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Journal Articles

Single-Cell Transcriptomics Reveals Similarity of Aggressive Infant Acute Lymphoblastic Leukemia Cells to Early Hematopoietic Progenitors

Irina Pushel, Midhat S. Farooqi, Byunggil Yoo, Kai Tan, Kathrin M. Bernt, Erin Guest
Journal: Blood
Blood (2022) 140 (Supplement 1): 6339–6340.
https://doi.org/10.1182/blood-2022-170028
Published: 2022
Journal Articles

A Pilot Study of Azacitidine As Epigenetic Priming for Chemotherapy in Infants Less Than 1 Year of Age with KMT2A -Rearranged Acute Lymphoblastic Leukemia (ALL); Results from the Children's Oncology Group (COG) Trial AALL15P1

Erin Guest, John Kairalla, Meenakshi Devidas, Emily Hibbitts, Andrew J. Carroll, Nyla A. Heerema, Holly Kubaney, Amanda August, Melinda Pauly, Daniel Wechsler, Rodney R. Miles, Joel M. Reid, Cynthia Kihei, Lia Gore, Elizabeth A. Raetz, Stephen P. Hunger, Mignon L. Loh, Patrick A. Brown
Journal: Blood
Blood (2022) 140 (Supplement 1): 3256–3257.
https://doi.org/10.1182/blood-2022-167765
Published: 2022
Journal Articles

Premedication and Therapeutic Drug Monitoring (TDM) for Pegaspargase: A Prospective Multicenter Multi-Ethnic Study of Pediatric and Adolescent Patients

Van T Huynh, Sonia Morales, Anurag K. Agrawal, Christine L. Phillips, Keith J August, Erin Guest, Beth Apsel Winger, Catherine Aftandilian, Janel R. Long-Boyle, Kirsten Kasper, Keri Zabokrtsky, Carol Hwang Lin
Journal: Blood
Blood (2022) 140 (Supplement 1): 8893–8895.
https://doi.org/10.1182/blood-2022-159255
Published: 2022
Journal Articles

Desensitization to Pegaspargase in Children with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma Is Safe and Does Not Require Intensive Care - a Single Center Experience

Keith J August, Tristan Flatt, Joy M. Fulbright, Alan S. Gamis, Julia A. Hays, Maxine J Hetherington, Karen Lewing, Amanda August, Erin Guest
Journal: Blood
Blood (2022) 140 (Supplement 1): 6037–6038.
https://doi.org/10.1182/blood-2022-167549
Published: 2022
Journal Articles

Single-Cell Genomic Analysis Identifies Prognostically Significant Gene Expression Programs in Infant Acute Lymphoblastic Leukemia

Irina Pushel, Midhat S. Farooqi, Byunggil Yoo, Daniel Louiselle, Tomi Pastinen, Patrick A. Brown, Erin Guest
Journal: Blood
Blood (2021) 138 (Supplement 1): 3480.
https://doi.org/10.1182/blood-2021-152828
Published: 2021
Journal Articles

Single-Cell Multiomics Reveals Increased Plasticity, Resistant Populations and Stem-Cell-like Blasts in KMT2A-Rearranged Leukemia

Changya Chen, Wenbao Yu, Fatemeh Alikarami, Qi Qiu, Chia-hui Chen, Jennifer Flournoy, Peng Gao, Yasin Uzun, Li Fang, Yuxuan Hu, Qin Zhu, Kai Wang, Clara Libbrecht, Alex Felmeister, Isaiah Rozich, Yang-yang Ding, Stephen P Hunger, Hao Wu, Patrick A. Brown, Erin Guest, David M Barrett, Kathrin M. Bernt, Kai Tan
Journal: Blood
Blood (2021) 138 (Supplement 1): 2203.
https://doi.org/10.1182/blood-2021-146102
Published: 2021
Journal Articles

Impact of Allogeneic Hematopoietic Stem Cell Transplantation in First Complete Remission and Additional Cytogenetic Aberrations at Diagnosis on Prognosis in 1256 Pediatric Patients with KMT2A-Rearranged Acute Myeloid Leukemia: A Retrospective Study By the I-BFM-SG

Romy E. Van Weelderen, Kim Klein, Christine J. Harrison, Hester A. De Groot-Kruseman, Jonas Abrahamsson, Nira Arad-Cohen, Emmanuelle Bart-Delabesse, Barbara Buldini, Barbara De Moerloose, Michael Dworzak, Sarah Elitzur, José M. Fernández Navarro, Marta Fiocco, Robert B. Gerbing, Bianca F. Goemans, Erin Guest, Shau-Yin Ha, Henrik Hasle, Kathy Jackson, Charikleia Kelaidi, Hélène Lapillonne, Guy Leverger, Franco Locatelli, Takako Miyamura, Sophia Polychronopoulou, Mareike Rasche, Jeffrey E. Rubnitz, Jan Stary, Daisuke Tomizawa, Femke Verwer, C. Michel Zwaan, Gertjan J.L. Kaspers
Journal: Blood
Blood (2021) 138 (Supplement 1): 2360.
https://doi.org/10.1182/blood-2021-148041
Published: 2021
Journal Articles

