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Pratip K Bhattacharya
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Journal Articles

CRISPR-Cas9 screen-driven identification of metabolic vulnerabilities reveals synthetic lethality via synergistic targeting of mitochondrial energy pathways and lactate export in oxphos-dependent T-ALL

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Natalia Baran, Alessia Lodi, Shraddha Patel, Jose Enriquez Ortiz, Meghan Collins, Priyanka Sharma, Vakul Mohanty, Merve Dede, Ivo Veletic, Cassandra L Ramage, Jun Hyoung Park, Yogesh Dhungana, Anna Skwarska, Yu Zhou, Zhihong Zeng, Connie Weng, Kala Hayes, Gheath Alatrash, Kenneth Dunner, Joseph R Marszalek, Gautam Borthakur, Jiyang Yu, Palaniraja Thandapani, Richard Davis, Benny A Kaipparettu, Ken Chen, Pratip K Bhattacharya, Stefano Tiziani, Marina Konopleva
Journal: Blood
Blood (2025) 146 (Supplement 1): 1538.
https://doi.org/10.1182/blood-2025-1538
Published: 2025
Journal Articles

Lipophagy As a Mechanism of Resistance in T-ALL Following Energetic Crisis Induced By Oxphos/MCT1 Blockade: Strategies to Eradicate Residual Disease

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Natalia Baran, Shraddha Patel, Cassandra L Ramage, Alessia Lodi, Jose Enriquez Ortiz, Yogesh Dhungana, Meghan Collins, Anna Skwarska, Connie Weng, Kala Hayes, Zhihong Zeng, Laurie Cooper, Richard Eric Davis, Gheath Alatrash, Joseph R Marszalek, Jiyang Yu, Pratip K Bhattacharya, Stefano Tiziani, Marina Konopleva
Journal: Blood
Blood (2022) 140 (Supplement 1): 8831–8832.
https://doi.org/10.1182/blood-2022-170713
Published: 2022
Journal Articles

Accumulation of Intracellular L-Lactate and Irreversible Disruption of Mitochondrial Membrane Potential upon Dual Inhibition of Oxphos and Lactate Transporter MCT-1 Induce Synthetic Lethality in T-ALL Via Mitochondrial Exhaustion

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Natalia Baran, Shraddha Patel, Alessia Lodi, Jose Enriquez Ortiz, Yogesh Dhungana, Meghan Collins, Anna Skwarska, Connie Weng, Cassandra L Ramage, Kala Hayes, Zhihong Zeng, Eric Davis, Gheath Alatrash, Joseph R Marszalek, Jiyang Yu, Pratip K Bhattacharya, Stefano Tiziani, Marina Konopleva
Journal: Blood
Blood (2021) 138 (Supplement 1): 680.
https://doi.org/10.1182/blood-2021-152845
Published: 2021
Journal Articles

Role of Glutamine in Metabolic and Epigenetic Reprogramming in AML

Free
Juliana Vélez Luján, PhDCandidate, Niki Zacharias, PhD, Dinesh Rakheja, MD, Tushar D Bhagat, PhD, Jaehyuk Lee, PhD, Prasanta Dutta, PhD, Doriann Gonzalez, MDStudent, Michael Andreeff, MD PhD, Pratip K Bhattacharya, PhD, Amit Verma, M.B.,B.S., Marina Konopleva, MD PhD
Journal: Blood
Blood (2015) 126 (23): 2559.
https://doi.org/10.1182/blood.V126.23.2559.2559
Published: 2015