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Nicholas Navin
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Journal Articles

Single-Cell Multiomics Unveils Venetoclax-Resistant Monocytic Differentiation and Immune Evasion in TP53 Mutant AML Clones

Edward Ayoub, David Lehotzky, Li Li, Muharrem Muftuoglu, Yuki Nishida, Vakul Mohanty, Jake S Leighton, Tallie Patsilevas, Mahesh Basyal, Andrea Bedoy, Torsten Haferlach, Koichi Takahashi, Ken Chen, Nicholas Navin, Ghayas C. Issa, Gad Getz, Michael Andreeff
Journal: Blood
Blood (2024) 144 (Supplement 1): 61.
https://doi.org/10.1182/blood-2024-211845
Published: 2024
Journal Articles

Single-Cell Genomics and Proteomics Reveals Venetoclax-Resistant Monocytic Differentiation of TP53 LOH Clones in TP53 Mutant AML

Edward Ayoub, Li Li, Muharrem Muftuoglu, Yuki Nishida, Vakul Mohanty, Jake S Leighton, Tallie Patsilevas, Mahesh Basyal, Andrea Bedoy, Torsten Haferlach, Koichi Takahashi, Ken Chen, Nicholas Navin, Ghayas C. Issa, Michael Andreeff
Journal: Blood
Blood (2023) 142 (Supplement 1): 5014.
https://doi.org/10.1182/blood-2023-187121
Published: 2023
Journal Articles

Stem-Cell Enriched Cellular Hierarchy of TP53 Mutant Acute Myeloid Leukemia Is Vulnerable to Targeted Protein Degradation of c-MYC

Yuki Nishida, Edward Ayoub, Darah Scruggs, Shayaun Khazaei, Faryal Munir, Lauren B. Ostermann, Po Yee Mak, Ke Baozhen, Bing Z. Carter, Natalia Baran, Abhishek Maiti, Vakul Mohanty, Ken Chen, Nicholas Navin, Torsten Haferlach, Zhihua Ren, Youzhi Tong, Dong Chen, Ghayas C. Issa, Michael Andreeff
Journal: Blood
Blood (2023) 142 (Supplement 1): 583.
https://doi.org/10.1182/blood-2023-174938
Published: 2023
Journal Articles

Somatic Mutations in TP53 Identified in T-Cells of Patients with TP53- mutated AML

Ghayas C. Issa, Aram Bidikian, Edward Ayoub, Feng Wang, Vakul Mohanty, Jake Leighton, Xiaogang Wu, Tallie Patsilevas, Zoe Alaniz, Jabra Zarka, Rashmi Kanagal-Shamanna, Naval Daver, Andy Futreal, Marina Konopleva, Nicholas Navin, Jianhua Zhang, Ken Chen, Michael Andreeff
Journal: Blood
Blood (2022) 140 (Supplement 1): 6267–6269.
https://doi.org/10.1182/blood-2022-165439
Published: 2022
Journal Articles

Characterization of Dysregulated Transcription in TP53 -Mutated AML Subpopulations

Ghayas C. Issa, Vakul Mohanty, Edward Ayoub, Feng Wang, Jake Leighton, Xiaogang Wu, Aram Bidikian, Tallie Patsilevas, Zoe Alaniz, Jabra Zarka, Rashmi Kanagal-Shamanna, Andy Futreal, Naval Daver, Marina Konopleva, Nicholas Navin, Jianhua Zhang, Ken Chen, Michael Andreeff
Journal: Blood
Blood (2022) 140 (Supplement 1): 6323–6325.
https://doi.org/10.1182/blood-2022-168136
Published: 2022
Journal Articles

Targeting Polo-like Kinase 4 Triggers Polyploidy and Apoptotic Cell Death in TP53-Mutant Acute Myeloid Leukemia

Edward Ayoub, Rafael Heinz Montoya, Vakul Mohanty, Wencke Walter, Tallie Patsilevas, Ghayas C. Issa, Gautam Borthakur, Ken Chen, Marina Konopleva, Nicholas Navin, Torsten Haferlach, Michael Andreeff
Journal: Blood
Blood (2021) 138 (Supplement 1): 1167.
https://doi.org/10.1182/blood-2021-153436
Published: 2021
Journal Articles

