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Journal Articles

High frequency of inactivating tetraspanin C D37 mutations in diffuse large B-cell lymphoma at immune-privileged sites

Brief Report
Suraya Elfrink, Charlotte M. de Winde, Michiel van den Brand, Madeleine Berendsen, Margaretha G. M. Roemer, Frank Arnold, Luuk Janssen, Alie van der Schaaf, Erik Jansen, Patricia J. T. A. Groenen, Astrid Eijkelenboom, Wendy Stevens, Corine J. Hess, J. Han van Krieken, Joost S. P. Vermaat, Arjen H. G. Cleven, Ruben A. L. de Groen, Viviana Neviani, Daphne de Jong, Sjoerd van Deventer, Blanca Scheijen, Annemiek B. van Spriel
Journal: Blood
Blood (2019) 134 (12): 946–950.
https://doi.org/10.1182/blood.2019001185
Published: 2019
Includes: Supplemental data
Journal Articles

Glucocorticoid Resistance in IKZF1-Deleted BCP-ALL: It Is PTEN Again

Laurens Van Der Meer, PhD, Rene Marke, MSc, Miriam Butler, MSc, Dorette van Ingen Schenau, MSc, Blanca Scheijen, PhD, Frank van Leeuwen, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4088.
https://doi.org/10.1182/blood-2018-99-112888
Published: 2018
Journal Articles

Targeted Locus Amplification & Next Generation Sequencing for the Detection of Recurrent and Novel Gene Fusions for Improved Treatment Decisions in Pediatric Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Simon V. van Reijmersdal, Marieke Simonis, PhD, Jiangyan Yu, MSc, Edwin Sonneveld, PhD, Blanca Scheijen, PhD, Judith M. Boer, PhD, Aurélie Boeree, BSc, Petra Klous, MSc, Peter M Hoogerbrugge, MD PhD, Mehmet Yilmaz, MSc, Frank N. van Leeuwen, PhD, Monique L. Den Boer, PhD, Erik Splinter, PhD
Journal: Blood
Blood (2015) 126 (23): 696.
https://doi.org/10.1182/blood.V126.23.696.696
Published: 2015
Journal Articles

Tumor Suppressors BTG1 and IKZF1 Cooperate during Mouse Leukemia Development and Impact Relapse Rate in Childhood Acute Lymphoblastic Leukemia

Blanca Scheijen, PhD, Esther Tijchon, Dorette van Ingen Schenau, Rene Marke, Liesbeth van Emst, Laurens T Van Der Meer, PhD, Roland P Kuiper, PhD, Judith M. Boer, PhD, Rob Pieters, MD PhD, Peter M Hoogerbrugge, MD PhD, Monique L. Den Boer, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2015) 126 (23): 905.
https://doi.org/10.1182/blood.V126.23.905.905
Published: 2015
Journal Articles

The Leukemia-Associated Protein BTG1 Is Required for ATF4-Mediated Cellular Stress Responses

Laurensia Yuniati, MSc, Laurens T van der Meer, PhD, Geert JV Poelmans, MD PhD, Sander AL Palit, BSc, Caroline Rodenbach, Dorette S van IngenSchenau, MSc, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N van Leeuwen, PhD
Journal: Blood
Blood (2014) 124 (21): 3587.
https://doi.org/10.1182/blood.V124.21.3587.3587
Published: 2014
Journal Articles

Btg1-Deficiency Promotes ETV6-RUNX1-Mediated Leukemic Transformation By Upregulation of BCL6

Esther Tijchon, MSc, Liesbeth van Emst, Bsc, Dorette van Ingen Schenau, MSc, Laurens T van der Meer, PhD, Simone de Rijk, BSc, Owen Williams, PhD, Peter M Hoogerbrugge, MD PhD, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2014) 124 (21): 5193.
https://doi.org/10.1182/blood.V124.21.5193.5193
Published: 2014
Journal Articles

Tumor Suppressors Btg1 and Btg2 Regulate B Lineage Commitment through Modulation of Ebf1 Activity

