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Karen R. Rabin
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Journal Articles

Blinatumomab Added to Chemotherapy Improves Disease-Free Survival in Newly Diagnosed NCI Standard Risk Pediatric B-Acute Lymphoblastic Leukemia: Results from the Randomized Children's Oncology Group Study AALL1731

Rachel E. Rau, Sumit Gupta, John A. Kairalla, Karen R Rabin, Anne Angiolillo, Cindy Wang, Andrew J. Carroll, Susan Conway, Meenakshi Devidas, Lia Gore, Ilan R. Kirsch, Holly R. Kubaney, Amanda M Li, Jennifer L. McNeer, Olga Militano, Yvonne Moyer, Maureen M. O'Brien, Maki Okada, Shalini C. Reshmi, Mary Shago, Elizabeth R. Wagner, Naomi J. Winick, Brent L. Wood, Faraz Zaman, Gerhard Zugmaier, Sue Zupanec, Stephen P. Hunger, David T. Teachey, Elizabeth A. Raetz, Mignon L. Loh
Journal: Blood
Blood (2024) 144 (Supplement 1): 1.
https://doi.org/10.1182/blood-2024-207450
Published: 2024
Journal Articles

Prognostic Impact of t(1;19) in Pediatric B-Cell Acute Lymphoblastic Leukemia (B-ALL) Patients Treated on Contemporary Children's Oncology Group (COG) Protocols

Ashley Pinchinat, John A. Kairalla, Meenakshi Devidas, Andrew J. Carroll, Mary Shago, Anne Angiolillo, Michael J. Burke, Wanda L. Salzer, Naomi J. Winick, Mignon L. Loh, David T. Teachey, Elizabeth A. Raetz, Karen R Rabin, Rachel E. Rau, Sumit Gupta
Journal: Blood
Blood (2024) 144 (Supplement 1): 315.
https://doi.org/10.1182/blood-2024-198507
Published: 2024
Journal Articles

Mapping the Dynamic DNA Methylation Landscape in Pre-B ALL from Diagnosis to Relapse Reveals a Role for Aberrant PRC2 Regulation

Athanasia Liapodimitri, Oscar Camacho, Kayleigh Lunsford, Ashley R Tetens, Jordyn Craig-Schwartz, Kegan Skalitzky, Karen R Rabin, Andy Feinberg, Michael Koldobskiy
Journal: Blood
Blood (2024) 144 (Supplement 1): 4127.
https://doi.org/10.1182/blood-2024-208641
Published: 2024
Journal Articles

Trial in Progress: Update on the TACL T2020-003 Randomized Phase 2 Trial to Improve Diet and Exercise in Acute Lymphoblastic Leukemia (IDEAL-2)

Etan Orgel, Sarah K. Tasian, Yueh-Yun Chi, Jemily Malvar, Christina M. Dieli-Conwright, Rubi Buxton, Mackenzie Frederick, Hannah Williams, Karen R Rabin, Susan R Rheingold, Robin Norris, Tamara P. Miller, Brent L. Wood, Ellynore Florendo, Ellen Chang, Lisa Hartman, Mallorie M. Heneghan, Michelle L. Hermiston, Joel Kaplan, Tamra Slone, Deepa Bhojwani, Alan S. Wayne, Steven D. Mittelman
Journal: Blood
Blood (2024) 144 (Supplement 1): 2828.1.
https://doi.org/10.1182/blood-2024-201871
Published: 2024
Journal Articles

A Children's Oncology Group Clinical Trial of Long-Term Outcomes in Survivors of Down Syndrome-Associated Acute Leukemia (ALTE22C1): Clinical Trial in Progress

