1-20 of 40
Josef Vormoor
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Single-Cell Dissection of the B-ALL Niche Reveals Distinct Mesenchymal Stromal Cell Subtypes with Differential Leukemic Cell Support and Relapse Implications

Mauricio Nicolás Ferrao Blanco, Bexultan Kazybay, Olaf Heidenreich, Josef Vormoor
Journal: Blood
Blood (2024) 144 (Supplement 1): 1299.
https://doi.org/10.1182/blood-2024-205911
Published: 2024
Journal Articles

RUNX1::RUNX1T1 Impairs the Differentiation Potential of Primary AML Cells

Polina K Derevianko, Laura E. Swart, Minoo Ashtiani, Sophie Kellaway, Anja Krippner-Heidenreich, Raymond M. Schiffelers, Josef Vormoor, Olaf Heidenreich
Journal: Blood
Blood (2023) 142 (Supplement 1): 1573.
https://doi.org/10.1182/blood-2023-182804
Published: 2023
Journal Articles

The MEK Inhibitor Selumetinib in Combination with Dexamethasone Leads to Responses in Adult and Pediatric Patients with Relapsed RAS-Pathway Mutated Acute Lymphoblastic Leukemia: Results of a Phase 1/2 Study

Britta Julia Vormoor, Tobias Menne, Joshua Savage, Amit Patel, Anna Castleton, Adele Kay Fielding, Donna Lancaster, Anne Louise Latif, Nick Morley, Geoff Shenton, Gareth Veal, Julie Irving, Pam Kearns, Lucinda Billingham, Josef Vormoor
Journal: Blood
Blood (2023) 142 (Supplement 1): 2874.
https://doi.org/10.1182/blood-2023-185855
Published: 2023
Journal Articles

Oncogenic RAS Signaling Promotes an Immunosuppressive Niche in Acute Lymphoblastic Leukemia

Mauricio Nicolás Ferrao Blanco, Elizabeth Schweighart, Lennart Kester, Jayne Hehir-Kwa, Mirjam E. Belderbos, Monique L. den Boer, Olaf Heidenreich, Josef Vormoor
Journal: Blood
Blood (2023) 142 (Supplement 1): 4080.
https://doi.org/10.1182/blood-2023-188899
Published: 2023
Journal Articles

Inhibition of the Menin-MLL1 Interaction in MLL -Rearranged Primary Mixed-Phenotype Acute Leukemia Samples Promotes Leukemic Differentiation

Katarzyna Szoltysek, Rachel L. Cameron, Anja Krippner-Heidenreich, Milad Rasouli, Jayne Y. Hehir-Kwa, Elizabeth K. Schweighart, Minoo Ashtiani, Janine Stutterheim, Josef Vormoor, Olaf Heidenreich
Journal: Blood
Blood (2022) 140 (Supplement 1): 9191.
https://doi.org/10.1182/blood-2022-166326
Published: 2022
Journal Articles

Epigenetic regulator genes direct lineage switching in  MLL/AF4 leukemia

Ricky Tirtakusuma, Katarzyna Szoltysek, Paul Milne, Vasily V. Grinev, Anetta Ptasinska, Paulynn S. Chin, Claus Meyer, Sirintra Nakjang, Jayne Y. Hehir-Kwa, Daniel Williamson, Pierre Cauchy, Peter Keane, Salam A. Assi, Minoo Ashtiani, Sophie G. Kellaway, Maria R. Imperato, Fotini Vogiatzi, Elizabeth K. Schweighart, Shan Lin, Mark Wunderlich, Janine Stutterheim, Alexander Komkov, Elena Zerkalenkova, Paul Evans, Hesta McNeill, Alex Elder, Natalia Martinez-Soria, Sarah E. Fordham, Yuzhe Shi, Lisa J. Russell, Deepali Pal, Alex Smith, Zoya Kingsbury, Jennifer Becq, Cornelia Eckert, Oskar A. Haas, Peter Carey, Simon Bailey, Roderick Skinner, Natalia Miakova, Matthew Collin, Venetia Bigley, Muzlifah Haniffa, Rolf Marschalek, Christine J. Harrison, Catherine A. Cargo, Denis Schewe, Yulia Olshanskaya, Michael J. Thirman, Peter N. Cockerill, James C. Mulloy, Helen J. Blair, Josef Vormoor, James M. Allan, Constanze Bonifer, Olaf Heidenreich, Simon Bomken
Journal: Blood
Blood (2022) 140 (17): 1875–1890.
https://doi.org/10.1182/blood.2021015036
Published: 2022
Includes: Supplemental data
Journal Articles

