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Michael Andreeff
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Journal Articles

A Multi-Site Break through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib (Trial In Progress)

Ghayas C. Issa, Alexander J. Ambinder, Wenbin Xiao, Scott Manalis, Alex K Shalek, Lukasz P. Gondek, Alex Kentsis, Nicholas J. Short, Naval Daver, Jing Ning, Lianchun Xiao, Michael Hemann, Ken Chen, Keyur P. Patel, Pavan Bachireddy, Andrew A. Lane, Marina Konopleva, Omar Abdel-Wahab, Jeffrey J. Molldrem, Ross L Levine, Mark J. Levis, Richard M Stone, Michael Andreeff, Farhad Ravandi, Aaron D. Goldberg, Jacqueline S. Garcia
Journal: Blood
Blood (2024) 144 (Supplement 1): 4265.2.
https://doi.org/10.1182/blood-2024-201582
Published: 2024
Journal Articles

Decitabine-Venetoclax Treatment Reactivates Endogenous Retrovirus RNA Signaling in AML Cells and Induces T Cell Activation

Kotoko Yamatani, Kaori Saito, Abhishek Maiti, Abdullah Khasawneh, Faith Jessica Paran, Tastuya Suzuki, Toru Okamoto, Kala Hayes, Zhihong Zeng, Courtney D. DiNardo, Michael Andreeff, Marina Konopleva, Yoko Tabe
Journal: Blood
Blood (2024) 144 (Supplement 1): 1389.
https://doi.org/10.1182/blood-2024-202722
Published: 2024
Journal Articles

Spatial Analysis of Human p53 Mutated AML Bone Marrow Reveals Novel MRD Clusters and Spatial Microenvironmental Features of p53 Mutated AML

Hideaki Mizuno, Yuki Nishida, Edward Ayoub, Akshay Basi, Andrea Bedoy, Javier A. Gomez, Jared K. Burks, Rashmi Kanagal-Shamanna, Michael Andreeff
Journal: Blood
Blood (2024) 144 (Supplement 1): 1301.
https://doi.org/10.1182/blood-2024-209852
Published: 2024
Journal Articles

A Phase II Trial of Azacitidine with Ipilimumab, Nivolumab, or Ipilimumab and Nivolumab with or without Azacitidine in Relapsed or Refractory Myelodysplastic Syndrome

Ian M. Bouligny, Guillermo Montalban-Bravo, Koji Sasaki, Naval Daver, Elias Jabbour, Yesid Alvarado Valero, Courtney D. DiNardo, Farhad Ravandi, Naveen Pemmaraju, Tapan M. Kadia, Lucia Masarova, Koichi Takahashi, Michael Andreeff, Alexandre Bazinet, Hui Yang, Rashmi Kanagal-Shamanna, Sherry Pierce, Meghan Anne Meyer, Xuelin Huang, Guillermo Garcia-Manero
Journal: Blood
Blood (2024) 144 (Supplement 1): 3212.
https://doi.org/10.1182/blood-2024-205186
Published: 2024
Journal Articles

Targeting Lipid Droplet Biogenesis to Enhance Ferroptosis in Acute Myeloid Leukemia

Liang Zhang, Ran Zhao, Hiroki Akiyama, Jalen Nguyen, Kazuharu Kamachi, Saurabh Kumar Gupta, Valeria Impedovo, G. Lavender Hackman, Michael Andreeff, Alessia Lodi, Jo Ishizawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 1400.
https://doi.org/10.1182/blood-2024-208616
Published: 2024
Journal Articles

Single-Cell Multiomics Unveils Venetoclax-Resistant Monocytic Differentiation and Immune Evasion in TP53 Mutant AML Clones

Edward Ayoub, David Lehotzky, Li Li, Muharrem Muftuoglu, Yuki Nishida, Vakul Mohanty, Jake S Leighton, Tallie Patsilevas, Mahesh Basyal, Andrea Bedoy, Torsten Haferlach, Koichi Takahashi, Ken Chen, Nicholas Navin, Ghayas C. Issa, Gad Getz, Michael Andreeff
Journal: Blood
Blood (2024) 144 (Supplement 1): 61.
https://doi.org/10.1182/blood-2024-211845
Published: 2024
Journal Articles

Failure to Execute Caspase Activation Drives Therapy Resistance in TP53 Mutated AML

Ahmed M Mamdouh, Fang Qi Lim, Yang Mi, Elyse A Olesinski, Yichen Wang, Shaista Shabbir Jasdanwala, Karanpreet Singh Bhatia, Xiao Xian Lin, Valeriia Sapozhnikova, Philipp Mertins, Brandon D. Brown, Yihua Qiu, Anthony G. Letai, Alexandre Puissant, Steven M. Kornblau, Jan Krönke, Edward Ayoub, Koji Itahana, Michael Andreeff, Shruti Bhatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 53.
https://doi.org/10.1182/blood-2024-211997
Published: 2024
Journal Articles

