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Journal Articles

ERK1/2 Inhibition Mediates Bax Dependent Proteolysis of OPA1 and Induces Mitochondrial Cristae Remodeling to Overcome Resistance to Venetoclax

Priyanka Sharma, Natalia Baran, Qi Zhang, M. Anna Zal, Joanne Munck, Martin Sims, Bing Z. Carter, Michael Andreeff, Gautam Borthakur

Blood (2024) 144 (Supplement 1): 2759.

https://doi.org/10.1182/blood-2024-210698

Published: 2024

Journal Articles

Elucidating Transcriptional Heterogeneity in Venetoclax Resistant AMLs

Vakul Mohanty, Natalia Baran, Yuefan Huang, Cassandra L. Ramage, Laurie Cooper, Sarah Gwen Pelletier, Shan He, Ramiz Iqbal, May Daher, MD, Jeffrey W. Tyner, Gordon B Mills, Marina Konopleva, Ken Chen

Blood (2024) 144 (Supplement 1): 2753.

https://doi.org/10.1182/blood-2024-204333

Published: 2024

Journal Articles

Annamycin, a Non-Cardiotoxic Anthracycline Demonstrates Unique Organotropism and Activity Against Ara-C and Venetoclax Resistant AML

Rafal Jerzy Zielinski, Krzysztof Grela, Roberto Cardenas-Zuniga, Stanislaw Skora, Izabela Fokt, Mihai Gagea, Michael Andreeff, Natalia Baran, Waldemar Priebe

Blood (2024) 144 (Supplement 1): 5796.

https://doi.org/10.1182/blood-2024-206164

Published: 2024

Journal Articles

River-81: A Multicenter, Open-Label, Dose-Finding Clinical Trial to Assess Safety, PK, PD, Clinical Efficacy of RVU120 in Combination with Venetoclax in Patients with AML Failing Prior Venetoclax Plus Hypomethylating Agent Therapy

Blood (2024) 144 (Supplement 1): 5999.

https://doi.org/10.1182/blood-2024-200055

Published: 2024

Journal Articles

Minimal Residual Disease in Acute Myeloid Leukemia Following Induction Chemotherapy Can be Effectively Eradicated By Targeting Mitochondrial Metabolism

Blood (2023) 142 (Supplement 1): 2952.

https://doi.org/10.1182/blood-2023-186514

Published: 2023

Journal Articles

IFNγ Signaling in Acute Myeloid Leukemia Mediates Immunomodulation and Reveals Therapeutic Strategies

Blood (2023) 142 (Supplement 1): 2796.

https://doi.org/10.1182/blood-2023-175010

Published: 2023

Journal Articles

ERK1/2 Inhibition Overcomes Resistance to Venetoclax in AML By Inhibiting Drp1 Dependent Mitochondrial Fission

Priyanka Sharma, Lauren B. Ostermann, Sujan Piya, Baozhen Ke, Natalia Baran, Anudishi Tyagi, Muharrem Muftuoglu, Mahesh Basyal, Qi Zhang, Joanne Munck, Kim-Hien Dao, Martin Sims, Bing Z. Carter, Venkata Lokesh Battula, Michael Andreeff, Gautam Borthakur

Blood (2023) 142 (Supplement 1): 412.

https://doi.org/10.1182/blood-2023-185700

Published: 2023

Journal Articles

Stem-Cell Enriched Cellular Hierarchy of TP53 Mutant Acute Myeloid Leukemia Is Vulnerable to Targeted Protein Degradation of c-MYC

Blood (2023) 142 (Supplement 1): 583.

https://doi.org/10.1182/blood-2023-174938

Published: 2023

Journal Articles

Mdm2 Loss of Heterozygosity Cooperates with Mutant p53 in the Development of Acute Myeloid Leukemia

Rasoul Pourebrahim, Rafael Heinz Montoya, Edward Ayoub, Hiroki Akiyama, Natalia Baran, Tom Lesluyes, Lauren B Ostermann, Bin Liu, Jo Ishizawa, Joseph D. Khoury, Marina Konopleva, Peter Van Loo, Michael Andreeff

Blood (2022) 140 (Supplement 1): 5876–5878.

https://doi.org/10.1182/blood-2022-167859

Published: 2022

Journal Articles

Single Cell RNA-Seq Reveals Intra-Tumoral Heterogeneity Relevant to Differentiation States and Outcomes Among Newly Diagnosed Acute Myeloid Leukemia Patients

Bofei Wang, Fatima Zahra Jelloul, Pamella Borges, Poonam Desai, Guilin Tang, Marina Konopleva, Natalia Baran, Michael R Green, Qing Deng, Naval Daver, Andy Futreal, Dapeng Hao, Hussein A Abbas