Fludarabine Exposure Predicts Outcome after CD19 CAR T Cell Therapy in Children and Young Adults with Acute Leukemia; An Exploratory, Observational Study

Linde Dekker, Friso Calkoen, Yilin Jiang, Hilly Blok, Maike Spoon, Rick Admiraal, Peter Hoogerbrugge, Britta Julia Vormoor, Josef Vormoor, C. Michel Zwaan, Henk Visscher, Marc Bierings, Marieke Van Der Vlugt, Harm Van Tinteren, A. Laura Nijstad, Kim Van Der Elst, Alwin D. R. Huitema, Rob Pieters, Caroline Lindemans, Stefan Nierkens
Journal: Blood
Blood (2021) 138 (Supplement 1): 3871.
https://doi.org/10.1182/blood-2021-146450
Published: 2021
Journal Articles

RNA-Sequencing Improves Diagnostics and Treatment of Pediatric Hematological Malignancies

Marco J. Koudijs, Lennart A. Kester, Jayne Y. Hehir-Kwa, Eugene T.P. Verwiel, Erik Strengman, Marc van Tuil, Douwe van der Leest, Edwin Sonneveld, Patrick Kemmeren, Valerie De Haas, Josef Vormoor, Bas B.J. Tops
Journal: Blood
Blood (2021) 138 (Supplement 1): 107.
https://doi.org/10.1182/blood-2021-147692
Published: 2021
Journal Articles

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Jordy C.G. Van Der Zwet, MD, Jessica G.C.A.M. Buijs-Gladdines, Valentina Cordo', MSc, Donna Debets, MSc, Willem K. Smits, Zhongli Chen, MSc, Jelle Dylus, Guido Zaman, PhD, Maarten Altelaar, PhD, Koichi Oshima, MD PhD, Beat Bornhauser, Jean-Pierre Bourquin, MD PhD, Jan Cools, PhD, Adolfo A. Ferrando, MD PhD, Josef Vormoor, MD PhD, Rob Pieters, MDPhDMSc, Britta Julia Vormoor, MD, Jules P.P. Meijerink, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 20.
https://doi.org/10.1182/blood-2020-139305
Published: 2020
Journal Articles

The SF3b Splicing Complex Regulates DNA Damage Response in Acute Lymphoblastic Leukemia

Shalini Sankar, Miriam Guillen Navarro, Frida Ponthan, PhD, Simon Bomken, MD, Sirintra Nakjang, Vasily Grinev, PhD, Hesta McNeill, Michel C Zwaan, MD PhD, Josef Vormoor, MD PhD, Ronald W. Stam, PhD, Olaf Heidenreich
Journal: Blood
Blood (2019) 134 (Supplement_1): 1237.
https://doi.org/10.1182/blood-2019-124787
Published: 2019
Journal Articles

Whole-Genome CRISPR Screen Reveals the Mechanism of Relapse in Patient-Derived Cells Representing High-Risk Paediatric ALL

Katarzyna Szoltysek, PhD, Helen Blair, Sirintra Nakjang, Ricky Tirtakusuma, Mankaran Singh, Ryan Nelson, Hesta McNeill, Catherine Dodd, Melanie Beckett, Lynsey McKenzie, Edward Law, Josef Vormoor, MD PhD, Deepali Pal, Olaf Heidenreich
Journal: Blood
Blood (2019) 134 (Supplement_1): 3952.
https://doi.org/10.1182/blood-2019-124818
Published: 2019
Journal Articles

Exploring Pre-B Cell Receptor Signalling As a Therapeutic Target in Acute Lymphoblastic Leukaemia

Ali Alhammer, M.Sc, Marian Case, MSc, Helen J Blair, PhD, Josef Vormoor, MD FRCPCH, Julie Irving, PhD
Journal: Blood
Blood (2016) 128 (22): 4066.
https://doi.org/10.1182/blood.V128.22.4066.4066
Published: 2016
Journal Articles

Identification of CCND2 As a RUNX1/ETO Target Required for Leukaemic Propagation

Lynsey McKenzie, PhD, Natalia Martinez-Soria, PhD, Julia Draper, DPhil, Sirintra Nakjang, PhD, Helen J Blair, PhD, Christian Wichmann, MD, Josef Vormoor, MD FRCPCH, Constanze Bonifer, PhD, Georges Lacaud, PhD, Olaf Heidenreich, PhD
Journal: Blood
Blood (2016) 128 (22): 835.
https://doi.org/10.1182/blood.V128.22.835.835
Published: 2016
Journal Articles

