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Willem K. Smits
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Journal Articles

Elevated Enhancer-Oncogene Contacts and Higher Oncogene Expression Levels By Recurrent CTCF inactivating Mutations in T Cell Acute Lymphoblastic Leukemia

Willem K. Smits, Carlo Vermeulen, Rico Hagelaar, Shunsuke Kimura, Eric Vroegindeweij, Jessica G.C.A.M. Buijs-Gladdines, Ellen Van De Geer, Marjon J.A.M. Verstegen, Erik Splinter, Simon V. van Reijmersdal, Arjan Buijs, Niels Galjart, Winfried Van Eyndhoven, Max Jan Van Min, Roland P Kuiper, Patrick Kemmeren, Charles G. Mullighan, Wouter De Laat, Jules P.P. Meijerink
Journal: Blood
Blood (2021) 138 (Supplement 1): 501.
https://doi.org/10.1182/blood-2021-152221
Published: 2021
Journal Articles

Manipulating MEF2C: Discovering Novel Drugs to Target ETP-ALL

Mariska T. Meijer, Valentina Cordo', Rico Hagelaar, Willem K. Smits, Jules PP Meijerink
Journal: Blood
Blood (2021) 138 (Supplement 1): 3325.
https://doi.org/10.1182/blood-2021-150176
Published: 2021
Journal Articles

The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Jordy C.G. Van Der Zwet, MD, Jessica G.C.A.M. Buijs-Gladdines, Valentina Cordo', MSc, Donna Debets, MSc, Willem K. Smits, Zhongli Chen, MSc, Jelle Dylus, Guido Zaman, PhD, Maarten Altelaar, PhD, Koichi Oshima, MD PhD, Beat Bornhauser, Jean-Pierre Bourquin, MD PhD, Jan Cools, PhD, Adolfo A. Ferrando, MD PhD, Josef Vormoor, MD PhD, Rob Pieters, MDPhDMSc, Britta Julia Vormoor, MD, Jules P.P. Meijerink, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 20.
https://doi.org/10.1182/blood-2020-139305
Published: 2020
Journal Articles

MAPK-ERK Pathway Activation: The Achilles' Heel of IL-7R‒Induced Steroid Resistance

Jordy C.G. Van Der Zwet, MD, Jessica G.C.A.M. Buijs-Gladdines, Willem K. Smits, Zhongli Chen, MSc, Jules P.P. Meijerink, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1292.
https://doi.org/10.1182/blood-2019-124721
Published: 2019
Journal Articles

PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events

Rui D. Mendes, Leonor M. Sarmento, Kirsten Canté-Barrett, Linda Zuurbier, Jessica G. C. A. M. Buijs-Gladdines, Vanda Póvoa, Willem K. Smits, Miguel Abecasis, J. Andres Yunes, Edwin Sonneveld, Martin A. Horstmann, Rob Pieters, João T. Barata, Jules P. P. Meijerink
Journal: Blood
Blood (2014) 124 (4): 567–578.
https://doi.org/10.1182/blood-2014-03-562751
Published: 2014
Includes: Supplemental data
Journal Articles

PTEN/AKT Pathway Mutations Are Reciprocal to NOTCH-Activating Mutations In Pediatric T-Cell Acute Lymphoblastic Lymphoma (T-ALL)

Linda Zuurbier, L, Maartje Vuerhard, Clarissa Kooi, Willem K Smits, W.K., Jessica Buijs-Gladdines, Martin A. Horstmann, MD, Válerie de Haas, MD, PhD, Rob Pieters, MD, PhD, Jules Meijerink, PhD
Journal: Blood
Blood (2010) 116 (21): 1710.
https://doi.org/10.1182/blood.V116.21.1710.1710
Published: 2010