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Journal Articles

iPSC-Derived Mesenchymal Stem Cells Supports the Ex Vivo expansion of Human Hematopoietic Stem and Progenitor Cells Via Sterile Inflammation Pathway

Maria Alejandra Kanashiro, Sudip Kumar Paul, Masamitsu Sone, Ikuyo Yoshino, Kyoko Tsujimura, Makoto Ikeya, Sou Nakamura, Koji Eto, Naoya Takayama
Journal: Blood
Blood (2023) 142 (Supplement 1): 2680.
https://doi.org/10.1182/blood-2023-181378
Published: 2023
Journal Articles

Transposable Elements Are Differentially Expressed in MDS Stem Cells in a Disease-Stage-Specific Manner

Shuhei Kurosawa, Motohiko Oshima, Yaeko Nakajima-Takagi, Naoya Takayama, Daisuke Shinoda, Satoshi Kaito, Takahiro Kamiya, Yuta Yamada, Shohei Andoh, Kensuke Kayamori, Emiko Sakaida, Eriko Sato, Nozomi Yusa, Kazuaki Yokoyama, Yasuhito Nannya, Arinobu Tojo, Seiya Imoto, Bahityar Rahmutulla, Atsushi Kaneda, Kiyoshi Yamaguchi, Yoichi Furukawa, Noriko Doki, Kei Nishikawa, Ye Ding, Tomohiro Myojo, Yuka Harada, Hironori Harada, Atsushi Iwama
Journal: Blood
Blood (2023) 142 (Supplement 1): 6458.
https://doi.org/10.1182/blood-2023-172607
Published: 2023
Journal Articles

Disease Model of Atherosclerosis Using Werner Syndrome Patient-Derived Induced Pluripotent Stem Cells Reveals Excessive Inflammatory Response Against Ox-LDL

Sudip Kumar Paul, MSc, Masamitsu Sone, PhD, Hisaya Kato, MD PhD, Yoshiro Maezawa, MD PhD, Yasuo Ouchi, PhD, Koutaro Yokote, MD PhD, Koji Eto, MD, Naoya Takayama, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3615.
https://doi.org/10.1182/blood-2019-123919
Published: 2019
Journal Articles

The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells

Satoru Miyagi, Patrycja Sroczynska, Yuko Kato, Yaeko Nakajima-Takagi, Motohiko Oshima, Ola Rizq, Naoya Takayama, Atsunori Saraya, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Yumi Matsuzaki, Jesper Christensen, Kristian Helin, Atsushi Iwama
Journal: Blood
Blood (2019) 133 (23): 2495–2506.
https://doi.org/10.1182/blood.2019000468
Published: 2019
Includes: Supplemental data
Journal Articles

Identification of Gene Regulatory Networks Governing Stemness Properties of Human HSC and LSC

Stanley W.K. Ng, Stephanie Zhi-Juan Xie, PhD, Elvin Wagenblast, PhD, Naoya Takayama, MD PhD, Liqing Jin, MD, Nathan Mbong, Alex Murison, Schoof E Erwin, Amanda Mitchell, PhD, Peter Van Galen, PhD, Mathieu Lupien, PhD, Mark D. Minden, MD PhD, Jean C.Y. Wang, MD PhD, Peter W. Zandstra, PhD, John E. Dick
Journal: Blood
Blood (2018) 132 (Supplement 1): 3832.
https://doi.org/10.1182/blood-2018-99-114314
Published: 2018
Journal Articles

Anagrelide Inhibits Proliferation and Platelet Generation in Immortalized Megakaryocyte Progenitor Cell Lines Established from Human Induced Pluripotent Stem Cells

Koji Takaishi, MD, Masahiro Takeuchi, MD PhD, Shokichi Tsukamoto, MD PhD, Naoya Takayama, MD PhD, Motohiko Oshima, PhD, Yusuke Isshiki, MD, Kensuke Kayamori, MD, Kenji Kimura, MD, Yutaro Hino, MD, Nagisa Oshima-Hasegawa, MD PhD, Shio Mitsukawa, MD PhD, Yusuke Takeda, MD PhD, Naoya Mimura, MD PhD, Chikako Ohwada, MD PhD, Tohru Iseki, MD PhD, Sou Nakamura, PhD, Koji Eto, MD PhD, Atsushi Iwama, MD PhD, Koutaro Yokote, MD PhD, Chiaki Nakaseko, MDPhD, Emiko Sakaida, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1789.
https://doi.org/10.1182/blood-2018-99-111683
Published: 2018
Journal Articles