Identification of Gene Expression Signatures in Leukemia Stem Cells and Minimal Residual Disease Following Treatment of Adverse Risk Acute Myeloid Leukemia

Ghayas C. Issa, MD, Christopher B. Benton, MD, Vakul Mohanty, PhD, Yifei Shen, PhD, Zoe Alaniz, Feng Wang, PhD, P. Andrew Futreal, PhD, Wei Wang, MD PhD, Jeffrey L. Jorgensen, MD PhD, Nicholas Navin, PhD, Marina Y Konopleva, MD PhD, Ken Chen, PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2717.
https://doi.org/10.1182/blood-2019-130540
Published: 2019
Journal Articles

Distinct Gene Expression Patterns of Minimal Residual Disease (MRD) Cells in High-Risk AML Patients Identified By RNA-Sequencing

Christopher B. Benton, MD, Ahmed Al Rawi, Feng Wang, PhD, Jianhua Zhang, PhD, Jeffrey L. Jorgensen, MD PhD, Hong Mu, MD PhD, Wendy Schober, Zoe Alaniz, Curtis Gumbs, Andy Futreal, PhD, Guillermo Garcia-Manero, MD, Hagop M. Kantarjian, MD, Nicholas Navin, PhD, Marina Y. Konopleva, MD PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2757.
https://doi.org/10.1182/blood-2018-99-120260
Published: 2018
Journal Articles

BET Bromodomain Inhibition Reduces Leukemic Burden and Prolongs Survival In The Eμ-TCL1 Transgenic Mouse Model Of Chronic Lymphocytic Leukemia (CLL) Independent Of TP53 Mutation Status

Connie A Larsson, Kensuke Kojima, MD, PhD, Yong Wang, PhD, Nicholas Navin, PhD, Miguel Gallardo, PhD, Daniel Primo, Jose L. Rojas, Joaquin Martinez, Taghi Manshouri, Ph.D., Hun Ju Lee, MD, James E Bradner, MD, Juan Ballesteros, Sean M. Post, PhD, Guillermina (Gigi) Lozano, PhD, Alfonso Quintás-Cardama, MD
Journal: Blood
Blood (2013) 122 (21): 876.
https://doi.org/10.1182/blood.V122.21.876.876
Published: 2013
Journal Articles

Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA)

Vladimir Grubor, Alex Krasnitz, Jennifer E. Troge, Jennifer L. Meth, B. Lakshmi, Jude T. Kendall, Boris Yamrom, Garrick Alex, Deepa Pai, Nicholas Navin, Lisa A. Hufnagel, Yoon-Ha Lee, Kerry Cook, Steven L. Allen, Kanti R. Rai, Rajendra N. Damle, Carlo Calissano, Nicholas Chiorazzi, Michael Wigler, Diane Esposito
Journal: Blood
Blood (2009) 113 (6): 1294–1303.
https://doi.org/10.1182/blood-2008-05-158865
Published: 2009
Includes: Supplemental data
Journal Articles

High-Resolution Array-Based Comparative Genome Hybridization (CGH) Identifies Novel and Recurrent Regions in CLL.

Vladimir Grubor, PhD, Alex Krasnitz, PhD, Jennifer E. Troge, Jennifer L. Meth, B. Lakshmi, PhD, Jude T. Kendall, Boris Yamrom, PhD, Garrick Alex, Deepa Pai, Nicholas Navin, Lisa A. Hufnagel, Yoon-ha Lee, PhD, Kerry Cook, Steven L. Allen, MD, Kanti R. Rai, MD, Rajendra Damle, PhD, Carlo Calissano, PhD, Nicholas Chiorazzi, MD, Michael H Wigler, PhD, Diane Esposito, PhD
Journal: Blood
Blood (2008) 112 (11): 2058.
https://doi.org/10.1182/blood.V112.11.2058.2058
Published: 2008