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Journal Articles

Leptin-Enhanced JAK-STAT Signaling in Acute Myeloid Leukemia-Derived Mesenchymal Stromal Cells and Its Implications for Disease Progression

Muzaffar Bhatti, Anthea Travas, Oyeronke Ayansola, Amirthagowri Ambalavanan, Jaeyoon John Kim, Danielle Pyne, Troy Ketela, Andrea Arruda, Mark D. Minden, Armand Keating, Dennis Dong Hwan Kim

Blood (2024) 144 (Supplement 1): 5664.

https://doi.org/10.1182/blood-2024-211349

Published: 2024

Journal Articles

Single-Cell Proteogenomic Analysis of Clonal Evolution in Patient-Derived Xenograft Models of AML Treated with IDH Inhibitors

Alex Liu, Severine Cathelin, Yitong Yang, Farzaneh Aboualizadeh, Amina Abow, Gurbaksh Basi, Lance Li, David L Dai, Abdula Maher, Eric Grignano, Mohsen Hosseini, Dhanoop Manikoth Ayyathan, Vivian Wang, Troy Ketela, Dylan Marchione, Adriana Tron, Andrea Arruda, Mark D. Minden, Steven M. Chan

Blood (2024) 144 (Supplement 1): 4995.

https://doi.org/10.1182/blood-2024-211634

Published: 2024

Journal Articles

The Mitochondrial Unfolded Protein Response (UPR mt ) Is Upregulated in Acute Myeloid Leukemia (AML) and Inhibiting the UPR mt Protease, LONP1, Leads to Mitochondrial Protein Aggregation and Cell Death Selectively in AML

Matthew Tcheng, Veronique Voisin, Marcela Gronda, Rose Hurren, Dakai Ling, Yongran Yan, Lan Xin Zhang, Yue Feng, Zaynab Mamai, Yulia Jitkova, Chaitra Sarathy, Andrea Arruda, Steven M. Kornblau, Mark D. Minden, Aaron D Schimmer

Blood (2024) 144 (Supplement 1): 2778.

https://doi.org/10.1182/blood-2024-205308

Published: 2024

Journal Articles

Blood-Based Proteomic Profiling Identifies Osmr As a Novel Biomarker

Hussein A. Abbas, Bofei Wang, Jennifer Marvin-Peek, Bin Yuan, Araceli Isabella Garza, Jessica Lynn Root, Andrea Arruda, Yiwei Liu, Courtney D. DiNardo, Tapan M. Kadia, Naval Daver, Philip L Lorenzi, Koji Sasaki, Steven M. Kornblau, Mark D. Minden, Farhad Ravandi, Hagop M. Kantarjian, Patrick K. Reville

Blood (2024) 144 (Supplement 1): 2912.

https://doi.org/10.1182/blood-2024-201725

Published: 2024

Journal Articles

Targeted Protein Degradation Reveals a Repressive Role of Mecom at the CEBPA Locus to Prevent Differentiation in High-Risk Acute Myeloid Leukemia

Travis Fleming, Richard A Voit, Mateusz Antoszewski, Sander Lambo, Michael Gundry, Riccardo Piussi, Sanjana Shah, Lara Wahlster, Andrea Arruda, Volker Hovestadt, Mark D. Minden, Vijay G. Sankaran

Blood (2024) 144 (Supplement 1): 953.

https://doi.org/10.1182/blood-2024-199697

Published: 2024

Journal Articles

The Exportin, CSE1L, Regulates Ribosome Biogenesis and Is a Selective Dependency in Childhood and Young Adult Acute Myeloid Leukemia

Grace Egan, Amit Kumar, Veronique Voisin, Rose Hurren, Ali Chegini, Dakai Ling, Geethu Emily Thomas, Youngran Yan, Yue Feng, Suraj Bansal, Andy G.X. Zeng, Andrea Arruda, John Edgar Dick, Gary D Bader, Mark D. Minden, Aaron D Schimmer

Blood (2024) 144 (Supplement 1): 2724.

https://doi.org/10.1182/blood-2024-200148

Published: 2024

Journal Articles

AML Cells Have Increased Mitochondrial RNA Degradation and Inhibiting This Degradation Promotes Cell Differentiation, Decreases Viability, and Increases Sensitivity to Immune-Mediated Killing

Geethu Emily Thomas, Kazem Nouri, Rose Hurren, JongBok Lee, Veronique Voisin, Yongran Yan, Neil Maclean, Marcela Gronda, Yulia Jitkova, Taylor Barbieri, Li Ma, Xiaoming Wang, Andrea Arruda, Mark D. Minden, Li Zhang, Aaron D Schimmer

Blood (2024) 144 (Supplement 1): 2723.

https://doi.org/10.1182/blood-2024-194861

Published: 2024

Journal Articles

Examining the Clinical Relevance of the AML Plasma Metabolome

Cristiana O'Brien, Nirvana Nursimulu, Rachel Culp-Hill, Julie A Reisz Haines, Andrea Arruda, Mark D. Minden, Angelo D'Alessandro, Sushant Kumar, Kristin J. Hope, Courtney Jones