Blood (2022) 140 (Supplement 1): 6272–6273.

https://doi.org/10.1182/blood-2022-167527

Published: 2022

Journal Articles

Lipophagy As a Mechanism of Resistance in T-ALL Following Energetic Crisis Induced By Oxphos/MCT1 Blockade: Strategies to Eradicate Residual Disease

Natalia Baran, Shraddha Patel, Cassandra L Ramage, Alessia Lodi, Jose Enriquez Ortiz, Yogesh Dhungana, Meghan Collins, Anna Skwarska, Connie Weng, Kala Hayes, Zhihong Zeng, Laurie Cooper, Richard Eric Davis, Gheath Alatrash, Joseph R Marszalek, Jiyang Yu, Pratip K Bhattacharya, Stefano Tiziani, Marina Konopleva

Blood (2022) 140 (Supplement 1): 8831–8832.

https://doi.org/10.1182/blood-2022-170713

Published: 2022

Journal Articles

ERK1/2 Inhibition Overcomes Resistance to Venetoclax in AML By Altering Drp1-Dependent Mitochondrial Fission and Metabolism

Priyanka Sharma, Sujan Piya, Natalia Baran, Anna Zal, Christopher J. Hindley, Kim-Hien Dao, Martin Sims, Tomasz Zal, Vivian Ruvolo, Michael Andreeff, Gautam Borthakur

Blood (2022) 140 (Supplement 1): 8789–8790.

https://doi.org/10.1182/blood-2022-167171

Published: 2022

Journal Articles

Mitochondrial Regulation of Ferroptosis in Acute Myeloid Leukemia

Hiroki Akiyama, Ran Zhao, Yuki Nishida, Natalia Baran, Ziyi Li, Lauren B Ostermann, Po Yee Mak, Edward Ayoub, Sujan Piya, Bing Z Carter, Michael Andreeff, Jo Ishizawa

Blood (2022) 140 (Supplement 1): 8785–8786.

https://doi.org/10.1182/blood-2022-162354

Published: 2022

Journal Articles

Single-Cell Profiling of CD8 Landscape in Treatment Naïve and Relapsed/Refractory AML Patients Reveals Distinct Effector Cellular States Predictive of Outcomes

Poonam Desai, Bofei Wang, Fatima Zahra Jelloul, Gheath Alatrash, Natalia Baran, Qing Deng, Michael R Green, Naval Daver, Marina Konopleva, Andy Futreal, Dapeng Hao, Hussein A Abbas

Blood (2022) 140 (Supplement 1): 9144–9145.

https://doi.org/10.1182/blood-2022-167225

Published: 2022

Journal Articles

Inhibition of ERK1/2 Reverses Venetoclax-Induced Autophagy to Overcome Resistance in Acute Myeloid Leukemia

Priyanka Sharma, Sujan Piya, Natalia Baran, Muharrem Muftuoglu, Mahesh Basyal, Vivian Ruvolo, Christopher J. Hindley, Kim-Hien Dao, Martin Sims, Michael Andreeff, Gautam Borthakur

Blood (2022) 140 (Supplement 1): 3093–3094.

https://doi.org/10.1182/blood-2022-165552

Published: 2022

Journal Articles

DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis

Yanchuan Li, Xiaoping Xie, Zuliang Jie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, Sung Yun Jung, Natalia Baran, Marina Y. Konopleva, Xuhong Cheng, Shao-Cong Sun

Blood (2021) 138 (23): 2360–2371.

https://doi.org/10.1182/blood.2021011247

Published: 2021

Includes: Supplemental data

Journal Articles

Accumulation of Intracellular L-Lactate and Irreversible Disruption of Mitochondrial Membrane Potential upon Dual Inhibition of Oxphos and Lactate Transporter MCT-1 Induce Synthetic Lethality in T-ALL Via Mitochondrial Exhaustion

Natalia Baran, Shraddha Patel, Alessia Lodi, Jose Enriquez Ortiz, Yogesh Dhungana, Meghan Collins, Anna Skwarska, Connie Weng, Cassandra L Ramage, Kala Hayes, Zhihong Zeng, Eric Davis, Gheath Alatrash, Joseph R Marszalek, Jiyang Yu, Pratip K Bhattacharya, Stefano Tiziani, Marina Konopleva

Blood (2021) 138 (Supplement 1): 680.

https://doi.org/10.1182/blood-2021-152845

Published: 2021

Journal Articles

Inhibition of De Novo Pyrimidine Synthesis Depletes Acute Myleogenous Leukemia Stem Cells (LSCs) Burden and Triggers Apoptosis and Differentiation Associated with Oxidative Stress

