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Lynne Minto
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Journal Articles

Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia

CME Clinical Trials & Observations
Julie A. E. Irving, Amir Enshaei, Catriona A. Parker, Rosemary Sutton, Roland P. Kuiper, Amy Erhorn, Lynne Minto, Nicola C. Venn, Tamara Law, Jiangyan Yu, Claire Schwab, Rosanna Davies, Elizabeth Matheson, Alysia Davies, Edwin Sonneveld, Monique L. den Boer, Sharon B. Love, Christine J. Harrison, Peter M. Hoogerbrugge, Tamas Revesz, Vaskar Saha, Anthony V. Moorman
Journal: Blood
Blood (2016) 128 (7): 911–922.
https://doi.org/10.1182/blood-2016-03-704973
Published: 2016
Includes: Supplemental data
Journal Articles

Gene Expression Profiling Implicates Attenuation of NFkB Signalling By Regulatory T Cells in Modulating Dendritic Cell Function

Lindsay Nicholson, PhD, Emily Mavin, PhD, Lynne Minto, Julie Irving, PhD, Anne Dickinson, PhD, Xiao-Nong Wang, MBBS, PhD
Journal: Blood
Blood (2015) 126 (23): 3068.
https://doi.org/10.1182/blood.V126.23.3068.3068
Published: 2015
Journal Articles

Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition

Julie Irving, Elizabeth Matheson, Lynne Minto, Helen Blair, Marian Case, Christina Halsey, Isabella Swidenbank, Frida Ponthan, Renate Kirschner-Schwabe, Stefanie Groeneveld-Krentz, Jana Hof, James Allan, Christine Harrison, Josef Vormoor, Arend von Stackelberg, Cornelia Eckert
Journal: Blood
Blood (2014) 124 (23): 3420–3430.
https://doi.org/10.1182/blood-2014-04-531871
Published: 2014
Includes: Supplemental data
Journal Articles

RAS Pathway Mutations Are Highly Prevalent In Relapsed Childhood Acute Lymphoblastic Leukaemia, Are Frequently Relapse-Drivers and Confer Sensitivity To MEK Inhibition

Julie Irving, PhD, Elizabeth C. Matheson, MPhil, Lynne Minto, Helen Blair, PhD, Marian Case, MSc, Christina Halsey, MD, PhD, Isabella Swidenbank, MRes, Frida Ponthan, PhD, Renate Kirschner-Schwabe, PhD, Stefanie Groeneveld-Krentz, MSc, Jana Hof, MSc, James Allan, PhD, Christine J. Harrison, PhD, Josef Vormoor, MD, Arend Stackelberg, MD, Cornelia Eckert, PhD
Journal: Blood
Blood (2013) 122 (21): 823.
https://doi.org/10.1182/blood.V122.21.823.823
Published: 2013
Journal Articles

Genetics of Teenage and Young Adult Acute Lymphoblastic T-Cell Leukaemia.

Frederik W Van Delft, MD PhD, Caroline L Furness, MA, MBBChir, MRCPCH, Marcela B Mansur, PhD, Lynne Minto, Julie Irving, Sameena Iqbal, Elda Noronha, Sue Colman, John G Gribben, Maria S Pombo-de-Oliveira, Mel Greaves, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2521.
https://doi.org/10.1182/blood.V120.21.2521.2521
Published: 2012
Journal Articles

Quantitative Proteomic Analysis Reveals Maturation As a Mechanism Underlying Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia and PAX5 As a Re-Sensitising Therapeutic Target

Lindsay Nicholson, PhD, Caroline Evans, PhD, Elizabeth C Matheson, MPhil, Lynne Minto, Christopher Keilty, Claire Schwab, Christine J Harrison, PhD, FRCPath, Andrew G. Hall, MB, BS, FRCPath, FRCP, PhD, Christopher Redfern, PhD, Anthony Whetton, PhD, Julie Irving, PhD
Journal: Blood
Blood (2011) 118 (21): 1411.
https://doi.org/10.1182/blood.V118.21.1411.1411
Published: 2011
Journal Articles

