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Journal Articles

Addition of Inotuzumab to a Pediatric Inspired Chemotherapy Regimen in Young Adult Patients with B-Cell Acute Lymphoblastic Leukemia: Findings from the Alliance A041501 Phase 3 Randomized Trial

Daniel J. DeAngelo, Jun Yin, Anjali S. Advani, Selina Luger, Jill Fulcher, Michaela Liedtke, Geoffrey L. Uy, Shira N. Dinner, Lindsay Wilde, Marlise R. Luskin, Caner Saygin, Ella Postich, Noreen Fulton, Richard C. Harvey, Gaby E Perez Burbano, Rebecca Teske, Harry P. Erba, Mark R. Litzow, Richard M. Stone, Wendy Stock
Journal: Blood
Blood (2024) 144 (Supplement 1): 308.
https://doi.org/10.1182/blood-2024-209438
Published: 2024
Journal Articles

Feasibility and Outcome of Post-Induction Therapy Incorporating Dasatinib for Patients with Newly Diagnosed ABL-Class Fusion B-Lymphoblastic Leukemia (ABL-class Fusion B-ALL): Children's Oncology Group AALL1131

Wanda L. Salzer, Michael J. Burke, Meenakshi Devidas, Zhiguo (Bruce) Chen, Michael J. Borowitz, Andrew J Carroll, I-Ming L. Chen, Julie M. Gastier-Foster, Richard C. Harvey, Nyla A. Heerema, Charles G. Mullighan, Karen R. Rabin, Shalini C Reshmi, Cheryl L. Willman, Brent L. Wood, Naomi J. Winick, William L. Carroll, Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger
Journal: Blood
Blood (2023) 142 (Supplement 1): 961.
https://doi.org/10.1182/blood-2023-190495
Published: 2023
Journal Articles

A Phase 2 Study of Ruxolitinib with Chemotherapy in Children with Philadelphia Chromosome-like Acute Lymphoblastic Leukemia (AALL1521/INCB18424-269): Biologic Characteristics and Minimal Residual Disease Response of Patients with Non- CRLF2 -Rearranged JAK Pathway Alterations

Sarah K Tasian, Deborah S Hunter, I-Ming L Chen, Richard C Harvey, Andrew J. Carroll, Elizabeth Wagner, Shalini C Reshmi, Michael J Borowitz, Brent L. Wood, Jeannie Daniel, Meenakshi Devidas, Elizabeth A. Raetz, Stephen P. Hunger, Albert Assad, Mignon L. Loh
Journal: Blood
Blood (2022) 140 (Supplement 1): 6117–6118.
https://doi.org/10.1182/blood-2022-164699
Published: 2022
Journal Articles

Comparison of Current and Enhanced Risk Stratification of 21,199 Children, Adolescents, and Young Adults with Acute Lymphoblastic Leukemia Using Objective Risk Categorization Criteria: A Children's Oncology Group Report

Natalie Delrocco, Mignon L. Loh, Michael Borowitz, Karen R Rabin, Patrick A Zweidler-McKay, Kelly W Maloney, Leonard A. Mattano, Eric C Larsen, Anne L Angiolillo, Reuven J Schore, Michael J. Burke, Wanda L Salzer, Brent L. Wood, Andrew J Carroll, Nyla A. Heerema, Shalini C Reshmi, Julie M Gastier-Foster, Richard C Harvey, I-Ming L Chen, Kathryn G Roberts, Charles G. Mullighan, Cheryl L Willman, Naomi J Winick, William L. Carroll, Stephen P. Hunger, Elizabeth A. Raetz, Meenakshi Devidas, John Kairalla
Journal: Blood
Blood (2021) 138 (Supplement 1): 2382.
https://doi.org/10.1182/blood-2021-148593
Published: 2021
Journal Articles

Enhanced Risk Stratification of 21,178 Children, Adolescents, and Young Adults with Acute Lymphoblastic Leukemia (ALL) Incorporating White Blood Count (WBC), Age, and Minimal Residual Disease (MRD) at Day 8 and 29 As Continuous Variables: A Children's Oncology Group (COG) Report

