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Journal Articles

Elevated Enhancer-Oncogene Contacts and Higher Oncogene Expression Levels By Recurrent CTCF inactivating Mutations in T Cell Acute Lymphoblastic Leukemia

Willem K. Smits, Carlo Vermeulen, Rico Hagelaar, Shunsuke Kimura, Eric Vroegindeweij, Jessica G.C.A.M. Buijs-Gladdines, Ellen Van De Geer, Marjon J.A.M. Verstegen, Erik Splinter, Simon V. van Reijmersdal, Arjan Buijs, Niels Galjart, Winfried Van Eyndhoven, Max Jan Van Min, Roland P Kuiper, Patrick Kemmeren, Charles G. Mullighan, Wouter De Laat, Jules P.P. Meijerink

Blood (2021) 138 (Supplement 1): 501.

https://doi.org/10.1182/blood-2021-152221

Published: 2021

Journal Articles

Genomic Architecture and Clonal Dynamics of Early Relapsed BCP-ALL

Zeljko Antic, MD, Jiangyan Yu, MSc, Simon V. van Reijmersdal, Renske Kuiper, Edwin Sonneveld, PhD, Frank N. van Leeuwen, PhD, Peter M. Hoogerbrugge, MD PhD, Esmé Waanders, PhD, Roland P. Kuiper, PhD

Blood (2016) 128 (22): 4072.

https://doi.org/10.1182/blood.V128.22.4072.4072

Published: 2016

Journal Articles

Genetic Architecture of Relapsed Pediatric B Cell Precursor Acute Lymphoblastic Leukemia Are Related to the Intensity of Upfront Therapy

Jiangyan Yu, MSc, Esmé Waanders, PhD, Simon V. van Reijmersdal, Edwin Sonneveld, PhD, Frank N. van Leeuwen, PhD, Rob Pieters, MD PhD, Ad Geurts van Kessel, PhD, Peter M. Hoogerbrugge, MD PhD, Roland P. Kuiper, PhD

Blood (2015) 126 (23): 247.

https://doi.org/10.1182/blood.V126.23.247.247

Published: 2015

Journal Articles

Accurate Detection of Low Mosaic Mutations Associated with Therapy Resistance in Pediatric Acute Lymphoblastic Leukemia Using Single Molecule Tagging and Deep-Sequencing

Jiangyan Yu, MSc, Simon V. van Reijmersdal, Alexander Hoischen, PhD, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, MD PhD, Esmé Waanders, PhD, Roland P. Kuiper, PhD

Blood (2015) 126 (23): 2608.

https://doi.org/10.1182/blood.V126.23.2608.2608

Published: 2015

Journal Articles

Targeted Locus Amplification & Next Generation Sequencing for the Detection of Recurrent and Novel Gene Fusions for Improved Treatment Decisions in Pediatric Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Simon V. van Reijmersdal, Marieke Simonis, PhD, Jiangyan Yu, MSc, Edwin Sonneveld, PhD, Blanca Scheijen, PhD, Judith M. Boer, PhD, Aurélie Boeree, BSc, Petra Klous, MSc, Peter M Hoogerbrugge, MD PhD, Mehmet Yilmaz, MSc, Frank N. van Leeuwen, PhD, Monique L. Den Boer, PhD, Erik Splinter, PhD

Blood (2015) 126 (23): 696.

https://doi.org/10.1182/blood.V126.23.696.696

Published: 2015

Journal Articles

The Majority of RAS Pathway Mutations Detected in Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Are Present in Major or Minor Subclones at Diagnosis

Jiangyan Yu, Esmé Waanders, PhD, Simon V. van Reijmersdal, Edwin Sonneveld, PhD, Peter M Hoogerbrugge, MD PhD, Frank N. van Leeuwen, PhD, Ad Geurts van Kessel, PhD, Roland P. Kuiper, PhD

Blood (2014) 124 (21): 2397.

https://doi.org/10.1182/blood.V124.21.2397.2397

Published: 2014

Journal Articles

B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Specific Copy Number Alterations Are Unique For Progressive Pediatric Chronic Myeloid Leukemia (CML): A Large Cohort Study

