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Journal Articles

Chromatin Modifier Hmga1 Maintains Hematopoietic Stem Cell Integrity in Stress Conditions

Jie Bai, Supannika Sorin, Arusyak Ivanyan, Mihoko Iimori, Ai Hamashima, Gang Huang, Kimi Araki, Goro Sashida

Blood (2024) 144 (Supplement 1): 26.

https://doi.org/10.1182/blood-2024-212002

Published: 2024

Journal Articles

Late B Cell-Specific Dis3-Knockout Mice Do Not Develop Plasma Cell Neoplasm

Hiroto Ohguchi, Yasuyo Ohguchi, Sho Kubota, Takako Yokomizo-Nakano, Ai Hamashima, Kimi Araki, Goro Sashida

Blood (2023) 142 (Supplement 1): 4658.

https://doi.org/10.1182/blood-2023-173003

Published: 2023

Journal Articles

Trisomy 8 Remodels Chromatin and Activates Transcription of Runx1-Target Genes in Hematopoietic Stem Cell

Jie Bai, Kimi Araki, Yasuhiro Kazuki, Sho Kubota, Kenta Kikuchi, Ai Hamashima, Mihoko Iimori, Supannika Sorin, Minetaro Ogawa, Daisuke Kurotaki, Mitsuo Oshimura, Goro Sashida

Blood (2023) 142 (Supplement 1): 951.

https://doi.org/10.1182/blood-2023-179728

Published: 2023

Journal Articles

TIF1β Enhances Self-Renewal Capacity of BCR-ABL Leukemic Stem Cells and Inhibits the Myeloid Differentiation

Mariko Morii, Sho Kubota, Mihoko Iimori, Ai Hamashima, Kimi Araki, Goro Sashida

Blood (2022) 140 (Supplement 1): 93–94.

https://doi.org/10.1182/blood-2022-165638

Published: 2022

Journal Articles

HMGA2 Maintains Hematopoietic Stem Cell Via Pleiotropic Regulation of the Transcription in Stress Conditions

Sho Kubota, Yuqi Sun, Jie Bai, Takako Yokomizo-Nakano, Mariko Morii, Takako Ideue, Motomi Osato, Terumasa Umemoto, Kimi Araki, Goro Sashida

Blood (2021) 138 (Supplement 1): 3262.

https://doi.org/10.1182/blood-2021-152472

Published: 2021

Journal Articles

Calreticulin haploinsufficiency augments stem cell activity and is required for onset of myeloproliferative neoplasms in mice

Kotaro Shide, Takuro Kameda, Ayako Kamiunten, Yoshinori Ozono, Yuki Tahira, Takako Yokomizo-Nakano, Sho Kubota, Masaya Ono, Kazuhiko Ikeda, Masaaki Sekine, Keiichi Akizuki, Kenichi Nakamura, Tomonori Hidaka, Yoko Kubuki, Hisayoshi Iwakiri, Satoru Hasuike, Kenji Nagata, Goro Sashida, Kazuya Shimoda

Blood (2020) 136 (1): 106–118.

https://doi.org/10.1182/blood.2019003358

Published: 2020

Includes: Supplemental data

Journal Articles

The Role of Calreticulin in Normal Hematopoiesis and Neoplastic Hematopoiesis of Myeloproliferative Neoplasms

Kotaro Shide, MD PhD, Takuro Kameda, MD PhD, Ayako Kamiunten, MD, Yoshinori Ozono, MD, Yuki Tahira, MD, Masaaki Sekine, MD, Masaya Ono, MD PhD, Takako Yokomizo, PhD, Sho Kubota, Keiichi Akizuki, MD, Yoko Kubuki, MD PhD, Tomonori Hidaka, MD, Goro Sashida, MD PhD, Kazuya Shimoda, MD PhD

Blood (2019) 134 (Supplement_1): 309.

https://doi.org/10.1182/blood-2019-130034

Published: 2019

Journal Articles

Hmga2 Functions As an Oncogene upon the Deletion of Tet2 and Promotes the Pathogenesis of Myelodysplastic Syndrome

Jie Bai, Sho Kubota, PhD, Takako Yokomizo, PhD, Akinori Kanai, PhD, Yuqi Sun, MD, Mihoko Iimori, CLS, Hironori Harada, MD PhD, Naomi Nakagata, PhD, Atsushi Iwama, MD PhD, Goro Sashida, MD PhD

Blood (2019) 134 (Supplement_1): 3782.

https://doi.org/10.1182/blood-2019-127583

Published: 2019

Journal Articles

Haploinsufficiency of CALR Confers Hematopoietic Stem Cells (HSCs) with a Clonal Advantage over Wild-Type Cells, and, in Setting of Myeloproliferative Neoplasms, Compensates for the Functions of HSCs Impaired By the Calr Mutation