The ability to cross the blood–cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts

Mark T. S. Williams, Yasar M. Yousafzai, Alex Elder, Klaus Rehe, Simon Bomken, Liron Frishman-Levy, Sigal Tavor, Paul Sinclair, Katie Dormon, Dino Masic, Tracey Perry, Victoria J. Weston, Pamela Kearns, Helen Blair, Lisa J. Russell, Olaf Heidenreich, Julie A. E. Irving, Shai Izraeli, Josef Vormoor, Gerard J. Graham, Christina Halsey
Journal: Blood
Blood (2016) 127 (16): 1998–2006.
https://doi.org/10.1182/blood-2015-08-665034
Published: 2016
Includes: Supplemental data
Journal Articles

A Whole Genome In Vivo Crispr Screen in Primary ALL Predicts Leukaemic Relapse

Katherine Dormon, MSci, Elda S Latif, PhD, Matthew Bashton, PhD, Deepali Pal, PhD, Matthew Selby, MSci, Helen Blair, PhD, Vikki Rand, PhD, Andrew G Hall, PhD, Josef Vormoor, MD FRCPCH, Olaf Heidenreich, PhD
Journal: Blood
Blood (2015) 126 (23): 2619.
https://doi.org/10.1182/blood.V126.23.2619.2619
Published: 2015
Journal Articles

High Abundance of Acute Lymphoblastic Leukaemia Founder Clones Does Not Translate to Functional Heterogeneity

Alex Elder, PhD, Helen Blair, PhD, Katherine Dormon, Simon Bomken, PhD MBBS, Simon J Cockell, PhD, Olaf Heidenreich, PhD, Josef Vormoor, MD FRCPCH
Journal: Blood
Blood (2015) 126 (23): 844.
https://doi.org/10.1182/blood.V126.23.844.844
Published: 2015
Journal Articles

A Genome-Wide RNAi Screen to Identify Novel Genes Involved in Clonal Maintenance of ALL

Frida Ponthan, PhD, Simon Bomken, PhD MBBS, Deepali Pal, PhD, Alex Elder, PhD, Hesta McNeill, Josef Vormoor, MD FRCPCH, Olaf Heidenreich, PhD
Journal: Blood
Blood (2014) 124 (21): 2390.
https://doi.org/10.1182/blood.V124.21.2390.2390
Published: 2014
Journal Articles

Development of in Vivo Models of Paediatric Burkitt Lymphoma Allowing Therapeutic Target Analysis and Drug Testing

Natalie Bell, PhD, Helen J Blair, PhD, Josef Vormoor, MD FRCPCH, Chris Bacon, MBChB, PhD, Vikki Rand, PhD, Olaf Heidenreich, PhD, Simon Bomken, PhD MBBS
Journal: Blood
Blood (2014) 124 (21): 5501.
https://doi.org/10.1182/blood.V124.21.5501.5501
Published: 2014
Journal Articles

Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition

Julie Irving, Elizabeth Matheson, Lynne Minto, Helen Blair, Marian Case, Christina Halsey, Isabella Swidenbank, Frida Ponthan, Renate Kirschner-Schwabe, Stefanie Groeneveld-Krentz, Jana Hof, James Allan, Christine Harrison, Josef Vormoor, Arend von Stackelberg, Cornelia Eckert
Journal: Blood
Blood (2014) 124 (23): 3420–3430.
https://doi.org/10.1182/blood-2014-04-531871
Published: 2014
Includes: Supplemental data
Journal Articles

An Analysis Of Mechanisms Of Central Nervous System Infiltration In Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice

Yasar M Yousafzai, MBBS, Mark TS Williams, PhD, Klaus Rehe, MD, Michelle Le Brocq, PhD, Simon Bomken, MBBS, PhD, Paul B Sinclair, PhD, Katie Dormon, MSc, Dino Masic, MRes, Leanne Archer, B.Sc, Jennifer Watt, BSc, Tracey A Perry, BSc, Victoria J Weston, PhD, Pamela R Kearns, MBChB, PhD, FRCPCH, Helen Blair, PhD, Russel Lisa, PhD, Olaf Heidenreich, PhD, Julie Irving, PhD, Josef Vormoor, MD, Brenda Gibson, MD, Gerard J Graham, PhD, Christina Halsey, PhD, FRCPath
Journal: Blood
Blood (2013) 122 (21): 3866.
https://doi.org/10.1182/blood.V122.21.3866.3866
Published: 2013