Naomi E van der Sligte, Manuela Krumbholz, PhD, Agata Pastorczak, MD, Blanca Scheijen, PhD, Josephine T. Tauer, Christina Nowasz, Edwin Sonneveld, PhD, Truuske H. de Bock, PhD, Tiny G. Meeuwsen - de Boer, BSc, Simon V. van Reijmersdal, BSc, Roland P. Kuiper, PhD, Jutta Bradtke, PhD, Markus Metzler, MD, Meinolf Suttorp, Evelina S. De Bont, Frank N. van Leeuwen, PhD

Blood (2013) 122 (21): 2715.

https://doi.org/10.1182/blood.V122.21.2715.2715

Published: 2013

Journal Articles

Identification of distinct protein Signatures Associated with genetic Abnormalities In Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Blanca Scheijen, PhD, Agata Pastorczak, MD, Simon V. van Reijmersdal, BSc, Deborah A. Thomas, MD, Niangxiang Zhang, PhD, Kevin R. Coombes, PhD, Hagop M. Kantarjian, MD, Elias J. Jabbour, MD, Eveline S.J.M De Bont, MD, PhD, Frank N. van Leeuwen, PhD, Steven M. Kornblau, MD

Blood (2013) 122 (21): 1313.

https://doi.org/10.1182/blood.V122.21.1313.1313

Published: 2013

Journal Articles

Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL

Arian van der Veer, Esmé Waanders, Rob Pieters, Marieke E. Willemse, Simon V. Van Reijmersdal, Lisa J. Russell, Christine J. Harrison, William E. Evans, Vincent H. J. van der Velden, Peter M. Hoogerbrugge, Frank Van Leeuwen, Gabriele Escherich, Martin A. Horstmann, Leila Mohammadi Khankahdani, Dimitris Rizopoulos, Hester A. De Groot-Kruseman, Edwin Sonneveld, Roland P. Kuiper, Monique L. Den Boer

Blood (2013) 122 (15): 2622–2629.

https://doi.org/10.1182/blood-2012-10-462358

Published: 2013

Includes: Supplemental data

Journal Articles

Exome Sequencing and Ultra-Deep Sequencing of Paired Diagnosis, Remission and Relapse Samples Reveals the Clonal Diversity and Treatment-Induced Evolution of Childhood Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Simon V. van Reijmersdal, BSc, Marc M Hahn, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, MD, PhD, Ad Geurts van Kessel, PhD

Blood (2012) 120 (21): 126.

https://doi.org/10.1182/blood.V120.21.126.126

Published: 2012

Journal Articles

Focal BTG1 Deletions Occur in Specific Precursor B-Cell Acute Lymphoblastic Leukemia Subtypes At Defined Hotspots Due to Aberrant V(D)J Recombination

Blanca Scheijen, PhD, Esmé Waanders, PhD, Simon V. van Reijmersdal, BSc, Laurens T. van der Meer, PhD, Liesbeth van Emst, BSc, Eugene Verwiel, MSc, Yvet Kroeze, MSc, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, MD, PhD, Ad Geurts van Kessel, PhD, Frank N. van Leeuwen, PhD, Roland P. Kuiper, PhD

Blood (2011) 118 (21): 399.

https://doi.org/10.1182/blood.V118.21.399.399

Published: 2011

Journal Articles

Exome Sequencing of Late Recurrence T-Cell Acute Lymphoblastic Leukemia in Children Confirms Second Leukemia and Exposes Predisposition Candidate Genes

Esmé Waanders, PhD, Vincent H.J. van der Velden, PhD, Tomasz Szczepanski, Lisenka E.L.M. Vissers, PhD, Joep de Ligt, MSc, Christian Gilissen, Anke A.H. van Dijk, BSc, Simon V. van Reijmersdal, BSc, Peter M. Hoogerbrugge, MD, PhD, Ad Geurts van Kessel, PhD, Jacques J.M. van Dongen, PhD, Roland P. Kuiper, PhD

Blood (2011) 118 (21): 755.