Maria Monica Gramatges, Lauren N Sanclemente, Lacey Hall, Danielle L Mitchell, Olga A Taylor, Tanya Shannon, Tyler Brown, Michelle M Nuño, Smita Bhatia, Eric J. Chow, Kelly D. Getz, Johann K. Hitzler, Amanda M Li, Kaitlin McCloskey, Paul C Nathan, Maureen M. O'Brien, Serina Patel, Anupam Verma, Angela R Yarbrough, Geraldine Aubert, Tracie C Rosser, Lisa M Jacola, Philip J Lupo, Karen R Rabin
Journal: Blood
Blood (2024) 144 (Supplement 1): 2808.1.
https://doi.org/10.1182/blood-2024-203724
Published: 2024
Journal Articles

A Retrospective Study of Inotuzumab Ozogamicin in Individuals with Down Syndrome and B-Cell Acute Lymphoblastic Leukemia

Amanda M Li, Catherine Aftandilian, Susan Colace, Sarah Fanizzi, Kelly Elizabeth Faulk, Erin M. Guest, Ammar Hayani, Richard Ho, Anjali Khanna, Kasey Leger, David McCall, Tamara P. Miller, Holly Pacenta, Troy Quigg, Jeremy D. Rubinstein, Deepa Bhojwani, Susan R Rheingold, Maureen M. O'Brien, Karen R Rabin
Journal: Blood
Blood (2024) 144 (Supplement 1): 4204.
https://doi.org/10.1182/blood-2024-209455
Published: 2024
Journal Articles

Co-Targeting of the Thymic Stromal Lymphopoietin Receptor to Decrease Immunotherapeutic Resistance in CRLF2 -Rearranged Ph-like and Down Syndrome ALL

Tommaso Balestra, Lisa M Niswander, Asen Bagashev, Joseph P Loftus, Savannah L Ross, Robert K Chen, Samantha M McClellan, Jacob J Junco, Diego Alberto Barcenas-Lopez, Karen R Rabin, Terry J Fry, Sarah K. Tasian
Journal: Blood
Blood (2024) 144 (Supplement 1): 3424.
https://doi.org/10.1182/blood-2024-208383
Published: 2024
Journal Articles

Immunoglobulin Sequencing Biologically Distinguishes B-Lymphoblastic Lymphoma from Acute Lymphoblastic Leukemia and Reveals a Spectrum of Disease Dissemination across Clinical Stages

Carol Fries Simpson, Lik Wee Lee, Hongyue Wang, Diana G. Adlowitz, Philip Rock, Brent L. Wood, Rachel E. Rau, Kara L. Davis, Anne Angiolillo, Meenakshi Devidas, David T. Teachey, Karen R Rabin, Birte Wistinghausen, Donald Barkauskas, Robert J. Hayashi, Richard Burack, Carl E Allen, Michelle L. Hermiston, Ilan R. Kirsch
Journal: Blood
Blood (2024) 144 (Supplement 1): 2838.
https://doi.org/10.1182/blood-2024-201634
Published: 2024
Journal Articles

Understanding the Associations between High-Dose Methotrexate Pharmacokinetics and the Risk of Adverse Events in Children and Adolescents with Down Syndrome Associated High-Risk Acute Lymphoblastic Leukemia

Kate D. Westmoreland, Zachary L Taylor, Tamara P. Miller, Ashley Chavana, Karen R Rabin, Austin L Brown, Melanie Brooke Bernhardt, Eric S. Schafer, Maureen M. O'Brien, Sharon M. Castellino, Laura B. Ramsey
Journal: Blood
Blood (2024) 144 (Supplement 1): 1438.
https://doi.org/10.1182/blood-2024-211870
Published: 2024
Journal Articles

Evaluation of Methotrexate Pharmacogenomic Variants to Predict Acute Neurotoxicity in Children with Acute Lymphoblastic Leukemia

Austin L Brown, Rachel Harris, Olga A Taylor, Mark Zobeck, Melanie Brooke Bernhardt, Maria Monica Monica Gramatges, Ashley Chavana, Alanna Morrison, Kathleen Ludwig, Laura J. Klesse, Kenneth Matthew Heym, Timothy Griffin, Rodrigo Erana, Juan C. Bernini, Han Chen, Bing Yu, Melissa A. Richard, Philip J Lupo, Karen R Rabin, Michael E. Scheurer
Journal: Blood
Blood (2024) 144 (Supplement 1): 4190.
https://doi.org/10.1182/blood-2024-200891
Published: 2024
Journal Articles

