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Julie Irving
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Journal Articles

The MEK Inhibitor Selumetinib in Combination with Dexamethasone Leads to Responses in Adult and Pediatric Patients with Relapsed RAS-Pathway Mutated Acute Lymphoblastic Leukemia: Results of a Phase 1/2 Study

Britta Julia Vormoor, Tobias Menne, Joshua Savage, Amit Patel, Anna Castleton, Adele Kay Fielding, Donna Lancaster, Anne Louise Latif, Nick Morley, Geoff Shenton, Gareth Veal, Julie Irving, Pam Kearns, Lucinda Billingham, Josef Vormoor
Journal: Blood
Blood (2023) 142 (Supplement 1): 2874.
https://doi.org/10.1182/blood-2023-185855
Published: 2023
Journal Articles

Dual Targeting of MDM2 and BCL2/Bclxl Demonstrates Potent Synergistic Activity in High-Risk Adult Acute Lymphoblastic Leukemia

Hayden L Bell, Mankaran Singh, Helen J Blair, Olaf Heidenreich, Frederik W. van Delft, Anthony V. Moorman, John Lunec, Julie Irving
Journal: Blood
Blood (2022) 140 (Supplement 1): 9181–9182.
https://doi.org/10.1182/blood-2022-159573
Published: 2022
Journal Articles

Identification of Minimal Residual Disease in B-Acute Lymphoblastic Leukaemia Using Uniform Manifold Approximation Projection

Rabab Allawati, Dino Mašić, Sarah Lawon, Ajay Vora, Julie Irving
Journal: Blood
Blood (2022) 140 (Supplement 1): 3471–3472.
https://doi.org/10.1182/blood-2022-165187
Published: 2022
Journal Articles

Preclinical Investigation of the p53-MDM2 Antagonist Idasanutlin (RG7388) Demonstrates Significant Activity in High Risk Adult Acute Lymphoblastic Leukemia

Hayden L Bell, Mankaran Singh, MSc, Helen J Blair, PhD, Frederik W. van Delft, MD PhD, Anthony V. Moorman, PhD, John Lunec, PhDMRCR(Hon) FRCPath, Julie Irving, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 38.
https://doi.org/10.1182/blood-2020-139536
Published: 2020
Journal Articles

International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia

CME Clinical Trials & Observations
Ondrej Hrusak, Valerie de Haas, Jitka Stancikova, Barbora Vakrmanova, Iveta Janotova, Ester Mejstrikova, Vaclav Capek, Jan Trka, Marketa Zaliova, Ales Luks, Kirsten Bleckmann, Anja Möricke, Julie Irving, Benigna Konatkowska, Thomas B. Alexander, Hiroto Inaba, Kjeld Schmiegelow, Simone Stokley, Zuzana Zemanova, Anthony V. Moorman, Jorge Gabriel Rossi, Maria Sara Felice, Luciano Dalla-Pozza, Jessa Morales, Michael Dworzak, Barbara Buldini, Giuseppe Basso, Myriam Campbell, Maria Elena Cabrera, Neda Marinov, Sarah Elitzur, Shai Izraeli, Drorit Luria, Tamar Feuerstein, Alexandra Kolenova, Peter Svec, Olena Kreminska, Karen R. Rabin, Sophia Polychronopoulou, Elaine da Costa, Hanne Vibeke Marquart, Antonis Kattamis, Richard Ratei, Dirk Reinhardt, John K. Choi, Martin Schrappe, Jan Stary
Journal: Blood
Blood (2018) 132 (3): 264–276.
https://doi.org/10.1182/blood-2017-12-821363
Published: 2018
Includes: Supplemental data
Journal Articles

Dexamethasone Pharmacokinetics Following Standard and Short Dosing Schedules in Patients on the UKALL2011 Trial

