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C. Michel Zwaan
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Journal Articles

Daratumumab in pediatric relapsed/refractory acute lymphoblastic leukemia or lymphoblastic lymphoma: the DELPHINUS study

Clinical Trials & Observations
Teena Bhatla, Laura E. Hogan, David T. Teachey, Francisco Bautista, John Moppett, Pablo Velasco Puyó, Concetta Micalizzi, Claudia Rossig, Neerav Shukla, Gil Gilad, Franco Locatelli, André Baruchel, C. Michel Zwaan, Natalie S. Bezler, Alba Rubio-San-Simón, David C. Taussig, Elizabeth A. Raetz, Zhengwei J. Mao, Brent L. Wood, Diana Alvarez Arias, Maria Krevvata, Ivo Nnane, Nibedita Bandyopadhyay, Lorena Lopez Solano, Robyn M. Dennis, Robin Carson, Ajay Vora
Journal: Blood
Blood (2024) 144 (21): 2237–2247.
https://doi.org/10.1182/blood.2024024493
Published: 2024
Includes: Supplemental data
Journal Articles

Brigatinib Monotherapy in Children with R/R ALK+ ALCL, IMT, or Other Solid Tumors: Updated Results from the Brigaped (ITCC-098) Phase 1 Dose-Escalation Study

Charlotte Rigaud, Kim P.J. Schellekens, Christine Damm-Welk, Veronique Minard-Colin, Samuel D. Abbou, Gertruud Bakker, Auke Beishuizen, Maaike Boonstra-Schelfhorst, Laurence Brugières, Michela Casanova, Pascal Chastagner, Rana Dandis, Stéphane Ducassou, Natasha K.A. van Eijkelenburg, Nathalie Garnier, Michael J. Hanley, Alwin D.R. Huitema, Samantha Lampron, Yousif H. Matloub, Nicole Scobie, Florin Vranceanu, Jen-Hao Wu, Wilhelm Woessmann, C. Michel Zwaan, Reineke A. Schoot
Journal: Blood
Blood (2024) 144 (Supplement 1): 3108.
https://doi.org/10.1182/blood-2024-200077
Published: 2024
Journal Articles

Sinusoidal Obstruction Syndrome in Children with CD22+ B-Cell Precursors Acute Lymphoblastic Leukemia (BCP-ALL) Treated with Inotuzumab Ozogamicin in Trial ITCC-059: Risk Factors and Outcomes

Erica Brivio, Edoardo Pennesi, Yilin Jang, Anneke Ammerlaan, Susana Rives, Inge M. van der Sluis, Caroline Lindemans, Bella Bielorai, Cristina Díaz De Heredia, Andrej Lissat, Claudia Rossig, Arnaud Petit, Fanny Rialland Battisti, Carmelo Rizzari, Anna B Nilsson, Benedicte Bruno, Alba Rubio-san-Simón, Lucie Sramkova, Gernot Engstler, Uta Dirksen, Benoit Brethon, Barbara De Moerloose, Marlène Pasquet, Peter McCarthy, Karsten Nysom, Carine Halfon-Domenech, Nicoletta Bertorello, Jochen Büchner, Franco Locatelli, C. Michel Zwaan
Journal: Blood
Blood (2024) 144 (Supplement 1): 310.
https://doi.org/10.1182/blood-2024-193946
Published: 2024
Journal Articles

Updated Results and Longer Follow-up from the AUGMENT-101 Phase 2 Study of Revumenib in All Patients with Relapsed or Refractory (R/R) KMT2Ar Acute Leukemia

Ibrahim Aldoss, Ghayas C. Issa, James S. Blachly, Michael J. Thirman, Gabriel N Mannis, Martha L. Arellano, John F. DiPersio, Elie Traer, C. Michel Zwaan, Neerav Shukla, Branko Cuglievan, Carolyn S. Grove, Matthew Greenwood, Christine M. McMahon, Alexander E. Perl, Richard M. Stone, Cristina Papayannidis, David S. Dickens, Maël Heiblig, Andrius Žučenka, Pau Montesinos, Ioannis Mantzaris, Tibor Kovacsovics, Paul J. Shami, Li Yu, Rebecca G. Bagley, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2024) 144 (Supplement 1): 211.
https://doi.org/10.1182/blood-2024-194384
Published: 2024
Journal Articles