Mignon L. Loh, MD, Natalie DelRocco, Michael J Borowitz, MD PhD, Karen R Rabin, MDPhD, Patrick A Zweidler-McKay, MDPhD, Kelly W Maloney, MD, Leonard A. Mattano, MD, Eric C Larsen, MD, Anne L Angiolillo, MD, Reuven J Schore, MD, Michael J Burke, MD, Wanda L Salzer, MD, Brent L Wood, MD PhD, Andrew J Carroll, PhD, Nyla A Heerema, PhD, Shalini C Reshmi, PhD, Julie M Gastier-Foster, PhD, Richard C Harvey, PhD, I-Ming L Chen, DVM, MS, Cheryl L Willman, MD, Naomi J Winick, MD, William Carroll, MD, Stephen P Hunger, MD, Elizabeth A. Raetz, MD, Meenakshi Devidas, PhD, John Kairalla, Kathryn G Roberts, PhD, Charles G Mullighan, MBBS, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-139081
Published: 2020
Journal Articles

Outcomes of Patients with Down Syndrome and CRLF2 -Overexpressing Acute Lymphoblastic Leukemia (ALL): A Report from the Children's Oncology Group (COG)

Karen R Rabin, MDPhD, Meenakshi Devidas, PhD, Zhiguo Chen, Yunfeng Dai, PhD, Sarah K Tasian, MD, Johann K Hitzler, MD, Kathryn G Roberts, PhD, Andrew J Carroll, PhD, Nyla A Heerema, PhD, Michael J Borowitz, MD PhD, Brent L Wood, MD PhD, Charles G Mullighan, MBBS, MD, Richard C Harvey, PhD, I-Ming L Chen, Cheryl L Willman, MD, Shalini C Reshmi, PhD, Julie M Gastier-Foster, PhD, Kelly W Maloney, MD, Eric C Larsen, MD, Reuven J Schore, MD, Michael J Burke, MD, Wanda L Salzer, MD, Naomi J Winick, MD, William L. Carroll, MD, Elizabeth A. Raetz, MD, Anne Angiolillo, MD, Mignon L. Loh, MD, Stephen P Hunger, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
https://doi.org/10.1182/blood-2020-143165
Published: 2020
Journal Articles

Outcomes of Patients with CRLF2 -Overexpressing Acute Lymphoblastic Leukemia without Down Syndrome: A Report from the Children's Oncology Group

Sarah K Tasian, MD, Yunfeng Dai, PhD, Meenakshi Devidas, PhD, Kathryn G Roberts, PhD, Richard C Harvey, PhD, I-Ming L Chen, DVM, MS, Andrew J Carroll, PhD, Nyla A Heerema, PhD, Shalini C Reshmi, PhD, Julie M Gastier-Foster, PhD, Michael J Borowitz, MD PhD, Brent L Wood, MD PhD, Charles G Mullighan, MBBS, MD, Cheryl L Willman, MD, Kelly W Maloney, MD, Eric C Larsen, MD, Anne L Angiolillo, MD, Reuven J Schore, MD, Michael J Burke, MD, Wanda L Salzer, MD, Naomi J Winick, MD, William L. Carroll, MD, Stephen P Hunger, MD, Elizabeth A. Raetz, MD, Karen R Rabin, MDPhD, Mignon L. Loh, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 45–46.
https://doi.org/10.1182/blood-2020-134327
Published: 2020
Journal Articles

The Genomic Landscape of Childhood Acute Lymphoblastic Leukemia

Kathryn G. Roberts, PhD, Samuel W. Brady, PhD, Zhaohui Gu, PhD, Lei Shi, PhD, Stanley Pounds, PhD, Deqing Pei, MS, Cheng Cheng, PhD, Yunfeng Dai, PhD, Meenakshi Devidas, PhD, Chunxu Qu, PhD, Ashley Hill, BS, Xiaotu Ma, Lei Wei, PhD, Sasi Arunachalam, PhD, Kohei Hagiwara, MD, Yangling Liu, Diane Flasch, Yu Liu, PhD, Matthew Parker, PhD, Xiaolong Chen, PhD, Yongjin Li, PhD, Yiping Fan, PhD, Robert Michael, PhD, Michael Rusch, BS, Mark Wilkinson, Scott Foy, PhD, Dale Hedges, PhD, Scott Newman, PhD, Xin Zhou, PhD, Jian Wang, Shalini C. Reshmi, PhD, Julie M. Gastier-Foster, PhD, Patee Gesuwan, Malcolm A Smith, MD PhD, Daniela S. Gerhard, PhD, Naomi Winick, MD, Andrew J. Carroll, PhD, Nyla A. Heerema, PhD, Richard C. Harvey, PhD, Cheryl L. Willman, MD, Eric Larsen, MD, Elizabeth A. Raetz, MD, Michael J. Borowitz, MD PhD, Brent L Wood, MD PhD, William L. Carroll, MD, Patrick A. Zweidler-McKay, MD PhD, Karen R. Rabin, MD PhD, Leonard A. Mattano, MD, Kelly Maloney, MD, Stuart S. Winter, MD, Michael J. Burke, MD, Wanda L. Salzer, MD, Kimberly P. Dunsmore, Anne Angiolillo, MD, Kristine R Crews, PharmD, James R. Downing, MD, Sima Jeha, MD, William E. Evans, PharmD, Ching-Hon Pui, MD, Jun J. Yang, PhD, Mary V. Relling, PharmD, Stephen P. Hunger, MD, Mignon L. Loh, MD, Jinghui Zhang, PhD, Charles G. Mullighan, MBBS, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 649.
https://doi.org/10.1182/blood-2019-124881
Published: 2019
Journal Articles