Esther Tijchon, MSc, Liesbeth van Emst, Bsc, Dorette van Ingen Schenau, MSc, Laurensia Yuniati, MSc, Jorn Havinga, MSc, Felice Tirone, PhD, Jean-Pierre Rouault, PhD, Peter M Hoogerbrugge, MD PhD, Frank N. van Leeuwen, PhD, Blanca Scheijen, PhD
Journal: Blood
Blood (2014) 124 (21): 4311.
https://doi.org/10.1182/blood.V124.21.4311.4311
Published: 2014
Journal Articles

B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Specific Copy Number Alterations Are Unique For Progressive Pediatric Chronic Myeloid Leukemia (CML): A Large Cohort Study

Naomi E van der Sligte, Manuela Krumbholz, PhD, Agata Pastorczak, MD, Blanca Scheijen, PhD, Josephine T. Tauer, Christina Nowasz, Edwin Sonneveld, PhD, Truuske H. de Bock, PhD, Tiny G. Meeuwsen - de Boer, BSc, Simon V. van Reijmersdal, BSc, Roland P. Kuiper, PhD, Jutta Bradtke, PhD, Markus Metzler, MD, Meinolf Suttorp, Evelina S. De Bont, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2013) 122 (21): 2715.
https://doi.org/10.1182/blood.V122.21.2715.2715
Published: 2013
Journal Articles

Loss Of BTG1 Function Promotes ETV6-RUNX1 -Mediated Leukemic Transformation

Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Dorette van Ingen Schenau, Msc, Laurens T. van der Meer, PhD, Owen Williams, PhD, Peter M. Hoogerbrugge, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2013) 122 (21): 2545.
https://doi.org/10.1182/blood.V122.21.2545.2545
Published: 2013
Journal Articles

Loss Of IKZF1 Function Mediates Resistance Towards Glucocorticoid-Induced Apoptosis

Jorn Havinga, MSc, Laurensia Yuniati, MSc, Marc Demkes, BSc, Dorette van Ingen Schenau, Msc, Roland P. Kuiper, PhD, Peter M. Hoogerbrugge, Frank N. van Leeuwen, PhD, Blanca Scheijen, PhD
Journal: Blood
Blood (2013) 122 (21): 3865.
https://doi.org/10.1182/blood.V122.21.3865.3865
Published: 2013
Journal Articles

Loss Of Tumor Suppressor BTG1 Enhances ATF4 Function and Promotes Cell Survival

Laurens T. van der Meer, PhD, Laurensia Yuniati, MSc, Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Manon Alkema, Caroline Rodenbach, Blanca Scheijen, PhD, Peter M. Hoogerbrugge, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2013) 122 (21): 3796.
https://doi.org/10.1182/blood.V122.21.3796.3796
Published: 2013
Journal Articles

P190 BCR-ABL1 Signaling Modulates The Function Of Tumor Suppressor Protein IKZF1

Marc Demkes, BSc, Edwin Lasonder, PhD, Edo Luijten, BSc, Peter M. Hoogerbrugge, Frank N. van Leeuwen, PhD, Blanca Scheijen, PhD
Journal: Blood
Blood (2013) 122 (21): 3809.
https://doi.org/10.1182/blood.V122.21.3809.3809
Published: 2013
Journal Articles

Identification of distinct protein Signatures Associated with genetic Abnormalities In Acute Lymphoblastic Leukemia

Roland P. Kuiper, PhD, Blanca Scheijen, PhD, Agata Pastorczak, MD, Simon V. van Reijmersdal, BSc, Deborah A. Thomas, MD, Niangxiang Zhang, PhD, Kevin R. Coombes, PhD, Hagop M. Kantarjian, MD, Elias J. Jabbour, MD, Eveline S.J.M De Bont, MD, PhD, Frank N. van Leeuwen, PhD, Steven M. Kornblau, MD
Journal: Blood
Blood (2013) 122 (21): 1313.
https://doi.org/10.1182/blood.V122.21.1313.1313
Published: 2013
Journal Articles

Tumor Suppressors BTG1 and BTG2 Fulfill Both Unique and Overlapping Functions During Normal B Lymphocyte Development