Phase I/II Study of the All-Oral Combination of Revumenib (SNDX-5613) with Decitabine/Cedazuridine (ASTX727) and Venetoclax (SAVE) in R/R AML

Ghayas C. Issa, Branko Cuglievan, Naval Daver, Courtney D. DiNardo, Aziz Farhat, Nicholas J. Short, David McCall, Allison Pike, Sheila Tan, Brianna Kammerer, Aimee Marshal, Musa Yilmaz, Tapan M. Kadia, Naveen Pemmaraju, Maro Ohanian, Hussein A. Abbas, Abhishek Maiti, Alexandre Bazinet, Elias Jabbour, Koji Sasaki, Gautam Borthakur, Guillermo Montalban-Bravo, Nitin Jain, Yesid Alvarado Valero, Farhad Ravandi, Guillermo Garcia-Manero, Michael Andreeff, Hagop M. Kantarjian
Journal: Blood
Blood (2024) 144 (Supplement 1): 216.
https://doi.org/10.1182/blood-2024-204375
Published: 2024
Journal Articles

Transcriptomic Signature of Resistance to Decitabine/Venetoclax in AML Patients

Abdullah Khasawneh, Faith Jessica Paran, Abhishek Maiti, Bofei Wang, Kala Hayes, Courtney D. DiNardo, Michael Andreeff, Hussein A. Abbas, Marina Konopleva, Yoko Tabe
Journal: Blood
Blood (2024) 144 (Supplement 1): 2766.
https://doi.org/10.1182/blood-2024-202806
Published: 2024
Journal Articles

Molecular Interactions between Mitochondrial Ferroptosis and Apoptosis Pathways in Acute Myeloid Leukemia

Kazuharu Kamachi, Hiroki Akiyama, Ran Zhao, Liang Zhang, Saurabh Kumar Gupta, Lauren B. Ostermann, Yuji Otsuki, Osamu Nagano, Hideyuki Saya, Ayumu Taguchi, Michael Andreeff, Jo Ishizawa
Journal: Blood
Blood (2024) 144 (Supplement 1): 2765.
https://doi.org/10.1182/blood-2024-201661
Published: 2024
Journal Articles

ERK1/2 Inhibition Mediates Bax Dependent Proteolysis of OPA1 and Induces Mitochondrial Cristae Remodeling to Overcome Resistance to Venetoclax

Priyanka Sharma, Natalia Baran, Qi Zhang, M. Anna Zal, Joanne Munck, Martin Sims, Bing Z. Carter, Michael Andreeff, Gautam Borthakur
Journal: Blood
Blood (2024) 144 (Supplement 1): 2759.
https://doi.org/10.1182/blood-2024-210698
Published: 2024
Journal Articles

Targeting Co-Regulatory Feedback Loop of MYC and GSPT1 By MYC/GSPT1 Dual Degradation Is Synthetic Lethal in Combination with Ven/Aza in TP53 Mutant Acute Myeloid Leukemia Stem and Progenitor Cells

Yuki Nishida, Hideaki Mizuno, Edward Ayoub, Eiji Sugihara, Lauren B. Ostermann, Shayaun Khazaei, Darah Scruggs, Po Yee Mak, Baozhen Ke, Bing Z. Carter, Abhishek Maiti, Liandong Ma, Michael Andreeff
Journal: Blood
Blood (2024) 144 (Supplement 1): 2755.
https://doi.org/10.1182/blood-2024-207812
Published: 2024
Journal Articles

Clinical Outcomes Using Frontline “Triplet” Regimens for Newly Diagnosed IDH -Mutated Acute Myeloid Leukemia (AML): A Pooled Analysis of Two Phase Ib/2 Clinical Trials

Jennifer Marvin-Peek, Himachandana Atluri, Nicholas J. Short, Abhishek Maiti, Koichi Takahashi, Sanam Loghavi, Curtis A Lachowiez, Yesid Alvarado Valero, Guillermo Montalban-Bravo, Koji Sasaki, Fadi G. Haddad, Ghayas C. Issa, Lucia Masarova, Hussein A. Abbas, Michael Andreeff, Gautam Borthakur, Jillian Mullin, George Donovan Tippett, Kelly S. Chien, Danielle Hammond, Jo Ishizawa, Nitin Jain, Patrick K. Reville, Mahesh Swaminathan, Musa Yilmaz, Naval Daver, Tapan M. Kadia, Farhad Ravandi, Guillermo Garcia-Manero, Hagop M. Kantarjian, Courtney D. DiNardo
Journal: Blood
Blood (2024) 144 (Supplement 1): 2883.
https://doi.org/10.1182/blood-2024-200387
Published: 2024
Journal Articles

