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Shayaun Khazaei
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Journal Articles

Mitigating Therapy-Related Myeloid Neoplasia in p53-Mutant Clones through Targeted DNA Repair Pathway Inhibition with PARP Inhibitors

Rasoul Pourebrahim, Priyanka Khanna, Dexin Yang, Muharrem Muftuoglu, Lauren B. Ostermann, Shayaun Khazaei, Ran Zhao, Amma Asare, Richard A. Hajek, Sanghoon Lee, Sara Corvingo, Mihai Gagea, Anil Sood, Ruoyan Li, Koichi Takahashi, Michael Andreeff
Journal: Blood
Blood (2024) 144 (Supplement 1): 726.
https://doi.org/10.1182/blood-2024-208373
Published: 2024
Journal Articles

Novel p53 Mutant Mouse Model Recapitulates the Biology of Human Therapy-Related Myeloid Neoplasms

Rasoul Pourebrahim, Dexin Yang, Priyanka Khanna, Muharrem Muftuoglu, Lauren B. Ostermann, Shayaun Khazaei, Ran Zhao, Mihai Gagea, Simona Colla, Guillermo Garcia-Manero, Ruoyan Li, Michael Andreeff, Koichi Takahashi
Journal: Blood
Blood (2024) 144 (Supplement 1): 882.
https://doi.org/10.1182/blood-2024-207582
Published: 2024
Journal Articles

Targeting Co-Regulatory Feedback Loop of MYC and GSPT1 By MYC/GSPT1 Dual Degradation Is Synthetic Lethal in Combination with Ven/Aza in TP53 Mutant Acute Myeloid Leukemia Stem and Progenitor Cells

Yuki Nishida, Hideaki Mizuno, Edward Ayoub, Eiji Sugihara, Lauren B. Ostermann, Shayaun Khazaei, Darah Scruggs, Po Yee Mak, Baozhen Ke, Bing Z. Carter, Abhishek Maiti, Liandong Ma, Michael Andreeff
Journal: Blood
Blood (2024) 144 (Supplement 1): 2755.
https://doi.org/10.1182/blood-2024-207812
Published: 2024
Journal Articles

Stem-Cell Enriched Cellular Hierarchy of TP53 Mutant Acute Myeloid Leukemia Is Vulnerable to Targeted Protein Degradation of c-MYC

Yuki Nishida, Edward Ayoub, Darah Scruggs, Shayaun Khazaei, Faryal Munir, Lauren B. Ostermann, Po Yee Mak, Ke Baozhen, Bing Z. Carter, Natalia Baran, Abhishek Maiti, Vakul Mohanty, Ken Chen, Nicholas Navin, Torsten Haferlach, Zhihua Ren, Youzhi Tong, Dong Chen, Ghayas C. Issa, Michael Andreeff
Journal: Blood
Blood (2023) 142 (Supplement 1): 583.
https://doi.org/10.1182/blood-2023-174938
Published: 2023
Journal Articles

Targeted Protein Degradation for c-MYC Overcomes Therapy Resistance in T-Cell Acute Lymphoblastic Leukemias

Faryal Munir, Shayaun Khazaei, Phoebe H. Calkins, Darah Scruggs, Hideaki Mizuno, Lauren B. Ostermann, Branko Cuglievan, Miriam B. Garcia, Dong Chen, Youzhi Tong, Zhihua Ren, Michael Andreeff, Yuki Nishida
Journal: Blood
Blood (2023) 142 (Supplement 1): 1447.
https://doi.org/10.1182/blood-2023-187496
Published: 2023
Journal Articles

Age-Specific Induction of Mutant p53 Drives Clonal Hematopoiesis in Adult Mice Leading to Acute Myeloid Leukemia

Rasoul Pourebrahim, Shayaun Khazaei, Lauren B. Ostermann, Ran Zhao, Muharrem Muftuoglu, Michael Andreeff
Journal: Blood
Blood (2023) 142 (Supplement 1): 1382.
https://doi.org/10.1182/blood-2023-186454
Published: 2023