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Olga I. Gan
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Journal Articles

KDM6 Demethylases Integrate DNA Repair Gene Regulation: Loss of KDM6A Sensitizes AML to PARP Inhibition and Potentiates with BCL2 Blockade

Liberalis Debraj Boila, Liqing Jin, Alex Murison, Subham K. Bandyopadhyay, Subhadeep Ghosh, Siva Sai Naga Anurag Muddineni, Andy G.X. Zeng, Sayantani Sinha, Shankha Subhra Chatterjee, Mayukh Biswas, Nathan Mbong, Olga I. Gan, Andrea Arruda, Wasim Shaikh, Anwesha Bose, Satyaki Bhowmik, Sayan Chakraborty, James A. Kennedy, Amanda Mitchell, Eric R. Lechman, Debasis Banerjee, Michael Milyavsky, Mark D. Minden, John E. Dick, Amitava Sengupta
Journal: Blood
Blood (2021) 138 (Supplement 1): 25.
https://doi.org/10.1182/blood-2021-145491
Published: 2021
Journal Articles

Mir-125b Regulates the Self-Renewal of Acute Myeloid Leukemia Stem Cells through PTPN18 and GSK3

Qiang Liu, PhD BSc, Olga I. Gan, PhD, Gabriela Krivdova, BSc, Aaron Trotman-Grant, Stephanie M. Dobson, PhD, Karin G. Hermans, Mark D. Minden, Shai Izraeli, MD, John E. Dick, PhD FRS, Jean C.Y. Wang, MD PhD, Eric R. Lechman,, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-141733
Published: 2020
Journal Articles

Functional Investigation of the Argonaute Proteins in Human Hematopoietic Stem and Progenitor Cells

Gordon G. L. Wong, BS, Gabriela Krivdova, BSc, Olga I. Gan, PhD, Jessica L. McLeod, John E. Dick, PhD FRS, Eric R. Lechman, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32.
https://doi.org/10.1182/blood-2020-142963
Published: 2020
Journal Articles

Dichotomous Regulation of Lysosomes By MYC and Tfeb Controls Hematopoietic Stem Cell Fate

Laura Garcia Prat, PhD BSc, MSc, Kerstin B Kaufmann, PhD, Florin Schneiter, Veronique Voisin, PhD, Alex Murison, Michelle Chan-Seng-Yue, Olga I. Gan, PhD, Jessica L. McLeod, Michelle Shoong, Kristele Pan, Kinam Gupta, Shin-Ichiro Takayanagi, PhD, Elvin Wagenblast, PhD, Weijia Wang, Timm Schroeder, PhD, Stephanie Zhi-Juan Xie, PhD, John E. Dick, PhD FRS
Journal: Blood
Blood (2020) 136 (Supplement 1): 34.
https://doi.org/10.1182/blood-2020-142671
Published: 2020
Journal Articles

Erythropoiesis Failure in Diamond-Blackfan Anemia Starts at the Oligopotent Common Myeloid and Megakaryocyte-Erythroid Progenitor Stage

Richard N Armstrong, PhDBSc, Mariana Benicio, PhD, Houtan Moshiri, PhD, Hongbing Li, PhD, Bozana Zlateska, MD MSc, Olga I. Gan, PhD, Eric R Lechman, PhD, John E. Dick, PhD FRS, Yigal Dror, MD FRCPC
Journal: Blood
Blood (2020) 136 (Supplement 1): 37.
https://doi.org/10.1182/blood-2020-143103
Published: 2020
Journal Articles

A Human Model of Down Syndrome Associated Leukemia Reveals Different Cell of Origins for Initiation and Progression

Elvin Wagenblast, PhD, Joana Araújo, MD, Olga I. Gan, PhD, Sarah K Cutting, Alex Murison, Jessica L. McLeod, Gabriela Krivdova, BSc, Maria Azkanaz, Sabrina A Smith, Johann K Hitzler, MD, John E. Dick, PhD FRS, Eric R Lechman, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-135867
Published: 2020
Journal Articles

Divergent Levels of CD112 and INKA1 Define a Subset of Human Hematopoietic Stem Cells That Resists Regenerative Stress to Preserve Stemness