https://doi.org/10.1182/blood.V118.21.755.755

Published: 2011

Journal Articles

Integrated Use of Minimal Residual Disease Classification and IKZF1 Alteration Status Accurately Predicts 79% of Relapses In Pediatric Acute Lymphoblastic Leukemia

Esmé Waanders, PhD, Vincent H.J. van der elden, PhD, Ellen van der Schoot, MD, PhD, Frank N. van Leeuwen, PhD, Simon V. van Reijmersdal, BSc, Valerie de Haas, PhD, Anjo J. Veerman, MD, PhD, Ad Geurts van Kessel, PhD, Peter M. Hoogerbrugge, MD, PhD, Roland P. Kuiper, PhD, Jacques J.M. van Dongen, PhD

Blood (2010) 116 (21): 272.

https://doi.org/10.1182/blood.V116.21.272.272

Published: 2010

Journal Articles

BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia

Joost C. van Galen, Roland P. Kuiper, Liesbeth van Emst, Marloes Levers, Esther Tijchon, Blanca Scheijen, Esmé Waanders, Simon V. van Reijmersdal, Christian Gilissen, Ad Geurts van Kessel, Peter M. Hoogerbrugge, Frank N. van Leeuwen

Blood (2010) 115 (23): 4810–4819.

https://doi.org/10.1182/blood-2009-05-223081

Published: 2010

Includes: Supplemental data

Journal Articles

Deletion of IKZF1 in Pediatric Precursor-B ALL Is a Strong Prognostic Marker for Relapse.

Roland P. Kuiper, PhD, Esmee Waanders, PhD, Vincent H.J. Van der Velden, PhD, Simon V van Reijmersdal, Blanca Scheijen, PhD, Jayne Hehir-Kwa, Suzanne T.M. Keijzers-Vloet, Edwin Sonneveld, PhD, Jacques JM van Dongen, Ph.D, Frank N. van Leeuwen, PhD, Ad Geurts van Kessel, Peter M. Hoogerbrugge

Blood (2009) 114 (22): 1104.

https://doi.org/10.1182/blood.V114.22.1104.1104

Published: 2009

Journal Articles

Pediatric Precursor-B ALL with BTG1 Deletions Show a Distinct Genomic Profile.

Esmee Waanders, PhD, Frank N. van Leeuwen, PhD, Eugene Verwiel, Simon V van Reijmersdal, Marloes R Levers, Joost C van Galen, PhD, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, Ad Geurts van Kessel, Roland P. Kuiper, PhD

Blood (2009) 114 (22): 3244.

https://doi.org/10.1182/blood.V114.22.3244.3244

Published: 2009

Journal Articles

BTG1, a Gene Frequently Deleted in Pre-B ALL, Controls Glucocorticoid Receptor-Mediated Gene Expression.

Frank N. van Leeuwen, PhD, Joost Casper van Galen, PhD, Roland P. Kuiper, PhD, Liesbeth van Emst, Marloes R Levers, Esther Tijchon, Msc, Blanca Scheijen, Esmee Waanders, PhD, Simon V van Reijmersdal, Christian Gillissen, Msc., Ad Geurts van Kessel, Peter M. Hoogerbrugge

Blood (2009) 114 (22): 3458.

https://doi.org/10.1182/blood.V114.22.3458.3458

Published: 2009

Journal Articles

BTG1 Controls Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia by Regulating Nuclear Receptor-Mediated Transcription.

Joost C. van Galen, MSc, Roland P. Kuiper, PhD, Liesbeth van Emst, BSc, Marloes R. Levers, BSc, Simon V. van Reijmersdal, BSc, Ad Geurts van Kessel, PhD, Peter M. Hoogerbrugge, MD, PhD, Frank N. van Leeuwen, PhD

Blood (2008) 112 (11): 2262.

https://doi.org/10.1182/blood.V112.11.2262.2262

Published: 2008

Journal Articles

Ikaros Is a Frequently Affected Hematopoietic Differentiation Factor in Pediatric Relapse-Prone Precursor B-Cell Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Frank N. van Leeuwen, PhD, Vincent van der Velden, Simon V. van Reijmersdal, Jeltje de Vries, PhD, Suzanne T.M. Keijzers-Vloet, Jayne Hehir-Kwa, E. van Wering, Jacques JM van Dongen, Ph.D, Peter M. Hoogerbrugge, Ad Geurts van Kessel

Blood (2008) 112 (11): 4144.

https://doi.org/10.1182/blood.V112.11.4144.4144

Published: 2008

Journal Articles

Detection of Genomic Lesions in Childhood Precursor-B Cell ALL in Diagnosis and Relapse Samples Using High Resolution Genomic Profiling.

