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Journal Articles

Akt Inhibition Differently Controls PRC2 Components and Synergizes with Dual EZH2/1 Inhibitor in the Treatment of Multiple Myeloma

Mohamed Rizk, BSc, MSc, Ola Rizq, MD PhD, Motohiko Oshima, PhD, Yaeko Nakajima-Takagi, PhD, Shuhei Koide, PhD, Atsunori Saraya, Yusuke Isshiki, MD PhD, Tetsuhiro Chiba, MD PhD, Satoshi Yamazaki, PhD, Anqi Ma, PhD, Jian Jin, PhD, Atsushi Iwama, MD PhD, Naoya Mimura, MD PhD

Blood (2019) 134 (Supplement_1): 4400.

https://doi.org/10.1182/blood-2019-122157

Published: 2019

Journal Articles

The Preclinical Activities of PTC596, a Novel Tubulin Binding Agent That Down-Regulates BMI1, Alone and in Combination with Bortezomib in Multiple Myeloma

Blood (2019) 134 (Supplement_1): 4414.

https://doi.org/10.1182/blood-2019-122350

Published: 2019

Journal Articles

The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells

Satoru Miyagi, Patrycja Sroczynska, Yuko Kato, Yaeko Nakajima-Takagi, Motohiko Oshima, Ola Rizq, Naoya Takayama, Atsunori Saraya, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Yumi Matsuzaki, Jesper Christensen, Kristian Helin, Atsushi Iwama

Blood (2019) 133 (23): 2495–2506.

https://doi.org/10.1182/blood.2019000468

Published: 2019

Includes: Supplemental data

Journal Articles

Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome

Shiro Tara, Yusuke Isshiki, Yaeko Nakajima-Takagi, Motohiko Oshima, Kazumasa Aoyama, Tomoyuki Tanaka, Daisuke Shinoda, Shuhei Koide, Atsunori Saraya, Satoru Miyagi, Ichiro Manabe, Hirotaka Matsui, Haruhiko Koseki, Vivian J. Bardwell, Atsushi Iwama

Blood (2018) 132 (23): 2470–2483.

https://doi.org/10.1182/blood-2018-01-827964

Published: 2018

Includes: Supplemental data

Journal Articles

Role of KDM2B and Non-Canonical PRC1.1 As a Tumor Suppressor in T-ALL

Yusuke Isshiki, MD, Yaeko Nakajima-Takagi, PhD, Motohiko Oshima, PhD, Kazumasa Aoyama, PhD, Atsunori Saraya, Emiko Sakaida, MD PhD, Chiaki Nakaseko, MD PhD, Koutaro Yokote, MD PhD, Haruhiko Koseki, PhD, Atsushi Iwama, MD PhD

Blood (2018) 132 (Supplement 1): 2597.

https://doi.org/10.1182/blood-2018-99-117831

Published: 2018

Journal Articles

Utx Insufficiency Cooperates with Braf V600E in the Induction of Myeloma in Mice

Ola Rizq, MD PhD, Naoya Mimura, MD PhD, Motohiko Oshima, PhD, Shuji Momose, MD PhD, Yaeko Nakajima-Takagi, PhD, Kazumasa Aoyama, PhD, Atsunori Saraya, Tohru Iseki, MD PhD, Emiko Sakaida, MD PhD, Chiaki Nakaseko, MDPhD, Yutaka Okuno, MD, PhD, Hiroaki Honda, MD PhD, Jun-ichi Tamaru, MDPhD, Atsushi Iwama, MD PhD

Blood (2018) 132 (Supplement 1): 1005.

https://doi.org/10.1182/blood-2018-99-114053

Published: 2018

Journal Articles

Insufficiency of Non-Canonical PRC1 Complex Cooperates with an Activating JAK2 Mutation in the Pathogenesis of Myelofibrosis

Daisuke Shinoda, MD, Yaeko Nakajima-Takagi, PhD, Motohiko Oshima, PhD, Atsunori Saraya, Hironori Harada, MD PhD, Haruhiko Koseki, PhD, Kazuya Shimoda, MD PhD, Goro Sashida, MD PhD, Atsushi Iwama, MD PhD

Blood (2018) 132 (Supplement 1): 100.

https://doi.org/10.1182/blood-2018-99-117741

Published: 2018

Journal Articles

Molecular Mechanism behind the Synergistic Activity of Proteasome Inhibition and PRC2 Inhibition in the Treatment of Multiple Myeloma