Kerstin B Kaufmann, PhD, Andy G.X. Zeng, BSc, Etienne Coyaud, Laura Garcia Prat, PhD BSc, MSc, Efthymia Papalexi, BA, Estelle MN Laurent, Michelle Chan-Seng-Yue, Olga I. Gan, PhD, Kristele Pan, Jessica L. McLeod, Sasan Zandi, Shin-Ichiro Takayanagi, PhD, Rahul Satija, Brian Raught, Stephanie Zhi-Juan Xie, PhD, John E. Dick, PhD FRS
Journal: Blood
Blood (2020) 136 (Supplement 1): 5.
https://doi.org/10.1182/blood-2020-137725
Published: 2020
Journal Articles

Understanding Pre-Leukemia in Trisomy 21 Human HSC and Modeling Progression Towards Down Syndrome Associated Leukemia Using CRISPR/Cas9 at Single Cell Resolution

Elvin Wagenblast, PhD, Olga I. Gan, PhD, Maria Azkanaz, Sabrina A. Smith, Joana Araújo, MD, Lorien Shakib, Jessica L. McLeod, Gabriela Krivdova, Johann K. Hitzler, MD, Eric R. Lechman, PhD, John E. Dick, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2531.
https://doi.org/10.1182/blood-2019-129259
Published: 2019
Journal Articles

Genetic Analysis of B-Cell Acute Lymphoblastic Leukemia Dissemination to the Central Nervous System Identifies Clonal Selection and Therapeutic Vulnerability

Robert Vanner, MD PhD, Stephanie M. Dobson, PhD, Ildiko Grandal, MSc, Olga I. Gan, PhD, Jessica McLeod, BSc, James Kennedy, MD PhD, Veronique Voisin, PhD, Cynthia Guidos, PhD, Jayne S. Danska, PhD, Esme Waanders, PhD, Mark D. Minden, MD PhD, Charles G. Mullighan, MBBS, MD, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1542.
https://doi.org/10.1182/blood-2018-99-115191
Published: 2018
Journal Articles

Modeling the Initiation and Evolution of Down Syndrome Associated Leukemia Using CRISPR/Cas9

Elvin Wagenblast, PhD, Gabriela Krivdova, BSc, MSc, Lorien Shakib, Maria Azkanaz, Olga I. Gan, Eric R. Lechman,, PhD MSC, John E. Dick
Journal: Blood
Blood (2018) 132 (Supplement 1): 3891.
https://doi.org/10.1182/blood-2018-99-110363
Published: 2018
Journal Articles

A Stemness Screen Reveals C3ORF54/INKA1 As a Gate-Keeper of Human Stem Cell Latency

Kerstin B. Kaufmann, PhD, Laura Garcia Prat, Shin-Ichiro Takayanagi, PhD, Jessica McLeod, BSc, Olga I. Gan, Kristele Pan, Stephanie Zhi-Juan Xie, PhD, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 325.
https://doi.org/10.1182/blood-2018-99-115065
Published: 2018
Journal Articles

Relapse-Initiating Clones Preexisting at Diagnosis in B- Cell Acute Lymphoblastic Leukemia Help Predict Molecular Pathways of Relapse

Laura Garcia Prat, Stephanie M. Dobson, PhD, Michelle Chan-Seng-Yue, Robert Vanner, MD PhD, Alex Murison, Jeffery Wintersinger, Esme Waanders, PhD, Olga I. Gan, PhD, Jessica McLeod, BSc, Debbie Payne-Turner, Michael Edmonson, Zhaohui Gu, PhD, Xiaotu Ma, Yiping Fan, Pankaj Gupta, Michael Rusch, BS, Ying Shao, John Easton, PhD, Jinghui Zhang, Mark D. Minden, MD PhD, Quaid Morris, Mathieu Lupien, Charles G. Mullighan, MBBS, MD, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 915.
https://doi.org/10.1182/blood-2018-99-118998
Published: 2018
Journal Articles

Functional and Molecular Consequences of Trisomy 21 on Human Fetal Hematopoiesis

Elvin Wagenblast, PhD, Gabriela Krivdova, BSc, MSc, Olga I. Gan, PhD, Johann K. Hitzler, MD, John E. Dick, PhD, Eric R. Lechman, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1317.
https://doi.org/10.1182/blood-2018-99-119734
Published: 2018
Journal Articles

Sphingosine-1-Phosphate Receptor 3 (S1PR3) Promotes Myeloid Commitment of Human Hematopoietic and Leukemic Stem Cells

Stephanie Zhi-Juan Xie, PhD, Kerstin Kaufmann, PhD, Olga I. Gan, PhD, Elisa Laurenti, PhD, Stanley W.K. Ng, Qiang Liu, Melissa Kleinau, Joseph Jargostf, Gareth Holmes, Chiara Luberto, PhD, Lina M Obeid, MD, Yusuf A. Hannun, MD, Jean C.Y. Wang, MD PhD, Mark D. Minden, MD PhD, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1329.
https://doi.org/10.1182/blood-2018-99-119128
Published: 2018
Journal Articles