Ras Signalling Pathway and Novel Target Genes Related to Down Syndrome Contribute to the Development of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in iAMP21 Patients

Sarra L Ryan, PhD, Vikki Rand, PhD, Claire Schwab, BSc, Heather Morrison, BSc, Elizabeth Matheson, MPhil, Lynne Minto, Thahira Rahman, PhD, Bernard Keavney, MD, Nicholas Bown, PhD, Roderick Skinner, PhD, MBChB, FRCPCH, Susanne Schnittger, PhD, Mauro Santibanez Koref, PhD, Vera Grossmann, MSc, Alexander Kohlmann, PhD, Julie Irving, PhD, Christine J Harrison, PhD, FRCPath
Journal: Blood
Blood (2011) 118 (21): 70.
https://doi.org/10.1182/blood.V118.21.70.70
Published: 2011
Journal Articles

Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia

Vikki Rand, Helen Parker, Lisa J. Russell, Claire Schwab, Hannah Ensor, Julie Irving, Lisa Jones, Dino Masic, Lynne Minto, Heather Morrison, Sarra Ryan, Hazel Robinson, Paul Sinclair, Anthony V. Moorman, Jonathan C. Strefford, Christine J. Harrison
Journal: Blood
Blood (2011) 117 (25): 6848–6855.
https://doi.org/10.1182/blood-2011-01-329961
Published: 2011
Includes: Supplemental data
Journal Articles

Quantitative Proteomic Analysis Implicates An Altered B-Cell Differentiation State as a Mechanism Underlying GC-Resistance in An Acute Lymphoblastic Leukaemia (ALL) Cell Line Model.

Lindsay Nicholson, PhD, Caroline Evans, PhD, Elizabeth Matheson, M.Phil., Lynne Minto, Christopher Keilty, Andrew Hall, PhD, FRCPath, Christopher Redfern, PhD, Anthony Whetton, PhD, Julie Irving, PhD
Journal: Blood
Blood (2009) 114 (22): 1736.
https://doi.org/10.1182/blood.V114.22.1736.1736
Published: 2009
Journal Articles

What Is the Initiating Mechanism of iAMP21 in Childhood B Cell Precursor ALL?.

Vikki Rand, Helen Parker, Lisa J Russell, Julie Irving, Lisa Jones, Dino Masic, Lynne Minto, Heather Morrison, Hazel Robinson, Claire Schwab, Paul Sinclair, Anthony V Moorman, Jonathan C Strefford, Christine J Harrison
Journal: Blood
Blood (2009) 114 (22): 581.
https://doi.org/10.1182/blood.V114.22.581.581
Published: 2009
Journal Articles

Deregulated expression of cytokine receptor gene, CRLF2 , is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia

Lisa J. Russell, Melania Capasso, Inga Vater, Takashi Akasaka, Olivier A. Bernard, Maria Jose Calasanz, Thiruppavaii Chandrasekaran, Elise Chapiro, Stephan Gesk, Mike Griffiths, David S. Guttery, Claudia Haferlach, Lana Harder, Olaf Heidenreich, Julie Irving, Lyndal Kearney, Florence Nguyen-Khac, Lee Machado, Lynne Minto, Aneela Majid, Anthony V. Moorman, Heather Morrison, Vikki Rand, Jonathan C. Strefford, Claire Schwab, Holger Tönnies, Martin J. S. Dyer, Reiner Siebert, Christine J. Harrison
Journal: Blood
Blood (2009) 114 (13): 2688–2698.
https://doi.org/10.1182/blood-2009-03-208397
Published: 2009
Includes: Supplemental data
Journal Articles

A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups

Sarina Sulong, Anthony V. Moorman, Julie A. E. Irving, Jonathan C. Strefford, Zoe J. Konn, Marian C. Case, Lynne Minto, Kerry E. Barber, Helen Parker, Sarah L. Wright, Adam R. M. Stewart, Simon Bailey, Nick P. Bown, Andrew G. Hall, Christine J. Harrison
Journal: Blood
Blood (2009) 113 (1): 100–107.
https://doi.org/10.1182/blood-2008-07-166801
Published: 2009
Journal Articles