Prognostic significance of ETP phenotype and minimal residual disease in T-ALL: a Children’s Oncology Group study

Clinical Trials & Observations
Brent L. Wood, Meenakshi Devidas, Ryan J. Summers, Zhiguo Chen, Barbara Asselin, Karen R. Rabin, Patrick A. Zweidler-McKay, Naomi J. Winick, Michael J. Borowitz, William L. Carroll, Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger, Kimberly P. Dunsmore, David T. Teachey, Stuart S. Winter
Journal: Blood
Blood (2023) 142 (24): 2069–2078.
https://doi.org/10.1182/blood.2023020678
Published: 2023
Includes: Supplemental data
Journal Articles

A Novel Transgenic Mouse Model of Down Syndrome Acute Lymphoblastic Leukemia Identifies Targetable Vulnerabilities

Jacob J. Junco, Raushan Rashid, Maci Terrell, Michelle Alozie, Max Rochette, Barry Zorman, Pavel Sumazin, Lauren Rowland, Gino Dettorre, Reid T. Powell, Clifford C. Stephan, Peter J. Davies, Margie M. Moczygemba, Jun J. Yang, Karen R. Rabin
Journal: Blood
Blood (2023) 142 (Supplement 1): 2981.
https://doi.org/10.1182/blood-2023-187324
Published: 2023
Journal Articles

Feasibility and Outcome of Post-Induction Therapy Incorporating Dasatinib for Patients with Newly Diagnosed ABL-Class Fusion B-Lymphoblastic Leukemia (ABL-class Fusion B-ALL): Children's Oncology Group AALL1131

Wanda L. Salzer, Michael J. Burke, Meenakshi Devidas, Zhiguo (Bruce) Chen, Michael J. Borowitz, Andrew J Carroll, I-Ming L. Chen, Julie M. Gastier-Foster, Richard C. Harvey, Nyla A. Heerema, Charles G. Mullighan, Karen R. Rabin, Shalini C Reshmi, Cheryl L. Willman, Brent L. Wood, Naomi J. Winick, William L. Carroll, Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger
Journal: Blood
Blood (2023) 142 (Supplement 1): 961.
https://doi.org/10.1182/blood-2023-190495
Published: 2023
Journal Articles

Real-World Performance of 2022 Revised World Health Organization (WHO) Criteria for Mixed Phenotype Acute Leukemia (MPAL) B/Myeloid Defined Only By Isolated MPO Expression (isoMPO)

Alexandra E. Kovach, Sunil S. Raikar, Jemily Malvar, Matthew J. Oberley, Gerald Wertheim, Karen R. Rabin, Jyotinder N. Punia, Alix Seif, Reuven J. Schore, Dragos C. Luca, Terri L. Guinipero, William G. Woods, Viviane Cahen, Yueh-Yun Chi, Maurice R.G. O'Gorman, Brent L. Wood, Etan Orgel
Journal: Blood
Blood (2023) 142 (Supplement 1): 1467.
https://doi.org/10.1182/blood-2023-174110
Published: 2023
Journal Articles

Patients with Down Syndrome and High-Risk B-Acute Lymphoblastic Leukemia Demonstrate Improved Outcomes on a Modified Chemotherapy Regimen: A Report from Children's Oncology Group Study AALL1131

Vilmarie Rodriguez, Meenakshi Devidas, Zhiguo (Bruce) Chen, Andrew J Carroll, Nyla A. Heerema, Michael J. Borowitz, Brent L. Wood, William L. Carroll, Naomi J Winick, Elizabeth A. Raetz, Mignon L. Loh, Michael J. Burke, Wanda L. Salzer, Stephen P. Hunger, Karen R. Rabin
Journal: Blood
Blood (2023) 142 (Supplement 1): 824.
https://doi.org/10.1182/blood-2023-185368
Published: 2023
Journal Articles