A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403

Clinical Trials & Observations
Wendy Stock, Selina M. Luger, Anjali S. Advani, Jun Yin, Richard C. Harvey, Charles G. Mullighan, Cheryl L. Willman, Noreen Fulton, Kristina M. Laumann, Greg Malnassy, Elisabeth Paietta, Edy Parker, Susan Geyer, Krzysztof Mrózek, Clara D. Bloomfield, Ben Sanford, Guido Marcucci, Michaela Liedtke, David F. Claxton, Matthew C. Foster, Jeffrey A. Bogart, John C. Grecula, Frederick R. Appelbaum, Harry Erba, Mark R. Litzow, Martin S. Tallman, Richard M. Stone, Richard A. Larson
Journal: Blood
Blood (2019) 133 (14): 1548–1559.
https://doi.org/10.1182/blood-2018-10-881961
Published: 2019
Includes: Supplemental data
Journal Articles

Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children’s Oncology Group

Clinical Trials & Observations
Kathryn G. Roberts, Shalini C. Reshmi, Richard C. Harvey, I-Ming Chen, Kinnari Patel, Eileen Stonerock, Heather Jenkins, Yunfeng Dai, Marc Valentine, Zhaohui Gu, Yaqi Zhao, Jinghui Zhang, Debbie Payne-Turner, Meenakshi Devidas, Nyla A. Heerema, Andrew J. Carroll, Elizabeth A. Raetz, Michael J. Borowitz, Brent L. Wood, Leonard A. Mattano, Jr, Kelly W. Maloney, William L. Carroll, Mignon L. Loh, Cheryl L. Willman, Julie M. Gastier-Foster, Charles G. Mullighan, Stephen P. Hunger
Journal: Blood
Blood (2018) 132 (8): 815–824.
https://doi.org/10.1182/blood-2018-04-841676
Published: 2018
Includes: Supplemental data
Journal Articles

Genomic and Outcome Analyses of Philadelphia Chromosome-like (Ph-like) NCI Standard Risk B-Acute Lymphoblastic Leukemia (SR B-ALL) Patients Treated on Children's Oncology Group (COG) AALL0331

Shalini C. Reshmi, PhD, Richard C. Harvey, PhD, Kathryn G. Roberts, PhD, Eileen Stonerock, BS, ASCP(MB), Yunfeng Dai, PhD, I-Ming L. Chen, DVM, MS, Marc Valentine, BA, Yu Liu, PhD, Yongjin Li, PhD, Jinghui Zhang, PhD, Debbie Payne-Turner, BS, Meenakshi Devidas, PhD, Nyla A. Heerema, PhD, Andrew Carroll, PhD, Elizabeth A. Raetz, MD, Michael Borowitz, MD PhD, Brent Wood, MDPhD, Anne Angiolillo, MD, Michael J. Burke, MD, Wanda Salzer, MD, Patrick A. Zweidler-McKay, MDPhD, Karen R. Rabin, MD PhD, Leonard A. Mattano, MD, Kelly Maloney, MD, William L. Carroll, MD, Mignon L. Loh, MD, Charles G. Mullighan, MBBS, MD, Cheryl L. Willman, MD, Julie M. Gastier-Foster, PhD, Stephen P. Hunger, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 477.
https://doi.org/10.1182/blood.V130.Suppl_1.477.477
Published: 2017
Journal Articles

Targetable kinase gene fusions in high-risk B-ALL: a study from the Children’s Oncology Group

