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Journal Articles

A Multi-Site Break through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib (Trial In Progress)

Ghayas C. Issa, Alexander J. Ambinder, Wenbin Xiao, Scott Manalis, Alex K Shalek, Lukasz P. Gondek, Alex Kentsis, Nicholas J. Short, Naval Daver, Jing Ning, Lianchun Xiao, Michael Hemann, Ken Chen, Keyur P. Patel, Pavan Bachireddy, Andrew A. Lane, Marina Konopleva, Omar Abdel-Wahab, Jeffrey J. Molldrem, Ross L Levine, Mark J. Levis, Richard M Stone, Michael Andreeff, Farhad Ravandi, Aaron D. Goldberg, Jacqueline S. Garcia
Journal: Blood
Blood (2024) 144 (Supplement 1): 4265.2.
https://doi.org/10.1182/blood-2024-201582
Published: 2024
Journal Articles

Single-Cell Multiomics Unveils Venetoclax-Resistant Monocytic Differentiation and Immune Evasion in TP53 Mutant AML Clones

Edward Ayoub, David Lehotzky, Li Li, Muharrem Muftuoglu, Yuki Nishida, Vakul Mohanty, Jake S Leighton, Tallie Patsilevas, Mahesh Basyal, Andrea Bedoy, Torsten Haferlach, Koichi Takahashi, Ken Chen, Nicholas Navin, Ghayas C. Issa, Gad Getz, Michael Andreeff
Journal: Blood
Blood (2024) 144 (Supplement 1): 61.
https://doi.org/10.1182/blood-2024-211845
Published: 2024
Journal Articles

Elucidating Transcriptional Heterogeneity in Venetoclax Resistant AMLs

Vakul Mohanty, Natalia Baran, Yuefan Huang, Cassandra L. Ramage, Laurie Cooper, Sarah Gwen Pelletier, Shan He, Ramiz Iqbal, May Daher, MD, Jeffrey W. Tyner, Gordon B Mills, Marina Konopleva, Ken Chen
Journal: Blood
Blood (2024) 144 (Supplement 1): 2753.
https://doi.org/10.1182/blood-2024-204333
Published: 2024
Journal Articles

“Guided” Unsupervised Multiplexed Cytof Analysis Enhances Detection of Minimal/Measurable Residual Disease in Acute Myeloid Leukemia

Muharrem Muftuoglu, Li Li, Mahesh Basyal, Jiangxing Lv, Yukun Tan, Ken Chen, Michael Andreeff
Journal: Blood
Blood (2024) 144 (Supplement 1): 6178.
https://doi.org/10.1182/blood-2024-212260
Published: 2024
Journal Articles

Generation and Screening of Various CD70 CAR NK Cells Identify the Most Effective Construct Against Hematologic Malignancies

Sunil Acharya, Rafet Basar, May Daher, MD, Ping Li, Hind Rafei, Nadima Uprety, Emily Ensley, Mayra Shanley, Bijender Kumar, Pinaki Banerjee, Luciana Melo Garcia, Paul Lin, Vakul Mohanty, Yuchen Pan, Qi Miao, Kun Hee Kim, Xianli Jiang, Ye Li, Bin Liu, Ana K. Nunez Cortes, Patrick Zhang, Mohsen Fathi, Ali Rezvan, Melisa J Montalvo, Enli Liu, Navin Varadarajan, Ken Chen, David Marin, Richard E. Champlin, Elizabeth J. Shpall, Katayoun Rezvani
Journal: Blood
Blood (2023) 142 (Supplement 1): 4824.
https://doi.org/10.1182/blood-2023-189475
Published: 2023
Journal Articles

Epigenetic Scarring Leads to Irreversible NK Cell Dysfunction in Myeloid Malignancies