Rosanna Jackson, BSc, MSc, Philip Berry, BSc, Julie Errington, MSc, John Moppett, MD, Sujith Samarasinghe, Rachael Hough, MD BMBS, FRCP, FRCPath, Clare Rowntree, MD, Nicholas John Goulden, MD PhD MRCPath, Ajay Vora, MD, Pamela R. Kearns, PhDFRCPC, Julie Irving, PhD, Gareth J Veal, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 101.
https://doi.org/10.1182/blood.V130.Suppl_1.101.101
Published: 2017
Journal Articles

Label-Free Analyses of Minimal Residual Disease in ALL Using Deep Learning and Imaging Flow Cytometry

Minh Doan, Marian Case, Dino Mašić, PhD, Holger Hennig, Claire McQuin, Allen Goodman, Juan Caicedo, Olaf Wolkenhauer, Huw Summers, Anne E Carpenter, Andy Filby, Paul Rees, Julie Irving, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1437.
https://doi.org/10.1182/blood.V130.Suppl_1.1437.1437
Published: 2017
Journal Articles

Exploring Pre-B Cell Receptor Signalling As a Therapeutic Target in Acute Lymphoblastic Leukaemia

Ali Alhammer, M.Sc, Marian Case, MSc, Helen J Blair, PhD, Josef Vormoor, MD FRCPCH, Julie Irving, PhD
Journal: Blood
Blood (2016) 128 (22): 4066.
https://doi.org/10.1182/blood.V128.22.4066.4066
Published: 2016
Journal Articles

Acute Leukemia of Ambiguous Lineage: A Comprehensive Survival Analysis Enables Designing New Treatment Strategies

Ondrej Hrusak, MD PhD, Valerie De Haas, MD PhD, Ales Luks, Iveta Janotova, Ester Mejstrikova, MD PhD, Kirsten Bleckmann, MD, Anja Moricke, MD, Julie Irving, PhD, Benigna Konatkowska, Thomas B. Alexander, MD MPH, Hiroto Inaba, MD PhD, Kjeld Schmiegelow, MD DMSc, Simone Stokley, FRCPath,, Jorge Gabriel Rossi, PhD, Maria Sara Felice, MD PhD, Luciano Dalla-Pozza, MB BS FRACP, Jessa Morales, Michael Dworzak, MD, Barbara Buldini, MD, Giuseppe Basso, Myriam Campbell, Maria Elena Cabrera, Neda Marinov, Sarah Elitzur, MD, Shai Izraeli, MD, Drorit Luria, PhD, Tamar Feuerstein, PhD, Alexandra Kolenova, MD PhD, Peter Svec, Elena Kreminska, Karen R. Rabin, MD, Sophia Polychronopoulou, MD PhD, Elaine da Costa, Hanne Vibeke Marquart, MD PhD, Antonis Kattamis, MD, Richard Ratei, Dirk Reinhardt, MD PhD, Anthony V Moorman, PhD, Martin Schrappe, MD, Jan Stary, MD D.Sc.
Journal: Blood
Blood (2016) 128 (22): 584.
https://doi.org/10.1182/blood.V128.22.584.584
Published: 2016
Journal Articles

Dexamethasone Accumulation in Dexamethasone Sensitive and Resistant Acute Lymphoblastic Leukemia

Rosanna K Jackson, MRes, Ali Alhammer, M.Sc, Zach Dixon, MRes, Gareth J Veal, PhD, Julie Irving, PhD
Journal: Blood
Blood (2016) 128 (22): 5140.
https://doi.org/10.1182/blood.V128.22.5140.5140
Published: 2016
Journal Articles

