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Journal Articles

CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias

Blood (2025) 146 (25): 3019–3035.

https://doi.org/10.1182/blood.2025028954

Published: 2025

Includes: Supplemental data

Journal Articles

Plasma lipid levels predict chemotherapy response and survival in acute myeloid leukemia

Cristiana O’Brien, Nirvana Nursimulu, Anit Tyagi, Rachel Culp-Hill, Andrea Arruda, Tracy Murphy, Mark D. Minden, Andrew Kent, Brett Stevens, Daniel A. Pollyea, Kristin Hope, Sushant Kumar, Julie A. Reisz, Angelo D'Alessandro, Courtney L. Jones

Blood (2025) 146 (21): 2589–2596.

https://doi.org/10.1182/blood.2025029132

Published: 2025

Includes: Supplemental data

Journal Articles

Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation

Blood blood.2025028933.

https://doi.org/10.1182/blood.2025028933

Published: 2025

Includes: Supplemental data

Journal Articles

Clonal persistence and early cooperative mutations shape transformation in myelofibrosis

Noushin Farnoud, Kamal Menghrajani, Paola Guglielmelli, Christopher Famulare, Erin McGovern, Giuseppe Gaetano Loscocco, Andriy Derkach, Andrew Dunbar, Naseema Gangat, Vikas Gupta, Andrea Arruda, Taghi Manshouri, Srdan Verstovsek, Andrew Kuykendall, Vincent Ho, Auro Viswabandya, Joachim Deeg, Thomas Monahan, Tania Jain, Jeanne Palmer, Alla Keyzner, Aaron Gerds, Alexandra Gomez-Arteaga, Nikolai Podoltsev, Roni Tamari, Helen Ajufo, Satyajit Kosuri, Haris Ali, Idoroenyi Amanam, Jordan Chervin, Minal Patel, Jesús Gutiérrez-Abril, Sarun Sereewattanawoot, Juan Arango Ossa, Francesco Passamonti, Francesco Maura, Maymona Abdelmagid, Ahmed Abdelrheem, Yassin Bashir, Muhammad Yousuf, Animesh Pardanani, Kapila Viges, David Shoultz, Rick Winneker, Omar Abdel-Wahab, John Mascarenhas, Ronald Hoffman, Ross Levine, Elli Papaemmanuil, Alessandro Vannucchi, Ayalew Tefferi, Raajit Rampal

Blood (2025) 146 (Supplement 1): 2046.

https://doi.org/10.1182/blood-2025-2046

Published: 2025

Journal Articles

The mitochondrial protease YME1L regulates type 1 interferon signaling via the cgas-sting pathway in AML

Yihe Zhang, Geethu Thomas, Rose Hurren, Yongran Yan, Dakai Ling, Marcela Gronda, Andrea Arruda, Mark Minden, Aaron Schimmer

Blood (2025) 146 (Supplement 1): 6765.

https://doi.org/10.1182/blood-2025-6765

Published: 2025

Journal Articles

Emergence of new somatic mutations in CML patients optimally responding to tyrosine kinase inhibitor therapy: Proposal of long-term genomic monitoring

Yael Morgenstern, Gopila Gupta, Flavia Patino, Maria Perusini, Daniela Zackova, Ivana Jeziskova, Anezka Kvetkova, Tomas Jurcek, Azin Keshavarz, Danielle Pyne, Oyeronke Ayansola, Amirthagowri Ambalavanan, Jiri Mayer, Andrea Arruda, Mark Minden, Jessie Medeiros, Sagi Abelson, Dennis Kim

Blood (2025) 146 (Supplement 1): 3767.

https://doi.org/10.1182/blood-2025-3767

Published: 2025

Journal Articles

Blood-based proteomic profiling identifies OSMR as a novel biomarker of AML outcomes

Blood (2025) 145 (25): 3015–3029.

https://doi.org/10.1182/blood.2024027244

Published: 2025

Includes: Supplemental data

Journal Articles

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells

Blood (2025) 145 (20): 2361–2373.

https://doi.org/10.1182/blood.2024025886

Published: 2025

Includes: Supplemental data

Journal Articles

Single-Cell Proteogenomic Analysis of Clonal Evolution in Patient-Derived Xenograft Models of AML Treated with IDH Inhibitors

Alex Liu, Severine Cathelin, Yitong Yang, Farzaneh Aboualizadeh, Amina Abow, Gurbaksh Basi, Lance Li, David L Dai, Abdula Maher, Eric Grignano, Mohsen Hosseini, Dhanoop Manikoth Ayyathan, Vivian Wang, Troy Ketela, Dylan Marchione, Adriana Tron, Andrea Arruda, Mark D. Minden, Steven M. Chan