Ola Rizq, MD, Naoya Mimura, MD PhD, Motohiko Oshima, PhD, Atsunori Saraya, Shuhei Koide, PhD, Yuko Kato, PhD, Kazumasa Aoyama, PhD, Yaeko Nakajima-Takagi, PhD, Changshan Wang, PhD, Anqi Ma, Jian Jin, PhD, Tohru Iseki, MD PhD, Chiaki Nakaseko, MD, PhD, Atsushi Iwama, MD PhD

Blood (2016) 128 (22): 312.

https://doi.org/10.1182/blood.V128.22.312.312

Published: 2016

Journal Articles

Distinctive Genetic Features of Plasma Cells in POEMS Syndrome

Blood (2016) 128 (22): 4404.

https://doi.org/10.1182/blood.V128.22.4404.4404

Published: 2016

Journal Articles

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes

Shuhei Koide, Motohiko Oshima, Keiyo Takubo, Satoshi Yamazaki, Eriko Nitta, Atsunori Saraya, Kazumasa Aoyama, Yuko Kato, Satoru Miyagi, Yaeko Nakajima-Takagi, Tetsuhiro Chiba, Hirotaka Matsui, Fumio Arai, Yutaka Suzuki, Hiroshi Kimura, Hiromitsu Nakauchi, Toshio Suda, Yoichi Shinkai, Atsushi Iwama

Blood (2016) 128 (5): 638–649.

https://doi.org/10.1182/blood-2016-01-694810

Published: 2016

Includes: Supplemental data

Journal Articles

Combinatorial Epigenetic Aberration Propagates in Myelodysplastic Syndrome in the Setting of Concurrent Loss of Tet2 and Ezh2

Nagisa Hasegawa, MD, Goro Sashida, MD PhD, Motohiko Oshima, PhD, Hirotaka Matsui, MD PhD, Atsunori Saraya, Changshan Wang, PhD, Tomoya Muto, MD PhD, Chiaki Nakaseko, MD PhD, Koutaro Yokote, MD PhD, Atsushi Iwama, MD PhD

Blood (2015) 126 (23): 712.

https://doi.org/10.1182/blood.V126.23.712.712

Published: 2015

Journal Articles

Role of the Polycomb Gene Bcor in Hematopoiesis

Tomoyuki Tanaka, MD, Yaeko Nakajima-Takagi, PhD, Sha Si, Atsunori Saraya, MS, Sone Hirohito, MDPhD, Haruhiko Koseki, MD PhD, Atsushi Iwama, MD, PhD

Blood (2014) 124 (21): 4312.

https://doi.org/10.1182/blood.V124.21.4312.4312

Published: 2014

Journal Articles

Histone Acetylation Mediated by Brd1 Is Crucial for Cd8 Gene Activation during Early Thymocyte Development

Yuta Mishima, PhD, Changshan Wang, PhD, Satoru Miyagi, PhD, Atsunori Saraya, MS, Hiroyuki Hosokawa, PhD, Naoto Yamaguchi, PhD, Toshinori Nakayama, MD PhD, Haruhiko Koseki, MD PhD, Ichiro Taniuchi, MD PhD, Atsushi Iwama, MD PhD

Blood (2014) 124 (21): 1576.

https://doi.org/10.1182/blood.V124.21.1576.1576

Published: 2014

Journal Articles

Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia

Changshan Wang, Goro Sashida, Atsunori Saraya, Reiko Ishiga, Shuhei Koide, Motohiko Oshima, Kyoichi Isono, Haruhiko Koseki, Atsushi Iwama

Blood (2014) 123 (21): 3336–3343.

https://doi.org/10.1182/blood-2013-12-544544

Published: 2014

Includes: Supplemental data

Journal Articles

Concurrent Loss Of Ezh2 and Tet2 Cooperates In The Pathogenesis Of Myelodysplastic Disorders,

Tomoya Muto, MD, PhD, Goro Sashida, MD, PhD, Motohiko Oshima, PhD, George R Wendt, Makiko Mochizuki-Kashio, PhD, Masashi Sanada, MD, Satoru Miyagi, PhD., Atsunori Saraya, MS, Chiaki Nakaseko, M.D., Ph.D., Koutaro Yokote, MD, PhD, Kazuya Shimoda, MD, PhD, Haruhiko Koseki, MD, PhD, Yutaka Suzuki, PhD, Sumio Sugano, PhD, Seishi Ogawa, MD, PhD, Atsushi Iwama, MD, PhD

Blood (2013) 122 (21): 480.