When InO says no: understanding escape

Judith M. Boer, C. Michel Zwaan
Journal: Blood
Blood (2024) 144 (1): 2–4.
https://doi.org/10.1182/blood.2024024713
Published: 2024
Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemia: Topline Efficacy and Safety Results from the Pivotal Augment-101 Phase 2 Study

Ibrahim Aldoss, Ghayas C. Issa, Michael Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel N. Mannis, Alexander Perl, David S. Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J. Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G. Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 2): LBA-5.
https://doi.org/10.1182/blood-2023-192042
Published: 2023
Journal Articles

First-in-Human Study of the CD123 NK Cell Engager SAR443579 in Relapsed or Refractory Acute Myeloid Leukemia, B-Cell Acute Lymphoblastic Leukemia or High Risk-Myelodysplasia: Updated Safety, Efficacy, Pharmacokinetics and Pharmacodynamics

Ashish Bajel, Sylvain Garciaz, Pinkal Desai, Gerwin A Huls, Abhishek Maiti, Mojca Jongen-Lavrencic, Nicolas Boissel, Stephane De Botton, David C. de Leeuw, Shaun Fleming, C. Michel Zwaan, Martha Arellano, David Avigan, Jennifer N. Saultz, Ioannis Mantzaris, Kyle Jensen, Timothy Wagenaar, Gu Mi, Samira Ziti-Ljajic, Dobrin Draganov, Giovanni Abbadessa, Anthony Selwyn Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 3474.
https://doi.org/10.1182/blood-2023-173162
Published: 2023
Journal Articles

Revumenib Monotherapy in Patients with Relapsed/Refractory KMT2Ar Acute Leukemias: Efficacy and Safety Results from the Augment-101 Phase 1/2 Study

Ibrahim Aldoss, Ghayas C. Issa, Michael J Thirman, John DiPersio, Martha Arellano, James S. Blachly, Gabriel Mannis, Alexander Perl, David Dickens, Christine M. McMahon, Elie Traer, C. Michel Zwaan, Carolyn Grove, Richard Stone, Paul J Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan, Yu Gu, Rebecca G Bagley, Kate Madigan, Soujanya Sunkaraneni, Huy Van Nguyen, Nicole McNeer, Eytan M. Stein
Journal: Blood
Blood (2023) 142 (Supplement 1): 2907.
https://doi.org/10.1182/blood-2023-189762
Published: 2023
Journal Articles

Europeanpediatric Acute Leukemia (EuPAL) Registry

Katarzyna Majstrowicz, Katharina Waack, Evangelia Antoniou, Naghmeh Niktoreh, Gwen Nichols, Laura Di Laurenzio, Michele S. Redell, Todd Cooper, E. Anders Kolb, Sarah K. Tasian, Franco Locatelli, C. Michel Zwaan, Dirk Reinhardt
Journal: Blood
Blood (2023) 142 (Supplement 1): 1496.
https://doi.org/10.1182/blood-2023-189684
Published: 2023
Journal Articles

Chip-AML22 Master Protocol: An Open-Label Clinical Trial in Newly Diagnosed Pediatric De Novo Acute Myeloid Leukemia (AML) Patients Including a Linked Phase II Trial with Quizartinib in FLT3 -ITD/ NPM1 wt Patients - a Study By the NOPHO-DB-SHIP Consortium

Gertjan J.L. Kaspers, Noa E. Wijnen, Joost B. Koedijk, Sae Ishimaru, Renske Benedictus, Ellen C. Van Opstal, Harm Van Tinteren, C. Michel Zwaan, Noha Biserna, Pamela Downs, Yvonne Duong, Yasser Mostafa Kamel, Jonas Abrahamsson, Nira Arad-Cohen, Nicole Bodmer, Luis Castillo, Daniel Cheuk, Vitor Costa, Barbara De Moerloose, Jose Maria Fernandez Navarro, Linda Fogelstrand, Bianca F. Goemans, Henrik Hasle, Olafur G. Jonsson, Zhanna Kovalova, Monica C. Munthe-Kaas, Ulrika Norén-Nyström, Sauli Palmu, Ramune Pasauliene, Kadri Saks, Anne Maria Tierens, Dominik Turkiewicz, Cornelis Jan Pronk
Journal: Blood
Blood (2023) 142 (Supplement 1): 1532.
https://doi.org/10.1182/blood-2023-181792
Published: 2023
Journal Articles