Variable Breakpoints Target PAX5 in Patients with Dicentric Chromosomes: A Model for the Basis of Unbalanced Translocations in Cancer

Jonathan C Strefford, PhD, Qian An, PhD, Sarah L Wright, BSc, Zoe J Konn, BSc, Elizabeth Matherson, PhD, Lynne Minto, PhD, Anthony V Moorman, PhD, Helen Parker, PhD, Andrew Hall, PhD, Julie Irving, PhD, Christine J Harrison, PhD
Journal: Blood
Blood (2008) 112 (11): 790.
https://doi.org/10.1182/blood.V112.11.790.790
Published: 2008
Journal Articles

The CD34 + CD38 Low CD19 + Candidate Leukemic Stem Cell Phenotype Revisited: Useful for Flow MRD Monitoring?

Kerrie Wilson, BSc(Hons), Marian Case, MSc, Lynne Minto, Simon Bailey, MD, PhD, FRCPCH, Josef Vormoor, MD, FRCPCH, Julie Irving, PhD
Journal: Blood
Blood (2008) 112 (11): 2505.
https://doi.org/10.1182/blood.V112.11.2505.2505
Published: 2008
Journal Articles

Inactivation of CDKN2A in Childhood Acute Lymphoblastic Leukemia (ALL) Occurs Principally by Deletion and Is Strongly Correlated with Cytogenetic Subgroups.

Anthony V. Moorman, Sarina Sulong, Julie A.E. Irving, Jonathan C. Strefford, Marian C. Case, Lynne Minto, Christine J. Harrison, Andrew G. Hall
Journal: Blood
Blood (2007) 110 (11): 457.
https://doi.org/10.1182/blood.V110.11.457.457
Published: 2007
Journal Articles

Mutation in Genes Impacting on the RAS-RAF-MEK-ERK Pathway Are Found at High Incidence in Childhood Acute Lymphoblastic Leukemia at Both Diagnosis and at Relapse.

Julie Irving, Lynne Minto, Elizabeth Matheson, Marian Case, Simon Bailey, Nick Bown, Rosline Hassan, Christine Harrison, Andrew Hall
Journal: Blood
Blood (2006) 108 (11): 4328.
https://doi.org/10.1182/blood.V108.11.4328.4328
Published: 2006
Journal Articles

Comprehensive Analysis of p16 INK4a in Childhood Acute Lymphoblastic Leukemia Reveals Homozygous Deletion, Haploinsufficiency and Acquired Isodisomy at the 9p Locus with Intact p16 INK4a .

Sarina Sulong, Julie Irving, Marian Case, Lynne Minto, Nick Bown, Simon Bailey, Christine Harrison, Andrew Hall
Journal: Blood
Blood (2006) 108 (11): 4332.
https://doi.org/10.1182/blood.V108.11.4332.4332
Published: 2006
Journal Articles

Assessment of Aneuploidy in Childhood Acute Lymphoblastic Leukaemia Using High Density Oligonucleotide Arrays.

Andrew G. Hall, PhD, Sarina Sulong, Christine Harrison, PhD, Lynne Minto, Nick Bown, PhD, Marian C. Case, Simon Bailey, PhD, Julie Irving, PhD
Journal: Blood
Blood (2006) 108 (11): 104.
https://doi.org/10.1182/blood.V108.11.104.104
Published: 2006
Journal Articles

Genetic Variants of Ataxia Telangiectasia Mutated ( ATM ) and Susceptibility for Childhood T-Lineage Acute Lymphoblastic Leukemia.

Marrit Meier, MSc, Monique L. Den Boer, PhD, Andrew G. Hall, MD, PhD, Julie Irving, PhD, Monique Passier, BSc, Lynne Minto, BSc, Elisabeth R. Van Wering, Gritta E. Janka-Schaub, Rob Pieters, MD, PhD
Journal: Blood
Blood (2004) 104 (11): 1892.
https://doi.org/10.1182/blood.V104.11.1892.1892
Published: 2004