Sphingolipid Perturbation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal

Stephanie Zhi-Juan Xie, PhD, Laura Garcia Prat, Veronique Voisin, PhD, Alex Murison, Olga I. Gan, Robin Ferrari, Naoya Takayama, MD PhD, Kerstin B. Kaufmann, PhD, Ishita Patel, Esther Lee, Gareth Holmes, Tiago Medina, PhD, Aditi Vedi, Chiara Luberto, PhD, Gary D Bader, Elisa Laurenti, PhD, Mathieu Lupien, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 170.
https://doi.org/10.1182/blood-2018-170
Published: 2018
Journal Articles

A Cluster of Enhancer Modules Directs Differential Myc Expression Along the Normal and Leukemic Hematopoietic Stem Cell Hierarchies

Carsten Bahr, MSc, Lisa von Paleske, PhD, Veli Vural Uslu, PhD, Silvia Remeseiro, PhD, Naoya Takayama, MD PhD, Stanley W.K. Ng, Alex Murison, PhD, Katja Langenfeld, Massimo Petretich, PhD, Roberta Scognamiglio, PhD, Petra Zeisberger, Amelie Benk, PhD, Ido Amit, PhD, Peter W. Zandstra, PhD, John E. Dick, PhD, Mathieu Lupien, PhD, Andreas Trumpp, Prof, PhD, Francois Spitz, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1150.
https://doi.org/10.1182/blood.V130.Suppl_1.1150.1150
Published: 2017
Journal Articles

Sphingolipids Regulate Myeloid-Erythroid Fate Determination in Human Hematopoiesis

Stephanie Zhi-Juan Xie, PhD, Kerstin Kaufmann, Olga I Gan, PhD, Sasan Zandi, MD PhD, Naoya Takayama, John E. Dick, PhD
Journal: Blood
Blood (2016) 128 (22): 3865.
https://doi.org/10.1182/blood.V128.22.3865.3865
Published: 2016
Journal Articles

Chromatin Accessibility Identifies CTCF As a Gatekeeper of Stemness Functions in Human Hematopoietic Development

Naoya Takayama, MD PhD, Alex Murison, PhD, Shin-ichiro Takayanagi, PhD, Sasan Zandi, MD PhD, Nadia Penrod, PhD, Amanda Mitchel, James A. Kennedy, MD PhD, Stanley W.K. Ng, MSc, Stephanie Zhi-Juan Xie, PhD, Mark D. Minden, MD PhD, John E. Dick, PhD, Mathieu Lupien, PhD
Journal: Blood
Blood (2016) 128 (22): 3873.
https://doi.org/10.1182/blood.V128.22.3873.3873
Published: 2016
Journal Articles

The Human Blood Hierarchy Is Shaped By Distinct Progenitor Lineages Across Development

Sasan Zandi, MDPhD, Faiyaz Notta, John E. Dick, PhD, Naoya Takayama, Stephanie M Dobson, MSc, Olga I Gan, PhD, Gavin Wilson, Kerstin Kaufmann, Jessica McLeod, Elisa Laurenti, PhD, Cyrille Dunant, Mcpherson John, Lincoln Stein, Yigal Dror, MD FRCP(C)
Journal: Blood
Blood (2015) 126 (23): 2360.
https://doi.org/10.1182/blood.V126.23.2360.2360
Published: 2015
Journal Articles

Distinct Regulatory Networks Govern Human Hematopoietic Stem Cell Across Development

Sasan Zandi, MDPhD, John E. Dick, PhD, Faiyaz Notta, Naoya Takayama
Journal: Blood
Blood (2015) 126 (23): 2375.
https://doi.org/10.1182/blood.V126.23.2375.2375
Published: 2015
Journal Articles

Disease-Specific Induced Pluripotent Stem Cells Recapitulate The Pathophysiology Of Familial Platelet Disorder With Predisposition To Acute Myelogenous Leukemia