Blood (2024) 144 (Supplement 1): 2937.

https://doi.org/10.1182/blood-2024-203960

Published: 2024

Journal Articles

AML Drug Tolerant Persister (DTP) Cells Survive Chemotherapy By Transiently Altering Cellular Lipidomics to Increase Plasma Membrane Rigidity, but Also Increases Sensitivity to Immune Cell Killing

Yael Morgenstern, JongBok Lee, Yoosu Na, William Gwynne, Rose Hurren, Li Ma, Marcela Gronda, Chaitra Sarathy, Arvind Mer, Andrea Arruda, Avraham Frisch, Tsila Zuckerman, Yishai Ofran, Mark D. Minden, Li Zhang, Catherine O'Brien, J. Rafael Montenegro-Burke, Aaron D. Schimmer

Blood (2023) 142 (Supplement 1): 2806.

https://doi.org/10.1182/blood-2023-178995

Published: 2023

Journal Articles

Inhibiting Mitochondrial RNA Degradosome Complex SUV3 and PNPT1 Increases dsRNA in the Cytoplasm, Triggers Viral Mimicry Response and Sensitizes AML Cells to Immune Mediated Killing

Geethu Emily Thomas, Kazem Nouri, Jong Bok Lee, Rose Hurren, Yongran Yan, Neil Maclean, Yulia Jitkova, Li Ma, Xiaoming Wang, Chaitra Sarathy, Andrea Arruda, Mark D. Minden, Li Zhang, Vito Spadavecchio, Aaron D. Schimmer

Blood (2023) 142 (Supplement 1): 2742.

https://doi.org/10.1182/blood-2023-178696

Published: 2023

Journal Articles

Polyamines Are Required for AML LSC Function through Their Role in Regulating eIF5A Dependent Protein Synthesis

Vincent Rondeau, Rachel Culp-Hill, Julie A Reisz, Duhan Yendi, Aarushi Gupta, Jacob Berman, Cristiana O'Brien, Tianyi Ling, Aleksandra Bourdine, Mary Shi, Jonathan St-Germain, Soheil Jahangiri, Anastasia N. Tikhonova, Andrea Arruda, Mark D. Minden, Brian Raught, Angelo D'Alessandro, Courtney L Jones

Blood (2023) 142 (Supplement 1): 585.

https://doi.org/10.1182/blood-2023-187283

Published: 2023

Journal Articles

Intracellular IL-23 Receptor (IL-23R) Is a Regulator of Mitotic Spindle and Centrosome Formation and Is Essential for AML Viability

Blood (2023) 142 (Supplement 1): 5694.

https://doi.org/10.1182/blood-2023-174536

Published: 2023

Journal Articles

Presence of Recurrent Somatic Mutations in Mesenchymal Stromal Cell Fractions Isolated from Acute Myeloid Leukemia As an Evidence of Clonality

Muzaffar Bhatti, Taehyung Kim, Jenny Warrington, Amirthagowri Ambalavanan, Sarah Zarabi, Anthea Travas, Jaeyoon John Kim, Danielle Pyne, Troy Ketela, Andrea Arruda, Mark D. Minden, Armand Keating, Dennis Dong Hwan Kim

Blood (2023) 142 (Supplement 1): 6042.

https://doi.org/10.1182/blood-2023-185149

Published: 2023

Journal Articles

The Atpase Domain of LONP1 Is Necessary for Mitochondrial Protein Solubility and the Viability of Acute Myeloid Leukemia (AML) Cells

Matthew Tcheng, Aaron D. Schimmer, Marcela Gronda, Rose Hurren, Shahbaz Khan, Lan Xin Zhang, Chaitra Sarathy, Yongran Yan, Andrea Arruda, Thomas Kislinger, Mark D. Minden

Blood (2023) 142 (Supplement 1): 1420.

https://doi.org/10.1182/blood-2023-178399

Published: 2023

Journal Articles

Inflammatory Signatures Define a New High-Risk T-Lineage ALL Subtype

Blood (2023) 142 (Supplement 1): 2969.

https://doi.org/10.1182/blood-2023-182412

Published: 2023

Journal Articles

DNA Methylation Instability: A Novel Biomarker for Aging, Clonality, and Cancer

Salman Basrai, Robert Kridel, Mehran Bakhtiari, Dennis D. H. Kim, Fernando L. Scolari, Filio Billia, Andrea Arruda, Mark D. Minden, Sagi Abelson

Blood (2023) 142 (Supplement 1): 4059.

https://doi.org/10.1182/blood-2023-173489

Published: 2023

Journal Articles

Identification of Unexpected Responders to Gilteritinib in a Cohort of FLT3-WT AML Patients Using Ex-Vivo Testing