Bijender Kumar, Anand Singh, Rafet Basar, Nadima Uprety, Ye Li, Huihui Fan, Mayra Shanley, Sunil Acharya, Mayela Carolina Mendt, Paul Lin, Alexander Biederstädt, Hind Rafei, Pinaki Banerjee, Vakul Mohanty, Hila Shaim, Merve Dede, Luciana Melo Garcia, Lucila Nassif Kerbauy, Ana K. Nunez Cortes, Qi Miao, Jinzhuang Dou, Francia Silva Reyes, Xingliang Guo, Mecit Kaplan, Sonny Ang, Xin Ru Jiang, Enli Liu, Bin Liu, Richard E. Champlin, Hagop Kantarjian, David Marin, Ken Chen, Hussein A Abbas, Elizabeth J. Shpall, Kunal Rai, Katayoun Rezvani, May Daher, MD
Journal: Blood
Blood (2023) 142 (Supplement 1): 2088.
https://doi.org/10.1182/blood-2023-187626
Published: 2023
Journal Articles

Single-Cell Genomics and Proteomics Reveals Venetoclax-Resistant Monocytic Differentiation of TP53 LOH Clones in TP53 Mutant AML

Edward Ayoub, Li Li, Muharrem Muftuoglu, Yuki Nishida, Vakul Mohanty, Jake S Leighton, Tallie Patsilevas, Mahesh Basyal, Andrea Bedoy, Torsten Haferlach, Koichi Takahashi, Ken Chen, Nicholas Navin, Ghayas C. Issa, Michael Andreeff
Journal: Blood
Blood (2023) 142 (Supplement 1): 5014.
https://doi.org/10.1182/blood-2023-187121
Published: 2023
Journal Articles

DAP10 Co-Stimulation Imparts Memory-like Features to CD5 Targeting Cord Blood Derived CAR-NK Cells

Rafet Basar, May Daher, MD, Nadima Uprety, Emily Ensley, Ana K. Nunez Cortes, Sunil Acharya, Rejeena Shrestha, Bin Liu, Mayra Shanley, Ye Li, Francia Silva Reyes, Merve Dede, Hind Rafei, Hila Shaim, Mecit Kaplan, Paul Lin, Pinaki Banerjee, Vakul Mohanty, Jinhuang Dou, Mayela Carolina Mendt, Qi Miao, Mariam Ammari, Enli Liu, Xingliang Guo, Bijender Kumar, Alexander Biederstädt, Xin Ru Jiang, Sonny Ang, Navin Varadarajan, Richard E. Champlin, Ken Chen, David Marin, Elizabeth J. Shpall, Katayoun Rezvani
Journal: Blood
Blood (2023) 142 (Supplement 1): 2089.
https://doi.org/10.1182/blood-2023-187665
Published: 2023
Journal Articles

Stem-Cell Enriched Cellular Hierarchy of TP53 Mutant Acute Myeloid Leukemia Is Vulnerable to Targeted Protein Degradation of c-MYC

Yuki Nishida, Edward Ayoub, Darah Scruggs, Shayaun Khazaei, Faryal Munir, Lauren B. Ostermann, Po Yee Mak, Ke Baozhen, Bing Z. Carter, Natalia Baran, Abhishek Maiti, Vakul Mohanty, Ken Chen, Nicholas Navin, Torsten Haferlach, Zhihua Ren, Youzhi Tong, Dong Chen, Ghayas C. Issa, Michael Andreeff
Journal: Blood
Blood (2023) 142 (Supplement 1): 583.
https://doi.org/10.1182/blood-2023-174938
Published: 2023
Journal Articles

Somatic Mutations in TP53 Identified in T-Cells of Patients with TP53- mutated AML

Ghayas C. Issa, Aram Bidikian, Edward Ayoub, Feng Wang, Vakul Mohanty, Jake Leighton, Xiaogang Wu, Tallie Patsilevas, Zoe Alaniz, Jabra Zarka, Rashmi Kanagal-Shamanna, Naval Daver, Andy Futreal, Marina Konopleva, Nicholas Navin, Jianhua Zhang, Ken Chen, Michael Andreeff
Journal: Blood
Blood (2022) 140 (Supplement 1): 6267–6269.
https://doi.org/10.1182/blood-2022-165439
Published: 2022
Journal Articles

Polyploidy Is Necessary for Apoptotic Cell Death in TP53 -Mut AML in Response to Polo-like-Kinase 4 (PLK4) Inhibition and Results in Caspase 3 Cleavage