Acute Leukemias of Ambiguous Lineage; Study on 247 Pediatric Patients

Ondrej Hrusak, MD PhD, Ales Luks, Iveta Janotova, Ester Mejstrikova, MD PhD, Martina Vaskova, Kirsten Bleckmann, MD, Benigna Konatkowska, Julie Irving, Kamila Polgarova, MD, Hiroto Inaba, MD PhD, Kjeld Schmiegelow, Jorge Gabriel Rossi, PhD, Maria Sara Felice, MD PhD, Luciano Dalla-Pozza, Jessa Morales, Mary Sartor, PhD, Michael Dworzak, MD, Anja Moricke, Myriam Campbell, Maria Elena Cabrera, MD, Neda Marinov, Sarah Elitzur, MD, Shai Izraeli, MD, Valerie De Haas, MD PhD, Alexandra Kolenova, MD PhD, Peter Svec, Elena Kreminska, Simone Stokley, FRCPath,, Sophia Polychronopoulou, MD PhD, Elaine da Costa, Hanne Vibeke Marquart, Antonis Kattamis, Richard Ratei, Dirk Reinhardt, MD, Kathy Jackson, Anthony V Moorman, PhD, Martin Schrappe, MD PhD, Jan Stary
Journal: Blood
Blood (2015) 126 (23): 252.
https://doi.org/10.1182/blood.V126.23.252.252
Published: 2015
Journal Articles

Gene Expression Profiling Implicates Attenuation of NFkB Signalling By Regulatory T Cells in Modulating Dendritic Cell Function

Lindsay Nicholson, PhD, Emily Mavin, PhD, Lynne Minto, Julie Irving, PhD, Anne Dickinson, PhD, Xiao-Nong Wang, MBBS, PhD
Journal: Blood
Blood (2015) 126 (23): 3068.
https://doi.org/10.1182/blood.V126.23.3068.3068
Published: 2015
Journal Articles

Validation of MRD Quantification By Flow Cytometry for Pediatric BCP ALL Relapsed Patients Treated on the Intreall Protocol

Ester Mejstrikova, MD PhD, Julie Irving, Leonid Karawajew, Marian Case, Jenny Jesson, Vaskar Saha, PhD FRCP, FRCPath, Nicholas Goulden, MD PhD, Jeremy Hancock, PhD, Arend Stackelberg, MD, Sarah Lawson, Michael Dworzak, MD, Renate Panzer-Grumayer, Barbara Buldini, Lisa Eyre, Giuseppe Basso, MD, Maddalena Paganin, Jan Trka, Daniela Kužílková, Jan Stary, Lucie Sramkova, MD, Ondrej Hrusak, MD PhD, Cornelia Eckert
Journal: Blood
Blood (2015) 126 (23): 1414.
https://doi.org/10.1182/blood.V126.23.1414.1414
Published: 2015
Journal Articles

Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition

Julie Irving, Elizabeth Matheson, Lynne Minto, Helen Blair, Marian Case, Christina Halsey, Isabella Swidenbank, Frida Ponthan, Renate Kirschner-Schwabe, Stefanie Groeneveld-Krentz, Jana Hof, James Allan, Christine Harrison, Josef Vormoor, Arend von Stackelberg, Cornelia Eckert
Journal: Blood
Blood (2014) 124 (23): 3420–3430.
https://doi.org/10.1182/blood-2014-04-531871
Published: 2014
Includes: Supplemental data
Journal Articles

An Analysis Of Mechanisms Of Central Nervous System Infiltration In Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice

Yasar M Yousafzai, MBBS, Mark TS Williams, PhD, Klaus Rehe, MD, Michelle Le Brocq, PhD, Simon Bomken, MBBS, PhD, Paul B Sinclair, PhD, Katie Dormon, MSc, Dino Masic, MRes, Leanne Archer, B.Sc, Jennifer Watt, BSc, Tracey A Perry, BSc, Victoria J Weston, PhD, Pamela R Kearns, MBChB, PhD, FRCPCH, Helen Blair, PhD, Russel Lisa, PhD, Olaf Heidenreich, PhD, Julie Irving, PhD, Josef Vormoor, MD, Brenda Gibson, MD, Gerard J Graham, PhD, Christina Halsey, PhD, FRCPath
Journal: Blood
Blood (2013) 122 (21): 3866.
https://doi.org/10.1182/blood.V122.21.3866.3866
Published: 2013
Journal Articles