Shalini C. Reshmi, Richard C. Harvey, Kathryn G. Roberts, Eileen Stonerock, Amy Smith, Heather Jenkins, I-Ming Chen, Marc Valentine, Yu Liu, Yongjin Li, Ying Shao, John Easton, Debbie Payne-Turner, Zhaohui Gu, Thai Hoa Tran, Jonathan V. Nguyen, Meenakshi Devidas, Yunfeng Dai, Nyla A. Heerema, Andrew J. Carroll, III, Elizabeth A. Raetz, Michael J. Borowitz, Brent L. Wood, Anne L. Angiolillo, Michael J. Burke, Wanda L. Salzer, Patrick A. Zweidler-McKay, Karen R. Rabin, William L. Carroll, Jinghui Zhang, Mignon L. Loh, Charles G. Mullighan, Cheryl L. Willman, Julie M. Gastier-Foster, Stephen P. Hunger
Journal: Blood
Blood (2017) 129 (25): 3352–3361.
https://doi.org/10.1182/blood-2016-12-758979
Published: 2017
Includes: Supplemental data
Journal Articles

Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults

Clinical Trials & Observations
Nitin Jain, Kathryn G. Roberts, Elias Jabbour, Keyur Patel, Agda Karina Eterovic, Ken Chen, Patrick Zweidler-McKay, Xinyan Lu, Gloria Fawcett, Sa A. Wang, Sergej Konoplev, Richard C. Harvey, I-Ming Chen, Debbie Payne-Turner, Marcus Valentine, Deborah Thomas, Guillermo Garcia-Manero, Farhad Ravandi, Jorge Cortes, Steven Kornblau, Susan O’Brien, Sherry Pierce, Jeffrey Jorgensen, Kenna R. Mills Shaw, Cheryl L. Willman, Charles G. Mullighan, Hagop Kantarjian, Marina Konopleva
Journal: Blood
Blood (2017) 129 (5): 572–581.
https://doi.org/10.1182/blood-2016-07-726588
Published: 2017
Includes: Supplemental data
Journal Articles

Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia

Sarah K. Tasian, David T. Teachey, Yong Li, Feng Shen, Richard C. Harvey, I-Ming Chen, Theresa Ryan, Tiffaney L. Vincent, Cheryl L. Willman, Alexander E. Perl, Stephen P. Hunger, Mignon L. Loh, Martin Carroll, Stephan A. Grupp
Journal: Blood
Blood (2017) 129 (2): 177–187.
https://doi.org/10.1182/blood-2016-05-707653
Published: 2017
Includes: Supplemental data
Journal Articles

High-Risk Subtype of Ph-like Acute Lymphoblastic Leukemia (ALL) in Adults: Dismal Outcomes of CRLF2+ ALL Patients Treated with Intensive Chemotherapy

Nitin Jain, MD, Kathryn G. Roberts, PhD, Elias J. Jabbour, MD, Keyur Patel, MD, Karina Eterovic, PhD, Gloria Fawcett, PhD, Patrick Zweidler-McKay, MD PhD, Xinyan Lu, MD, Sa Wang, MD, Sergej Konoplev, MD PhD, Richard C Harvey, PhD, I-Ming L. Chen, DVM, MS, Debbie Payne-Turner, BA, Marcus Valentine, PhD, Deborah A Thomas, MD, Guillermo Garcia-Manero, MD, Farhad Ravandi, MD, Jorge E. Cortes, MD, Steven M. Kornblau, MD, Susan M. O'Brien, MD, Sherry Pierce, BSN, BA, Jeffrey L. Jorgensen, MD PhD, Kenna Shaw, PhD, Cheryl L. Willman, MD, Charles Mullighan, MBBS, MSc, MD, Hagop M. Kantarjian, MD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1082.
https://doi.org/10.1182/blood.V128.22.1082.1082
Published: 2016
Journal Articles

The Frequency and Outcome of Ph-like ALL Associated Abnormalities in Childhood Acute Lymphoblastic Leukaemia Treated on MRC UKALL2003

Claire Schwab, Amir Enshaei, PhD, Kathryn G. Roberts, PhD, Lisa J. Russell, PhD, Richard C Harvey, PhD, I-Ming L. Chen, DVM, MS, Cheryl L. Willman, Charles Mullighan, MBBS, MSc, MD, Ajay J. Vora, Anthony V. Moorman, PhD, Christine Harrison
Journal: Blood
Blood (2016) 128 (22): 2914.
https://doi.org/10.1182/blood.V128.22.2914.2914
Published: 2016
Journal Articles

Outcomes of Children, Adolescents, and Young Adults with Acute Lymphoblastic Leukemia Based on Blast Genotype at Diagnosis: A Report from the Children's Oncology Group