Edward Ayoub, Akhil Marupudi, Yuki Nishida, Rafael Heinz Montoya, Vakul Mohanty, Wencke Walter, Mark R Bray, Tallie Patsilevas, Steffen Boettcher, Ghayas C. Issa, Ken Chen, Torsten Haferlach, Gautam Borthakur, Michael Andreeff
Journal: Blood
Blood (2022) 140 (Supplement 1): 5941–5943.
https://doi.org/10.1182/blood-2022-170152
Published: 2022
Journal Articles

Characterization of Dysregulated Transcription in TP53 -Mutated AML Subpopulations

Ghayas C. Issa, Vakul Mohanty, Edward Ayoub, Feng Wang, Jake Leighton, Xiaogang Wu, Aram Bidikian, Tallie Patsilevas, Zoe Alaniz, Jabra Zarka, Rashmi Kanagal-Shamanna, Andy Futreal, Naval Daver, Marina Konopleva, Nicholas Navin, Jianhua Zhang, Ken Chen, Michael Andreeff
Journal: Blood
Blood (2022) 140 (Supplement 1): 6323–6325.
https://doi.org/10.1182/blood-2022-168136
Published: 2022
Journal Articles

Blinatumomab maintenance after allogeneic hematopoietic cell transplantation for B-lineage acute lymphoblastic leukemia

Clinical Trials & Observations
Mahmoud R. Gaballa, Pinaki Banerjee, Denái R. Milton, Xianli Jiang, Christina Ganesh, Sajad Khazal, Vandana Nandivada, Sanjida Islam, Mecit Kaplan, May Daher, Rafet Basar, Amin Alousi, Rohtesh Mehta, Gheath Alatrash, Issa Khouri, Betul Oran, David Marin, Uday Popat, Amanda Olson, Priti Tewari, Nitin Jain, Elias Jabbour, Farhad Ravandi, Hagop Kantarjian, Ken Chen, Richard Champlin, Elizabeth Shpall, Katayoun Rezvani, Partow Kebriaei
Journal: Blood
Blood (2022) 139 (12): 1908–1919.
https://doi.org/10.1182/blood.2021013290
Published: 2022
Includes: Supplemental data
Journal Articles

Single-Cell Proteomics Identifies Leukemia Landscape Associated with Clinical Outcomes in R/R AML Treated with MDM2i (Milademetan) and FLT3i (Quizartinib): Putative Role of CD68 and Diversity Index

Muharrem Muftuoglu, Li Li, Mahesh Basyal, Shaoheng Liang, Carissa J. Ball, Ken Chen, Prasanna Kumar, Arnaud Lesegretain, Naval Daver, Michael Andreeff
Journal: Blood
Blood (2021) 138 (Supplement 1): 3443.
https://doi.org/10.1182/blood-2021-154376
Published: 2021
Journal Articles

Targeting Polo-like Kinase 4 Triggers Polyploidy and Apoptotic Cell Death in TP53-Mutant Acute Myeloid Leukemia

Edward Ayoub, Rafael Heinz Montoya, Vakul Mohanty, Wencke Walter, Tallie Patsilevas, Ghayas C. Issa, Gautam Borthakur, Ken Chen, Marina Konopleva, Nicholas Navin, Torsten Haferlach, Michael Andreeff
Journal: Blood
Blood (2021) 138 (Supplement 1): 1167.
https://doi.org/10.1182/blood-2021-153436
Published: 2021
Journal Articles

Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells

May Daher, Rafet Basar, Elif Gokdemir, Natalia Baran, Nadima Uprety, Ana Karen Nunez Cortes, Mayela Mendt, Lucila Nassif Kerbauy, Pinaki P. Banerjee, Mayra Shanley, Nobuhiko Imahashi, Li Li, Francesca Lorraine Wei Inng Lim, Mohsen Fathi, Ali Rezvan, Vakul Mohanty, Yifei Shen, Hila Shaim, Junjun Lu, Gonca Ozcan, Emily Ensley, Mecit Kaplan, Vandana Nandivada, Mustafa Bdiwi, Sunil Acharya, Yuanxin Xi, Xinhai Wan, Duncan Mak, Enli Liu, Xin Ru Jiang, Sonny Ang, Luis Muniz-Feliciano, Ye Li, Jing Wang, Shahram Kordasti, Nedyalko Petrov, Navin Varadarajan, David Marin, Lorenzo Brunetti, Richard J. Skinner, Shangrong Lyu, Leiser Silva, Rolf Turk, Mollie S. Schubert, Garrett R. Rettig, Matthew S. McNeill, Gavin Kurgan, Mark A. Behlke, Heng Li, Natalie W. Fowlkes, Ken Chen, Marina Konopleva, Richard E. Champlin, Elizabeth J. Shpall, Katayoun Rezvani
Journal: Blood
Blood (2021) 137 (5): 624–636.
https://doi.org/10.1182/blood.2020007748
Published: 2021
Includes: Supplemental data
Journal Articles