Kotaro Shide, MD PhD, Takuro Kameda, MD, Ayako Kamiunten, MD, Masaaki Sekine, MD, Yoshinori Ozono, MD, Takako Yokomizo, PhD, Keiichi Akizuki, MD, Yuki Tahira, MD, Yoko Kubuki, MD PhD, Tomonori Hidaka, MD, Goro Sashida, MD PhD, Kazuya Shimoda, MD PhD

Blood (2018) 132 (Supplement 1): 97.

https://doi.org/10.1182/blood-2018-99-114304

Published: 2018

Journal Articles

Insufficiency of Non-Canonical PRC1 Complex Cooperates with an Activating JAK2 Mutation in the Pathogenesis of Myelofibrosis

Daisuke Shinoda, MD, Yaeko Nakajima-Takagi, PhD, Motohiko Oshima, PhD, Atsunori Saraya, Hironori Harada, MD PhD, Haruhiko Koseki, PhD, Kazuya Shimoda, MD PhD, Goro Sashida, MD PhD, Atsushi Iwama, MD PhD

Blood (2018) 132 (Supplement 1): 100.

https://doi.org/10.1182/blood-2018-99-117741

Published: 2018

Journal Articles

Lineage-Specific RUNX2 Super-Enhancer Activates MYC Via Translocation (6;8) to Promote the Development of Blastic Plasmacytoid Dendritic Cell Neoplasm

Sho Kubota, PhD, Kenji Tokunaga, MD, Tomohiro Umezu, PhD, Takako Yokomizo, PhD, Motohiko Oshima, PhD, Eisaku Iwanaga, MD PhD, Norio Asou, MDPhD, Atsushi Iwama, MD PhD, Kazuma Ohyashiki, MD PhD, Motomi Osato, MD, PhD, Goro Sashida, MD PhD

Blood (2018) 132 (Supplement 1): 761.

https://doi.org/10.1182/blood-2018-99-110333

Published: 2018

Journal Articles

RUNX3 Promotes the Development of MDS/MPN Overlap Syndrome Via Enhancing Expression of Myc in the Absence of Tet2

Takako Yokomizo, PhD, Daiki Tanaka, Sho Kubota, PhD, Motohiko Oshima, PhD, Yuka Harada, MD PhD, Akinori Kanai, PhD, Atsushi Iwama, MD PhD, Hironori Harada, Motomi Osato, MD PhD, Goro Sashida, MD PhD

Blood (2017) 130 (Supplement 1): 2494.

https://doi.org/10.1182/blood.V130.Suppl_1.2494.2494

Published: 2017

Journal Articles

Role of the Polycomb Methyltransferase Ezh1 in Myelodysplastic Syndrome Induced By Ezh2 Insufficiency

Kazumasa Aoyama, PhD, Makiko Mochizuki-Kashio, PhD, Motohiko Oshima, PhD, Shuhei Koide, PhD, Yaeko Nakajima-Takagi, PhD, Mitsutaka Maeda, Goro Sashida, MD PhD, Atsushi Iwama, MD PhD

Blood (2016) 128 (22): 1968.

https://doi.org/10.1182/blood.V128.22.1968.1968

Published: 2016

Journal Articles

Combinatorial Epigenetic Aberration Propagates in Myelodysplastic Syndrome in the Setting of Concurrent Loss of Tet2 and Ezh2

Nagisa Hasegawa, MD, Goro Sashida, MD PhD, Motohiko Oshima, PhD, Hirotaka Matsui, MD PhD, Atsunori Saraya, Changshan Wang, PhD, Tomoya Muto, MD PhD, Chiaki Nakaseko, MD PhD, Koutaro Yokote, MD PhD, Atsushi Iwama, MD PhD

Blood (2015) 126 (23): 712.

https://doi.org/10.1182/blood.V126.23.712.712

Published: 2015

Journal Articles

HIF-1a Pathway, As a Signal Funnel for Genetic, Epigenetic, and Metabolic Aberrations, Is Sufficient and Essential for MDS Development

Blood (2015) 126 (23): 303.

https://doi.org/10.1182/blood.V126.23.303.303

Published: 2015

Journal Articles

Ezh2 Loss Promotes the Transformation of Early T Cell Precursor Leukemia Via Suppressing Critical Genes for T-Cell Differentiation

Goro Sashida, MD PhD, Changshan Wang, MD PhD, Daisuke Sato, MS, Motohiko Oshima, PhD, Atsushi Iwama, MD PhD