Esther J.H. Tijchon, MSc, Liesbeth van Emst, BSc, Jørn Havinga, MSc, Jean-Pierre Rouault, PhD, Felice Tirone, PhD, Peter M. Hoogerbrugge, MD, PhD, Blanca Scheijen, PhD, Frank N. van Leeuwen, PhD
Journal: Blood
Blood (2012) 120 (21): 1303.
https://doi.org/10.1182/blood.V120.21.1303.1303
Published: 2012
Journal Articles

Focal BTG1 Deletions Occur in Specific Precursor B-Cell Acute Lymphoblastic Leukemia Subtypes At Defined Hotspots Due to Aberrant V(D)J Recombination

Blanca Scheijen, PhD, Esmé Waanders, PhD, Simon V. van Reijmersdal, BSc, Laurens T. van der Meer, PhD, Liesbeth van Emst, BSc, Eugene Verwiel, MSc, Yvet Kroeze, MSc, Edwin Sonneveld, PhD, Peter M. Hoogerbrugge, MD, PhD, Ad Geurts van Kessel, PhD, Frank N. van Leeuwen, PhD, Roland P. Kuiper, PhD
Journal: Blood
Blood (2011) 118 (21): 399.
https://doi.org/10.1182/blood.V118.21.399.399
Published: 2011
Journal Articles

BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia

Joost C. van Galen, Roland P. Kuiper, Liesbeth van Emst, Marloes Levers, Esther Tijchon, Blanca Scheijen, Esmé Waanders, Simon V. van Reijmersdal, Christian Gilissen, Ad Geurts van Kessel, Peter M. Hoogerbrugge, Frank N. van Leeuwen
Journal: Blood
Blood (2010) 115 (23): 4810–4819.
https://doi.org/10.1182/blood-2009-05-223081
Published: 2010
Includes: Supplemental data
Journal Articles

Deletion of IKZF1 in Pediatric Precursor-B ALL Is a Strong Prognostic Marker for Relapse.

Roland P. Kuiper, PhD, Esmee Waanders, PhD, Vincent H.J. Van der Velden, PhD, Simon V van Reijmersdal, Blanca Scheijen, PhD, Jayne Hehir-Kwa, Suzanne T.M. Keijzers-Vloet, Edwin Sonneveld, PhD, Jacques JM van Dongen, Ph.D, Frank N. van Leeuwen, PhD, Ad Geurts van Kessel, Peter M. Hoogerbrugge
Journal: Blood
Blood (2009) 114 (22): 1104.
https://doi.org/10.1182/blood.V114.22.1104.1104
Published: 2009
Journal Articles

BTG1, a Gene Frequently Deleted in Pre-B ALL, Controls Glucocorticoid Receptor-Mediated Gene Expression.

Frank N. van Leeuwen, PhD, Joost Casper van Galen, PhD, Roland P. Kuiper, PhD, Liesbeth van Emst, Marloes R Levers, Esther Tijchon, Msc, Blanca Scheijen, Esmee Waanders, PhD, Simon V van Reijmersdal, Christian Gillissen, Msc., Ad Geurts van Kessel, Peter M. Hoogerbrugge
Journal: Blood
Blood (2009) 114 (22): 3458.
https://doi.org/10.1182/blood.V114.22.3458.3458
Published: 2009
Journal Articles

FOXO Transcription Factors Are Negatively Regulated by p38 Map Kinases Downstream of FLT3 Receptor Signaling.

Blanca Scheijen, PhD, Hai T. Ngo, James D. Griffin, MD
Journal: Blood
Blood (2005) 106 (11): 203.
https://doi.org/10.1182/blood.V106.11.203.203
Published: 2005
Journal Articles

Identification of Common Target Genes of the BCR/ABL and FLT3-ITD Tyrosine Kinases by Microarray Analysis.

Lolita Banerji, Ph.D., Blanca Scheijen, Ph.D., James D. Griffin, MD.
Journal: Blood
Blood (2004) 104 (11): 3551.
https://doi.org/10.1182/blood.V104.11.3551.3551
Published: 2004