Blood (2024) 144 (Supplement 1): 4995.

https://doi.org/10.1182/blood-2024-211634

Published: 2024

Journal Articles

The Exportin, CSE1L, Regulates Ribosome Biogenesis and Is a Selective Dependency in Childhood and Young Adult Acute Myeloid Leukemia

Grace Egan, Amit Kumar, Veronique Voisin, Rose Hurren, Ali Chegini, Dakai Ling, Geethu Emily Thomas, Youngran Yan, Yue Feng, Suraj Bansal, Andy G.X. Zeng, Andrea Arruda, John Edgar Dick, Gary D Bader, Mark D. Minden, Aaron D Schimmer

Blood (2024) 144 (Supplement 1): 2724.

https://doi.org/10.1182/blood-2024-200148

Published: 2024

Journal Articles

AML Cells Have Increased Mitochondrial RNA Degradation and Inhibiting This Degradation Promotes Cell Differentiation, Decreases Viability, and Increases Sensitivity to Immune-Mediated Killing

Geethu Emily Thomas, Kazem Nouri, Rose Hurren, JongBok Lee, Veronique Voisin, Yongran Yan, Neil Maclean, Marcela Gronda, Yulia Jitkova, Taylor Barbieri, Li Ma, Xiaoming Wang, Andrea Arruda, Mark D. Minden, Li Zhang, Aaron D Schimmer

Blood (2024) 144 (Supplement 1): 2723.

https://doi.org/10.1182/blood-2024-194861

Published: 2024

Journal Articles

Targeted Protein Degradation Reveals a Repressive Role of Mecom at the CEBPA Locus to Prevent Differentiation in High-Risk Acute Myeloid Leukemia

Travis Fleming, Richard A Voit, Mateusz Antoszewski, Sander Lambo, Michael Gundry, Riccardo Piussi, Sanjana Shah, Lara Wahlster, Andrea Arruda, Volker Hovestadt, Mark D. Minden, Vijay G. Sankaran

Blood (2024) 144 (Supplement 1): 953.

https://doi.org/10.1182/blood-2024-199697

Published: 2024

Journal Articles

The Mitochondrial Unfolded Protein Response (UPR mt) Is Upregulated in Acute Myeloid Leukemia (AML) and Inhibiting the UPR mt Protease, LONP1, Leads to Mitochondrial Protein Aggregation and Cell Death Selectively in AML

Matthew Tcheng, Veronique Voisin, Marcela Gronda, Rose Hurren, Dakai Ling, Yongran Yan, Lan Xin Zhang, Yue Feng, Zaynab Mamai, Yulia Jitkova, Chaitra Sarathy, Andrea Arruda, Steven M. Kornblau, Mark D. Minden, Aaron D Schimmer

Blood (2024) 144 (Supplement 1): 2778.

https://doi.org/10.1182/blood-2024-205308

Published: 2024

Journal Articles

Examining the Clinical Relevance of the AML Plasma Metabolome

Cristiana O'Brien, Nirvana Nursimulu, Rachel Culp-Hill, Julie A Reisz Haines, Andrea Arruda, Mark D. Minden, Angelo D'Alessandro, Sushant Kumar, Kristin J. Hope, Courtney Jones

Blood (2024) 144 (Supplement 1): 2937.

https://doi.org/10.1182/blood-2024-203960

Published: 2024

Journal Articles

Blood-Based Proteomic Profiling Identifies Osmr As a Novel Biomarker

Hussein A. Abbas, Bofei Wang, Jennifer Marvin-Peek, Bin Yuan, Araceli Isabella Garza, Jessica Lynn Root, Andrea Arruda, Yiwei Liu, Courtney D. DiNardo, Tapan M. Kadia, Naval Daver, Philip L Lorenzi, Koji Sasaki, Steven M. Kornblau, Mark D. Minden, Farhad Ravandi, Hagop M. Kantarjian, Patrick K. Reville

Blood (2024) 144 (Supplement 1): 2912.

https://doi.org/10.1182/blood-2024-201725

Published: 2024

Journal Articles

Leptin-Enhanced JAK-STAT Signaling in Acute Myeloid Leukemia-Derived Mesenchymal Stromal Cells and Its Implications for Disease Progression

Muzaffar Bhatti, Anthea Travas, Oyeronke Ayansola, Amirthagowri Ambalavanan, Jaeyoon John Kim, Danielle Pyne, Troy Ketela, Andrea Arruda, Mark D. Minden, Armand Keating, Dennis Dong Hwan Kim

Blood (2024) 144 (Supplement 1): 5664.