Roland P. Kuiper, PhD, Frank N. van Leeuwen, PhD, Suzanne T.M. Keijzers-Vloet, Simon V. van Reijmersdal, Jayne Y. Hehir-Kwa, Elisabeth R. van Wering, PhD, Vincent H.J. van der Velden, PhD, Jacques J.M. van Dongen, MD/PhD, Eric F.P.M. Schoenmakers, PhD, Ad Geurts van Kessel, PhD, Peter M. Hoogerbrugge, MD/PhD

Blood (2007) 110 (11): 995.

https://doi.org/10.1182/blood.V110.11.995.995

Published: 2007

NARROW

Elevated Enhancer-Oncogene Contacts and Higher Oncogene Expression Levels By Recurrent CTCF inactivating Mutations in T Cell Acute Lymphoblastic Leukemia

Genomic Architecture and Clonal Dynamics of Early Relapsed BCP-ALL

Genetic Architecture of Relapsed Pediatric B Cell Precursor Acute Lymphoblastic Leukemia Are Related to the Intensity of Upfront Therapy

Accurate Detection of Low Mosaic Mutations Associated with Therapy Resistance in Pediatric Acute Lymphoblastic Leukemia Using Single Molecule Tagging and Deep-Sequencing

Targeted Locus Amplification & Next Generation Sequencing for the Detection of Recurrent and Novel Gene Fusions for Improved Treatment Decisions in Pediatric Acute Lymphoblastic Leukemia

The Majority of RAS Pathway Mutations Detected in Relapsed B-Cell Precursor Acute Lymphoblastic Leukemia Are Present in Major or Minor Subclones at Diagnosis

B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Specific Copy Number Alterations Are Unique For Progressive Pediatric Chronic Myeloid Leukemia (CML): A Large Cohort Study

Identification of distinct protein Signatures Associated with genetic Abnormalities In Acute Lymphoblastic Leukemia

Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL

Exome Sequencing and Ultra-Deep Sequencing of Paired Diagnosis, Remission and Relapse Samples Reveals the Clonal Diversity and Treatment-Induced Evolution of Childhood Acute Lymphoblastic Leukemia

Focal BTG1 Deletions Occur in Specific Precursor B-Cell Acute Lymphoblastic Leukemia Subtypes At Defined Hotspots Due to Aberrant V(D)J Recombination

Exome Sequencing of Late Recurrence T-Cell Acute Lymphoblastic Leukemia in Children Confirms Second Leukemia and Exposes Predisposition Candidate Genes

Integrated Use of Minimal Residual Disease Classification and IKZF1 Alteration Status Accurately Predicts 79% of Relapses In Pediatric Acute Lymphoblastic Leukemia

BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia

Deletion of IKZF1 in Pediatric Precursor-B ALL Is a Strong Prognostic Marker for Relapse.

Pediatric Precursor-B ALL with BTG1 Deletions Show a Distinct Genomic Profile.

BTG1, a Gene Frequently Deleted in Pre-B ALL, Controls Glucocorticoid Receptor-Mediated Gene Expression.

BTG1 Controls Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia by Regulating Nuclear Receptor-Mediated Transcription.

Ikaros Is a Frequently Affected Hematopoietic Differentiation Factor in Pediatric Relapse-Prone Precursor B-Cell Acute Lymphoblastic Leukemia

Detection of Genomic Lesions in Childhood Precursor-B Cell ALL in Diagnosis and Relapse Samples Using High Resolution Genomic Profiling.

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American Society of Hematology

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American Society of Hematology

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