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Journal Articles

Notch Pathway Activation Targets Leukemic Stem Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML)

Gillian A. Horne, BSc hons, MBChB, MRCP, MRes, Heather Morrison, BSc hons, Victoria Campbell, BSc hons, MBBS, MRCP, FRCPath, Ross Kinstrie, PhD BSc, Jennifer Cassels, BSc hons, Alan Hair, BSc, PhD, David Vetrie, BSc, PhD, Helen Wheadon, PhD, Tessa L. Holyoake, MD PhD FRCP, FRCPath, Mhairi Copland, BSc (Hons) MB ChB PhDFRCP FRCPath
Journal: Blood
Blood (2016) 128 (22): 3057.
https://doi.org/10.1182/blood.V128.22.3057.3057
Published: 2016
Journal Articles

CD93 Is a Novel Biomarker of Leukemia Stem Cells in Chronic Myeloid Leukemia

Ross Kinstrie, PhD BSc, Gillian A. Horne, BSc hons, MBChB, MRCP, MRES, Heather Morrison, BSc hons, Hothri A. Moka, BSc hons, Jennifer Cassels, BSc hons, Karen Dunn, BSc hons, Pawel Herzyk, MSc, PhD, David A. Irvine, BSc, MBBChir, MRCP, FRCPath, PhD, Mhairi Copland, BSc (Hons) MB ChB PhDFRCP FRCPath
Journal: Blood
Blood (2015) 126 (23): 49.
https://doi.org/10.1182/blood.V126.23.49.49
Published: 2015
Journal Articles

BGB324 Represents an Axl and BCR-ABL1 Inhibitor with Activity in the T315I Mutant

Robert Erdmann, PhDMSc, Heather Jorgensen, PhD, Isabel Ben-Batalla, PhD, Nils Kruse, PhD, David Micklem, PhD, Gunhild von Amsberg, MD, Philippe Schafhausen, MD, Alexander Schultze, MD MSc, Mark Wroblewski, MSc, Mascha Binder, Miguel Cubas-Cordova, MSc, Tobias Hadlich, MD, Melanie Janning, MD MSc, Stefanie Sawall, Victoria Gensch, Elaine K Allan, Leena Mukherjee, PhD, Heather Morrison, BSc, Jennifer Cassells, Nicolaus Kroeger, MD, James Lorens, MD, Richard E. Clark, MD, Steffen Koschmieder, MD, Peter Vandenberghe, MD PhD, Tim H. Brümmendorf, MD, Andreas Hochhaus, MD, Peter Carmeliet, MD PhD, Tessa L. Holyoake, MD PhD, Klaus Pantel, MD PhD, Carsten Bokemeyer, MD, Sonja Loges, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4512.
https://doi.org/10.1182/blood.V124.21.4512.4512
Published: 2014
Journal Articles

Leukemia Stem Cell Potential of Different Progenitor Subpopulations in Myeloid Blast Phase CML

Ross Kinstrie, PhD BSc, Dimitris Karamitros, Nicolas Goardon, Heather Morrison, BSc, Richard E Clark, MBBS MD, Paresh Vyas, Mhairi Copland, PhD BSc, MRCP, FRCPath
Journal: Blood
Blood (2014) 124 (21): 3489.
https://doi.org/10.1182/blood.V124.21.3489.3489
Published: 2014
Journal Articles

Axl Represents a Therapeutic Target In T315I-Mutated and WT Chronic Myeloid Leukemia

Robert Erdmann, PhD MSc, Heather Jorgensen, PhD, Alexander Schultze, MD, MSc, Gunhild von Amsberg, MD, Isabel Ben-Battala, PhD, MSc, Mark Wroblewski, MSc, Miguel Cubas Cordova, MSc, Stefanie Sawall, Victoria Witzke, Elaine K Allan, Leena Mukherjee, PhD, Heather Morrison, Jennifer Cassels, Philippe Schafhausen, MD, Nicolaus Kroeger, MD, James Lorens, MD, Richard E. Clark, MBBS, MD, FRCP, FRCPath, Peter Vandenberghe, MD, PhD, Tim H. Brümmendorf, MD, Andreas Hochhaus, MD, Peter Carmeliet, MD, PhD, Klaus Pantel, MD, PhD, Carsten Bokemeyer, MD, Tessa L. Holyoake, PhD, FRCP, FRCPath, Sonja Loges, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1469.
https://doi.org/10.1182/blood.V122.21.1469.1469
Published: 2013
Journal Articles

Autocrine TNF-α production supports CML stem and progenitor cell survival and enhances their proliferation

Brief Report
Paolo Gallipoli, Francesca Pellicano, Heather Morrison, Kamilla Laidlaw, Elaine K. Allan, Ravi Bhatia, Mhairi Copland, Heather G. Jørgensen, Tessa L. Holyoake
Journal: Blood
Blood (2013) 122 (19): 3335–3339.
https://doi.org/10.1182/blood-2013-02-485607
Published: 2013
Includes: Supplemental data
Journal Articles