Sujan Piya, Huaxian Ma, Priyanka Sharma, Kensuke Kojima, Vivian Ruvolo, Mahesh Basyal, Natalia Baran, Marla Weetall, Josephine Sheedy, Balmiki Ray, Michael Andreeff, Gautam Borthakur

Blood (2021) 138 (Supplement 1): 2249.

https://doi.org/10.1182/blood-2021-148136

Published: 2021

Journal Articles

Combination Therapy of FLT3 Tyrosine Kinase Inhibitors and BH3 Mimetics Targeting Antiapoptotic MCL-1 Synergistically Eliminates FLT3-ITD Acute Myeloid Leukemia Cells in Vitro and In Vivo

Blood (2021) 138 (Supplement 1): 2248.

https://doi.org/10.1182/blood-2021-151042

Published: 2021

Journal Articles

ERK1/2 Inhibition Overcomes Resistance in Acute Myeloid Leukemia (AML) and Alters Mitochondrial Dynamics

Priyanka Sharma, Sujan Piya, Huaxian Ma, Natalia Baran, Malgorzata Anna Zal, Christopher J. Hindley, Kim-Hien Dao, Martin Sims, Tomasz Zal, Vivian Ruvolo, Michael Andreeff, Gautam Borthakur

Blood (2021) 138 (Supplement 1): 3338.

https://doi.org/10.1182/blood-2021-151579

Published: 2021

NARROW

ERK1/2 Inhibition Mediates Bax Dependent Proteolysis of OPA1 and Induces Mitochondrial Cristae Remodeling to Overcome Resistance to Venetoclax

Elucidating Transcriptional Heterogeneity in Venetoclax Resistant AMLs

Annamycin, a Non-Cardiotoxic Anthracycline Demonstrates Unique Organotropism and Activity Against Ara-C and Venetoclax Resistant AML

River-81: A Multicenter, Open-Label, Dose-Finding Clinical Trial to Assess Safety, PK, PD, Clinical Efficacy of RVU120 in Combination with Venetoclax in Patients with AML Failing Prior Venetoclax Plus Hypomethylating Agent Therapy

Minimal Residual Disease in Acute Myeloid Leukemia Following Induction Chemotherapy Can be Effectively Eradicated By Targeting Mitochondrial Metabolism

IFNγ Signaling in Acute Myeloid Leukemia Mediates Immunomodulation and Reveals Therapeutic Strategies

ERK1/2 Inhibition Overcomes Resistance to Venetoclax in AML By Inhibiting Drp1 Dependent Mitochondrial Fission

Stem-Cell Enriched Cellular Hierarchy of TP53 Mutant Acute Myeloid Leukemia Is Vulnerable to Targeted Protein Degradation of c-MYC

Mdm2 Loss of Heterozygosity Cooperates with Mutant p53 in the Development of Acute Myeloid Leukemia

Single Cell RNA-Seq Reveals Intra-Tumoral Heterogeneity Relevant to Differentiation States and Outcomes Among Newly Diagnosed Acute Myeloid Leukemia Patients

Lipophagy As a Mechanism of Resistance in T-ALL Following Energetic Crisis Induced By Oxphos/MCT1 Blockade: Strategies to Eradicate Residual Disease

ERK1/2 Inhibition Overcomes Resistance to Venetoclax in AML By Altering Drp1-Dependent Mitochondrial Fission and Metabolism

Mitochondrial Regulation of Ferroptosis in Acute Myeloid Leukemia

Single-Cell Profiling of CD8 Landscape in Treatment Naïve and Relapsed/Refractory AML Patients Reveals Distinct Effector Cellular States Predictive of Outcomes

Inhibition of ERK1/2 Reverses Venetoclax-Induced Autophagy to Overcome Resistance in Acute Myeloid Leukemia

DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis

Accumulation of Intracellular L-Lactate and Irreversible Disruption of Mitochondrial Membrane Potential upon Dual Inhibition of Oxphos and Lactate Transporter MCT-1 Induce Synthetic Lethality in T-ALL Via Mitochondrial Exhaustion

Inhibition of De Novo Pyrimidine Synthesis Depletes Acute Myleogenous Leukemia Stem Cells (LSCs) Burden and Triggers Apoptosis and Differentiation Associated with Oxidative Stress

Combination Therapy of FLT3 Tyrosine Kinase Inhibitors and BH3 Mimetics Targeting Antiapoptotic MCL-1 Synergistically Eliminates FLT3-ITD Acute Myeloid Leukemia Cells in Vitro and In Vivo

ERK1/2 Inhibition Overcomes Resistance in Acute Myeloid Leukemia (AML) and Alters Mitochondrial Dynamics

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American Society of Hematology

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American Society of Hematology

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