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Josephine Sheedy
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Journal Articles

Inhibition of De Novo Pyrimidine Synthesis Depletes Acute Myleogenous Leukemia Stem Cells (LSCs) Burden and Triggers Apoptosis and Differentiation Associated with Oxidative Stress

Free
Sujan Piya, Huaxian Ma, Priyanka Sharma, Kensuke Kojima, Vivian Ruvolo, Mahesh Basyal, Natalia Baran, Marla Weetall, Josephine Sheedy, Balmiki Ray, Michael Andreeff, Gautam Borthakur
Journal: Blood
Blood (2021) 138 (Supplement 1): 2249.
https://doi.org/10.1182/blood-2021-148136
Published: 2021
Journal Articles

The Novel Dihydroorotate Dehydrogenase (DHODH) Inhibitor PTC299 Inhibit De Novo Pyrimidine Synthesis with Broad Anti-Leukemic Activity Against Acute Myeloid Leukemia

Free
Sujan Piya, PhD, Marla Weetall, PhD, Josephine Sheedy, BS, MSc, Balmiki Ray, PhD, Huaxian Ma, MS, Kensuke Kojima, MD PhD, Vivian Ruvolo, MS, Mahesh Basyal, BS, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD, Gautam Borthakur, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-139940
Published: 2020
Journal Articles

Efficacy of Tubulin Polymerization Inhibitor in Myelodysplastic Syndrome

Free
Cheng Zhong, Kensuke Kayamori, MD PhD, Shuhei Koide, Daisuke Shinoda, MD, Motohiko Oshima, PhD, Yaeko Nakajima-Takagi, PhD, Yurie Nagai, MD, Naoya Mimura, MD PhD, William Lennox, Josephine Sheedy, BS, MSc, Marla Weetall, PhD, Atsushi Iwama, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 35.
https://doi.org/10.1182/blood-2020-134754
Published: 2020
Journal Articles

The Preclinical Activities of PTC596, a Novel Tubulin Binding Agent That Down-Regulates BMI1, Alone and in Combination with Bortezomib in Multiple Myeloma

Free
Yurie Nagai, MD, Naoya Mimura, MD PhD, Ola Rizq, MD PhD, Yusuke Isshiki, MD PhD, Motohiko Oshima, PhD, Mohamed Rizk, BSc, MSc, Atsunori Saraya, Shuhei Koide, PhD, Yaeko Nakajima-Takagi, PhD, Makiko Miyota, Nagisa Oshima-Hasegawa, MD PhD, Shokichi Tsukamoto, MD PhD, Shio Mitsukawa, MD PhD, Yusuke Takeda, MD PhD, Chikako Ohwada, MD PhD, Masahiro Takeuchi, MD PhD, Tohru Iseki, MD PhD, Chiaki Nakaseko, MD PhD, Josephine Sheedy, BS, MSc, Marla Weetall, PhD, Atsushi Iwama, MD PhD, Emiko Sakaida, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4414.
https://doi.org/10.1182/blood-2019-122350
Published: 2019
Journal Articles

Synergistic Effect of DHODH Inhibitor PTC299 with DNA Demethylating Agent Decitabine in Myelodysplastic Syndromes

Free
Kensuke Kayamori, Cheng Zhong, Daisuke Shinoda, MD, Shuhei Koide, PhD, Motohiko Oshima, PhD, Yaeko Nakajima-Takagi, PhD, Naoya Mimura, MD PhD, Ryoji Ito, Kaoru Tohyama, MD PhD, William Lennox, Marla Weetall, PhD, Josephine Sheedy, BS, MSc, Emiko Sakaida, MD PhD, Koutaro Yokote, MD PhD, Atsushi Iwama, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5407.
https://doi.org/10.1182/blood-2019-125200
Published: 2019
Journal Articles

Nonsense Suppression Approaches in Treating Hemophilia

Free
Yi-Lin Liu, Paris Margaritis, Fayaz Khazi, Harre Downey, Stephan Kadauke, Nicole Hasbrouck, Josephine Sheedy, Ellen Welch, Marla Weetall, Katherine A. High, MD
Journal: Blood
Blood (2008) 112 (11): 512.
https://doi.org/10.1182/blood.V112.11.512.512
Published: 2008