https://doi.org/10.1182/blood.V122.21.480.480

Published: 2013

Journal Articles

Loss of Ezh2 Promotes the Development of Mutant-RUNX1 Induced MDS

Goro Sashida, MD, PhD, Satomi Tanaka, MD, Makiko Mochizuki-Kashio, PhD, Atsunori Saraya, MS, Tomoya Muto, MD, Atsushi Iwama, MD, PhD

Blood (2012) 120 (21): 402.

https://doi.org/10.1182/blood.V120.21.402.402

Published: 2012

Journal Articles

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells

Makiko Mochizuki-Kashio, Yuta Mishima, Satoru Miyagi, Masamitsu Negishi, Atsunori Saraya, Takaaki Konuma, Jun Shinga, Haruhiko Koseki, Atsushi Iwama

Blood (2011) 118 (25): 6553–6561.

https://doi.org/10.1182/blood-2011-03-340554

Published: 2011

Includes: Supplemental data

Journal Articles

The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis

Yuta Mishima, Satoru Miyagi, Atsunori Saraya, Masamitsu Negishi, Mitsuhiro Endoh, Takaho A. Endo, Tetsuro Toyoda, Jun Shinga, Takuo Katsumoto, Tetsuhiro Chiba, Naoto Yamaguchi, Issay Kitabayashi, Haruhiko Koseki, Atsushi Iwama

Blood (2011) 118 (9): 2443–2453.

https://doi.org/10.1182/blood-2011-01-331892

Published: 2011

Includes: Supplemental data

Journal Articles

The Hbo1-Brd1/Brpf2 HAT Complex Is Required for Erythropoiesis In Fetal Liver

Yuta Mishima, Satoru Miyagi, Atsunori Saraya, Masamitsu Negishi, Mitsuhiro Endoh, Naoto Yamaguchi, Issay Kitabayashi, Haruhiko Koseki, Atsushi Iwama

Blood (2010) 116 (21): 3872.

https://doi.org/10.1182/blood.V116.21.3872.3872

Published: 2010

Journal Articles

Direct Activation of STAT5 by TEL-Lyn Fusion Protein Promotes Induction of Myeloproliferative Neoplasms with Myelofibrosis

Yusuke Takeda, M.D., PhD., Chiaki Nakaseko, M.D., PhD., Hiroaki Tanaka, M.D., PhD., Masahiro Takeuchi, M.D., PhD., Makiko Yui, Atsunori Saraya, Satoru Miyagi, PhD., Chikako Ohwada, M.D., PhD., Emiko Sakaida, M.D., PhD., Koutaro Yokote, M.D., PhD., Atsushi Iwama, M.D., PhD.

Blood (2010) 116 (21): 4114.

https://doi.org/10.1182/blood.V116.21.4114.4114

Published: 2010

NARROW

Akt Inhibition Differently Controls PRC2 Components and Synergizes with Dual EZH2/1 Inhibitor in the Treatment of Multiple Myeloma

The Preclinical Activities of PTC596, a Novel Tubulin Binding Agent That Down-Regulates BMI1, Alone and in Combination with Bortezomib in Multiple Myeloma

The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells

Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome

Role of KDM2B and Non-Canonical PRC1.1 As a Tumor Suppressor in T-ALL

Utx Insufficiency Cooperates with Braf V600E in the Induction of Myeloma in Mice

Insufficiency of Non-Canonical PRC1 Complex Cooperates with an Activating JAK2 Mutation in the Pathogenesis of Myelofibrosis

Molecular Mechanism behind the Synergistic Activity of Proteasome Inhibition and PRC2 Inhibition in the Treatment of Multiple Myeloma

Distinctive Genetic Features of Plasma Cells in POEMS Syndrome

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes

Combinatorial Epigenetic Aberration Propagates in Myelodysplastic Syndrome in the Setting of Concurrent Loss of Tet2 and Ezh2

Role of the Polycomb Gene Bcor in Hematopoiesis

Histone Acetylation Mediated by Brd1 Is Crucial for Cd8 Gene Activation during Early Thymocyte Development

Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia

Concurrent Loss Of Ezh2 and Tet2 Cooperates In The Pathogenesis Of Myelodysplastic Disorders,

Loss of Ezh2 Promotes the Development of Mutant-RUNX1 Induced MDS

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells

The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis

The Hbo1-Brd1/Brpf2 HAT Complex Is Required for Erythropoiesis In Fetal Liver

Direct Activation of STAT5 by TEL-Lyn Fusion Protein Promotes Induction of Myeloproliferative Neoplasms with Myelofibrosis

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American Society of Hematology

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American Society of Hematology

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