Combining CAR Engineering and CIS Checkpoint Deletion in NK Cells for the Treatment of B Cell Hematologic Malignancies

May Daher, MD, Rafet Basar, MD, Elif Gokdemir, BS, Natalia Baran, PhDMD, Nadima Uprety, MS, Mayela Carolina Mendt, PhD, Lucila Kerbauy, MD, Mayra Shanley, PhD, Ana Karen Nunez Cortes, MD, Li Li, MD, Pinaki P Banerjee, PhD, Vakul Mohanty, PhD, Junjun Lu, Gonca Ozcan, MD, Emily Ensley, BS, Vandana Nandivada, BS, MS, Mecit Kaplan, MS, Mustafa H Bdaiwi, MD, Enli Liu, MD, Sonny Ang, PhD, Ken Chen, PhD, Marina Y Konopleva, MD PhD, Richard E. Champlin, MD, Elizabeth J. Shpall, MD, Katayoun Rezvani, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1936.
https://doi.org/10.1182/blood-2019-126739
Published: 2019
Journal Articles

Identification of Gene Expression Signatures in Leukemia Stem Cells and Minimal Residual Disease Following Treatment of Adverse Risk Acute Myeloid Leukemia

Ghayas C. Issa, MD, Christopher B. Benton, MD, Vakul Mohanty, PhD, Yifei Shen, PhD, Zoe Alaniz, Feng Wang, PhD, P. Andrew Futreal, PhD, Wei Wang, MD PhD, Jeffrey L. Jorgensen, MD PhD, Nicholas Navin, PhD, Marina Y Konopleva, MD PhD, Ken Chen, PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2717.
https://doi.org/10.1182/blood-2019-130540
Published: 2019
Journal Articles

Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults

Clinical Trials & Observations
Nitin Jain, Kathryn G. Roberts, Elias Jabbour, Keyur Patel, Agda Karina Eterovic, Ken Chen, Patrick Zweidler-McKay, Xinyan Lu, Gloria Fawcett, Sa A. Wang, Sergej Konoplev, Richard C. Harvey, I-Ming Chen, Debbie Payne-Turner, Marcus Valentine, Deborah Thomas, Guillermo Garcia-Manero, Farhad Ravandi, Jorge Cortes, Steven Kornblau, Susan O’Brien, Sherry Pierce, Jeffrey Jorgensen, Kenna R. Mills Shaw, Cheryl L. Willman, Charles G. Mullighan, Hagop Kantarjian, Marina Konopleva
Journal: Blood
Blood (2017) 129 (5): 572–581.
https://doi.org/10.1182/blood-2016-07-726588
Published: 2017
Includes: Supplemental data
Journal Articles

DNA Sequence of the Cancer Genome of a Patient with Therapy-Related Acute Myeloid Leukemia

Laura Schuettpelz, Daniel C. Link, MD, Dong Shen, PhD, Matthew J. Walter, MD, Daniel C Koboldt, MS, David J. Dooling, PhD, Robert S. Fulton, MS, Heather Schmidt, BS, Rachel Maupin, Michelle O'Laughlin, BS, Ken Chen, Michael D. McLellan, Shashikant Kulkarni, PhD, Jennifer Ivanovich, PhD, Michelle Lebeau, Nobish Varghese, MS, Rakesh Nagarajan, MD, PhD, Li Ding, PhD, Timothy A. Graubert, MD, Timothy J Ley, MD, Richard K. Wilson, PhD, Elaine R. Mardis, PhD
Journal: Blood
Blood (2010) 116 (21): 580.
https://doi.org/10.1182/blood.V116.21.580.580
Published: 2010