Germline Variants Associated with Cancer Predisposition and Bone Marrow Failure Are Common in KMT2A- r Infant Acute Lymphoblastic Leukemia Patients

Sarah Mc Dermott, DO, Midhat S. Farooqi, MD PhD, Azhar Saeed, MD, Byunggil Yoo, MS, Emily Farrow, PhD CGC, Neil Miller, Patrick A. Brown, MD, Erin Guest, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 41.
https://doi.org/10.1182/blood-2020-139564
Published: 2020
Journal Articles

Outcome of (Novel) Subgroups in 1257 Pediatric Patients with KMT2A-Rearranged Acute Myeloid Leukemia (AML) and the Significance of Minimal Residual Disease (MRD) Status: A Retrospective Study By the I-BFM-SG

Romy E. Van Weelderen, Kim Klein, MD, Bianca F. Goemans, MD PhD, Christian M. Zwaan, MD PhD, Hester A. De Groot-Kruseman, PhD, Jonas Abrahamsson, MD PhD, Nira Arad-Cohen, MD PhD, Emmanuelle Bart-Delabesse, PharmD, PhD, Barbara Buldini, MD PhD, Barbara De Moerloose, MD PhD, Michael Dworzak, MD PhD, Sarah Elitzur, MD, José M. Fernández Navarro, MD, Robert B. Gerbing, MA, Erin Guest, MD, Shau-Yin Ha, MD PhD, Christine J. Harrison, PhD FRCPath, Henrik Hasle, PhD, Kathy Jackson, MD PhD, Charikleia Kelaidi, MD, Hélène Lapillonne, MD PhD, Guy Leverger, MD PhD, Franco Locatelli, MD PhD, Takako Miyamura, MD PhD, Sophia Polychronopoulou, MD PhD, Mareike Rasche, MD, Jeffrey E. Rubnitz, MD, Jan Stary, MD PhD, Daisuke Tomizawa, MD PhD, Femke Verwer, Gertjan J.L. Kaspers, Prof. MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 26–27.
https://doi.org/10.1182/blood-2020-136064
Published: 2020
Journal Articles

Single Cell Sequencing Reveals Heterogeneity of Gene Expression in KMT2A Rearranged Infant ALL at Relapse Compared to Diagnosis

Erin Guest, MD, Byunggil Yoo, MS, Rumen Kostadinov, PhD, Midhat S. Farooqi, MD PhD, Emily Farrow, PhD CGC, Margaret Gibson, Neil Miller, Karina Shah, Tomi Pastinen, MD PhD, Patrick A. Brown, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2756.
https://doi.org/10.1182/blood-2019-131999
Published: 2019
Journal Articles

Whole Genome Bisulfite Sequencing (WGBS) Robustly Measures the Pharmacodynamic Effect of Decitabine/Vorinostat Epigenetic Treatment in Relapsed Pediatric ALL Demonstrating Potent Hypomethylation Associated with Upregulation of PRC2 and TP53 Targets

Rumen Kostadinov, PhD, Byunggil Yoo, MS, Midhat S. Farooqi, MD PhD, Shannon Kelley, MS, Erin Guest, MD, Michael J. Burke, MD, Sarah Wheelan, MD PhD, Patrick Brown, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 918.
https://doi.org/10.1182/blood-2018-99-119206
Published: 2018
Journal Articles

Genomic Analysis and Pathway Characterization of Genes with Somatic Variants in Infant Acute Lymphoblastic Leukemia

Jillian Fry, Midhat S. Farooqi, MD PhD, Byunggil Yoo, MS, Rumen Kostadinov, PhD, Emily Farrow, PhD CGC, Shannon Kelley, MS, Margaret Gibson, Neil Miller, Jeffrey Johnston, Patrick Brown, MD, Erin Guest, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3970.
https://doi.org/10.1182/blood.V130.Suppl_1.3970.3970
Published: 2017
Journal Articles

Bortezomib Combined with Mitoxantrone, Vincristine, Peg-Asparaginase and Dexamethasone for Children with Relapsed Acute Lymphoblastic Leukemia

Keith J August, MD MS, Alan S Gamis, MD MPH, Julia A. Hays, MD, Karen Lewing, MD, Erin Guest, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5039.
https://doi.org/10.1182/blood.V130.Suppl_1.5039.5039
Published: 2017