Shovik Bandyopadhyay, Petri Pölönen, Abdelrahman Elsayed, Haley Newman, Brent L. Wood, Jianzhong Hu, Rawan Shraim, Mignon L. Loh, Elizabeth A. Raetz, Stephen P. Hunger, Stanley B. Pounds, Jun J. Yang, Charles G. Mullighan, David Frank, Kathrin M. Bernt, David T. Teachey, Kai Tan
Journal: Blood
Blood (2022) 140 (Supplement 1): 1273–1274.
https://doi.org/10.1182/blood-2022-167057
Published: 2022
Journal Articles

Comprehensive Genome Characterization of Childhood T-ALL Links Oncogene Activation Mechanism and Subtypes to Prognosis

Petri Pölönen, Abdelrahman Elsayed, Danika Di Giacomo, Lindsey Montefiori, Shunsuke Kimura, Jason Myers, Dale Hedges, Jason Xu, Yawei Hui, Zhongshan Cheng, Yiping Fan, Ilaria Iacobucci, Yunchao Chang, Rawan Shraim, Meenakshi Devidas, Stuart S. Winter, Kimberly P. Dunsmore, Jun J.J. Yang, Tiffaney L. Vincent, Kai Tan, Changya Chen, Haley Newman, Mignon L. Loh, Elizabeth A. Raetz, Stephen P. Hunger, Evadnie Rampersaud, Ti-Cheng Chang, Gang Wu, Stanley B. Pounds, Charles G. Mullighan, David T. Teachey
Journal: Blood
Blood (2022) 140 (Supplement 1): 1727–1729.
https://doi.org/10.1182/blood-2022-167157
Published: 2022
Journal Articles

Progenitor Sub-Populations in Treatment Resistant T-ALL

Jason Xu, Changya Chen, Tiffaney L. Vincent, Petri Pölönen, Abdelrahman Elsayed, Jianzhong Hu, Satoshi Yoshimura, Wenbao Yu, Chia-hui Chen, Elizabeth Li, Rawan Shraim, Marieke Lavaert, Haley Newman, Yang-yang Ding, Anusha Thadi, Kyung Jin Ahn, Jacqueline Peng, Chujie Gong, Yusha Sun, Shovik Bandyopadhyay, David Frank, Mignon L. Loh, Elizabeth A. Raetz, Zhiguo Chen, Brent L. Wood, Meenakshi Devidas, Kimberly P. Dunsmore, Stuart S. Winter, Gang Wu, Avinash Bhandoola, Stanley B. Pounds, Stephen P. Hunger, Jun J. Yang, Charles G. Mullighan, David T. Teachey, Kai Tan
Journal: Blood
Blood (2022) 140 (Supplement 1): 1724–1726.
https://doi.org/10.1182/blood-2022-166521
Published: 2022
Journal Articles

The Role of GATA2 in Drug Resistance in AML

Fatemeh Alikarami, Simone S. Riedel, Qinglan Li, Changya Chen, Taylor Yamauchi, Etienne Danis, Kai Tan, Liling Wan, Tobias Neff, Kathrin M. Bernt
Journal: Blood
Blood (2022) 140 (Supplement 1): 97–98.
https://doi.org/10.1182/blood-2022-166666
Published: 2022
Journal Articles

Graft-Versus-Host Disease Induces Immune Dysregulation through Irreversible Damage to Specialized Immune-Interacting Fibroblastic Stromal Cells in Secondary Lymphoid Organs

Leolene Carrington, Shovik Bandyopadhyay, Katlyn Lederer, Samantha Kelly, Ashley Vanderbeck, Gloria Jih, Frederick Allen, Daniela Gómez Atria, Anneka Allman, Eric Perkey, Kai Tan, Norbert Pardi, Burkhard Ludewig, Ronjon Chakraverty, Ivan Maillard
Journal: Blood
Blood (2022) 140 (Supplement 1): 7334–7335.
https://doi.org/10.1182/blood-2022-167650
Published: 2022
Journal Articles

Single-Cell Transcriptomics Reveals Similarity of Aggressive Infant Acute Lymphoblastic Leukemia Cells to Early Hematopoietic Progenitors

Irina Pushel, Midhat S. Farooqi, Byunggil Yoo, Kai Tan, Kathrin M. Bernt, Erin Guest
Journal: Blood
Blood (2022) 140 (Supplement 1): 6339–6340.
https://doi.org/10.1182/blood-2022-170028
Published: 2022
Journal Articles

Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis

Yiqing Yang, Melanie Mumau, Joanna Tober, Qin Zhu, Laura Bennett, Courtney Hong, Derek Sung, Thomas Keller, Yasin Uzun, Peng Gao, Swapnil Shewale, Mei Chen, Jisheng Yang, Xiaowen Chen, Steven A. Thomas, Kai Tan, Nancy A. Speck, Mark L. Kahn
Journal: Blood
Blood (2022) 139 (19): 2942–2957.
https://doi.org/10.1182/blood.2021013934
Published: 2022
Includes: Supplemental data
Journal Articles

Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A -rearranged leukemia

Changya Chen, Wenbao Yu, Fatemeh Alikarami, Qi Qiu, Chia-hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, James W. Davenport, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex Felmeister, Isaiah Rozich, Yang-yang Ding, Stephen P. Hunger, Carolyn A. Felix, Hao Wu, Patrick A. Brown, Erin M. Guest, David M. Barrett, Kathrin M. Bernt, Kai Tan
Journal: Blood
Blood (2022) 139 (14): 2198–2211.
https://doi.org/10.1182/blood.2021013442
Published: 2022
Includes: Supplemental data
Journal Articles

Single-Cell Multiomics Reveals Increased Plasticity, Resistant Populations and Stem-Cell-like Blasts in KMT2A-Rearranged Leukemia

Changya Chen, Wenbao Yu, Fatemeh Alikarami, Qi Qiu, Chia-hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex Felmeister, Isaiah Rozich, Yang-yang Ding, Stephen P Hunger, Hao Wu, Patrick A. Brown, Erin Guest, David M Barrett, Kathrin M. Bernt, Kai Tan
Journal: Blood
Blood (2021) 138 (Supplement 1): 2203.
https://doi.org/10.1182/blood-2021-146102
Published: 2021