RAS Pathway Mutations Are Highly Prevalent In Relapsed Childhood Acute Lymphoblastic Leukaemia, Are Frequently Relapse-Drivers and Confer Sensitivity To MEK Inhibition

Julie Irving, PhD, Elizabeth C. Matheson, MPhil, Lynne Minto, Helen Blair, PhD, Marian Case, MSc, Christina Halsey, MD, PhD, Isabella Swidenbank, MRes, Frida Ponthan, PhD, Renate Kirschner-Schwabe, PhD, Stefanie Groeneveld-Krentz, MSc, Jana Hof, MSc, James Allan, PhD, Christine J. Harrison, PhD, Josef Vormoor, MD, Arend Stackelberg, MD, Cornelia Eckert, PhD
Journal: Blood
Blood (2013) 122 (21): 823.
https://doi.org/10.1182/blood.V122.21.823.823
Published: 2013
Journal Articles

The Genomic Landscape Of Lineage Switch Acute Leukemia

Olaf Heidenreich, PhD, Ricky Tirtakusuma, MRes, Simon Bomken, PhD, MBBS, Dan Williamson, Sarah E Fordham, PhD, Hesta McNeill, Claus Meyer, PhD, Rolf Marschalek, PhD, Josef Vormoor, MD, Andrew Hall, Julie Irving, PhD, Helen J Blair, PhD, Dan Swan, Bronia Baker, Peter Carey, Nick Bown, David Bourn, Paul Evans, Roderick Skinner, PhD, MBChB, FRCPCH, Simon Bailey, Vikki Rand, PhD, James Allan, PhD
Journal: Blood
Blood (2013) 122 (21): 2552.
https://doi.org/10.1182/blood.V122.21.2552.2552
Published: 2013
Journal Articles

Genetics of Teenage and Young Adult Acute Lymphoblastic T-Cell Leukaemia.

Frederik W Van Delft, MD PhD, Caroline L Furness, MA, MBBChir, MRCPCH, Marcela B Mansur, PhD, Lynne Minto, Julie Irving, Sameena Iqbal, Elda Noronha, Sue Colman, John G Gribben, Maria S Pombo-de-Oliveira, Mel Greaves, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2521.
https://doi.org/10.1182/blood.V120.21.2521.2521
Published: 2012
Journal Articles

Quantitative Proteomic Analysis Reveals Maturation As a Mechanism Underlying Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia and PAX5 As a Re-Sensitising Therapeutic Target

Lindsay Nicholson, PhD, Caroline Evans, PhD, Elizabeth C Matheson, MPhil, Lynne Minto, Christopher Keilty, Claire Schwab, Christine J Harrison, PhD, FRCPath, Andrew G. Hall, MB, BS, FRCPath, FRCP, PhD, Christopher Redfern, PhD, Anthony Whetton, PhD, Julie Irving, PhD
Journal: Blood
Blood (2011) 118 (21): 1411.
https://doi.org/10.1182/blood.V118.21.1411.1411
Published: 2011
Journal Articles

Ras Signalling Pathway and Novel Target Genes Related to Down Syndrome Contribute to the Development of B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) in iAMP21 Patients

Sarra L Ryan, PhD, Vikki Rand, PhD, Claire Schwab, BSc, Heather Morrison, BSc, Elizabeth Matheson, MPhil, Lynne Minto, Thahira Rahman, PhD, Bernard Keavney, MD, Nicholas Bown, PhD, Roderick Skinner, PhD, MBChB, FRCPCH, Susanne Schnittger, PhD, Mauro Santibanez Koref, PhD, Vera Grossmann, MSc, Alexander Kohlmann, PhD, Julie Irving, PhD, Christine J Harrison, PhD, FRCPath
Journal: Blood
Blood (2011) 118 (21): 70.
https://doi.org/10.1182/blood.V118.21.70.70
Published: 2011