https://doi.org/10.1182/blood-2024-211349

Published: 2024

Journal Articles

Identification of Unexpected Responders to Gilteritinib in a Cohort of FLT3-WT AML Patients Using Ex-Vivo Testing

Blood (2023) 142 (Supplement 1): 7132.

https://doi.org/10.1182/blood-2023-181119

Published: 2023

Journal Articles

The Atpase Domain of LONP1 Is Necessary for Mitochondrial Protein Solubility and the Viability of Acute Myeloid Leukemia (AML) Cells

Matthew Tcheng, Aaron D. Schimmer, Marcela Gronda, Rose Hurren, Shahbaz Khan, Lan Xin Zhang, Chaitra Sarathy, Yongran Yan, Andrea Arruda, Thomas Kislinger, Mark D. Minden

Blood (2023) 142 (Supplement 1): 1420.

https://doi.org/10.1182/blood-2023-178399

Published: 2023

Journal Articles

Polyamines Are Required for AML LSC Function through Their Role in Regulating eIF5A Dependent Protein Synthesis

Vincent Rondeau, Rachel Culp-Hill, Julie A Reisz, Duhan Yendi, Aarushi Gupta, Jacob Berman, Cristiana O'Brien, Tianyi Ling, Aleksandra Bourdine, Mary Shi, Jonathan St-Germain, Soheil Jahangiri, Anastasia N. Tikhonova, Andrea Arruda, Mark D. Minden, Brian Raught, Angelo D'Alessandro, Courtney L Jones

Blood (2023) 142 (Supplement 1): 585.

https://doi.org/10.1182/blood-2023-187283

Published: 2023

Journal Articles

Inhibiting Mitochondrial RNA Degradosome Complex SUV3 and PNPT1 Increases dsRNA in the Cytoplasm, Triggers Viral Mimicry Response and Sensitizes AML Cells to Immune Mediated Killing

Geethu Emily Thomas, Kazem Nouri, Jong Bok Lee, Rose Hurren, Yongran Yan, Neil Maclean, Yulia Jitkova, Li Ma, Xiaoming Wang, Chaitra Sarathy, Andrea Arruda, Mark D. Minden, Li Zhang, Vito Spadavecchio, Aaron D. Schimmer

Blood (2023) 142 (Supplement 1): 2742.

https://doi.org/10.1182/blood-2023-178696

Published: 2023

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CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias

Plasma lipid levels predict chemotherapy response and survival in acute myeloid leukemia

Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation

Clonal persistence and early cooperative mutations shape transformation in myelofibrosis

The mitochondrial protease YME1L regulates type 1 interferon signaling via the cgas-sting pathway in AML

Emergence of new somatic mutations in CML patients optimally responding to tyrosine kinase inhibitor therapy: Proposal of long-term genomic monitoring

Blood-based proteomic profiling identifies OSMR as a novel biomarker of AML outcomes

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells

Single-Cell Proteogenomic Analysis of Clonal Evolution in Patient-Derived Xenograft Models of AML Treated with IDH Inhibitors

The Exportin, CSE1L, Regulates Ribosome Biogenesis and Is a Selective Dependency in Childhood and Young Adult Acute Myeloid Leukemia

AML Cells Have Increased Mitochondrial RNA Degradation and Inhibiting This Degradation Promotes Cell Differentiation, Decreases Viability, and Increases Sensitivity to Immune-Mediated Killing

Targeted Protein Degradation Reveals a Repressive Role of Mecom at the CEBPA Locus to Prevent Differentiation in High-Risk Acute Myeloid Leukemia

The Mitochondrial Unfolded Protein Response (UPR mt) Is Upregulated in Acute Myeloid Leukemia (AML) and Inhibiting the UPR mt Protease, LONP1, Leads to Mitochondrial Protein Aggregation and Cell Death Selectively in AML

Examining the Clinical Relevance of the AML Plasma Metabolome

Blood-Based Proteomic Profiling Identifies Osmr As a Novel Biomarker

Leptin-Enhanced JAK-STAT Signaling in Acute Myeloid Leukemia-Derived Mesenchymal Stromal Cells and Its Implications for Disease Progression

Identification of Unexpected Responders to Gilteritinib in a Cohort of FLT3-WT AML Patients Using Ex-Vivo Testing

The Atpase Domain of LONP1 Is Necessary for Mitochondrial Protein Solubility and the Viability of Acute Myeloid Leukemia (AML) Cells

Polyamines Are Required for AML LSC Function through Their Role in Regulating eIF5A Dependent Protein Synthesis

Inhibiting Mitochondrial RNA Degradosome Complex SUV3 and PNPT1 Increases dsRNA in the Cytoplasm, Triggers Viral Mimicry Response and Sensitizes AML Cells to Immune Mediated Killing

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