Combination of CPX-351 and Gemtuzumab Ozogamicin (GO) in Relapsed Refractory (R/R) Acute Myeloid Leukemia and Post Hypomethylating Agent (HMA) Failure High-Risk Myelodysplastic Syndrome (HR-MDS)

Jayastu Senapati, Farhad Ravandi, Emmanuel Almanza, Tapan M. Kadia, Guillermo Montalban-Bravo, Stefan Faderl, Koji Sasaki, Nicholas J. Short, Naval Daver, Courtney D. DiNardo, Lucia Masarova, Alessandra Ferrajoli, Fadi G. Haddad, Elias Jabbour, Gautam Borthakur, Sheila Tan, Sherry Pierce, Guillermo Garcia-Manero, Michael Andreeff, Yesid Alvarado Valero
Journal: Blood
Blood (2024) 144 (Supplement 1): 2903.
https://doi.org/10.1182/blood-2024-207962
Published: 2024
Journal Articles

Reactivation of p53 in TP53 -Y220C Mutant AML: Mechanism of Action and Mechanism-Based Drug Combinations

Bing Z. Carter, Po Yee Mak, Baozhen Ke, Xiaogang Wu, Steffen Boettcher, Lauren B. Ostermann, Andrea Bedoy, Georgina Gener-Ricos, Jayastu Senapati, Courtney D. DiNardo, Anna Puzio-Kuter, Arnold Levine, Michael Andreeff
Journal: Blood
Blood (2024) 144 (Supplement 1): 4155.
https://doi.org/10.1182/blood-2024-208403
Published: 2024
Journal Articles

Phase I/II Study of Quizartinib, Venetoclax, and Decitabine Triple Combination in FLT3-ITD Mutated AML

Musa Yilmaz, Muharrem Muftuoglu, Nicholas J. Short, Sanam Loghavi, Tapan M. Kadia, Courtney D. DiNardo, Gautam Borthakur, Naveen Pemmaraju, Yesid Alvarado Valero, Abhishek Maiti, Marina Konopleva, Lucia Masarova, Guillermo Montalban-Bravo, Carissa Jurisprudencia, Allison Pike, Keyur P. Patel, Guilin Tang, Jairo Matthews, Steven M. Kornblau, Elias Jabbour, Guillermo Garcia-Manero, Koichi Takahashi, Michael Andreeff, Farhad Ravandi, Hagop M. Kantarjian, Naval Daver
Journal: Blood
Blood (2024) 144 (Supplement 1): 4263.
https://doi.org/10.1182/blood-2024-204296
Published: 2024
Journal Articles

“Guided” Unsupervised Multiplexed Cytof Analysis Enhances Detection of Minimal/Measurable Residual Disease in Acute Myeloid Leukemia

Muharrem Muftuoglu, Li Li, Mahesh Basyal, Jiangxing Lv, Yukun Tan, Ken Chen, Michael Andreeff
Journal: Blood
Blood (2024) 144 (Supplement 1): 6178.
https://doi.org/10.1182/blood-2024-212260
Published: 2024
Journal Articles

Annamycin, a Non-Cardiotoxic Anthracycline Demonstrates Unique Organotropism and Activity Against Ara-C and Venetoclax Resistant AML

Rafal Jerzy Zielinski, Krzysztof Grela, Roberto Cardenas-Zuniga, Stanislaw Skora, Izabela Fokt, Mihai Gagea, Michael Andreeff, Natalia Baran, Waldemar Priebe
Journal: Blood
Blood (2024) 144 (Supplement 1): 5796.
https://doi.org/10.1182/blood-2024-206164
Published: 2024
Journal Articles

TP53 Mutations within T Cells Induce T-Cell Exhaustion and Functional Impairment in TP53 Mutant AML

Li Li, Muharrem Muftuoglu, Edward Ayoub, Aram Bidikian, Prashant Menon, Jiangxing Lv, Mahesh Basyal, Andrea Bedoy, Anudishi Tyagi, Amanda Eckstrom, Venkata Lokesh Battula, Navin Varadarajan, Ghayas C. Issa, Michael Andreeff
Journal: Blood
Blood (2024) 144 (Supplement 1): 330.
https://doi.org/10.1182/blood-2024-210412
Published: 2024
Journal Articles

Novel p53 Mutant Mouse Model Recapitulates the Biology of Human Therapy-Related Myeloid Neoplasms

Rasoul Pourebrahim, Dexin Yang, Priyanka Khanna, Muharrem Muftuoglu, Lauren B. Ostermann, Shayaun Khazaei, Ran Zhao, Mihai Gagea, Simona Colla, Guillermo Garcia-Manero, Ruoyan Li, Michael Andreeff, Koichi Takahashi
Journal: Blood
Blood (2024) 144 (Supplement 1): 882.
https://doi.org/10.1182/blood-2024-207582
Published: 2024