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Journal Articles

Single-Cell Multiomics Unveils Venetoclax-Resistant Monocytic Differentiation and Immune Evasion in TP53 Mutant AML Clones

Edward Ayoub, David Lehotzky, Li Li, Muharrem Muftuoglu, Yuki Nishida, Vakul Mohanty, Jake S Leighton, Tallie Patsilevas, Mahesh Basyal, Andrea Bedoy, Torsten Haferlach, Koichi Takahashi, Ken Chen, Nicholas Navin, Ghayas C. Issa, Gad Getz, Michael Andreeff
Journal: Blood
Blood (2024) 144 (Supplement 1): 61.
https://doi.org/10.1182/blood-2024-211845
Published: 2024
Journal Articles

Single-Cell Genomics and Proteomics Reveals Venetoclax-Resistant Monocytic Differentiation of TP53 LOH Clones in TP53 Mutant AML

Edward Ayoub, Li Li, Muharrem Muftuoglu, Yuki Nishida, Vakul Mohanty, Jake S Leighton, Tallie Patsilevas, Mahesh Basyal, Andrea Bedoy, Torsten Haferlach, Koichi Takahashi, Ken Chen, Nicholas Navin, Ghayas C. Issa, Michael Andreeff
Journal: Blood
Blood (2023) 142 (Supplement 1): 5014.
https://doi.org/10.1182/blood-2023-187121
Published: 2023
Journal Articles

Single-Cell Proteomic Analysis Reveals Menin Inhibition-Induced Proteomic Alterations in AML Patients Treated with Revumenib

Muharrem Muftuoglu, Li Li, Mahesh Basyal, Edward Ayoub, Jiangxing Lv, Andrea Bedoy, Tallie Patsilevas, Aram Bidikian, Ghayas C. Issa, Michael Andreeff
Journal: Blood
Blood (2023) 142 (Supplement 1): 2933.
https://doi.org/10.1182/blood-2023-191216
Published: 2023
Journal Articles

Somatic Mutations in TP53 Identified in T-Cells of Patients with TP53- mutated AML

Ghayas C. Issa, Aram Bidikian, Edward Ayoub, Feng Wang, Vakul Mohanty, Jake Leighton, Xiaogang Wu, Tallie Patsilevas, Zoe Alaniz, Jabra Zarka, Rashmi Kanagal-Shamanna, Naval Daver, Andy Futreal, Marina Konopleva, Nicholas Navin, Jianhua Zhang, Ken Chen, Michael Andreeff
Journal: Blood
Blood (2022) 140 (Supplement 1): 6267–6269.
https://doi.org/10.1182/blood-2022-165439
Published: 2022
Journal Articles

Polyploidy Is Necessary for Apoptotic Cell Death in TP53 -Mut AML in Response to Polo-like-Kinase 4 (PLK4) Inhibition and Results in Caspase 3 Cleavage

Edward Ayoub, Akhil Marupudi, Yuki Nishida, Rafael Heinz Montoya, Vakul Mohanty, Wencke Walter, Mark R Bray, Tallie Patsilevas, Steffen Boettcher, Ghayas C. Issa, Ken Chen, Torsten Haferlach, Gautam Borthakur, Michael Andreeff
Journal: Blood
Blood (2022) 140 (Supplement 1): 5941–5943.
https://doi.org/10.1182/blood-2022-170152
Published: 2022
Journal Articles

C-MYC Targeting By Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Induces TP53 -Independent Cell Death in Acute Myeloid Leukemia and Lymphomas

Yuki Nishida, Darah A Scruggs, Edward Ayoub, Tallie Patsilevas, Vivian Ruvolo, Po Yee Mak, Bing Z Carter, Steffen Boettcher, Abhishek Maiti, Qianxiang Zhou, Zhaohui Yang, Honghua Yan, Liandong Ma, Michael Andreeff
Journal: Blood
Blood (2022) 140 (Supplement 1): 483–484.
https://doi.org/10.1182/blood-2022-164968
Published: 2022
Journal Articles

Characterization of Dysregulated Transcription in TP53 -Mutated AML Subpopulations

Ghayas C. Issa, Vakul Mohanty, Edward Ayoub, Feng Wang, Jake Leighton, Xiaogang Wu, Aram Bidikian, Tallie Patsilevas, Zoe Alaniz, Jabra Zarka, Rashmi Kanagal-Shamanna, Andy Futreal, Naval Daver, Marina Konopleva, Nicholas Navin, Jianhua Zhang, Ken Chen, Michael Andreeff
Journal: Blood
Blood (2022) 140 (Supplement 1): 6323–6325.
https://doi.org/10.1182/blood-2022-168136
Published: 2022
Journal Articles

Targeting Polo-like Kinase 4 Triggers Polyploidy and Apoptotic Cell Death in TP53-Mutant Acute Myeloid Leukemia

Edward Ayoub, Rafael Heinz Montoya, Vakul Mohanty, Wencke Walter, Tallie Patsilevas, Ghayas C. Issa, Gautam Borthakur, Ken Chen, Marina Konopleva, Nicholas Navin, Torsten Haferlach, Michael Andreeff
Journal: Blood
Blood (2021) 138 (Supplement 1): 1167.
https://doi.org/10.1182/blood-2021-153436
Published: 2021
Journal Articles

Enhanced p53 Activation By Dual Inhibition of MDM2 and XPO1 Disrupts MYC Transcriptional Program and Restores Sensitivity to BCL-2 Inhibition in Ven/HMA Resistant AML

Yuki Nishida, Jo Ishizawa, Edward Ayoub, Tallie Patsilevas, Lauren Ostermann, Rafael Heinz Montoya, Muharrem Muftuoglu, Vivian Ruvolo, Po Yee Mak, Wenjing Tao, Bing Z Carter, Kensuke Kojima, Naval Daver, Arnaud Lesegretain, Takahiko Seki, Sharon Shacham, Marina Konopleva, Michael Andreeff
Journal: Blood
Blood (2021) 138 (Supplement 1): 505.
https://doi.org/10.1182/blood-2021-149260
Published: 2021