Clinical Relevance of Genes Commonly Deleted in Childhood B-Cell Precursor ALL (BCP-ALL)

Claire Schwab, BSc, Lucy Chilton, Amir Enshaie, PhD, Heather Morrison, BSc, Lisa Jones, BSc, Halima A Al-Shehhi, MD, Amy Erhorn, PhD, Lisa J Russell, Ajay J Vora, FRCPath, Christopher D Mitchell, FRCPCH, Sue M Richards, PhD, Nicholas Goulden, FRCPath, Sally Kinsey, FRCPath, Anthony V. Moorman, PhD, Christine J Harrison, PhD, FRCPath
Journal: Blood
Blood (2012) 120 (21): 290.
https://doi.org/10.1182/blood.V120.21.290.290
Published: 2012
Journal Articles

Genes Commonly Deleted in Childhood B-Cell Precursor ALL (BCP-ALL) Are Associated with Major Cytogenetic Subgroups

Claire Schwab, BSc, Lucy Chilton, Heather Morrison, BSc, Lisa Jones, BSc, Halima A Al-Shehhi, MD, Amy Erhorn, PhD, Lisa J Russell, PhD, Anthony V. Moorman, PhD, Christine J Harrison, PhD, FRCPath
Journal: Blood
Blood (2012) 120 (21): 1374.
https://doi.org/10.1182/blood.V120.21.1374.1374
Published: 2012
Journal Articles

Ras Signalling Pathway and Novel Target Genes Related to Down Syndrome Contribute to the Development of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in iAMP21 Patients

Sarra L Ryan, PhD, Vikki Rand, PhD, Claire Schwab, BSc, Heather Morrison, BSc, Elizabeth Matheson, MPhil, Lynne Minto, Thahira Rahman, PhD, Bernard Keavney, MD, Nicholas Bown, PhD, Roderick Skinner, PhD, MBChB, FRCPCH, Susanne Schnittger, PhD, Mauro Santibanez Koref, PhD, Vera Grossmann, MSc, Alexander Kohlmann, PhD, Julie Irving, PhD, Christine J Harrison, PhD, FRCPath
Journal: Blood
Blood (2011) 118 (21): 70.
https://doi.org/10.1182/blood.V118.21.70.70
Published: 2011
Journal Articles

Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia

Vikki Rand, Helen Parker, Lisa J. Russell, Claire Schwab, Hannah Ensor, Julie Irving, Lisa Jones, Dino Masic, Lynne Minto, Heather Morrison, Sarra Ryan, Hazel Robinson, Paul Sinclair, Anthony V. Moorman, Jonathan C. Strefford, Christine J. Harrison
Journal: Blood
Blood (2011) 117 (25): 6848–6855.
https://doi.org/10.1182/blood-2011-01-329961
Published: 2011
Includes: Supplemental data
Journal Articles

Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: results from the MRC ALL97 clinical trial

Clinical Trials & Observations
Hannah M. Ensor, Claire Schwab, Lisa J. Russell, Sue M. Richards, Heather Morrison, Dino Masic, Lisa Jones, Sally E. Kinsey, Ajay J. Vora, Christopher D. Mitchell, Christine J. Harrison, Anthony V. Moorman
Journal: Blood
Blood (2011) 117 (7): 2129–2136.
https://doi.org/10.1182/blood-2010-07-297135
Published: 2011
Includes: Supplemental data
Journal Articles

What Is the Initiating Mechanism of iAMP21 in Childhood B Cell Precursor ALL?.

Vikki Rand, Helen Parker, Lisa J Russell, Julie Irving, Lisa Jones, Dino Masic, Lynne Minto, Heather Morrison, Hazel Robinson, Claire Schwab, Paul Sinclair, Anthony V Moorman, Jonathan C Strefford, Christine J Harrison
Journal: Blood
Blood (2009) 114 (22): 581.
https://doi.org/10.1182/blood.V114.22.581.581
Published: 2009
Journal Articles

Deregulated expression of cytokine receptor gene, CRLF2 , is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia

Lisa J. Russell, Melania Capasso, Inga Vater, Takashi Akasaka, Olivier A. Bernard, Maria Jose Calasanz, Thiruppavaii Chandrasekaran, Elise Chapiro, Stephan Gesk, Mike Griffiths, David S. Guttery, Claudia Haferlach, Lana Harder, Olaf Heidenreich, Julie Irving, Lyndal Kearney, Florence Nguyen-Khac, Lee Machado, Lynne Minto, Aneela Majid, Anthony V. Moorman, Heather Morrison, Vikki Rand, Jonathan C. Strefford, Claire Schwab, Holger Tönnies, Martin J. S. Dyer, Reiner Siebert, Christine J. Harrison
Journal: Blood
Blood (2009) 114 (13): 2688–2698.
https://doi.org/10.1182/blood-2009-03-208397
Published: 2009
Includes: Supplemental data