Shunya Arai, MD, PhD, Hiromitsu Iiduka, MD, Naoya Takayama, M.D., Ph.D., Miyauchi Masashi, MD, Kazuki Taoka, MD, PhD, Keisuke Kataoka, MD, PhD, Masataka Hosoi, MD, PhD, Keiki Kumano, MD, PhD, Koji Eto, M.D., Ph.D., Mineo Kurokawa, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1188.
https://doi.org/10.1182/blood.V122.21.1188.1188
Published: 2013
Journal Articles

Role of SOX17 in hematopoietic development from human embryonic stem cells

Yaeko Nakajima-Takagi, Mitsujiro Osawa, Motohiko Oshima, Haruna Takagi, Satoru Miyagi, Mitsuhiro Endoh, Takaho A. Endo, Naoya Takayama, Koji Eto, Tetsuro Toyoda, Haruhiko Koseki, Hiromitsu Nakauchi, Atsushi Iwama
Journal: Blood
Blood (2013) 121 (3): 447–458.
https://doi.org/10.1182/blood-2012-05-431403
Published: 2013
Includes: Supplemental data
Journal Articles

Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples

Keiki Kumano, Shunya Arai, Masataka Hosoi, Kazuki Taoka, Naoya Takayama, Makoto Otsu, Genta Nagae, Koki Ueda, Kumi Nakazaki, Yasuhiko Kamikubo, Koji Eto, Hiroyuki Aburatani, Hiromitsu Nakauchi, Mineo Kurokawa
Journal: Blood
Blood (2012) 119 (26): 6234–6242.
https://doi.org/10.1182/blood-2011-07-367441
Published: 2012
Includes: Supplemental data
Journal Articles

In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling

e-blood
Satoshi Nishimura, Ichiro Manabe, Mika Nagasaki, Shigeru Kakuta, Yoichiro Iwakura, Naoya Takayama, Jun Ooehara, Makoto Otsu, Akihide Kamiya, Brian G. Petrich, Tetsumei Urano, Takafumi Kadono, Shinichi Sato, Atsu Aiba, Hiroshi Yamashita, Seiryo Sugiura, Takashi Kadowaki, Hiromitsu Nakauchi, Koji Eto, Ryozo Nagai
Journal: Blood
Blood (2012) 119 (8): e45–e56.
https://doi.org/10.1182/blood-2011-09-381400
Published: 2012
Includes: Multimedia, Supplemental data
Journal Articles

Platelet Production System Using An Immortalized Megakaryocyte Cell Line Derived From Human Pluripotent Stem Cells

Sou Nakamura, Naoya Takayama, M.D., Ph.D., Hiromitsu Nakauchi, MD, PhD, Koji Eto, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 2.
https://doi.org/10.1182/blood.V118.21.2.2
Published: 2011
Journal Articles

Platelet Production System Using An Immortalized Megakaryocyte Cell Line Derived From Human Pluripotent Stem Cells

Sou Nakamura, Naoya Takayama, M.D., Ph.D., Hiromitsu Nakauchi, MD, PhD, Koji Eto, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): MRG-1.
https://doi.org/10.1182/blood.V118.21.MRG-1.MRG-1
Published: 2011
Journal Articles

Direct and Continuous Inhibition of ADAM17 Using a Novel Selective Inhibitor Restores Functional Platelet Yield From Human Pluripotent Stem Cells

Shinji Hirata, Ryoko Jono-Ohnishi, Satoshi Nishimura, M.D., Ph.D, Naoya Takayama, M.D., Ph.D., Sou Nakamura, Hiromitsu Nakauchi, MD, PhD, Takahiko Murata, Ph.D., Koji Eto, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 2323.
https://doi.org/10.1182/blood.V118.21.2323.2323
Published: 2011
Journal Articles

Stepwise Signaling and Low Oxygen Promote Hematopoietic Progenitor Emergence From Human Pluripotent Stem Cells

Hiroshi Endo, M.D., Naoya Takayama, M.D., Ph.D., Tomo Koike, Hiromitsu Nakauchi, MD, PhD, Koji Eto, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 1317.
https://doi.org/10.1182/blood.V118.21.1317.1317
Published: 2011