Treatment of Molecular Relapses in Pediatric AML Saves Toxicities Prior to Hematopoietic Stem Cell Transplantation (HSCT) - Results of AMoRe2017 Trial

Amelie Polutta, Dirk Reinhardt, Andre Baruchel, Henrik Hasle, Franco Locatelli, C. Michel Zwaan, Michael Frühwald, Silke Westphal, Michael Dworzak, Heidrun Boztug, Gabriele Escherich, Thomas Lehrnbecher, Bianca F. Goemans, Brigitte Strahm, Markus Schneider, Lina Hoffmeister, Katharina Waack
Journal: Blood
Blood (2023) 142 (Supplement 1): 1521.
https://doi.org/10.1182/blood-2023-180820
Published: 2023
Journal Articles

Transcriptional Heterogeneity and Clonal Evolution between Diagnosis and Relapse in Pediatric Acute Myeloid Leukemia

Cristoforo Grasso, Peter Brazda, Brigit M. te Pas, Gitanjali Dharmadhikari, Joost B. Koedijk, Bianca F. Goemans, Olaf Heidenreich, Mirjam E. Belderbos, C. Michel Zwaan, Hendrik G. Stunnenberg, Wout Megchelenbrink
Journal: Blood
Blood (2023) 142 (Supplement 1): 2746.
https://doi.org/10.1182/blood-2023-182852
Published: 2023
Journal Articles

APAL2020SC Pediatric Acute Leukemia (PedAL) Screening Trial - Developing New Therapies for Relapsed Leukemias

Michele S. Redell, Todd A. Alonzo, Robert Gerbing, Jim Wang, Maureen M. O'Brien, Gwen Nichols, Laura Di Laurenzio, Sarah K. Tasian, C. Michel Zwaan, Dirk Reinhardt, E. Anders Kolb, Todd Cooper
Journal: Blood
Blood (2023) 142 (Supplement 1): 1492.
https://doi.org/10.1182/blood-2023-190947
Published: 2023
Journal Articles

Hydrocortisone or Placebo to Reduce Dexamethasone-Induced Neurobehavioral Side Effects: Results of a Phase 3 National, Double-Blind, Placebo-Controlled Randomized Trial with Crossover Design

Annelienke M. van Hulst, Erica L.T. van den Akker, Emma J. Verwaaijen, Marta Fiocco, Niki Rensen, Raphaële R.L. van Litsenburg, Saskia M.F. Pluijm, C. Michel Zwaan, Hanneke M. Van Santen, Rob Pieters, Andrea W.M. Evers, Martha A. Grootenhuis, Marry M. van den Heuvel-Eibrink
Journal: Blood
Blood (2022) 140 (Supplement 1): 3162–3163.
https://doi.org/10.1182/blood-2022-163329
Published: 2022
Journal Articles

Retrospective Lineage Tracing of Pediatric Acute Myeloid Leukemia Using Single-Cell Whole Genome Sequencing

Eline J.M. Bertrums, Sjors Middelkamp, Inge M. van der Werf, Freek Manders, Arianne M. Brandsma, Niels M. Groenen, Mark Verheul, Markus J. van Roosmalen, C. Michel Zwaan, Marry M. van den Heuvel-Eibrink, Bianca F. Goemans, Ruben Van Boxtel
Journal: Blood
Blood (2022) 140 (Supplement 1): 8725–8726.
https://doi.org/10.1182/blood-2022-166051
Published: 2022
Journal Articles

ITCC-101/APAL2020D: A Randomized Phase 3 Trial of Fludarabine/Cytarabine/Gemtuzumab Ozogamycin with or without Venetoclax in Children with Relapsed Acute Myeloid Leukemia