Inactivation of Stage-Specific B-Cell Commitment Genes Generates Distinct Molecular Subtypes of BCR-ABL1 Lymphoblastic Leukemia

Jaeseung C. Kim, MSc, Michelle Chan-Seng-Yue, Gavin W. Wilson, PhD, Andrea Arruda, Karen Ng, Olga I. Gan, PhD, Stephanie M. Dobson, PhD, Paul M. Krzyzanowski, PhD, Johann K. Hitzler, MD, Anne Tierens, MD PhD, John E. Dick, PhD, Mark D. Minden, MD PhD, John D. McPherson, PhD, Faiyaz Notta, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 569.
https://doi.org/10.1182/blood-2018-99-116981
Published: 2018
Journal Articles

Microrna-130a Regulates Hematopoietic Stem Cell Self-Renewal By Repressing Chromatin Modifiers and Shaping the Accessible Chromatin Landscape

Gabriela Krivdova, BSc, MSc, Schoof E Erwin, Veronique Voisin, PhD, Alex Murison, Karin G. Hermans, Laura Garcia Prat, Olga I. Gan, Elvin Wagenblast, PhD, Aaron Trotman-Grant, Eric R. Lechman,, PhD MSC, Mark D. Minden, MD PhD, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3824.
https://doi.org/10.1182/blood-2018-99-116866
Published: 2018
Journal Articles

Sphingolipid Perturbation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal

Stephanie Zhi-Juan Xie, PhD, Laura Garcia Prat, Veronique Voisin, PhD, Alex Murison, Olga I. Gan, Robin Ferrari, Naoya Takayama, MD PhD, Kerstin B. Kaufmann, PhD, Ishita Patel, Esther Lee, Gareth Holmes, Tiago Medina, PhD, Aditi Vedi, Chiara Luberto, PhD, Gary D Bader, Elisa Laurenti, PhD, Mathieu Lupien, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 170.
https://doi.org/10.1182/blood-2018-170
Published: 2018
Journal Articles

Linking Subclonal Genetic Diversity with Functional Heterogeneity Identifies Diagnosis Subclones Destined to Relapse

Stephanie M. Dobson, Esme Waanders, PhD, Robert Vanner, PhD, Olga I Gan, PhD, Jessica McLeod, Ildiko Grandal, MSc, Debbie Payne-Turner, BA, Michael Edmonson, PhD, Zhaohui Gu, PhD, Xiaotu Ma, PhD, Yiping Fan, Sagi Abelson, PhD, Pankaj Gupta, Michael Rusch, Ying Shao, Lei Shi, PhD, Stanley Pounds, PhD, Scott Olsen, Geoffrey A. Neale, PhD, John Easton, PhD, Cynthia J. Guidos, PhD, Jayne S. Danska, PhD, Jinghui Zhang, PhD, Mark D. Minden, MD PhD, Charles G. Mullighan, MBBS(Hons), MSc, MD, John E. Dick, PhD
Journal: Blood
Blood (2016) 128 (22): 605.
https://doi.org/10.1182/blood.V128.22.605.605
Published: 2016
Journal Articles

Sphingolipids Regulate Myeloid-Erythroid Fate Determination in Human Hematopoiesis

Stephanie Zhi-Juan Xie, PhD, Kerstin Kaufmann, Olga I Gan, PhD, Sasan Zandi, MD PhD, Naoya Takayama, John E. Dick, PhD
Journal: Blood
Blood (2016) 128 (22): 3865.
https://doi.org/10.1182/blood.V128.22.3865.3865
Published: 2016
Journal Articles

The Human Blood Hierarchy Is Shaped By Distinct Progenitor Lineages Across Development

Sasan Zandi, MDPhD, Faiyaz Notta, John E. Dick, PhD, Naoya Takayama, Stephanie M Dobson, MSc, Olga I Gan, PhD, Gavin Wilson, Kerstin Kaufmann, Jessica McLeod, Elisa Laurenti, PhD, Cyrille Dunant, Mcpherson John, Lincoln Stein, Yigal Dror, MD FRCP(C)
Journal: Blood
Blood (2015) 126 (23): 2360.
https://doi.org/10.1182/blood.V126.23.2360.2360
Published: 2015