Blood (2015) 126 (23): 308.

https://doi.org/10.1182/blood.V126.23.308.308

Published: 2015

Journal Articles

Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner

Makiko Mochizuki-Kashio, Kazumasa Aoyama, Goro Sashida, Motohiko Oshima, Takahisa Tomioka, Tomoya Muto, Changshan Wang, Atsushi Iwama

Blood (2015) 126 (10): 1172–1183.

https://doi.org/10.1182/blood-2015-03-634428

Published: 2015

Includes: Supplemental data

Journal Articles

Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator

Blood (2015) 125 (2): 304–315.

https://doi.org/10.1182/blood-2014-04-555508

Published: 2015

Includes: Supplemental data

Journal Articles

The Biological Function of DNA Hypermethylation in Murine MDS Model Lacking Tet2 and Ezh2

Nagisa Hasegawa, MD, Goro Sashida, MD PhD, Motohiko Oshima, PhD, Hirotaka Matsui, MD PhD, Changshan Wang, PhD, Tomoya Muto, MD PhD, Chiaki Nakaseko, MD PhD, Kotaro Yokote, MD PhD, Atsushi Iwama, MD PhD

Blood (2014) 124 (21): 4596.

https://doi.org/10.1182/blood.V124.21.4596.4596

Published: 2014

Journal Articles

Novel Myelodysplastic Syndromes-like Mouse Models By Cooperating Genetic/Epigenetic Mutations Reveal the Critical Role of HIF-1α for Disease Development

Yoshihiro Hayashi, MD PhD, Yue Zhang, MD, Xiaomei Yan, MD PhD, Goro Sashida, MD PhD, Zefeng Xu, MD, Yunzhu Dong, Hironori Harada, MD PhD, Zhijian Xiao, MD, Gang Huang, PhD

Blood (2014) 124 (21): 362.

https://doi.org/10.1182/blood.V124.21.362.362

Published: 2014

NARROW

Chromatin Modifier Hmga1 Maintains Hematopoietic Stem Cell Integrity in Stress Conditions

Late B Cell-Specific Dis3-Knockout Mice Do Not Develop Plasma Cell Neoplasm

Trisomy 8 Remodels Chromatin and Activates Transcription of Runx1-Target Genes in Hematopoietic Stem Cell

TIF1β Enhances Self-Renewal Capacity of BCR-ABL Leukemic Stem Cells and Inhibits the Myeloid Differentiation

HMGA2 Maintains Hematopoietic Stem Cell Via Pleiotropic Regulation of the Transcription in Stress Conditions

Calreticulin haploinsufficiency augments stem cell activity and is required for onset of myeloproliferative neoplasms in mice

The Role of Calreticulin in Normal Hematopoiesis and Neoplastic Hematopoiesis of Myeloproliferative Neoplasms

Hmga2 Functions As an Oncogene upon the Deletion of Tet2 and Promotes the Pathogenesis of Myelodysplastic Syndrome

Haploinsufficiency of CALR Confers Hematopoietic Stem Cells (HSCs) with a Clonal Advantage over Wild-Type Cells, and, in Setting of Myeloproliferative Neoplasms, Compensates for the Functions of HSCs Impaired By the Calr Mutation

Insufficiency of Non-Canonical PRC1 Complex Cooperates with an Activating JAK2 Mutation in the Pathogenesis of Myelofibrosis

Lineage-Specific RUNX2 Super-Enhancer Activates MYC Via Translocation (6;8) to Promote the Development of Blastic Plasmacytoid Dendritic Cell Neoplasm

RUNX3 Promotes the Development of MDS/MPN Overlap Syndrome Via Enhancing Expression of Myc in the Absence of Tet2

Role of the Polycomb Methyltransferase Ezh1 in Myelodysplastic Syndrome Induced By Ezh2 Insufficiency

Combinatorial Epigenetic Aberration Propagates in Myelodysplastic Syndrome in the Setting of Concurrent Loss of Tet2 and Ezh2

HIF-1a Pathway, As a Signal Funnel for Genetic, Epigenetic, and Metabolic Aberrations, Is Sufficient and Essential for MDS Development

Ezh2 Loss Promotes the Transformation of Early T Cell Precursor Leukemia Via Suppressing Critical Genes for T-Cell Differentiation

Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner

Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator

The Biological Function of DNA Hypermethylation in Murine MDS Model Lacking Tet2 and Ezh2

Novel Myelodysplastic Syndromes-like Mouse Models By Cooperating Genetic/Epigenetic Mutations Reveal the Critical Role of HIF-1α for Disease Development

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American Society of Hematology

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ASH Publications

American Society of Hematology

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