Sae Ishimaru, Gwenaëlle Gueguen, Seth E. Karol, Francisco J. Bautista Sirvent, Valeria Ceolin, Bianca F. Goemans, Marlous Bakker, Laura Di Laurenzio, Jennifer Lukin, Harm Van Tinteren, Gauri B. Sunkersett, Maika Onishi, Kristina Unnebrink, Dirk Reinhardt, Gwen L Nichols, E. Anders Kolb, C. Michel Zwaan
Journal: Blood
Blood (2022) 140 (Supplement 1): 3369–3370.
https://doi.org/10.1182/blood-2022-168818
Published: 2022
Journal Articles

Germline GATA1s-generating mutations predispose to leukemia with acquired trisomy 21 and Down syndrome-like phenotype

Brief Report
Henrik Hasle, Ronald M. Kline, Eigil Kjeldsen, Nik F. Nik-Abdul-Rashid, Deepa Bhojwani, Jeffrey M. Verboon, Stephanie P. DiTroia, Katherine R. Chao, Klas Raaschou-Jensen, Josefine Palle, C. Michel Zwaan, Charlotte Guldborg Nyvold, Vijay G. Sankaran, Alan B. Cantor
Journal: Blood
Blood (2022) 139 (21): 3159–3165.
https://doi.org/10.1182/blood.2021011463
Published: 2022
Includes: Supplemental data
Journal Articles

Isatuximab in Combination with Chemotherapy in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia (ISAKIDS): Interim Analysis

Andre Baruchel, Jonas Abrahamsson, Yves Bertrand, Oscar Gonzalez, Karsten Nysom, Willy Quinones, Carmelo Rizzari, Jochen Buechner, Simone Cesaro, Joaquin Duarte, Franca Fagioli, Hyoung Jin Kang, Antonis Kattamis, Guy Leverger, Kathleen Ludwig, Monica L Makiya, Concetta Micalizzi, Brigitte Nelken, Camilla Tøndel, Keon Hee Yoo, Inna Ivanina, Claire Brillac, Lynn Wang, Corina Oprea, Giovanni Abbadessa, C. Michel Zwaan
Journal: Blood
Blood (2021) 138 (Supplement 1): 516.
https://doi.org/10.1182/blood-2021-150272
Published: 2021
Journal Articles

Impact of Allogeneic Hematopoietic Stem Cell Transplantation in First Complete Remission and Additional Cytogenetic Aberrations at Diagnosis on Prognosis in 1256 Pediatric Patients with KMT2A-Rearranged Acute Myeloid Leukemia: A Retrospective Study By the I-BFM-SG

Romy E. Van Weelderen, Kim Klein, Christine J. Harrison, Hester A. De Groot-Kruseman, Jonas Abrahamsson, Nira Arad-Cohen, Emmanuelle Bart-Delabesse, Barbara Buldini, Barbara De Moerloose, Michael Dworzak, Sarah Elitzur, José M. Fernández Navarro, Marta Fiocco, Robert B. Gerbing, Bianca F. Goemans, Erin Guest, Shau-Yin Ha, Henrik Hasle, Kathy Jackson, Charikleia Kelaidi, Hélène Lapillonne, Guy Leverger, Franco Locatelli, Takako Miyamura, Sophia Polychronopoulou, Mareike Rasche, Jeffrey E. Rubnitz, Jan Stary, Daisuke Tomizawa, Femke Verwer, C. Michel Zwaan, Gertjan J.L. Kaspers
Journal: Blood
Blood (2021) 138 (Supplement 1): 2360.
https://doi.org/10.1182/blood-2021-148041
Published: 2021
Journal Articles

Fludarabine Exposure Predicts Outcome after CD19 CAR T Cell Therapy in Children and Young Adults with Acute Leukemia; An Exploratory, Observational Study

Linde Dekker, Friso Calkoen, Yilin Jiang, Hilly Blok, Maike Spoon, Rick Admiraal, Peter Hoogerbrugge, Britta Julia Vormoor, Josef Vormoor, C. Michel Zwaan, Henk Visscher, Marc Bierings, Marieke Van Der Vlugt, Harm Van Tinteren, A. Laura Nijstad, Kim Van Der Elst, Alwin D. R. Huitema, Rob Pieters, Caroline Lindemans, Stefan Nierkens
Journal: Blood
Blood (2021) 138 (Supplement 1): 3871.
https://doi.org/10.1182/blood-2021-146450
Published: 2021