Blood (2023) 142 (Supplement 1): 7132.

https://doi.org/10.1182/blood-2023-181119

Published: 2023

Journal Articles

Functional Ex-Vivo Testing Combined with Machine Learning Predicts Clinical Response to Azacitidine+Venetoclax in AML

Blood (2023) 142 (Supplement 1): 2274.

https://doi.org/10.1182/blood-2023-187284

Published: 2023

Journal Articles

Stem Cell-Derived Gene Expression Scores Predict Survival and Leukemic Transformation in Myelofibrosis

Jessie J.F. Medeiros, Andy G.X. Zeng, Michelle Chan-Seng-Yue, Tristan Woo, Jessica L McLeod, Andrea Arruda, Hubert Tsui, Burhan Goraya, Jaime O. Claudio, Jenny M. Ho, James A. Kennedy, Dawn Maze, Hassan Sibai, Mark D. Minden, Jean C.Y. Wang, John E. Dick, Vikas Gupta

Blood (2022) 140 (Supplement 1): 9681–9682.

https://doi.org/10.1182/blood-2022-163722

Published: 2022

Journal Articles

Inhibiting the Mitochondrial RNA Degradosome Complex SUV3 and Pnpase Increases dsRNA in the Cytoplasm, Triggers a Viral Mimicry Response and Kills AML Cells and Progenitors

Geethu Emily Thomas, Kazem Nouri, Rose Hurren, Yongran Yan, Neil MacLean, Yulia Jitkova, Li Ma, Xiaoming Wang, Chaitra Sarathy, Andrea Arruda, Mark D. Minden, Vito Spadevecchio, Aaron D. Schimmer

Blood (2022) 140 (Supplement 1): 8723–8724.

https://doi.org/10.1182/blood-2022-158326

Published: 2022

NARROW

Leptin-Enhanced JAK-STAT Signaling in Acute Myeloid Leukemia-Derived Mesenchymal Stromal Cells and Its Implications for Disease Progression

Single-Cell Proteogenomic Analysis of Clonal Evolution in Patient-Derived Xenograft Models of AML Treated with IDH Inhibitors

The Mitochondrial Unfolded Protein Response (UPR mt ) Is Upregulated in Acute Myeloid Leukemia (AML) and Inhibiting the UPR mt Protease, LONP1, Leads to Mitochondrial Protein Aggregation and Cell Death Selectively in AML

Blood-Based Proteomic Profiling Identifies Osmr As a Novel Biomarker

Targeted Protein Degradation Reveals a Repressive Role of Mecom at the CEBPA Locus to Prevent Differentiation in High-Risk Acute Myeloid Leukemia

The Exportin, CSE1L, Regulates Ribosome Biogenesis and Is a Selective Dependency in Childhood and Young Adult Acute Myeloid Leukemia

AML Cells Have Increased Mitochondrial RNA Degradation and Inhibiting This Degradation Promotes Cell Differentiation, Decreases Viability, and Increases Sensitivity to Immune-Mediated Killing

Examining the Clinical Relevance of the AML Plasma Metabolome

AML Drug Tolerant Persister (DTP) Cells Survive Chemotherapy By Transiently Altering Cellular Lipidomics to Increase Plasma Membrane Rigidity, but Also Increases Sensitivity to Immune Cell Killing

Inhibiting Mitochondrial RNA Degradosome Complex SUV3 and PNPT1 Increases dsRNA in the Cytoplasm, Triggers Viral Mimicry Response and Sensitizes AML Cells to Immune Mediated Killing

Polyamines Are Required for AML LSC Function through Their Role in Regulating eIF5A Dependent Protein Synthesis

Intracellular IL-23 Receptor (IL-23R) Is a Regulator of Mitotic Spindle and Centrosome Formation and Is Essential for AML Viability

Presence of Recurrent Somatic Mutations in Mesenchymal Stromal Cell Fractions Isolated from Acute Myeloid Leukemia As an Evidence of Clonality

The Atpase Domain of LONP1 Is Necessary for Mitochondrial Protein Solubility and the Viability of Acute Myeloid Leukemia (AML) Cells

Inflammatory Signatures Define a New High-Risk T-Lineage ALL Subtype

DNA Methylation Instability: A Novel Biomarker for Aging, Clonality, and Cancer

Identification of Unexpected Responders to Gilteritinib in a Cohort of FLT3-WT AML Patients Using Ex-Vivo Testing

Functional Ex-Vivo Testing Combined with Machine Learning Predicts Clinical Response to Azacitidine+Venetoclax in AML

Stem Cell-Derived Gene Expression Scores Predict Survival and Leukemic Transformation in Myelofibrosis

Inhibiting the Mitochondrial RNA Degradosome Complex SUV3 and Pnpase Increases dsRNA in the Cytoplasm, Triggers a Viral Mimicry Response and Kills AML Cells and Progenitors

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American Society of Hematology

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ASH Publications

American Society of Hematology

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