Mignon L. Loh, MD, Elizabeth Raetz, MD, Meenakshi Devidas, PhD, Yunfeng Dai, PhD, Michael J. Borowitz, MD PhD, Andrew J. Carroll, PhD, I-Ming Chen, DVM, MS, Julie M. Gastier-Foster, PhD, Alison M. Friedmann, MD MSC, Richard C. Harvey, PhD, Nyla A. Heerema, PhD, Eric Larsen, MD, Yongjin Li, PhD, Kelly W. Maloney, MD, Leonard A. Mattano, Jr., MD, Charles G. Mullighan, MBBS, MSc, PhD, Karen R. Rabin, MD PhD, Shalini C. Reshmi, PhD, Kathryn G. Roberts, PhD, Cheryl L. Willman, MD, Brent L. Wood, MD PhD, Patrick Zweidler-McKay, MD PhD, Jinghui Zhang, PhD, Naomi Winick, MD, Stephen Hunger, MD, William L. Carroll, MD
Journal: Blood
Blood (2016) 128 (22): 451.
https://doi.org/10.1182/blood.V128.22.451.451
Published: 2016
Journal Articles

Whole Exome Sequencing of Pediatric Acute Lymphoblastic Leukemia Patients Identify Mutations in 11 Pathways: A Report from the Children's Oncology Group

Mignon L. Loh, MD, Jinghui Zhang, PhD, Deqing Pei, Yunfeng Dai, Xiaotu Ma, PhD, Meenakshi Devidas, PhD, Michael Edmondson, Michael Rusch, Andrew J. Carroll, PhD, I-Ming Chen, Julie Gastier-Foster, PhD, Richard C. Harvey, PhD, Nyla A. Heerema, PhD, Ilaria Iacobucci, PhD, Deborah Payne, Kelly W. Maloney, MD, Eric Larsen, MD, Elizabeth Raetz, MD, Cheryl L. Willman, MD, Naomi Winick, MD, William L. Carroll, MD, Charles G. Mullighan, MBBS(Hons), MSc, MD, Stephen P. Hunger, MD
Journal: Blood
Blood (2016) 128 (22): 455.
https://doi.org/10.1182/blood.V128.22.455.455
Published: 2016
Journal Articles

Genetic and Response-Based Risk Classification Identifies a Subgroup of NCI High Risk Childhood B-Lymphoblastic Leukemia (HR B-ALL) with Outstanding Outcomes: A Report from the Children's Oncology Group (COG)

Elizabeth Raetz, MD, Mignon L. Loh, MD, Meenakshi Devidas, PhD, Kelly Maloney, MD, Eric C. Larsen, MD, Leonard A. Mattano, Jr., MD, Michael J. Borowitz, MD PhD, Brent L Wood, MD PhD, Andrew J. Carroll, PhD, Nyla A. Heerema, PhD, I-Ming Chen, DVM, MS, Alison M. Friedmann, MD MSC, Kirk R. Schultz, MD, Mary V. Relling, PharmD, Richard C Harvey, PhD, Julie Gastier-Foster, PhD, Cheryl L. Willman, MD, Naomi J. Winick, MD, Stephen P Hunger, MD, William L. Carroll, MD
Journal: Blood
Blood (2015) 126 (23): 807.
https://doi.org/10.1182/blood.V126.23.807.807
Published: 2015
Journal Articles

The Genomic Landscape of Childhood T-Lineage Acute Lymphoblastic Leukemia

Yu Liu, PhD, John Easton, PhD, Ying Shao, Mark Wilkinson, Michael Edmonson, PhD, Xiaotu Ma, PhD, Malcolm A. Smith, MD PhD, Michael Rusch, BA, Jaime Guidry Auvil, Daniela S. Gerhard, PhD, Mary V. Relling, PharmD, Naomi J. Winick, MD, Elizabeth Raetz, MD, Meenakshi Devidas, PhD, Cheryl L. Willman, MD, Richard C. Harvey, PhD, William L. Carroll, MD, Kimberly P. Dunsmore, MD, Stuart S. Winter, MD, Brent L Wood, MD PhD, James R. Downing, MD, Mignon L. Loh, MD, Stephen P Hunger, MD, Jinghui Zhang, PhD, Charles G. Mullighan, MBBS, MSc, MD
Journal: Blood
Blood (2015) 126 (23): 691.
https://doi.org/10.1182/blood.V126.23.691.691
Published: 2015