Association of Latino Ethnicity with Cytogenetic Subtypes in Pediatric Acute Myeloid Leukemia

Kevin Wells Tien, Jennifer M. Geris, Chi-Fan Lin, Charles Cook, Olga Taylor, Maria Isabel Castellanos, Van Thu Huynh, Kathleen Ludwig, Laura J. Klesse, Sandi Pruitt, Amy Hughes, Kenneth Matthew Heym, Timothy Griffin, Rodrigo Erana, Juan C. Bernini, Karen R. Rabin, Michael E. Scheurer, Philip J. Lupo, Maria Monica Gramatges
Journal: Blood
Blood (2023) 142 (Supplement 1): 4313.
https://doi.org/10.1182/blood-2023-186968
Published: 2023
Journal Articles

Development of a Novel Methotrexate-Related Neurotoxicity Risk Score in Pediatric Acute Leukemia: A Report from the Reducing Ethnic Disparities in Acute Leukemia (REDIAL) Consortium

Rachel Harris, Olga Taylor, Melanie Brooke Bernhardt, Ashley Chavana, Mark Zobeck, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L Brown
Journal: Blood
Blood (2023) 142 (Supplement 1): 2828.
https://doi.org/10.1182/blood-2023-189986
Published: 2023
Journal Articles

Risk-Adjusted Therapies Yield Equivalent Outcomes for Adolescents and Young Adults (AYAs) Treated for Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (T-ALL) on Children's Oncology Group (COG) Studies AALL0434 and AALL1231

Susan I. Colace, Meenakshi Devidas, Zhiguo (Bruce) Chen, Robert J. Hayashi, Brent L. Wood, Natia Esiashvili, Samir Patel, Andrew J Carroll, Nyla A. Heerema, Barbara Asselin, Karen R. Rabin, Patrick A. Zweidler-McKay, Elizabeth A. Raetz, Mignon L. Loh, Naomi J. Winick, William L. Carroll, David T. Teachey, Stuart S. Winter, Kimberly P. Dunsmore
Journal: Blood
Blood (2023) 142 (Supplement 1): 517.
https://doi.org/10.1182/blood-2023-190141
Published: 2023
Journal Articles

Heritable Variation in Lymphocyte-Related Traits and Risk of Down Syndrome Acute Lymphoblastic Leukemia: A Mendelian Randomization Study

Yunqi Li, Melissa A. Richard, Linda Kachuri, Yao Yu, Ching-Ju Ruu Hsu, Tracie C. Rosser, Elizabeth J. Leslie, Meenakshi Devidas, Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger, Neetha Paul Eduthan, Matthew D. Galbraith, Joaquin Espinosa, Jun J. Yang, Stephanie L. Sherman, Chad D. Huff, Karen R. Rabin, Philip J. Lupo, Adam J. de Smith
Journal: Blood
Blood (2023) 142 (Supplement 1): 4198.
https://doi.org/10.1182/blood-2023-188434
Published: 2023
Journal Articles

Association of Latino Ethnicity with Cytogenetic Subtype in Pediatric Acute Lymphoblastic Leukemia: A Report from the Reducing Ethnic Disparities in Acute Leukemia Consortium

Maria D. Leon-Camarena, Jennifer M. Geris, Maria Isabel Castellanos, Olga Taylor, Veronica Garcia-Morales, Austin L Brown, Pagna Sok, Van Thu Huynh, Kathleen Ludwig, Laura J. Klesse, Sandi Pruitt, Amy Hughes, Kevin Wells Tien, Kenneth Matthew Heym, Timothy Griffin, Rodrigo Erana, Juan C. Bernini, Philip J. Lupo, M. Monica Gramatges, Michael E. Scheurer, Karen R. Rabin
Journal: Blood
Blood (2023) 142 (Supplement 1): 4206.
https://doi.org/10.1182/blood-2023-188022
Published: 2023